Search

Your search keyword '"Kikuchi, Kiyoshi"' showing total 729 results
Start Over Author "Kikuchi, Kiyoshi"
729 results on '"Kikuchi, Kiyoshi"'

13. Phenotypic and Genomic Signatures of Latitudinal Local Adaptation Along With Prevailing Ocean Current in a Coastal Goby.

Author

Hirase, Shotaro, Nagano, Atsushi J., Nohara, Kenji, Kikuchi, Kiyoshi, and Kokita, Tomoyuki

Subjects
TSUSHIMA Current, OCEAN currents, SEA ice, DEMOGRAPHY, GLACIATION
Abstract

In the marine realm, unidirectional ocean currents often lead to high migration rates of marine organisms and, therefore, inhibit the formation of their latitudinal genetic structure. In contrast, cryptic latitudinal structures associated with local adaptation may frequently exist in widespread species generally exposed to a strong environmental heterogeneity. However, our understanding of the evolvability of locally adapted populations in open marine environments still needs to be completed. The coastal area along the Sea of Japan, where the Tsushima Warm Current flows from south to north in the Japanese Archipelago, provides a good model system for exploring this question. This study explored evidence for latitudinal local adaptation along with the prevailing ocean current in the ice goby Leucopsarion petersii at the phenotypic and genomic levels. Common garden experiments clearly showed genetically based clinal variation in growth rate, strongly suggesting local adaptation through conutergradient selection of this fitness‐related trait. Analyses based on reduced‐representation sequencing revealed a slight signal of genetic differentiation between the southern and northern populations, although continuous historical gene flow between them was supported by demographic modelling. Also, whole‐genome resequencing showed their independent demographic history during the last glacial period. Thus, these results suggest that gene flow along with the prevailing ocean current is somewhat limited, and the populations are not completely panmictic. Furthermore, the selection scan based on low‐coverage genome‐wide sequencing detected putative genomic signatures of latitudinal adaptation of growth‐related genes. Thus, our integrative study provided a novel example of marine local adaptation under a large ocean current. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

17. Genomic landscape of introgression from the ghost lineage in a gobiid fish uncovers the generality of forces shaping hybrid genomes.

Author

Kato, Shuya, Arakaki, Seiji, Nagano, Atsushi J., Kikuchi, Kiyoshi, and Hirase, Shotaro

Subjects
GENOMICS, INTROGRESSION (Genetics), PHYLOGEOGRAPHY, GENOMES, BIODIVERSITY, DEMOGRAPHY
Abstract

Extinct lineages can leave legacies in the genomes of extant lineages through ancient introgressive hybridization. The patterns of genomic survival of these extinct lineages provide insight into the role of extinct lineages in current biodiversity. However, our understanding on the genomic landscape of introgression from extinct lineages remains limited due to challenges associated with locating the traces of unsampled 'ghost' extinct lineages without ancient genomes. Herein, we conducted population genomic analyses on the East China Sea (ECS) lineage of Chaenogobius annularis, which was suspected to have originated from ghost introgression, with the aim of elucidating its genomic origins and characterizing its landscape of introgression. By combining phylogeographic analysis and demographic modelling, we demonstrated that the ECS lineage originated from ancient hybridization with an extinct ghost lineage. Forward simulations based on the estimated demography indicated that the statistic γ of the HyDe analysis can be used to distinguish the differences in local introgression rates in our data. Consistent with introgression between extant organisms, we found reduced introgression from extinct lineage in regions with low recombination rates and with functional importance, thereby suggesting a role of linked selection that has eliminated the extinct lineage in shaping the hybrid genome. Moreover, we identified enrichment of repetitive elements in regions associated with ghost introgression, which was hitherto little known but was also observed in the re‐analysis of published data on introgression between extant organisms. Overall, our findings underscore the unexpected similarities in the characteristics of introgression landscapes across different taxa, even in cases of ghost introgression. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. 1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

Author

Kikuchi, Kiyoshi, primary, Otsuka, Shotaro, additional, Takada, Seiya, additional, Nakanishi, Kazuki, additional, Setoyama, Kentaro, additional, Sakakima, Harutoshi, additional, Tanaka, Eiichiro, additional, and Maruyama, Ikuro, additional

Published
2023
Full Text
View/download PDF

47. Syndromic Surveillance for Early Detection of Nosocomial Outbreaks

Author

Kikuchi, Kiyoshi, Ohkusa, Yasushi, Sugawara, Tamie, Taniguchi, Kiyosu, Okabe, Nobuhiko, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Zeng, Daniel, editor, Gotham, Ivan, editor, Komatsu, Ken, editor, Lynch, Cecil, editor, Thurmond, Mark, editor, Madigan, David, editor, Lober, Bill, editor, Kvach, James, editor, and Chen, Hsinchun, editor

Published
2007
Full Text
View/download PDF

48. Uric acid enhances alteplase-mediated thrombolysis as an antioxidant

Author

Kikuchi, Kiyoshi, Setoyama, Kentaro, Tanaka, Eiichiro, Otsuka, Shotaro, Terashi, Takuto, Nakanishi, Kazuki, Takada, Seiya, Sakakima, Harutoshi, Ampawong, Sumate, Kawahara, Ko-ichi, Nagasato, Tomoka, Hosokawa, Kazuya, Harada, Yoichiro, Yamamoto, Mika, Kamikokuryo, Chinatsu, Kiyama, Ryoji, Morioka, Motohiro, Ito, Takashi, Maruyama, Ikuro, and Tancharoen, Salunya

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results