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15 results on '"Kikwai, Gilbert"'

1. Seroconversion and seroprevalence of TORCH infections in a pregnant women cohort study, Mombasa, Kenya, 2017-2019

Author

Hunsperger, Elizabeth, primary, Osoro, Eric, additional, Munyua, Peninah, additional, Njenga, M. Kariuki, additional, Mirieri, Harriet, additional, Kikwai, Gilbert, additional, Odhiambo, Dennis, additional, Dayan, Moshe, additional, Omballa, Victor, additional, Agogo, George O., additional, Mugo, Cyrus, additional, Widdowson, Marc-Alain, additional, and Inwani, Irene, additional

Published
2024
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2. Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021

Author

Munywoki, Patrick K., primary, Bigogo, Godfrey, additional, Nasimiyu, Carolyne, additional, Ouma, Alice, additional, Aol, George, additional, Oduor, Clifford O., additional, Rono, Samuel, additional, Auko, Joshua, additional, Agogo, George O., additional, Njoroge, Ruth, additional, Oketch, Dismas, additional, Odhiambo, Dennis, additional, Odeyo, Victor W., additional, Kikwai, Gilbert, additional, Onyango, Clayton, additional, Juma, Bonventure, additional, Hunsperger, Elizabeth, additional, Lidechi, Shirley, additional, Ochieng, Caroline Apondi, additional, Lo, Terrence Q., additional, Munyua, Peninah, additional, and Herman-Roloff, Amy, additional

Published
2023
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3. Surveillance of respiratory viruses at health facilities from across Kenya, 2014

Author

Murunga, Nickson, primary, Nyawanda, Bryan, additional, Nyiro, Joyce U., additional, Otieno, Grieven P., additional, Kamau, Everlyn, additional, Agoti, Charles N., additional, Lewa, Clement, additional, Gichuki, Alex, additional, Mutunga, Martin, additional, Otieno, Nancy, additional, Mayieka, Lilian, additional, Ochieng, Melvin, additional, Kikwai, Gilbert, additional, Hunsperger, Elizabeth, additional, Onyango, Clayton, additional, Emukule, Gideon, additional, Bigogo, Godfrey, additional, Verani, Jennifer R., additional, Chaves, Sandra S., additional, Nokes, D. James, additional, and Munywoki, Patrick K., additional

Published
2023
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4. Use of Sentinel Surveillance Platforms for Monitoring SARS-CoV-2 Activity: Evidence From Analysis of Kenya Influenza Sentinel Surveillance Data (Preprint)

Author

Owusu, Daniel, primary, Ndegwa, Linus K, additional, Ayugi, Jorim, additional, Kinuthia, Peter, additional, Kalani, Rosalia, additional, Okeyo, Mary, additional, Otieno, Nancy A, additional, Kikwai, Gilbert, additional, Juma, Bonventure, additional, Munyua, Peninah, additional, Kuria, Francis, additional, Okunga, Emmanuel, additional, Moen, Ann C, additional, and Emukule, Gideon O, additional

Published
2023
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6. Surveillance of respiratory viruses at health facilities from across Kenya, 2014

Author

Murunga, Nickson, primary, Nyawanda, Bryan, additional, Nyiro, Joyce U., additional, Otieno, Grieven P., additional, Kamau, Everlyn, additional, Agoti, Charles N., additional, Lewa, Clement, additional, Gichuki, Alex, additional, Mutunga, Martin, additional, Otieno, Nancy, additional, Mayieka, Lilian, additional, Ochieng, Melvin, additional, Kikwai, Gilbert, additional, Hunsperger, Elizabeth, additional, Onyango, Clayton, additional, Emukule, Gideon, additional, Bigogo, Godfrey, additional, Verani, Jennifer R., additional, Chaves, Sandra S., additional, Nokes, D. James, additional, and Munywoki, Patrick K., additional

Published
2022
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7. Seroprevalence and risk factors of SARS-CoV-2 infection in an urban informal settlement in Nairobi, Kenya, December 2020

Author

Munywoki, Patrick K, primary, Nasimiyu, Caroline, additional, Alando, Moshe Dayan, additional, Otieno, Nancy, additional, Ombok, Cynthia, additional, Njoroge, Ruth, additional, Kikwai, Gilbert, additional, Odhiambo,, Dennis, additional, Osita, Mike Powel, additional, Ouma, Alice, additional, Odour, Clifford, additional, Juma, Bonventure, additional, Ochieng, Caroline A, additional, Mutisya, Immaculate, additional, Ngere, Isaac, additional, Dawa, Jeanette, additional, Osoro, Eric, additional, Njenga, M Kariuki, additional, Bigogo, Godfrey, additional, Munyua, Peninah, additional, Lo, Terrence Q, additional, Hunsperger, Elizabeth, additional, and Herman-Roloff, Amy, additional

Published
2022
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10. Characterizing the Countrywide Epidemic Spread of Influenza A(H1N1)pdm09 Virus in Kenya between 2009 and 2018

Author

Owuor, D. Collins, primary, de Laurent, Zaydah R., additional, Kikwai, Gilbert K., additional, Mayieka, Lillian M., additional, Ochieng, Melvin, additional, Müller, Nicola F., additional, Otieno, Nancy A., additional, Emukule, Gideon O., additional, Hunsperger, Elizabeth A., additional, Garten, Rebecca, additional, Barnes, John R., additional, Chaves, Sandra S., additional, Nokes, D. James, additional, and Agoti, Charles N., additional

Published
2021
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11. Seroprevalence and risk factors of SARS-CoV-2 infection in an urban informal settlement in Nairobi, Kenya, December 2020

Author

Munywoki, Patrick K, primary, Nasimiyu, Caroline, additional, Alando, Moshe Dayan, additional, Otieno, Nancy, additional, Ombok, Cynthia, additional, Njoroge, Ruth, additional, Kikwai, Gilbert, additional, Odhiambo,, Dennis, additional, Osita, Mike Powel, additional, Ouma, Alice, additional, Odour, Clifford, additional, Juma, Bonventure, additional, Ochieng, Caroline A, additional, Mutisya, Immaculate, additional, Ngere, Isaac, additional, Dawa, Jeanette, additional, Osoro, Eric, additional, Njenga, M Kariuki, additional, Bigogo, Godfrey, additional, Munyua, Peninah, additional, Lo, Terrence Q, additional, Hunsperger, Elizabeth, additional, and Herman-Roloff, Amy, additional

Published
2021
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12. Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya

Author

Hunsperger, Elizabeth, Juma, Bonventure, Onyango, Clayton, Ochieng, John B., Omballa, Victor, Fields, Barry S., Njenga, M. Kariuki, Mwangi, Jane, Bigogo, Godfrey, Omore, Richard, Otieno, Nancy, Chaves, Sandra S., Munyua, Peninah, Njau, Daniel Macharia, Verani, Jennifer, Lowther, Sara, Breiman, Robert F., Montgomery, Joel M., de Cock, Kevin M., Widdowson, Marc-Alain, Apondi, Evans, Nyaundi, Jeremiah, Mayieka, Lillian, Mwasi, Lydia, Wamola, Newton, Gikunju, Stella, Kikwai, Gilbert, Ochieng, Caroline, Mujete, Timothy, Odhiambo, Dennis, Ogolla, Melvin Ochieng, Abisinwa, Everlyne, Mugoh, Robert, Odiembo, Herrine, Ade, Frederick, Onyiengo, Jane Juma, Katieno, Jim, Emojong, Patrick, Lidechi, Shirley, Achieng, Baryl, Okloyo, Arthur, Odindo, Dorothy, Agai, Wilfrida, Oumo, Carol, Arita, Lillian, Abuom, Jairus, Amon, Derrick, Achieng, Loicer, Osita, Mike, Alando, Mose, Mott, Josh, Njenga, Henry, Ndegwa, Linus, Joseph, Rachael, Ope, Maurice, Okello, Charles, Wachira, Cyrus, Wamburu, Kabura, Wakhule, Lilian, Jeruto, Carolyne, Gikundi, Solomon, Nderitu, Leonard, Omulo, Sylvia, Wanjala, Rose, Obiya, Joshua, Ngotho, Patricia, Ngore, Regina, Awiti, George, Gumbi, Wilson, Korir, Kipyegon, Oungo, Collins, APH - Global Health, Graduate School, and AII - Infectious diseases

Subjects
Kenya, medicine.medical_specialty, Capacity Building, Biosecurity, 030209 endocrinology & metabolism, Laboratory capacity, Global Health, Disease Outbreaks, 03 medical and health sciences, Biosafety, 0302 clinical medicine, Environmental health, Correspondence, parasitic diseases, medicine, Global health, Humans, 030212 general & internal medicine, Diagnostics, Accreditation, business.industry, Public health, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, Global health security, lcsh:RA1-1270, TaqMan Array card (TAC), medicine.disease, Infectious disease (medical specialty), business, Laboratories, Public Health Administration, Malaria
Abstract

Since 1979, multiple CDC Kenya programs have supported the development of diagnostic expertise and laboratory capacity in Kenya. In 2004, CDC’s Global Disease Detection (GDD) program within the Division of Global Health Protection in Kenya (DGHP-Kenya) initiated close collaboration with Kenya Medical Research Institute (KEMRI) and developed a laboratory partnership called the Diagnostic and Laboratory Systems Program (DLSP). DLSP built onto previous efforts by malaria, human immunodeficiency virus (HIV) and tuberculosis (TB) programs and supported the expansion of the diagnostic expertise and capacity in KEMRI and the Ministry of Health. First, DLSP developed laboratory capacity for surveillance of diarrheal, respiratory, zoonotic and febrile illnesses to understand the etiology burden of these common illnesses and support evidenced-based decisions on vaccine introductions and recommendations in Kenya. Second, we have evaluated and implemented new diagnostic technologies such as TaqMan Array Cards (TAC) to detect emerging or reemerging pathogens and have recently added a next generation sequencer (NGS). Third, DLSP provided rapid laboratory diagnostic support for outbreak investigation to Kenya and regional countries. Fourth, DLSP has been assisting the Kenya National Public Health laboratory-National Influenza Center and microbiology reference laboratory to obtain World Health Organization (WHO) certification and ISO15189 accreditation respectively. Fifth, we have supported biosafety and biosecurity curriculum development to help Kenyan laboratories safely and appropriately manage infectious pathogens. These achievements, highlight how in collaboration with existing CDC programs working on HIV, tuberculosis and malaria, the Global Health Security Agenda can have significantly improve public health in Kenya and the region. Moreover, Kenya provides an example as to how laboratory science can help countries detect and control of infectious disease outbreaks and other public health threats more rapidly, thus enhancing global health security.

Published
2019

15. Use of Sentinel Surveillance Platforms for Monitoring SARS-CoV-2 Activity: Evidence From Analysis of Kenya Influenza Sentinel Surveillance Data.

Author

Owusu D, Ndegwa LK, Ayugi J, Kinuthia P, Kalani R, Okeyo M, Otieno NA, Kikwai G, Juma B, Munyua P, Kuria F, Okunga E, Moen AC, and Emukule GO

Subjects
Child, Humans, SARS-CoV-2, Hospital Mortality, Kenya epidemiology, Pandemics, Sentinel Surveillance, Influenza, Human epidemiology, COVID-19 epidemiology, Coinfection
Abstract

Background: Little is known about the cocirculation of influenza and SARS-CoV-2 viruses during the COVID-19 pandemic and the use of respiratory disease sentinel surveillance platforms for monitoring SARS-CoV-2 activity in sub-Saharan Africa., Objective: We aimed to describe influenza and SARS-CoV-2 cocirculation in Kenya and how the SARS-CoV-2 data from influenza sentinel surveillance correlated with that of universal national surveillance., Methods: From April 2020 to March 2022, we enrolled 7349 patients with severe acute respiratory illness or influenza-like illness at 8 sentinel influenza surveillance sites in Kenya and collected demographic, clinical, underlying medical condition, vaccination, and exposure information, as well as respiratory specimens, from them. Respiratory specimens were tested for influenza and SARS-CoV-2 by real-time reverse transcription polymerase chain reaction. The universal national-level SARS-CoV-2 data were also obtained from the Kenya Ministry of Health. The universal national-level SARS-CoV-2 data were collected from all health facilities nationally, border entry points, and contact tracing in Kenya. Epidemic curves and Pearson r were used to describe the correlation between SARS-CoV-2 positivity in data from the 8 influenza sentinel sites in Kenya and that of the universal national SARS-CoV-2 surveillance data. A logistic regression model was used to assess the association between influenza and SARS-CoV-2 coinfection with severe clinical illness. We defined severe clinical illness as any of oxygen saturation <90%, in-hospital death, admission to intensive care unit or high dependence unit, mechanical ventilation, or a report of any danger sign (ie, inability to drink or eat, severe vomiting, grunting, stridor, or unconsciousness in children younger than 5 years) among patients with severe acute respiratory illness., Results: Of the 7349 patients from the influenza sentinel surveillance sites, 76.3% (n=5606) were younger than 5 years. We detected any influenza (A or B) in 8.7% (629/7224), SARS-CoV-2 in 10.7% (768/7199), and coinfection in 0.9% (63/7165) of samples tested. Although the number of samples tested for SARS-CoV-2 from the sentinel surveillance was only 0.2% (60 per week vs 36,000 per week) of the number tested in the universal national surveillance, SARS-CoV-2 positivity in the sentinel surveillance data significantly correlated with that of the universal national surveillance (Pearson r=0.58; P<.001). The adjusted odds ratios (aOR) of clinical severe illness among participants with coinfection were similar to those of patients with influenza only (aOR 0.91, 95% CI 0.47-1.79) and SARS-CoV-2 only (aOR 0.92, 95% CI 0.47-1.82)., Conclusions: Influenza substantially cocirculated with SARS-CoV-2 in Kenya. We found a significant correlation of SARS-CoV-2 positivity in the data from 8 influenza sentinel surveillance sites with that of the universal national SARS-CoV-2 surveillance data. Our findings indicate that the influenza sentinel surveillance system can be used as a sustainable platform for monitoring respiratory pathogens of pandemic potential or public health importance., (©Daniel Owusu, Linus K Ndegwa, Jorim Ayugi, Peter Kinuthia, Rosalia Kalani, Mary Okeyo, Nancy A Otieno, Gilbert Kikwai, Bonventure Juma, Peninah Munyua, Francis Kuria, Emmanuel Okunga, Ann C Moen, Gideon O Emukule. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 25.03.2024.)

Published
2024
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