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4. sj-pdf-3-imr-10.1177_03000605231152100 - Supplemental material for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro

Author

Kim, Eun-Jung, Yoon, Ji-Uk, Kim, Cheul-Hong, Yoon, Ji-Young, Kim, Joo-Young, Kim, Hyang-Sook, and Choi, Eun-Ji

Subjects
111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Research Data for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro by Eun-Jung Kim, Ji-Uk Yoon, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim and Eun-Ji Choi in Journal of International Medical Research

Published
2023
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5. sj-pdf-2-imr-10.1177_03000605231152100 - Supplemental material for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro

Author

Kim, Eun-Jung, Yoon, Ji-Uk, Kim, Cheul-Hong, Yoon, Ji-Young, Kim, Joo-Young, Kim, Hyang-Sook, and Choi, Eun-Ji

Subjects
111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Research Data for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro by Eun-Jung Kim, Ji-Uk Yoon, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim and Eun-Ji Choi in Journal of International Medical Research

Published
2023
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8. Lidocaine intensifies the anti-osteogenic effect on inflammation-induced human dental pulp stem cells via mitogen-activated protein kinase inhibition.

Author

Lee, Sang-Hoon, Kim, Cheul-Hong, Yoon, Ji-Young, Choi, Eun-Ji, Kim, Mi Kyoung, Yoon, Ji-Uk, Kim, Hee Young, and Kim, Eun-Jung

Subjects
MITOGEN-activated protein kinases, DENTAL pulp, STEM cells, LIDOCAINE, PROTEIN kinases, TUMOR necrosis factors, ALKALINE phosphatase
Abstract

Human dental pulp stem cells (hDPSCs) are an emerging source of mesenchymal stem cells (MSCs) for bone tissue regeneration and engineering. In bone regeneration using transplanted MSCs, the extracellular environment or co-injected drugs can affect their success or failure. In this study, we investigated the effects and signaling mechanisms of lidocaine on osteogenic differentiation of hDPSCs after inducing inflammatory conditions with lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-α). To investigate the effect of lidocaine on the osteogenic differentiation of LPS/TNF-α-treated hDPSCs, alkaline phosphatase (ALP) and Alizarin red S (ARS) staining were conducted. The expression of osteogenesis-related genes was assessed using quantitative real-time polymerase chain reaction and western blotting. The expression of mitogen-activated protein kinases was analyzed to evaluate the effect of lidocaine on osteogenic differentiation of LPS/TNF-α-treated hDPSCs. Various concentrations of lidocaine (0.05, 0.2, and 1 mM) further decreased ALP and ARS staining of LPS/TNF-α-treated hDPSCs. Similarly, the mRNA and protein expression of osteogenesis-related genes was suppressed via lidocaine treatment in LPS/TNF-α-treated hDPSCs. Lidocaine treatment downregulated the protein expression of p-ERK and p-JNK in LPS/TNF-α-treated hDPSCs. Lidocaine intensified the inhibition of osteogenic differentiation on inflammation-induced hDPSCs by inhibiting the ERK and JNK signaling pathways. This in vitro study suggested that lidocaine may have an inhibitory effect on bone regeneration. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection

Author

Kim, Eunsoo, Kim, Cheul Hong, Kim, Hae Kyu, Kwon, Jae Young, Lee, Do Won, and Kim, Hee Young

Subjects
Neuromuscular blocking agents -- Health aspects, Phenols -- Health aspects, Nitrous oxide -- Health aspects, Propofol -- Health aspects, Health
Abstract

Purpose This prospective, double-blind, placebo-controlled study was designed to determine the efficacy of nitrous oxide ([N.sub.2]O) in alleviating the pain that followed sequential injection of propofol and rocuronium. Methods A total of 205 adult patients (age, 18-68 years) received one of the following combinations: NaCl and 100% [O.sub.2] (group C); 0.5 mg/kg lidocaine and 100% [O.sub.2] (group L); NaCl and a mixture of 67% [N.sub.2]O / [O.sub.2] (group N); or 0.5 mg/kg lidocaine and a mixture of 67% [N.sub.2]O/[O.sub.2] (group LN). Vein occlusion was released after 1 min, and 5 ml propofol was injected over 10 s. Pain was evaluated on a visually enlarged, laminated, numeric rating (0-10) scale. The remainder of the induction dose of propofol (with a 3-ml bolus of normal saline and 0.6 mg/kg rocuronium) was then injected. The response to the rocuronium injection was assessed with a four-point scale (0-3). Results The incidence and severity of pain from the propofol injection in groups L, N, and LN were significantly lower than those in group C (P < 0.001). Frequency and intensity of the withdrawal response were significantly less in groups N and LN than in groups C and L (no response, P < 0.001; severe response, P < 0.001). Conclusions Pretreatment with inhaled [N.sub.2]O can reduce the pain associated with propofol and rocuronium injection. Moreover, [N.sub.2]O (with or without lidocaine) is more effective than lidocaine alone in reducing rocuronium-related withdrawal reactions associated with sequential injection of propofol and rocuronium. Keywords Nitrous oxide * Pain * Propofol * Rocuronium, Introduction Propofol is a popular anesthesia induction drug because of its quick onset of action and smooth recovery. Rocuronium is an amino-steroidal, nondepolarizing muscle relaxant with an intermediate duration of [...]

Published
2013
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14. List of Contributors

Author

Ahn, Yong, primary, Arias, Carlos F., additional, Baek, Seung-Hun, additional, Baik, Seong-Wan, additional, Ban, Sung-Bae, additional, Bini, Walter, additional, Chiu, John, additional, Choi, Sang-Sik, additional, Choi, Won-Chul, additional, Choi, Won-Gyu, additional, Coutinho, Etevaldo, additional, Furieri, Fabio P., additional, Jang, Jee-Soo, additional, Kang, Ho-Yeong, additional, Kim, Cheul-Hong, additional, Kim, Daniel H., additional, Kim, Hae-Kyu, additional, Kim, Hak-Jin, additional, Kim, Inn-Se, additional, Kim, Kyung-Hoon, additional, Kim, Seong Oh, additional, Kim, Tae-Kyun, additional, Kim, Yong-Chul, additional, Kwon, Jae-Young, additional, Lee, Chul-Joong, additional, Lee, Ho-Yeon, additional, Lee, Hyeon-Jung, additional, Lee, In-Sook, additional, Lee, Mi-Guem, additional, Lee, Mi-Kyung, additional, Lee, Pyung-Bok, additional, Lee, Sang-Chul, additional, Lee, Sang-Ho, additional, Lee, Seung-Cheol, additional, Leu, Hansjorg Franz, additional, Lhamby, Juliano, additional, Mazza, Jason S., additional, Oliveira, Leonardo, additional, Pimenta, Luiz M., additional, Reuter, Merrill W., additional, Ruetten, Sebastian, additional, Schaffa, Thomas, additional, Shim, Chan-Shik, additional, Shim, John H., additional, Shim, Seung-Eun, additional, Shin, Sang-Wook, additional, and Yoon, Ji-Young, additional

Published
2010
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19. Comparison of the efficacy and safety of 2% lidocaine HCl with different epinephrine concentration for local anesthesia in participants undergoing surgical extraction of impacted mandibular third molars

Author

Karm, Myong-Hwan, Park, Fiona Daye, Kang, Moonkyu, Kim, Hyun Jeong, Kang, Jeong Wan, Kim, Seungoh, Kim, Yong-Deok, Kim, Cheul-Hong, Seo, Kwang-Suk, Kwon, Kyung-Hwan, Kim, Chul-Hwan, Lee, Jung-Woo, Hong, Sung-Woon, Lim, Mi Hyoung, Nam, Seung Kwan, and Cho, Jae Min

Subjects
Male, Pain, Postoperative, Cross-Over Studies, Dose-Response Relationship, Drug, Epinephrine, Tooth, Impacted, Blood Loss, Surgical, Lidocaine, Clinical Trial/Experimental Study, hemodynamics, Young Adult, Treatment Outcome, Double-Blind Method, Patient Satisfaction, Tooth Extraction, Humans, Female, Molar, Third, third molar, Anesthetics, Local, local anesthesia, Research Article, Anesthesia, Local, Pain Measurement
Abstract

Background: The most commonly impacted tooth is the third molar. An impacted third molar can ultimately cause acute pain, infection, tumors, cysts, caries, periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for removing the third molar. This study aimed to evaluate the efficacy and safety of 2% lidocaine with 1:80,000 or 1:200,000 epinephrine for surgical extraction of bilateral impacted mandibular third molars. Methods: Sixty-five healthy participants underwent surgical extraction of bilateral impacted mandibular third molars in 2 separate visits while under local anesthesia with 2% lidocaine with different epinephrine concentration (1:80,000 or 1:200,000) in a double-blind, randomized, crossover trial. Visual analog scale pain scores obtained immediately after surgical extraction were primarily evaluated for the 2 groups receiving different epinephrine concentrations. Visual analog scale pain scores were obtained 2, 4, and 6 hours after administering an anesthetic. Onset and duration of analgesia, onset of pain, intraoperative bleeding, operator's and participant's overall satisfaction, drug dosage, and hemodynamic parameters were evaluated for the 2 groups. Results: There were no statistically significant differences between the 2 groups in any measurements except hemodynamic factors (P >.05). Changes in systolic blood pressure and heart rate following anesthetic administration were significantly greater in the group receiving 1:80,000 epinephrine than in that receiving 1:200,000 epinephrine (P ≤.01). Conclusion: The difference in epinephrine concentration between 1:80,000 and 1:200,000 in 2% lidocaine liquid does not affect the medical efficacy of the anesthetic. Furthermore, 2% lidocaine with 1:200,000 epinephrine has better safety with regard to hemodynamic parameters than 2% lidocaine with 1:80,000 epinephrine. Therefore, we suggest using 2% lidocaine with 1:200,000 epinephrine rather than 2% lidocaine with 1:80,000 epinephrine for surgical extraction of impacted mandibular third molars in hemodynamically unstable patients.

Published
2017

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