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1. Systemic Therapy for Small Cell Lung Cancer: ASCO Guideline Rapid Recommendation Update

Author

Kalemkerian, Gregory P., Khurshid, Humera, Ismaila, Nofisat, Khurshid, Humera, Ismaila, Nofisat, Bian, Jessica, Dabney, Raetasha, Das, Millie, Ellis, Peter, Feldman, Jill, Hann, Christine L., Kulkarni, Swati, Laskin, Janessa, Manochakian, Rami, Mishra, Deebya Raj, Preeshagul, Isabel, Reddy, Pavan, Saxena, Ashish, Weinberg, Frank, and Kalemkerian, Gregory P.

Published
2024
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4. NeoRad(Low): A phase 2 trial of neoadjuvant (NA) ipilimumab + nivolumab (ipi+nivo) with low dose stereotactic body radiation therapy (SBRT) as an immune stimulant in patients with resectable stage IB-III non-small cell lung cancer (NSCLC).

Author

DiPetrillo, Thomas A., primary, Garcia-Moliner, Maria, additional, Koffer, Paul, additional, Hepel, Jaroslaw T., additional, Khan, Hina, additional, Khurshid, Humera, additional, Abbas, Abbas, additional, Birnbaum, Ariel E., additional, Olszewski, Adam J., additional, Ferreira, Cheyenne, additional, Hassinger, Faith, additional, Carlin McCormick, Michele, additional, Giesing, Hannah, additional, Rodrigues, Nuno, additional, Rosati, Vallerie, additional, Wood, Roxanne, additional, Webber, Amy, additional, Maleki, Sara, additional, and Azzoli, Christopher G., additional

Published
2024
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6. Systemic Therapy for Small-Cell Lung Cancer: ASCO-Ontario Health (Cancer Care Ontario) Guideline

Author

Khurshid, Humera, primary, Ismaila, Nofisat, additional, Bian, Jessica, additional, Dabney, Raetasha, additional, Das, Millie, additional, Ellis, Peter, additional, Feldman, Jill, additional, Hann, Christine, additional, Kulkarni, Swati, additional, Laskin, Janessa, additional, Manochakian, Rami, additional, Mishra, Deebya Raj, additional, Preeshagul, Isabel, additional, Reddy, Pavan, additional, Saxena, Ashish, additional, Weinberg, Frank, additional, and Kalemkerian, Gregory P., additional

Published
2023
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7. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Harvey, Vernon, Tomek, Rudolf, Robert, Nicholas J., Gore, Ira, Jr., Smith, John W., II, Masuda, Norikazu, Di Sean Kendall, S., Harker, William Graydon, Petrakova, Katarina, Guerrero Zotano, Angel, Simon, Amparo Ruiz, Konstantinovic, Zora Neskovic, Iannotti, Nicholas O., Tassone, Pierfrancesco, Rodriguez, Gladys I., Jáñez Martinez, Noelia, Crespo Massieu, Carmen, Smickoska, Snezana, Somali, Isil, Yilmaz, Ugur, Alonso, Mirta Garcia, Rosales, Adolfo Murias, Cold, Soeren, Knoop, Ann Soegaard, Patt, Debra, Hellerstedt, Beth A., Morales Murillo, Serafin, Mayer, Ingrid A., Means-Powell, Julie Ann, Hui, Rina, Senecal, Francis M., De Boer, Richard Hendry, Shen, Zhenzhou, Luczak, Adam Andrzej, Chui, Joanna W.Y., Tsang, Janice Wing-hang, Lang, Istvan, Rai, Yoshiaki, Hozumi, Yasuo, Ten Tije, Albert J., Bhandari, Manish, Osborne, Cynthia R.C., Ohtani, Shoichiro, Higaki, Kenji, Watanabe, Kenichi, Taguchi, Kazunori, Takahashi, Masato, Filipovic, Sladjana, Hansen, Vincent L., Rao, Vijayarama Phooshkooru, Gupta, Manish, Petrov, Petar, Coudert, Bruno, Vojnovic, Zeljko, Polya, Zsofia, Miyaki, Toshiko, Yamamoto, Naohito, Brincat, Stephen, Lesniewski-Kmak, Krzysztof, Chmielowska, Ewa, Birhiray, Ruemu E., Citron, Marc L., Papish, Steven William, Berry, William R., Langkjer, Sven Tyge, Garcia Sáenz, José Angel, Arance, Ana Maria, Efrat, Noa, Sarosiek, Tomasz, Grzeda, Lukasz, Manalo, Yvonne, Smith, Julie C., Vaziri, Irfan, Healey, Tabitha, Rahim, Yasmin, Luk, Cynthia, Dingle, Brian, Franco, Sandra, Sorensen, Peter Grundtvig, Anand, Anjana, Khan, Sarah, Fountzilas, George, Aogi, Kenjiro, Shimizu, Satoru, Mikulova, Milada, Spanik, Stanislav, Somer, Robert A., Flynn, Patrick J., Coward, Jermaine, Mainwaring, Paul, Jerusalem, Guy, Segura-Ojezzar, Carine, Levy, Christelle, Delozier, Thierry, Khayat, David, Coleman, Robert E., Rolles, Martin J., Maisano, Robert, Nardi, Mario, Ito, Yoshinori, Yumuk, Perran Fulden, Basaran, Gul, Serdar Turhal, Nazim, Wilkinson, Mary J., Green, Nathan B., Sidrys, Algis P., Hallmeyer, Sigrun, Testori, Douglas J., Sridhar, Srikala, Chang, Jose, Sun, Qiang, Jara-Sanchez, Carlos, Rubio, Xabier, Garrido, Maria Lomas, De La Haba Rodriguez, Juan Rafael, Perello Martorell, Antonia, Avelia Mestre, Antoni, Rifa Ferrer, Julio, del Barco Berron, Sonia, Nagy, Zsuzsanna, Tanaka, Maki, Im, Young-Hyuck, Carroll, Robert R., Dickerson, Laura C., Mace, Joseph R., Rivera, Ragene, Klein, Leonard M., Ruxer, Robert, Wilks, Sharon T., Kotasek, Dusan, Popov, Vasil, Taskova, Violina, Marinova-Venkova, Violetka, Timcheva, Constanta, Desbiens, Christine, Ayoub, Jean-Pierre, Grenier, Debjani, Marschner, Norbert, Tesch, Hans, Lueck, Hans-Joachim, Janssen, Jan, Schwaner, Ingo, Wahlstrom, Stine, Brix, Eva Harder, Vallentin, Susanne, Kristensen, Dan, Andreeva, Anna, Glavicic, Vesna, Calvo Plaza, Isabel, Anton Torres, Antonio, Veyret, Corinne, Bergerat, Jean-Pierre, Bourbouloux, Emmanuelle, Ella, Wendy Ann, Algurafi, Hafiz, Robinson, Anne, Kim, Seung Jin, Taguchi, Tetsuya, Juozaityte, Elona, Madretsma, Stanley, Radema, Sandra, Czerniawska-Meier, Malgorzata, Rogowski, Wojciech, Wagnerova, Maria, Richards, Donald A., Tan-Chiu, Elizabeth, Vasileios, Asskikis, Henderson, Charles Arthur, Holden, Viran Roger, Wang, Xiaojia, Tong, Zhongsheng, Yang, Junlan, Gonzalez, Manuel Enrique, Rezai, Mahdi, Hackmann, John, de Dueñas, Eduardo Martinez, de las Heras, Begoña Bermejo, Dourthe, Louis Marie, Chocteau-Bouju, Dorothee, Bougnoux, Philippe, Kakolyris, Stylianos, Kalofonos, Haralabos, Pectasidis, Dimitrios, Ng, Ting Ying, Pajkos, Gabor, Somogyine, Eva Ezer, Tonini, Giuseppe, Giuffrida, Dario, Takao, Shintaro, Ishitobi, Makoto, Inaji, Hideo, Tokuda, Yutaka, Wozniak, Katarzyna, Lungulescu, Dan, Lu, Yen-Shen, Chang, King-Jen, Hill, Julian, Croot, Christopher Charles, Dekker, Albert, Belman, Neil D., Conde, Miguel, Michaelson, Richard A., Kemmer, Kathleen, Chui, Stephen, Luoh, Shiuh-Wen, Nahum, Kenneth, Greenspan, Andrew R., Nichols, Joni C., Encarnacion, Carlos A., Niederman, Thomas M.J., Lee, Theresa, Alexander, Roland, Gordon, Robert, Tomova, Antoanet, Rauch, Daniel, Popescu, Razvan Andrei, Rojas, Gustavo Adolfo, Vanasek, Jaroslav, Neunhoeffer, Tanja, Barinoff, Jana, Graffunder, Gerd, Wolfgang, Abenhardt, Bojko, Peter, Heinrich, Bernhard, von der Assen, Albert, Antonovic, Bogovic Jurij, Adrian, Lene, Ramos Vazquez, Manuel, Gonzalez Santiago, Santiago, Dieras, Veronique, Bishop, Jill Mercia, Perren, Timothy John, Varthalitis, Ioannis, Mavroudis, Dimitris, Georgoulias, Vassilis, Chow, Louis W.C., Yau, Chung Cheung Thomas, Liang, Raymond Hin-Suen, Pikó, Béla, Wéber, Agnes, Kaufman, Bella, Drumea, Karen, Nuzzo, Francesco, De Matteis, Andrea, Carteni, Giacomo, Tokunaga, Eriko, Ishida, Mayumi, Ohno, Shinji, Sato, Nobuaki, Kuroi, Katsumasa, Nishimura, Reiki, Watanabe, Junichiro, Choi, Yoon Ji, Park, Kyong Hwa, Wojtukiewicz, Marek, Jassem, Jacek, Loman, Niklas, Askoy, Sercan, Altundag, Mustafa Kadri, Saip, Pinar, Ali, Muhammad Amjad, Wade, James Lloyd, III, Chien, Amy Jo, Brandt, Debra, Novik, Yelena, Jani, Chirag, Rice, Robert L., Gaffar, Yousuf A. R, Keaton, Mark R., Bajaj, Rajesh, Kimmick, Gretchen, Campbell, David, Turnquest, Theodore, Lucas, Sideras, Dube, Pierre, Xu, Binghe, Schilling, Joerg, Apel, Klaus, Vestlev, Peter Michael, Jensen, Brita Bjerregaard, Haahr, Vera, Lescure, Alvaro Rodriguez, Grana Suarez, Begona, Saura Manich, Cristina, Jacquin, Jean-Philippe, Samreen, Ahmed, Boiangiu, Ion, Dank, Magdolna, Falci, Cristina, Jirillo, Antonio, Cinieri, Saverio, Ueno, Takayuki, Sato, Fumiaki, Yamashiro, Hiroyasu, Sugie, Tomoharu, Lee, Keun Seok, Ro, Jung Sil, Park, In Hae, Bustam, Anita Zarina, Suszko-Kazarnowicz, Malgorzata, Piktel, Artur, Krzemieniecki, Krzysztof, Iorga, Polizenia Georgeta, Yap, Yoon Sim, Kakalejcik, Marian, Sevinc, Alper, Ozguroglu, Mustafa, Chen, Shin-Cheh, Greenberg, Richard H., Eisemann, Allan Daniel, Droder, Robert, Abbasi, M. Rashid, Vaysburd, Marina, Caldera, Humberto Jose, Haley, Barbara Bacsik, Robin, Erwin, Inhorn, Roger C., Hufnagel, David, Kenyon, Peter D., Spremulli, Ellen, Silverman, Paula, Jain, Sharad, Weigand, Robert, Mebis, Jeroen, Koynova, Tatyana, Lesperance, Bernard, Prausova, Jana, Kohne, Claus-Henning, Schneeweiss, Andreas, Jackisch, Christian, Fuxius, Stefan, Cubedo Cervera, Ricardo, Urruticoechea Ribate, Ander, Pernas Simon, Sonia, Valero Gallego, Jose, Arcusa Lanza, Angels, del Pilar Alvarez, Maria, Florian Gerico, Jesus, Cany, Laurent, Stebbing, Justin, Labudovic, Dejan, Gugic, Damir, Vrbanec, Damir, Roila, Fausto, Barni, Sandro, Bidoli, Paolo, Mukai, Hirofumi, Bermudez, Vanessa, Eniu, Alexandru, Mirtsching, Barry C., Ibrahim, Emad, Trey, Joan, Hergenroeder, Paul Francis, Mahmood, Aftab, Gonzalez, Anneliese, Kaplan, Edward H., Ban, Stacy, Patel, Dhimant, Clowney, Billy, Hoelzer, Karen, Schwartz, Garry H., Salkeni, Mohamed, Abraham, Jame, Narula, Sunil, Jabboury, Khaled, Mocharnuk, Robert Scott, McDonough, Richard H., Sikes, David H., Kawanchi, Ronald H., Schlabach, Larry, McCachren, Samuel Spence, Jr., Cosgriff, Thomas M., Dreisbach, Luke, DeMichele, Angela, Pawl, Lawrence, Lucas, Jennifer, Shinn, Lowell C., Alkhouri, Nabiel, Monga, Manish, Lindquist, Deborah L., Anderson, Thomas C., Khurshid, Humera, Witherby, Sabrina, Erickson, Nicholette, Traynor, Ann, Bose, Ron, Pluard, Timothy J., Jones, Michael C., Prakash, Sucharu, Volterra, Fabio, Capo, Gerardo, Flaherty, Lawrence E., Gartner, Elaina, Baidas, Said, Okazaki, Ian, Nguyen, Bichlien, Rakowski, Thomas, Oliff, Ira, Leach, Joseph W., Anderson, Daniel, Kubiak, Kendra, Tsai, Michaela, Vroman, Philippe, Deleu, Ines, Lybaert, Willem, Borms, Marleen, Couture, Felix, Wilson, Jonathan J., Hunt, Gordon, Holland, David R., Mingrone, Walter, Wang, Shusen, Liu, Donggeng, Jiang, Zefei, Benesova, Vera, Smakal, Martin, Garnolova, Petra, Vesper, Anne-Sophie, Neumann, Monika, Janni, Wolfgang, Liedtke, Cornelia, Fischer, Dorothea, Grischke, Eva-Maria, Seeger, Dietmar, Moebus, Volker, Prechtl, Anita, Carlos Camara Toral, Juan, Sanchez Munoz, Alfonso, Gonzalez Jimenez, Sonia, Cassinello Espinosa, Javier, Cirauqui, Beatriz, Margeli Vila, Mireia, Batista Lopez, Norberto, Chacon Lopez-Muniz, Jose Ignacio, de la Cruz Mora, Miguel Angel, Mailliez, Audrey, Vanlemmens, Laurence, Pouessel, Damien, Espie, Marc, Conibear, John, Roylance, Rebecca, Harnett, Adrian, Geffen, David, Ruggeri, Enzo Maria, Gamucci, Teresa, Van Groeningen, Cees J., Banas, Renata, Alkis, Necati, Hou, Ming-Feng, Krie, Amy K., Vrindavanam, Nandagopal S., Howard, Orion M., Citrin, Dennis, Morginstin, Mark S., Desai, Ajit, Sanchez, Ines J., Nixon, David Allen, Jr., Beatty, Patrick G., Edmiston, Kathryn, McLaughlin, Marilyn, Eneman, Jonathan D., Lynch, Cynthia A., O'Brien, Edward, Call, Justin A., Lanier, Keith S., Conlin, Alison, Brooks, Donald J., McIntyre, Kristi, Saltzman, Marc A., Castine, Michael J., III, Ortega, Gregory L., Choi, Young M., Reynolds, Craig H., Brescia, Frankie Ann, Kramer, Rita, Kohn, Aimee D., Micha, John P., Rhee, Jessica M., Shah, Satish, Riseberg, David A., Patterson, William Kevin, Salmon, Jean-Paul, Andre, Chantal, Bols, Alain, D'hondt, Randal, Luce, Sylvie, Nouwynck, Claire, Pelgrims, Gino, Richard, Vincent, Verschuere, Johan, Geldhof, Kurt, Caspar, Clemens, Luo, Rongcheng, Bednarik, Otakar, Schwedler, Kathrin, Schmidt, Marcus, Neumeister, Romy, Bischoff, Joachim, Rack, Brigitte, Repp, Roland, Fries, Stefan, Adrion, Ralf, Schulz, Volker, Klare, Peter, Danei, Mahmoud, Ossenbuhl, Dirk, Kusche, Jakob Manfred, Griesinger, Frank, Baena Canada, Jose Manuel, Martinez del Prado, Purificacion, Machover, David, Mayeur, Didier, Trufflandier, Nathalie, Delecroix, Valerie, Mousseau, Mireille, Mouret-Reynier, Marie-Ange, Nabholtz, Jean-Marc, Chetiyawardana, Anula D., Papandreou, Christos, Hornyak, Lajos, Faluhelyi, Zsolt, Simo, Erzsebet, Di Palma, Mario, Cognetti, Francesco, Gorzegno, Gabriella, Dogliotti, Luigi, Gridelli, Cesare, Falcone, Alfredo, Soto Parra, Hector, Buscarino, Calogero, Im, Seock-Ah, Sanchez Llamas, Benito, Dercksen, Wouter, Erdkamp, Franciscus, Ruit, Jan B., Braun, Hans, Portielje, Joanneke E.A., Ciltas, Aydin, Buyukberber, Suleyman, Benekli, Mustafa, Zahalsky, Andrew J., Jaslow, Rebecca, Thomas, Gary W., Maini, Archana, Wiznitzer, Israel, Khojasteh, Ali, Francisco Gonzalez, Manuel, Kong, Lynn R., Padmanabhan, Aruna, Conkright, William A., Swain, Sandra M., Faig, Douglas E., Jain, Kirti, Yanagihara, Ronald H., Ottaviano, Yvonne, Delmas, Andrew, Steele, Heather A., Rainey, Gordon K., Harris, Penelope J., Burris, Jason K., Rupard, Erik J., Tan, Esther, Whitworth, Pat W., Bova, Abby R., Anderson, Ian C., Shirinian, Mihran, Tin-u, Caesar, O'Rourke, Timothy J., Roberts, Michael S., Francisco, Michael, Pierson, A. Scott, Byeff, Peter D., Kovach, Peter A., Caton, John R., Jr., Rarick, Mark Urban, Schimidt, William G., Jr., Stopeck, Alison T., Swart, Rachel, Carrillo Flores, Maria Regina, Alemany, Carlos A., Lozada, Brennely, Weinstein, Paul L., Wang, Wei, Porubcin, Michael, Ellison, David M., Geils, George F., Rivera, Edgardo, Charif, Mahmoud, Martin, Miguel, Holmes, Frankie A, Ejlertsen, Bent, Delaloge, Suzette, Moy, Beverly, Iwata, Hiroji, von Minckwitz, Gunter, Chia, Stephen K L, Mansi, Janine, Barrios, Carlos H, Gnant, Michael, Tomašević, Zorica, Denduluri, Neelima, Šeparović, Robert, Gokmen, Erhan, Bashford, Anna, Ruiz Borrego, Manuel, Kim, Sung-Bae, Jakobsen, Erik Hugger, Ciceniene, Audrone, Inoue, Kenichi, Overkamp, Friedrich, Heijns, Joan B, Armstrong, Anne C, Link, John S, Joy, Anil Abraham, Bryce, Richard, Wong, Alvin, Moran, Susan, Yao, Bin, Xu, Feng, Auerbach, Alan, Buyse, Marc, and Chan, Arlene

Published
2017
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10. Clinical characteristics, co-mutations and outcomes of advanced non-small cell lung cancer (NSCLC) patients with KRAS mutations.

Author

Muthiah, Arun, primary, Chudasama, Rani, additional, Olszewski, Adam J., additional, Saiganesh, Harish, additional, Kurt, Habibe, additional, Mingrino, Jennifer, additional, Garcia-Moliner, Maria, additional, Azzoli, Christopher G., additional, Khurshid, Humera, additional, Birnbaum, Ariel E., additional, and Khan, Hina, additional

Published
2021
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13. Is there a genomic fingerprint of Radon (Rn)-induced lung cancer (LC)? Comparison of genomic alterations in LC specimens from high and low Rn zones.

Author

Khan, Hina, primary, Saiganesh, Harish, additional, Olszewski, Adam J., additional, Baca, Yasmine, additional, Kastura, Michaela, additional, Vatkevich, John, additional, Patel, Nimesh, additional, Khurshid, Humera, additional, Birnbaum, Ariel E., additional, Liu, Stephen V., additional, Mamdani, Hirva, additional, Kim, Chul, additional, Vanderwalde, Ari M., additional, Raez, Luis E., additional, Socinski, Mark A., additional, Lopes, Gilberto, additional, Pai, Sachin Gopalkrishna, additional, Nieva, Jorge J., additional, Azzoli, Christopher G., additional, and Safran, Howard, additional

Published
2020
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14. TKI-resistant ALK-rearranged lung adenocarcinoma with secondary CTNNB1 p.S45V and tertiary ALK p.I1171N mutations

Author

Ouseph,Madhu M, Taber,Angela, Khurshid,Humera, Madison,Russell, Aswad,Bassam I, Resnick,Murray B, Yakirevich,Evgeny, Ali,Siraj M, and Patel,Nimesh R

Subjects
Targets and Therapy [Lung Cancer]
Abstract

Madhu M Ouseph,1 Angela Taber,2 Humera Khurshid,3 Russell Madison,4 Bassam I Aswad,1 Murray B Resnick,1 Evgeny Yakirevich,1 Siraj M Ali,4 Nimesh R Patel11Department of Pathology, Rhode Island Hospital and Alpert Medical School at Brown University, Providence, RI 02903, USA; 2Division of Medical Oncology, Miriam Hospital and Alpert Medical School at Brown University, Providence, RI 02906, USA; 3Division of Medical Oncology, Rhode Island Hospital and Alpert Medical School at Brown University, Providence, RI 02903, USA; 4Foundation Medicine, Inc., Cambridge, MA 02141, USAAbstract: Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is an important molecular subgroup of tumors that are typically sensitive to tyrosine kinase inhibitors (TKIs). Although a substantial portion of patients benefit from TKIs, this approach is complicated by intrinsic and acquired resistance. We report a patient with ALK-rearranged NSCLC who showed an initial response to targeted therapy, but developed resistance to multiple TKIs. Serial comprehensive genomic profiling (CGP) was performed at four independent points during the clinical course. We review the pathology and clonal progression of the tumor, with CGP identifying a secondary CTNNB1 p.S45V mutation after the initiation of targeted therapy, followed by tertiary ALK p.I1171N. The presence of an alteration in a second oncogenic driver gene suggests a possible mechanism for resistance, and a secondary therapeutic target. Due to the involvement of Wnt signaling in the pathogenesis of many tumors and its association with immune evasion, a variety of therapeutic strategies are being developed to target this pathway. This case exemplifies the challenges of targeted therapeutics in the face of tumor progression, as well as the increasing role of genomics in understanding tumor biology.Keywords: cancer, genomics, profiling, beta-catenin, resistance &nbsp

Published
2019

16. Prechemotherapy Education: Reducing Patient Anxiety Through Nurse-Led Teaching Sessions

Author

Apor, Emmanuel, primary, Connell, Nathan, additional, Faricy-Anderson, Katherine, additional, Barth, Peter, additional, Youssef, Rouba, additional, Fenton, Mary, additional, Sikov, William, additional, Thomas, Anthony, additional, Rosati, Kayla, additional, Schumacher, Andrew, additional, Lombardo, Alise, additional, Korber, Susan, additional, Khurshid, Humera, additional, Safran, Howard, additional, and Mega, Anthony, additional

Published
2018
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17. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Martin, Miguel, primary, Holmes, Frankie A, additional, Ejlertsen, Bent, additional, Delaloge, Suzette, additional, Moy, Beverly, additional, Iwata, Hiroji, additional, von Minckwitz, Gunter, additional, Chia, Stephen K L, additional, Mansi, Janine, additional, Barrios, Carlos H, additional, Gnant, Michael, additional, Tomašević, Zorica, additional, Denduluri, Neelima, additional, Šeparović, Robert, additional, Gokmen, Erhan, additional, Bashford, Anna, additional, Ruiz Borrego, Manuel, additional, Kim, Sung-Bae, additional, Jakobsen, Erik Hugger, additional, Ciceniene, Audrone, additional, Inoue, Kenichi, additional, Overkamp, Friedrich, additional, Heijns, Joan B, additional, Armstrong, Anne C, additional, Link, John S, additional, Joy, Anil Abraham, additional, Bryce, Richard, additional, Wong, Alvin, additional, Moran, Susan, additional, Yao, Bin, additional, Xu, Feng, additional, Auerbach, Alan, additional, Buyse, Marc, additional, Chan, Arlene, additional, Harvey, Vernon, additional, Tomek, Rudolf, additional, Robert, Nicholas J., additional, Gore, Ira, additional, Smith, John W., additional, Masuda, Norikazu, additional, Di Sean Kendall, S., additional, Harker, William Graydon, additional, Petrakova, Katarina, additional, Guerrero Zotano, Angel, additional, Simon, Amparo Ruiz, additional, Konstantinovic, Zora Neskovic, additional, Iannotti, Nicholas O., additional, Tassone, Pierfrancesco, additional, Rodriguez, Gladys I., additional, Jáñez Martinez, Noelia, additional, Crespo Massieu, Carmen, additional, Smickoska, Snezana, additional, Somali, Isil, additional, Yilmaz, Ugur, additional, Alonso, Mirta Garcia, additional, Rosales, Adolfo Murias, additional, Cold, Soeren, additional, Knoop, Ann Soegaard, additional, Patt, Debra, additional, Hellerstedt, Beth A., additional, Morales Murillo, Serafin, additional, Mayer, Ingrid A., additional, Means-Powell, Julie Ann, additional, Hui, Rina, additional, Senecal, Francis M., additional, De Boer, Richard Hendry, additional, Shen, Zhenzhou, additional, Luczak, Adam Andrzej, additional, Chui, Joanna W.Y., additional, Tsang, Janice Wing-hang, additional, Lang, Istvan, additional, Rai, Yoshiaki, additional, Hozumi, Yasuo, additional, Ten Tije, Albert J., additional, Bhandari, Manish, additional, Osborne, Cynthia R.C., additional, Ohtani, Shoichiro, additional, Higaki, Kenji, additional, Watanabe, Kenichi, additional, Taguchi, Kazunori, additional, Takahashi, Masato, additional, Filipovic, Sladjana, additional, Hansen, Vincent L., additional, Rao, Vijayarama Phooshkooru, additional, Gupta, Manish, additional, Petrov, Petar, additional, Coudert, Bruno, additional, Vojnovic, Zeljko, additional, Polya, Zsofia, additional, Miyaki, Toshiko, additional, Yamamoto, Naohito, additional, Brincat, Stephen, additional, Lesniewski-Kmak, Krzysztof, additional, Chmielowska, Ewa, additional, Birhiray, Ruemu E., additional, Citron, Marc L., additional, Papish, Steven William, additional, Berry, William R., additional, Langkjer, Sven Tyge, additional, Garcia Sáenz, José Angel, additional, Arance, Ana Maria, additional, Efrat, Noa, additional, Sarosiek, Tomasz, additional, Grzeda, Lukasz, additional, Manalo, Yvonne, additional, Smith, Julie C., additional, Vaziri, Irfan, additional, Healey, Tabitha, additional, Rahim, Yasmin, additional, Luk, Cynthia, additional, Dingle, Brian, additional, Franco, Sandra, additional, Sorensen, Peter Grundtvig, additional, Anand, Anjana, additional, Khan, Sarah, additional, Fountzilas, George, additional, Aogi, Kenjiro, additional, Shimizu, Satoru, additional, Mikulova, Milada, additional, Spanik, Stanislav, additional, Somer, Robert A., additional, Flynn, Patrick J., additional, Coward, Jermaine, additional, Mainwaring, Paul, additional, Jerusalem, Guy, additional, Segura-Ojezzar, Carine, additional, Levy, Christelle, additional, Delozier, Thierry, additional, Khayat, David, additional, Coleman, Robert E., additional, Rolles, Martin J., additional, Maisano, Robert, additional, Nardi, Mario, additional, Ito, Yoshinori, additional, Yumuk, Perran Fulden, additional, Basaran, Gul, additional, Serdar Turhal, Nazim, additional, Wilkinson, Mary J., additional, Green, Nathan B., additional, Sidrys, Algis P., additional, Hallmeyer, Sigrun, additional, Testori, Douglas J., additional, Sridhar, Srikala, additional, Chang, Jose, additional, Sun, Qiang, additional, Jara-Sanchez, Carlos, additional, Rubio, Xabier, additional, Garrido, Maria Lomas, additional, De La Haba Rodriguez, Juan Rafael, additional, Perello Martorell, Antonia, additional, Avelia Mestre, Antoni, additional, Rifa Ferrer, Julio, additional, del Barco Berron, Sonia, additional, Nagy, Zsuzsanna, additional, Tanaka, Maki, additional, Im, Young-Hyuck, additional, Carroll, Robert R., additional, Dickerson, Laura C., additional, Mace, Joseph R., additional, Rivera, Ragene, additional, Klein, Leonard M., additional, Ruxer, Robert, additional, Wilks, Sharon T., additional, Kotasek, Dusan, additional, Popov, Vasil, additional, Taskova, Violina, additional, Marinova-Venkova, Violetka, additional, Timcheva, Constanta, additional, Desbiens, Christine, additional, Ayoub, Jean-Pierre, additional, Grenier, Debjani, additional, Marschner, Norbert, additional, Tesch, Hans, additional, Lueck, Hans-Joachim, additional, Janssen, Jan, additional, Schwaner, Ingo, additional, Wahlstrom, Stine, additional, Brix, Eva Harder, additional, Vallentin, Susanne, additional, Kristensen, Dan, additional, Andreeva, Anna, additional, Glavicic, Vesna, additional, Calvo Plaza, Isabel, additional, Anton Torres, Antonio, additional, Veyret, Corinne, additional, Bergerat, Jean-Pierre, additional, Bourbouloux, Emmanuelle, additional, Ella, Wendy Ann, additional, Algurafi, Hafiz, additional, Robinson, Anne, additional, Kim, Seung Jin, additional, Taguchi, Tetsuya, additional, Juozaityte, Elona, additional, Madretsma, Stanley, additional, Radema, Sandra, additional, Czerniawska-Meier, Malgorzata, additional, Rogowski, Wojciech, additional, Wagnerova, Maria, additional, Richards, Donald A., additional, Tan-Chiu, Elizabeth, additional, Vasileios, Asskikis, additional, Henderson, Charles Arthur, additional, Holden, Viran Roger, additional, Wang, Xiaojia, additional, Tong, Zhongsheng, additional, Yang, Junlan, additional, Gonzalez, Manuel Enrique, additional, Rezai, Mahdi, additional, Hackmann, John, additional, de Dueñas, Eduardo Martinez, additional, de las Heras, Begoña Bermejo, additional, Dourthe, Louis Marie, additional, Chocteau-Bouju, Dorothee, additional, Bougnoux, Philippe, additional, Kakolyris, Stylianos, additional, Kalofonos, Haralabos, additional, Pectasidis, Dimitrios, additional, Ng, Ting Ying, additional, Pajkos, Gabor, additional, Somogyine, Eva Ezer, additional, Tonini, Giuseppe, additional, Giuffrida, Dario, additional, Takao, Shintaro, additional, Ishitobi, Makoto, additional, Inaji, Hideo, additional, Tokuda, Yutaka, additional, Wozniak, Katarzyna, additional, Lungulescu, Dan, additional, Lu, Yen-Shen, additional, Chang, King-Jen, additional, Hill, Julian, additional, Croot, Christopher Charles, additional, Dekker, Albert, additional, Belman, Neil D., additional, Conde, Miguel, additional, Michaelson, Richard A., additional, Kemmer, Kathleen, additional, Chui, Stephen, additional, Luoh, Shiuh-Wen, additional, Nahum, Kenneth, additional, Greenspan, Andrew R., additional, Nichols, Joni C., additional, Encarnacion, Carlos A., additional, Niederman, Thomas M.J., additional, Lee, Theresa, additional, Alexander, Roland, additional, Gordon, Robert, additional, Tomova, Antoanet, additional, Rauch, Daniel, additional, Popescu, Razvan Andrei, additional, Rojas, Gustavo Adolfo, additional, Vanasek, Jaroslav, additional, Neunhoeffer, Tanja, additional, Barinoff, Jana, additional, Graffunder, Gerd, additional, Wolfgang, Abenhardt, additional, Bojko, Peter, additional, Heinrich, Bernhard, additional, von der Assen, Albert, additional, Antonovic, Bogovic Jurij, additional, Adrian, Lene, additional, Ramos Vazquez, Manuel, additional, Gonzalez Santiago, Santiago, additional, Dieras, Veronique, additional, Bishop, Jill Mercia, additional, Perren, Timothy John, additional, Varthalitis, Ioannis, additional, Mavroudis, Dimitris, additional, Georgoulias, Vassilis, additional, Chow, Louis W.C., additional, Yau, Chung Cheung Thomas, additional, Liang, Raymond Hin-Suen, additional, Pikó, Béla, additional, Wéber, Agnes, additional, Kaufman, Bella, additional, Drumea, Karen, additional, Nuzzo, Francesco, additional, De Matteis, Andrea, additional, Carteni, Giacomo, additional, Tokunaga, Eriko, additional, Ishida, Mayumi, additional, Ohno, Shinji, additional, Sato, Nobuaki, additional, Kuroi, Katsumasa, additional, Nishimura, Reiki, additional, Watanabe, Junichiro, additional, Choi, Yoon Ji, additional, Park, Kyong Hwa, additional, Wojtukiewicz, Marek, additional, Jassem, Jacek, additional, Loman, Niklas, additional, Askoy, Sercan, additional, Altundag, Mustafa Kadri, additional, Saip, Pinar, additional, Ali, Muhammad Amjad, additional, Wade, James Lloyd, additional, Chien, Amy Jo, additional, Brandt, Debra, additional, Novik, Yelena, additional, Jani, Chirag, additional, Rice, Robert L., additional, Gaffar, Yousuf A. R, additional, Keaton, Mark R., additional, Bajaj, Rajesh, additional, Kimmick, Gretchen, additional, Campbell, David, additional, Turnquest, Theodore, additional, Lucas, Sideras, additional, Dube, Pierre, additional, Xu, Binghe, additional, Schilling, Joerg, additional, Apel, Klaus, additional, Vestlev, Peter Michael, additional, Jensen, Brita Bjerregaard, additional, Haahr, Vera, additional, Lescure, Alvaro Rodriguez, additional, Grana Suarez, Begona, additional, Saura Manich, Cristina, additional, Jacquin, Jean-Philippe, additional, Samreen, Ahmed, additional, Boiangiu, Ion, additional, Dank, Magdolna, additional, Falci, Cristina, additional, Jirillo, Antonio, additional, Cinieri, Saverio, additional, Ueno, Takayuki, additional, Sato, Fumiaki, additional, Yamashiro, Hiroyasu, additional, Sugie, Tomoharu, additional, Lee, Keun Seok, additional, Ro, Jung Sil, additional, Park, In Hae, additional, Bustam, Anita Zarina, additional, Suszko-Kazarnowicz, Malgorzata, additional, Piktel, Artur, additional, Krzemieniecki, Krzysztof, additional, Iorga, Polizenia Georgeta, additional, Yap, Yoon Sim, additional, Kakalejcik, Marian, additional, Sevinc, Alper, additional, Ozguroglu, Mustafa, additional, Chen, Shin-Cheh, additional, Greenberg, Richard H., additional, Eisemann, Allan Daniel, additional, Droder, Robert, additional, Abbasi, M. Rashid, additional, Vaysburd, Marina, additional, Caldera, Humberto Jose, additional, Haley, Barbara Bacsik, additional, Robin, Erwin, additional, Inhorn, Roger C., additional, Hufnagel, David, additional, Kenyon, Peter D., additional, Spremulli, Ellen, additional, Silverman, Paula, additional, Jain, Sharad, additional, Weigand, Robert, additional, Mebis, Jeroen, additional, Koynova, Tatyana, additional, Lesperance, Bernard, additional, Prausova, Jana, additional, Kohne, Claus-Henning, additional, Schneeweiss, Andreas, additional, Jackisch, Christian, additional, Fuxius, Stefan, additional, Cubedo Cervera, Ricardo, additional, Urruticoechea Ribate, Ander, additional, Pernas Simon, Sonia, additional, Valero Gallego, Jose, additional, Arcusa Lanza, Angels, additional, del Pilar Alvarez, Maria, additional, Florian Gerico, Jesus, additional, Cany, Laurent, additional, Stebbing, Justin, additional, Labudovic, Dejan, additional, Gugic, Damir, additional, Vrbanec, Damir, additional, Roila, Fausto, additional, Barni, Sandro, additional, Bidoli, Paolo, additional, Mukai, Hirofumi, additional, Bermudez, Vanessa, additional, Eniu, Alexandru, additional, Mirtsching, Barry C., additional, Ibrahim, Emad, additional, Trey, Joan, additional, Hergenroeder, Paul Francis, additional, Mahmood, Aftab, additional, Gonzalez, Anneliese, additional, Kaplan, Edward H., additional, Ban, Stacy, additional, Patel, Dhimant, additional, Clowney, Billy, additional, Hoelzer, Karen, additional, Schwartz, Garry H., additional, Salkeni, Mohamed, additional, Abraham, Jame, additional, Narula, Sunil, additional, Jabboury, Khaled, additional, Mocharnuk, Robert Scott, additional, McDonough, Richard H., additional, Sikes, David H., additional, Kawanchi, Ronald H., additional, Schlabach, Larry, additional, McCachren, Samuel Spence, additional, Cosgriff, Thomas M., additional, Dreisbach, Luke, additional, DeMichele, Angela, additional, Pawl, Lawrence, additional, Lucas, Jennifer, additional, Shinn, Lowell C., additional, Alkhouri, Nabiel, additional, Monga, Manish, additional, Lindquist, Deborah L., additional, Anderson, Thomas C., additional, Khurshid, Humera, additional, Witherby, Sabrina, additional, Erickson, Nicholette, additional, Traynor, Ann, additional, Bose, Ron, additional, Pluard, Timothy J., additional, Jones, Michael C., additional, Prakash, Sucharu, additional, Volterra, Fabio, additional, Capo, Gerardo, additional, Flaherty, Lawrence E., additional, Gartner, Elaina, additional, Baidas, Said, additional, Okazaki, Ian, additional, Nguyen, Bichlien, additional, Rakowski, Thomas, additional, Oliff, Ira, additional, Leach, Joseph W., additional, Anderson, Daniel, additional, Kubiak, Kendra, additional, Tsai, Michaela, additional, Vroman, Philippe, additional, Deleu, Ines, additional, Lybaert, Willem, additional, Borms, Marleen, additional, Couture, Felix, additional, Wilson, Jonathan J., additional, Hunt, Gordon, additional, Holland, David R., additional, Mingrone, Walter, additional, Wang, Shusen, additional, Liu, Donggeng, additional, Jiang, Zefei, additional, Benesova, Vera, additional, Smakal, Martin, additional, Garnolova, Petra, additional, Vesper, Anne-Sophie, additional, Neumann, Monika, additional, Janni, Wolfgang, additional, Liedtke, Cornelia, additional, Fischer, Dorothea, additional, Grischke, Eva-Maria, additional, Seeger, Dietmar, additional, Moebus, Volker, additional, Prechtl, Anita, additional, Carlos Camara Toral, Juan, additional, Sanchez Munoz, Alfonso, additional, Gonzalez Jimenez, Sonia, additional, Cassinello Espinosa, Javier, additional, Cirauqui, Beatriz, additional, Margeli Vila, Mireia, additional, Batista Lopez, Norberto, additional, Chacon Lopez-Muniz, Jose Ignacio, additional, de la Cruz Mora, Miguel Angel, additional, Mailliez, Audrey, additional, Vanlemmens, Laurence, additional, Pouessel, Damien, additional, Espie, Marc, additional, Conibear, John, additional, Roylance, Rebecca, additional, Harnett, Adrian, additional, Geffen, David, additional, Ruggeri, Enzo Maria, additional, Gamucci, Teresa, additional, Van Groeningen, Cees J., additional, Banas, Renata, additional, Alkis, Necati, additional, Hou, Ming-Feng, additional, Krie, Amy K., additional, Vrindavanam, Nandagopal S., additional, Howard, Orion M., additional, Citrin, Dennis, additional, Morginstin, Mark S., additional, Desai, Ajit, additional, Sanchez, Ines J., additional, Nixon, David Allen, additional, Beatty, Patrick G., additional, Edmiston, Kathryn, additional, McLaughlin, Marilyn, additional, Eneman, Jonathan D., additional, Lynch, Cynthia A., additional, O'Brien, Edward, additional, Call, Justin A., additional, Lanier, Keith S., additional, Conlin, Alison, additional, Brooks, Donald J., additional, McIntyre, Kristi, additional, Saltzman, Marc A., additional, Castine, Michael J., additional, Ortega, Gregory L., additional, Choi, Young M., additional, Reynolds, Craig H., additional, Brescia, Frankie Ann, additional, Kramer, Rita, additional, Kohn, Aimee D., additional, Micha, John P., additional, Rhee, Jessica M., additional, Shah, Satish, additional, Riseberg, David A., additional, Patterson, William Kevin, additional, Salmon, Jean-Paul, additional, Andre, Chantal, additional, Bols, Alain, additional, D'hondt, Randal, additional, Luce, Sylvie, additional, Nouwynck, Claire, additional, Pelgrims, Gino, additional, Richard, Vincent, additional, Verschuere, Johan, additional, Geldhof, Kurt, additional, Caspar, Clemens, additional, Luo, Rongcheng, additional, Bednarik, Otakar, additional, Schwedler, Kathrin, additional, Schmidt, Marcus, additional, Neumeister, Romy, additional, Bischoff, Joachim, additional, Rack, Brigitte, additional, Repp, Roland, additional, Fries, Stefan, additional, Adrion, Ralf, additional, Schulz, Volker, additional, Klare, Peter, additional, Danei, Mahmoud, additional, Ossenbuhl, Dirk, additional, Kusche, Jakob Manfred, additional, Griesinger, Frank, additional, Baena Canada, Jose Manuel, additional, Martinez del Prado, Purificacion, additional, Machover, David, additional, Mayeur, Didier, additional, Trufflandier, Nathalie, additional, Delecroix, Valerie, additional, Mousseau, Mireille, additional, Mouret-Reynier, Marie-Ange, additional, Nabholtz, Jean-Marc, additional, Chetiyawardana, Anula D., additional, Papandreou, Christos, additional, Hornyak, Lajos, additional, Faluhelyi, Zsolt, additional, Simo, Erzsebet, additional, Di Palma, Mario, additional, Cognetti, Francesco, additional, Gorzegno, Gabriella, additional, Dogliotti, Luigi, additional, Gridelli, Cesare, additional, Falcone, Alfredo, additional, Soto Parra, Hector, additional, Buscarino, Calogero, additional, Im, Seock-Ah, additional, Sanchez Llamas, Benito, additional, Dercksen, Wouter, additional, Erdkamp, Franciscus, additional, Ruit, Jan B., additional, Braun, Hans, additional, Portielje, Joanneke E.A., additional, Ciltas, Aydin, additional, Buyukberber, Suleyman, additional, Benekli, Mustafa, additional, Zahalsky, Andrew J., additional, Jaslow, Rebecca, additional, Thomas, Gary W., additional, Maini, Archana, additional, Wiznitzer, Israel, additional, Khojasteh, Ali, additional, Francisco Gonzalez, Manuel, additional, Kong, Lynn R., additional, Padmanabhan, Aruna, additional, Conkright, William A., additional, Swain, Sandra M., additional, Faig, Douglas E., additional, Jain, Kirti, additional, Yanagihara, Ronald H., additional, Ottaviano, Yvonne, additional, Delmas, Andrew, additional, Steele, Heather A., additional, Rainey, Gordon K., additional, Harris, Penelope J., additional, Burris, Jason K., additional, Rupard, Erik J., additional, Tan, Esther, additional, Whitworth, Pat W., additional, Bova, Abby R., additional, Anderson, Ian C., additional, Shirinian, Mihran, additional, Tin-u, Caesar, additional, O'Rourke, Timothy J., additional, Roberts, Michael S., additional, Francisco, Michael, additional, Pierson, A. Scott, additional, Byeff, Peter D., additional, Kovach, Peter A., additional, Caton, John R., additional, Rarick, Mark Urban, additional, Schimidt, William G., additional, Stopeck, Alison T., additional, Swart, Rachel, additional, Carrillo Flores, Maria Regina, additional, Alemany, Carlos A., additional, Lozada, Brennely, additional, Weinstein, Paul L., additional, Wang, Wei, additional, Porubcin, Michael, additional, Ellison, David M., additional, Geils, George F., additional, Rivera, Edgardo, additional, and Charif, Mahmoud, additional

Published
2017
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21. Clinical Trial Accrual Targeting Genomic Alterations After Next-Generation Sequencing at a Non-National Cancer Institute–Designated Cancer Program

Author

Mantripragada, Kalyan C., primary, Olszewski, Adam J., additional, Schumacher, Andrew, additional, Perez, Kimberly, additional, Birnbaum, Ariel, additional, Reagan, John L., additional, Mega, Anthony, additional, Khurshid, Humera, additional, Bartley, Carolyn, additional, Lombardo, Alise, additional, Rossiter, Rachael, additional, Papa, Alessandro, additional, Bakalarski, Pamela, additional, and Safran, Howard, additional

Published
2016
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23. BrUOG 387: Phase Ib investigator-initiated trial of a heat shock protein 90 inhibitor (HSP90i) combined with a CDK4/6i in advanced breast cancer progressing on CDK4/6i and in solid tumors with retinoblastoma (Rb)-deficiency (IND163592).

Author

El-Deiry, Wafik S., Graff, Stephanie L., Azzoli, Christopher G., Dizon, Don S., Fenton, Mary Anne, Sikov, William M., Safran, Howard, Khan, Hina, Khurshid, Humera, Schumacher, Andrew, Zhou, Lanlan, Zhao, Shuai, Seyhan, Attila A., Ryspayeva, Dinara, Wood, Roxanne, Winer, Arthur, Calleja, Elizabeth Martine, and Ross, Eric A.

Published
2023
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25. Cetuximab, Paclitaxel, Carboplatin, and Radiation for Head and Neck Cancer

Author

Birnbaum, Ariel, primary, Dipetrillo, Thomas, additional, Rathore, Ritesh, additional, Merriam, Priscilla, additional, Wanebo, Harry, additional, Thomas, Anthony, additional, Puthawala, Yacoub, additional, Joyce, Donald, additional, Luppe, Denise, additional, Khurshid, Humera, additional, Follett, Nancy, additional, Sio, Terence Tai-Weng, additional, and Safran, Howard, additional

Published
2014
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29. Neoadjuvant Bevacizumab, Oxaliplatin, 5-Fluorouracil, and Radiation for Rectal Cancer

Author

Dipetrillo, Tom, primary, Pricolo, Victor, additional, Lagares-Garcia, Jorge, additional, Vrees, Matt, additional, Klipfel, Adam, additional, Cataldo, Tom, additional, Sikov, William, additional, McNulty, Brendan, additional, Shipley, Joshua, additional, Anderson, Elliot, additional, Khurshid, Humera, additional, Oconnor, Brigid, additional, Oldenburg, Nicklas B.E., additional, Radie-Keane, Kathy, additional, Husain, Syed, additional, and Safran, Howard, additional

Published
2012
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30. A Phase I Study of Dasatinib with Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer

Author

Khurshid, Humera, primary, Dipetrillo, Thomas, additional, Ng, Thomas, additional, Mantripragada, Kalyan, additional, Birnbaum, Ariel, additional, Berz, David, additional, Radie-Keane, Kathy, additional, Perez, Kimberly, additional, Constantinou, Maria, additional, Luppe, Denise, additional, Schumacher, Andrew, additional, Leonard, Kara, additional, and Safran, Howard, additional

Published
2012
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31. NSCLC: An Update of Driver Mutations, Their Role in Pathogenesis and Clinical Significance.

Author

BLACK, ROBERT C. and KHURSHID, HUMERA

Subjects
*LUNG cancer, *EPIDERMAL growth factor receptors, *GENETIC mutation, *PLATINUM, *GENE rearrangement, *THERAPEUTICS
Abstract

Lung cancer is the most common malignancy in the US and causes the most cancer-related deaths. Non-smallcell lung carcinoma (NSCLC) accounts for the majority of cases. NSCLC historically was considered one entity, reflected by platinum-based therapy as the standard of care; however, with the discovery of EGFR mutations and ALK rearrangements, the landscape of treatment has become more personalized reflecting genomic heterogeneity. The molecular basis for tumor genesis was recognized and became a new method of classification. The availability of tumor sequencing and testing for these mutations is also becoming more accessible outside of major academic institutions. Targeted therapies offer alternatives to dangerous cytotoxic chemotherapy with equal or better efficacy. With these changes, driver mutations will play an increasing role in the diagnosis and treatment of NSCLC. In this review we will examine the characteristics of several NSCLC driver mutations and gene rearrangements and emerging data on therapies directed against them. [ABSTRACT FROM AUTHOR]

Published
2015

32. Use of Monoclonal Antibodies in Oncology.

Author

Khurshid, Humera and Sinclair, Natalie

Subjects
*IMMUNOGLOBULINS, *BLOOD proteins, *ANTIBODY diversity, *MONOCLONAL antibodies, *MONOCLONAL antibody probes, *ONCOLOGY, *RITUXIMAB, *TRASTUZUMAB
Abstract

The article focuses on the monoclonal antibodies (MCA) that are used in oncology. It mentions that MCA represents an important addition to therapeutic alternatives for several oncologic disorder, which are approved by the U.S. Food and Drug Administration (FDA). Moreover, it notes that the first MCA that gain approval was rituximab, which is chimeric IgG molecule binds with high specificity to the CD20 molecule. The article also discusses the humanized monoclonal antibody Trastuzumab and its effect in trials for treatment of metastatic breast cancer when combined with chemotherapy.

Published
2011

33. Shunt nephritis from Propionibacterium acnesin a solitary kidney

Author

Balogun, Rasheed A., Palmisano, Joseph, Kaplan, Andre A., Khurshid, Humera, Yamase, Harold, and Adams, Nancy D.

Abstract

Since its initial description in 1965, immune complex glomerulonephritis associated with ventriculoatrial shunts (VAS) has been reported widely in the literature. The most common incriminating organism is Staphylococcus epidermidis, but less often, an organism generally regarded as nonpathogenic, such as Propionibacterium acnes, has been noted as the cause. Shunt infection usually occurs within a few months after placement or manipulation of the shunt, and shunt nephritis (SN) develops gradually over months to years after. Treatment involves mandatory removal of the shunt and antibiotics; prognosis is variable. We report a case of SN with P acnesthat is unusual because of its occurrence in a solitary kidney 6 years after shunt placement, persistently negative blood cultures, and normal complement levels. Percutaneous biopsy of a solitary kidney should be considered if it is expected that the result may guide therapy of progressive renal failure. © 2001 by the National Kidney Foundation, Inc.

Published
2001
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34. The Evolving Role of Histology In the Treatment of Non-Small Cell Lung Cancer.

Author

Rana, Naveed and Khurshid, Humera

Subjects
*TISSUE differentiation, *CANCER treatment, *SMALL cell lung cancer, *VASCULAR endothelial growth factors, *DRUG therapy, *PROTEIN-tyrosine kinase inhibitors, *ENDOTHELIAL growth factors, *SQUAMOUS cell carcinoma, *RESEARCH methodology, *DOCETAXEL
Abstract

The article offers information on the use of histology as a guide to non-small cell lung cancer (NSCLC) therapy. It states that chemotherapy drugs have revealed to be more effective while others are related with increased rates of adverse effects in histological subgroups of NSCLC. Epidermal group factor receptor (EGFR) tyrosine kinase inhibitors (TKI) and anti-vascular endothelial growth factors inhibitors are related with increased toxicity in patients having squamous cell histology. A retrospective analysis with the use of subset histology data revealed better survival with premetrexed for non-squamous groups equating with docetaxel.

Published
2010

35. Assessment of Frailty and Risk of Chemotherapy Toxicity at a Geriatric-Oncology Multidisciplinary Clinic.

Author

RAZA, SAKEENA, RUDOLPH, JAMES L., MUJAHID, NADIA, ZHOU, EMILY, NEUPANE, IVA, MONTEIRO, JOAO FILIPE G., SINGH, MRIGANKA, and KHURSHID, HUMERA

Subjects
*RISK assessment, *CANCER chemotherapy, *GERIATRIC assessment, *FRAILTY, *BREAST cancer
Abstract

BACKGROUND: Multidisciplinary Geriatric-Oncology (GO-MDC) clinic performed comprehensive geriatric assessment (CGA) to determine frailty and chemotherapy toxicity risk. METHOD: Retrospective cohort study of patients ≥65 years seen between April 2017 to March 2022. We compared Eastern Cooperative Oncology Group-Performance Status (ECOG-PS) to CGA as a determinant of frailty and risk of toxicity from chemotherapy. RESULTS: Mean age of the 66 patients was 79 years. Eighty-five percent were Caucasian. Predominant cancers were breast (30%), and gynecological (26%). One-third were stage 4. The CGA identified fit (35%), vulnerable (48%), and frail (17%) patients whereas ECOG-PS classi- fied 80% as fit. CGA assessed 57% of ECOG-fit patients as vulnerable or frail (p<0.001). High chemotherapy toxicity risk using CGA was 41% and using ECOG was 17% (p=0.002). CONCLUSION: At GO-MDC, CGA was a better predictor of frailty and toxicity risk than ECOG-PS. Treatment modification was recommended in one-third of patients. [ABSTRACT FROM AUTHOR]

Published
2023

37. TKI-resistant ALK -rearranged lung adenocarcinoma with secondary CTNNB1 p.S45V and tertiary ALK p.I1171N mutations.

Author

Ouseph MM, Taber A, Khurshid H, Madison R, Aswad BI, Resnick MB, Yakirevich E, Ali SM, and Patel NR

Abstract

Anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer (NSCLC) is an important molecular subgroup of tumors that are typically sensitive to tyrosine kinase inhibitors (TKIs). Although a substantial portion of patients benefit from TKIs, this approach is complicated by intrinsic and acquired resistance. We report a patient with ALK -rearranged NSCLC who showed an initial response to targeted therapy, but developed resistance to multiple TKIs. Serial comprehensive genomic profiling (CGP) was performed at four independent points during the clinical course. We review the pathology and clonal progression of the tumor, with CGP identifying a secondary CTNNB1 p.S45V mutation after the initiation of targeted therapy, followed by tertiary ALK p.I1171N. The presence of an alteration in a second oncogenic driver gene suggests a possible mechanism for resistance, and a secondary therapeutic target. Due to the involvement of Wnt signaling in the pathogenesis of many tumors and its association with immune evasion, a variety of therapeutic strategies are being developed to target this pathway. This case exemplifies the challenges of targeted therapeutics in the face of tumor progression, as well as the increasing role of genomics in understanding tumor biology., Competing Interests: Russell Madison is employed by Foundation Medicine, Inc.; and has stock in Roche. Siraj M Ali, MD, PhD is employed by Foundation Medicine, Inc.; has equity interest in Roche; is on the Scientific Advisory Board for Incysus Therapeutics; and is a Consultant for Revolution Medicines. Murray B Resnick, MD, PhD reports personal fees from PathAI, outside the submitted work. The authors report no other conflicts of interest in this work., (© 2019 Ouseph et al.)

Published
2019
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