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1. Trends in Dual Antiplatelet Therapy of Aspirin and Clopidogrel and Outcomes in Ischemic Stroke Patients Noneligible for POINT/CHANCE Trial Treatment.

Author

Kim, Joon-Tae, Lee, Ji, Kim, Hyunsoo, Kim, Beom, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo, Kim, Jae, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi, Kim, Dong-Eog, Choi, Jay, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu, Sohn, Sung, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Ryu, Wi-Sun, Park, Kwang-Yeol, Lee, Juneyoung, Saver, Jeffrey, and Bae, Hee-Joon

Subjects
acute ischemic stroke, aspirin, clopidogrel, dual antiplatelet treatment, late‐presenting stroke, nonminor stroke, Humans, Clopidogrel, Aspirin, Male, Aged, Female, Ischemic Stroke, Dual Anti-Platelet Therapy, Platelet Aggregation Inhibitors, Registries, Middle Aged, Treatment Outcome, Aged, 80 and over, Time Factors, Japan, Secondary Prevention, Drug Therapy, Combination, Risk Factors
Abstract

BACKGROUND: Recent clinical trials established the benefit of dual antiplatelet therapy with aspirin and clopidogrel (DAPT-AC) in early-presenting patients with minor ischemic stroke. However, the impact of these trials over time on the use and outcomes of DAPT-AC among the patients with nonminor or late-presenting stroke who do not meet the eligibility criteria of these trials has not been delineated. METHODS AND RESULTS: In a multicenter stroke registry, this study examined yearly changes from April 2008 to August 2022 in DAPT-AC use for stroke patients ineligible for CHANCE/POINT (Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events/Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke) clinical trials due to National Institutes of Health Stroke Scale >4 or late arrival beyond 24 hours of onset. A total of 32 118 patients (age, 68.1±13.1 years; male, 58.5%) with National Institutes of Health Stroke Scale of 4 (interquartile range, 1-7) were analyzed. In 2008, DAPT-AC was used in 33.0%, other antiplatelets in 62.7%, and no antiplatelet in 4.3%. The frequency of DAPT-AC was relatively unchanged through 2013, when the CHANCE trial was published, and then increased steadily, reaching 78% in 2022, while other antiplatelets decreased to 17.8% in 2022 (Ptrend

Published
2024

2. Impact of non-traditional lipid profiles on 1-year vascular outcomes in ischemic stroke patients with prior statin therapy and LDL-C < 100 mg/dL

Author

Kim, Hyunsoo, Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Ryu, Wi-Sun, Park, Kwang-Yeol, Lee, Juneyoung, Saver, Jeffrey L., and Bae, Hee-Joon

Published
2024
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3. Effects of white matter hyperintensity burden on functional outcome after mild versus moderate-to-severe ischemic stroke

Author

Gwak, Dong-Seok, Ryu, Wi-Sun, Schellingerhout, Dawid, Chung, Jinyong, Kim, Hang-Rai, Jeong, Sang-Wuk, Kim, Beom Joon, Kim, Joon-Tae, Hong, Keun-Sik, Park, Jong-Moo, Park, Man-Seok, Choi, Kang-Ho, Park, Tai Hwan, Lee, Kyungbok, Park, Sang-Soon, Kang, Kyusik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi-Sun, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Lee, Jun, Han, Moon-Ku, Lee, Ji Sung, Bae, Hee-Joon, and Kim, Dong-Eog

Published
2024
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5. Differential impacts of admission LDL-cholesterol on early vascular outcomes by ischemic stroke subtypes

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Hyunsoo, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Ryu, Wi-Sun, Park, Kwang-Yeol, Lee, Juneyoung, and Bae, Hee-Joon

Published
2024
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6. Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study

Author

Ryu, Wi-Sun, Hong, Keun-Sik, Jeong, Sang-Wuk, Park, Jung E, Kim, Beom Joon, Kim, Joon-Tae, Lee, Kyung Bok, Park, Tai Hwan, Park, Sang-Soon, Park, Jong-Moo, Kang, Kyusik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Lee, Jun, Han, Moon-Ku, Park, Man Seok, Choi, Kang-Ho, Lee, Juneyoung, Saver, Jeffrey L, Lo, Eng H, Bae, Hee-Joon, and Kim, Dong-Eog

Subjects
Neurosciences, Brain Disorders, Stroke, Clinical Research, Aged, Aged, 80 and over, Circadian Rhythm, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Ischemic Stroke, Male, Middle Aged, Patient Acuity, Prospective Studies, Recovery of Function, Republic of Korea, Risk Factors, Time Factors, Treatment Outcome, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundPreclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth in rodent models with inactive phase (daytime) than active phase (nighttime) stroke onset. We aimed to examine the association of stroke onset time with presenting severity, early neurological deterioration (END), and long-term functional outcome in human ischemic stroke.Methods and findingsIn a Korean nationwide multicenter observational cohort study from May 2011 to July 2020, we assessed circadian effects on initial stroke severity (National Institutes of Health Stroke Scale [NIHSS] score at admission), END, and favorable functional outcome (3-month modified Rankin Scale [mRS] score 0 to 2 versus 3 to 6). We included 17,461 consecutive patients with witnessed ischemic stroke within 6 hours of onset. Stroke onset time was divided into 2 groups (day-onset [06:00 to 18:00] versus night-onset [18:00 to 06:00]) and into 6 groups by 4-hour intervals. We used mixed-effects ordered or logistic regression models while accounting for clustering by hospitals. Mean age was 66.9 (SD 13.4) years, and 6,900 (39.5%) were women. END occurred in 2,219 (12.7%) patients. After adjusting for covariates including age, sex, previous stroke, prestroke mRS score, admission NIHSS score, hypertension, diabetes, hyperlipidemia, smoking, atrial fibrillation, prestroke antiplatelet use, prestroke statin use, revascularization, season of stroke onset, and time from onset to hospital arrival, night-onset stroke was more prone to END (adjusted incidence 14.4% versus 12.8%, p = 0.006) and had a lower likelihood of favorable outcome (adjusted odds ratio, 0.88 [95% CI, 0.79 to 0.98]; p = 0.03) compared with day-onset stroke. When stroke onset times were grouped by 4-hour intervals, a monotonic gradient in presenting NIHSS score was noted, rising from a nadir in 06:00 to 10:00 to a peak in 02:00 to 06:00. The 18:00 to 22:00 and 22:00 to 02:00 onset stroke patients were more likely to experience END than the 06:00 to 10:00 onset stroke patients. At 3 months, there was a monotonic gradient in the rate of favorable functional outcome, falling from a peak at 06:00 to 10:00 to a nadir at 22:00 to 02:00. Study limitations include the lack of information on sleep disorders and patient work/activity schedules.ConclusionsNight-onset strokes, compared with day-onset strokes, are associated with higher presenting neurologic severity, more frequent END, and worse 3-month functional outcome. These findings suggest that circadian time of onset is an important additional variable for inclusion in epidemiologic natural history studies and in treatment trials of neuroprotective and reperfusion agents for acute ischemic stroke.

Published
2022

7. Effect of Transport Time on the Use of Reperfusion Therapy for Patients with Acute Ischemic Stroke in Korea.

Author

Choi, Jay Chol, Kim, Joong Goo, Kang, Chul Hoo, Bae, Hee Joon, Kang, Jihoon, Lee, Soo Joo, Park, Jong Moo, Park, Tai Hwan, Cho, Yong Jin, Lee, Kyung Bok, Lee, Jun, Kim, Dong Eog, Cha, Jae Kwan, Kim, Joon Tae, Lee, Byung Chul, Lee, Ji Sung, and Kim, Anthony S

Subjects
Endovascular Treatment, Ischemic Stroke, Reperfusion, Thrombolysis, Utilization, General & Internal Medicine
Abstract

BackgroundWe investigated the association between geographic proximity to hospitals and the administration rate of reperfusion therapy for acute ischemic stroke.MethodsWe identified patients with acute ischemic stroke who visited the hospital within 12 hours of symptom onset from a prospective nationwide multicenter stroke registry. Reperfusion therapy was classified as intravenous thrombolysis (IVT), endovascular therapy (EVT), or combined therapy. The association between the proportion of patients who were treated with reperfusion therapy and the ground transport time was evaluated using a spline regression analysis adjusted for patient-level characteristics. We also estimated the proportion of Korean population that lived within each 30-minute incremental service area from 67 stroke centers accredited by the Korean Stroke Society.ResultsOf 12,172 patients (mean age, 68 ± 13 years; men, 59.7%) who met the eligibility criteria, 96.5% lived within 90 minutes of ground transport time from the admitting hospital. The proportion of patients treated with IVT decreased significantly when stroke patients lived beyond 90 minutes of the transport time (P = 0.006). The proportion treated with EVT also showed a similar trend with the transport time. Based on the residential area, 98.4% of Korean population was accessible to 67 stroke centers within 90 minutes.ConclusionThe use of reperfusion therapy for acute stroke decreased when patients lived beyond 90 minutes of the ground transport time from the hospital. More than 95% of the South Korean population was accessible to 67 stroke centers within 90 minutes of the ground transport time.

Published
2021

9. Admission LDL-cholesterol, statin pretreatment and early outcomes in acute ischemic stroke

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Choi, Kang-Ho, Lee, Juneyoung, Park, Kwang-Yeol, and Bae, Hee-Joon

Published
2023
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10. Improvement in Delivery of Ischemic Stroke Treatments but Stagnation of Clinical Outcomes in Young Adults in South Korea

Author

Kim, Jonguk, Kim, Jun Yup, Kang, Jihoon, Kim, Beom Joon, Han, Moon-Ku, Lee, Jeong-Yoon, Park, Tai Hwan, Lee, Keon-Joo, Kim, Joon-Tae, Choi, Kang-Ho, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi-Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Lee, Ji Sung, Lee, Juneyoung, Gorelick, Philip B., and Bae, Hee-Joon

Published
2023
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11. Platelet-Derived Growth Factor Is Associated with Progression of Symptomatic Intracranial Atherosclerotic Stenosis

Author

Kim, Kyeong Joon, Jeong, Sang Wuk, Ryu, Wi-Sun, Kim, Dong-Eog, Saver, Jeffrey L, Kim, Jong S, Kwon, Sun U, and Group, TOSS-2 Study

Subjects
Brain Disorders, Clinical Research, Stroke, Prevention, 2.1 Biological and endogenous factors, Aetiology, Cardiovascular, platelet-derived growth factor, intracranial stenosis, ischemic stroke, magnetic resonance angiography, TOSS-2 Study Group, Neurosciences
Abstract

Background and purposeWe aimed to determine the relationships of 33 biomarkers of inflammation, oxidation, and adipokines with the risk of progression of symptomatic intracranial atherosclerotic stenosis (ICAS).MethodsFifty-two of 409 patients who participated in the TOSS-2 (Trial of Cilostazol in Symptomatic Intracranial Stenosis-2) showed progression of symptomatic ICAS in magnetic resonance angiography at 7 months after an index stroke. We randomly selected 20 patients with progression as well as 40 age- and sex-matched control patients. We serially collected blood samples at baseline, 1 month, and 7 months after an index stroke. Multiplex analysis of biomarkers was then performed.ResultsDemographic features and risk factors such as hypertension, diabetes, and smoking history were comparable between the two groups. Univariate analyses revealed that the levels of platelet-derived growth factor (PDGF)-AA [median (interquartile range)=1.64 (0.76-4.57) vs. 0.77 (0.51-1.71) ng/mL], PDGF-AB/BB [10.31 (2.60-25.90) vs. 2.35 (0.74-6.70) ng/mL], and myeloperoxidase [10.5 (7.5-22.3) vs. 7.8 (5.5-12.2) ng/mL] at 7 months were higher in the progression group. In the multivariate analysis using logistic regression, the PDGF AB/BB level at 7 months was independently associated with the progression of ICAS (p=0.02).ConclusionsThe PDGF-AB/BB level is associated with the progression of ICAS, and so may play a significant role in the progression of human ICAS.

Published
2021

12. Efficacy and safety of oxiracetam in patients with vascular cognitive impairment: A multicenter, randomized, double-blinded, placebo-controlled, phase IV clinical trial

Author

Lim, Jae-Sung, Lee, Juneyoung, Kang, Yeonwook, Park, Hyun-Tae, Kim, Dong-Eog, Cha, Jae-Kwan, Park, Tai Hwan, Heo, Jae-Hyuk, Lee, Kyung Bok, Park, Jong-Moo, Oh, Mi Sun, Kim, Eung-Gyu, Chang, Dae-Il, Heo, Sung Hyuk, Park, Man-Seok, Park, HyunYoung, Yi, SangHak, Lee, Yeong Bae, Park, Kwang-Yeol, Lee, Soo Joo, Kim, Jae Guk, Lee, Jun, Cho, Kyung-Hee, Rha, Joung-Ho, Kim, Yeong-In, Lee, Jun Hong, Choi, Jay Chol, Oh, Kyung-Mi, Kwon, Jee-Hyun, Kim, Chulho, Park, Jong-Ho, Jung, Keun-Hwa, Sung, Sang Min, Chung, Jong-Won, Lee, Yong-Seok, Kim, Hahn Young, Cho, Hyun-Ji, Park, Jeong Wook, Moon, Won-Jin, and Bae, Hee-Joon

Published
2023
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13. Frequency, management, and outcomes of early neurologic deterioration due to stroke progression or recurrence

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Choi, Kang-Ho, Lee, Juneyoung, Saver, Jeffrey L., and Bae, Hee-Joon

Published
2023
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14. Admission hyperglycemia, stroke subtypes, outcomes in acute ischemic stroke

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Choi, Kang-Ho, Ryu, Wi-Sun, Lee, Juneyoung, Saver, Jeffrey L., and Bae, Hee-Joon

Published
2023
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16. Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis

Author

Pulous, Fadi E., Cruz-Hernández, Jean C., Yang, Chongbo, Kaya, Ζeynep, Paccalet, Alexandre, Wojtkiewicz, Gregory, Capen, Diane, Brown, Dennis, Wu, Juwell W., Schloss, Maximilian J., Vinegoni, Claudio, Richter, Dmitry, Yamazoe, Masahiro, Hulsmans, Maarten, Momin, Noor, Grune, Jana, Rohde, David, McAlpine, Cameron S., Panizzi, Peter, Weissleder, Ralph, Kim, Dong-Eog, Swirski, Filip K., Lin, Charles P., Moskowitz, Michael A., and Nahrendorf, Matthias

Published
2022
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17. Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use

Author

Kang, You-Ri, Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Sohn, Sung Il, Hong, Jeong-Ho, Park, Man-Seok, Choi, Kang-Ho, Cho, Ki-Hyun, Park, Jong-Moo, Lee, Sang-Hwa, Lee, Juneyoung, and Bae, Hee-Joon

Published
2022
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18. Temporal Trends in Stroke Management and Outcomes between 2011 and 2020: Results from a Nationwide Multicenter Registry

Author

Park, Tai Hwan, primary, Hong, Keun-Sik, additional, Cho, Yong-Jin, additional, Ryu, Wi-Sun, additional, Kim, Dong-Eog, additional, Park, Man-Seok, additional, Choi, Kang-Ho, additional, Kim, Joon-Tae, additional, Kang, Jihoon, additional, Kim, Beom-Joon, additional, Han, Moon-Ku, additional, Lee, Jun, additional, Cha, Jae-Kwan, additional, Kim, Dae-Hyun, additional, Kim, Jae Guk, additional, Lee, Soo Joo, additional, Kwon, Jee-Hyun, additional, Kim, Wook-Joo, additional, Shin, Dong-Ick, additional, Yum, Kyu Sun, additional, Sohn, Sung Il, additional, Hong, Jeong-Ho, additional, Choi, Jay Chol, additional, Lee, Byung-Chul, additional, Yu, Kyung-Ho, additional, Oh, Mi-Sun, additional, Park, Jong-Moo, additional, Kang, Kyusik, additional, Lee, Kyungbok, additional, Lee, Sang-Hwa, additional, Jeong, Hae-Bong, additional, Park, Kwang-Yeol, additional, Lee, Ji Sung, additional, Lee, Juneyoung, additional, Gorelick, Philip B., additional, and Bae, Hee-Joon, additional

Published
2024
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20. Deep learning-based automatic classification of ischemic stroke subtype using diffusion-weighted images

Author

Ryu, Wi-Sun, primary, Schellingerhout, Dawid, additional, Lee, Hoyeon, additional, Lee, Keon-Joo, additional, Kim, Chi Kyung, additional, Kim, Beom Joon, additional, Chung, Jong-Won, additional, Lim, Jae-Sung, additional, Kim, Joon-Tae, additional, Kim, Dae-Hyun, additional, Cha, Jae-Kwan, additional, Sunwoo, Leonard, additional, Kim, Dongmin, additional, Suh, Sang-il, additional, Bang, Oh Young, additional, Bae, Hee-Joon, additional, and Kim, Dong-Eog, additional

Published
2024
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21. Abstract TMP107: Persistent Beta-Blocker Use and Mortality Reduction in Acute Ischemic Stroke Patients

Author

Lee, Keon-Joo, primary, Kim, Seong-eun, additional, Guk, Hyung Seok, additional, Kim, Beom Joon, additional, Han, Moon-Ku, additional, Kim, Joon-Tae, additional, Choi, Kangho, additional, Shin, Dong-Ick, additional, Cha, Jae-kwan, additional, Kim, Dae Hyun, additional, Kim, Dong-Eog, additional, Park, Jong-moo, additional, Kang, Kyusik, additional, Lee, Soo Joo, additional, Kim, Jae G, additional, Oh, Mi-Sun, additional, Yu, Kyung-Ho, additional, Lee, Byung-Chul, additional, Hong, Keun-Sik, additional, Cho, Yong-jin, additional, Choi, Jay Chol, additional, Park, Tai H, additional, Park, Sang-Soon, additional, Kwon, Jee-Hyun, additional, Kim, Wook-Joo, additional, Lee, Kyungbok, additional, Lee, Jun, additional, Lee, Ji Sung, additional, Lee, Juneyoung, additional, Bae, Hee-Joon, additional, and Kim, Nakhoon, additional

Published
2024
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25. Brain Frailty and Outcomes of Acute Minor Ischemic Stroke With Large-Vessel Occlusion

Author

Park, Je-Woo, primary, Kim, Joon-Tae, additional, Lee, Ji Sung, additional, Kim, Beom Joon, additional, Yoo, Joonsang, additional, Han, Jung Hoon, additional, Kim, Bum Joon, additional, Kim, Chi Kyung, additional, Kim, Jae Guk, additional, Baik, Sung Hyun, additional, Park, Jong-Moo, additional, Kang, Kyusik, additional, Lee, Soo Joo, additional, Park, Hyungjong, additional, Cha, Jae-Kwan, additional, Park, Tai Hwan, additional, Lee, Kyungbok, additional, Lee, Jun, additional, Hong, Keun-Sik, additional, Lee, Byung-Chul, additional, Kim, Dong-Eog, additional, Choi, Jay Chol, additional, Kwon, Jee-Hyun, additional, Shin, Dong-Ick, additional, Sohn, Sung Il, additional, Lee, Sang-Hwa, additional, Ryu, Wi-Sun, additional, Lee, Juneyoung, additional, and Bae, Hee-Joon, additional

Published
2024
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26. Effectiveness of Adding Antiplatelets to Oral Anticoagulants in Patients with Acute Ischemic Stroke with Atrial Fibrillation and Concomitant Large Artery Steno-Occlusion

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Park, Sang-Soon, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Sohn, Sung Il, Hong, Jeong-Ho, Park, Man-Seok, Choi, Kang-Ho, Cho, Ki-Hyun, Lee, Juneyoung, Gorelick, Philip B., and Bae, Hee-Joon

Published
2020
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27. CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea

Author

Lee, Hak-Loh, Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Park, Sang-Soon, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Sohn, Sung Il, Hong, Jeong-Ho, Park, Man-Seok, Choi, Kang-Ho, Cho, Ki-Hyun, Lee, Juneyoung, and Bae, Hee-Joon

Published
2021
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29. Association of Prestroke Glycemic Control With Vascular Events During 1-Year Follow-up

Author

Chang, Jun Young, Kim, Wook-Joo, Kwon, Jee Hyun, Lee, Ji Sung, Kim, Beom Joon, Kim, Joon-Tae, Lee, Jun, Cha, Jae Kwan, Kim, Dae-Hyun, Cho, Yong-Jin, Hong, Keun-Sik, Lee, Soo Joo, Park, Jong-Moo, Lee, Byung-Chul, Oh, Mi Sun, Lee, Sang-Hwa, Kim, Chulho, Kim, Dong-Eog, Lee, Kyung Bok, Park, Tai Hwan, Choi, Jay Chol, Shin, Dong-Ick, Sohn, Sung-Il, Hong, Jeong-Ho, Bae, Hee-Joon, and Han, Moon-Ku

Published
2021
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31. Efficacy of Endovascular Thrombectomy in Acute Basilar Artery Occlusion with Low PC‐ASPECTS: A Nationwide Prospective Registry‐Based Study.

Author

Chang, Jun Young, Lee, Ji Sung, Kim, Wook‐Joo, Kwon, Jee Hyun, Kim, Beom Joon, Kim, Joon‐Tae, Lee, Jun, Cha, Jae Kwan, Kim, Dae‐Hyun, Cho, Yong‐Jin, Hong, Keun‐Sik, Lee, Soo Joo, Park, Jong‐Moo, Kang, Kyusik, Lee, Byung‐Chul, Yu, Kyung‐Ho, Lee, Sang‐Hwa, Kim, Chulho, Park, Kwang‐Yeol, and Kim, Dong‐Eog

Subjects
BASILAR artery, ENDOVASCULAR surgery, ARTERIAL occlusions, STROKE patients, INTRACRANIAL hemorrhage
Abstract

Objective: We evaluated the efficacy of endovascular thrombectomy (EVT) on the functional outcome of patients with acute basilar artery occlusion and low posterior circulation acute stroke prognosis early computed tomography score (PC‐ASPECTS). Methods: We identified patients with acute ischemic stroke due to basilar artery occlusion and PC‐ASPECTS of 6 or less, presenting within 24 h between August 2008 and April 2022. The primary outcome was a favorable functional outcome, defined as a modified Rankin Scale (mRS) score of 0–3 at 90 days. The secondary outcomes included an mRS score of 0–2, a favorable shift in the ordinal mRS scale, the occurrence of symptomatic intracranial hemorrhage (sICH), and mortality at 90 days. We compared the outcome of patients treated with EVT and those without EVT, using the inverse probability of treatment weighting methods. Results: Out of 566 patients, 55.5% received EVT. In the EVT group, 106 (33.8%) achieved favorable outcomes, compared to 56 patients (22.2%) in the conservative group. EVT significantly increased the likelihood of achieving a favorable outcome compared to conservative treatment (relative risk [RR] 1.39, 95% confidence interval [CI], 1.11–1.74, p = 0.004). EVT was associated with a favorable shift in the mRS (RR 1.85, 95% CI, 1.49–2.29, p < 0.001) and reduced mortality without an increase in the risk of sICH. It did not have an impact on achieving an mRS score of 0–2. Interpretation: Patients with acute basilar artery occlusion and a PC‐ASPECTS of 6 or less might benefit from EVT without an increasing sICH. ANN NEUROL 2024;95:788–799 [ABSTRACT FROM AUTHOR]

Published
2024
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32. Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis

Author

Lim, Jae‐Sung, primary, Lee, Keon‐Joo, additional, Kim, Beom Joon, additional, Ryu, Wi‐Sun, additional, Chung, Jinyong, additional, Gwak, Dong‐Seok, additional, Lee, Ji Sung, additional, Kim, Seong‐Eun, additional, Ko, Eunvin, additional, Lee, Juneyoung, additional, Han, Moon‐Ku, additional, Smith, Eric E., additional, Kim, Dong‐Eog, additional, and Bae, Hee‐Joon, additional

Published
2023
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33. Differential Impacts of Admission LDL-Cholesterol on Early Vascular Outcomes by Ischemic Stroke Subtypes

Author

Kim, Joon-Tae, primary, Lee, Ji Sung, additional, Kim, Hyunsoo, additional, Kim, Beom Joon, additional, Kang, Jihoon, additional, Lee, Keon-Joo, additional, Park, Jong-Moo, additional, Kang, Kyusik, additional, Lee, Soo Joo, additional, Kim, Jae Guk, additional, Cha, Jae-Kwan, additional, Kim, Dae-Hyun, additional, Park, Tai Hwan, additional, Lee, Kyung Bok, additional, Lee, Jun, additional, Hong, Keun-Sik, additional, Cho, Yong-Jin, additional, Park, Hong-Kyun, additional, Lee, Byung-Chul, additional, Yu, Kyung-Ho, additional, Oh, Mi Sun, additional, Kim, Dong-Eog, additional, Choi, Jay Chol, additional, Kwon, Jee-Hyun, additional, Kim, Wook-Joo, additional, Shin, Dong-Ick, additional, Yum, Kyu Sun, additional, Sohn, Sung Il, additional, Hong, Jeong-Ho, additional, Lee, Sang-Hwa, additional, Park, Man-Seok, additional, Ryu, Wi-Sun, additional, Park, Kwang-Yeol, additional, Lee, Juneyoung, additional, and Bae, Hee-Joon, additional

Published
2023
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34. Statin Treatment in Patients With Stroke With Low‐Density Lipoprotein Cholesterol Levels Below 70 mg/dL

Author

Kim, Joon‐Tae, primary, Lee, Ji Sung, additional, Kim, Beom Joon, additional, Kang, Jihoon, additional, Lee, Keon‐Joo, additional, Park, Jong‐Moo, additional, Kang, Kyusik, additional, Lee, Soo Joo, additional, Kim, Jae Guk, additional, Cha, Jae‐Kwan, additional, Kim, Dae‐Hyun, additional, Park, Tai Hwan, additional, Lee, Kyungbok, additional, Lee, Jun, additional, Hong, Keun‐Sik, additional, Cho, Yong‐Jin, additional, Park, Hong‐Kyun, additional, Lee, Byung‐Chul, additional, Yu, Kyung‐Ho, additional, Oh, Mi Sun, additional, Kim, Dong‐Eog, additional, Ryu, Wi‐Sun, additional, Choi, Jay Chol, additional, Kwon, Jee‐Hyun, additional, Kim, Wook‐Joo, additional, Shin, Dong‐Ick, additional, Yum, Kyu Sun, additional, Sohn, Sung Il, additional, Hong, Jeong‐Ho, additional, Lee, Sang‐Hwa, additional, Park, Man‐Seok, additional, Choi, Kang‐Ho, additional, Lee, Juneyoung, additional, Park, Kwang‐Yeol, additional, and Bae, Hee‐Joon, additional

Published
2023
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39. Prevention of cardiovascular events in Asian patients with ischaemic stroke at high risk of cerebral haemorrhage (PICASSO): a multicentre, randomised controlled trial

Author

Kwon, Sun U, Lee, Juneyoung, Kang, Dong-Wha, Rha, Joung-Ho, Park, Jong-Moo, Lee, Yong-Seok, Lee, Ju-Hun, Kim, Yong-Jae, Hong, Keun-Sik, Yu, Kyung Ho, Sohn, Sung-Il, Ahn, Seong Hwan, Cha, Jae-Kwan, Park, Man-Seok, Kim, Jong S, Yoon, Byung-Woo, Lee, Byung-Chul, Nam, Cheong-Mo, Koo, Ja-Seong, Nam, Hyo-Seok, Park, Kwang-Yeol, Kim, Dae-Hyun, Nah, Hyun-Wook, Cho, Yong-Jin, Kim, Dong-Eog, Han, Moon-Ku, Lee, Kyung-Bok, Heo, Seong Hyuk, Heo, Ji Hoe, Kim, Bum Joon, Cho, Kyung-Hee, Kim, Han-Young, Kim, Young-Dae, Cho, Ah-Hyun, Lee, Kyeong-Yul, Lee, Jin-Soo, Park, Jong-Ho, Seo, Woo-Keun, Kim, Eung-Gyu, Koh, Im-Seok, Choi, Nak-Cheon, Kwon, Jee-Hyun, Lee, June, Hwang, Yang-Ha, Song, Hee-Jeong, Shin, Byung-Soo, Kim, June-Tae, Lee, Soo-Joo, Chung, Pil-Wook, Kim, Seong-Heon, Lee, June-Hong, Shin, Dong-Ik, Do, Jin Kuk, Lee, Sang-Bong, Lee, Young-Bae, Yoo, Bong-Goo, Sung, Sang Min, Jung, Jin-Man, Park, Jeong-Wook, Lee, Tae-Kyung, Navarro, Jose C, San Jos, Maria Cristina Z, Roxas, Artemio, Jr., Mallarl-Alvarez, Raquel J, Collantes, Ma. Epifania V, WONG, Lawrence K.S, Fong, Wing-Chi, Tsoi, Tak Hong, Ng, Ping Wing, Lee, Eun-Jae, Lee, Ji Sung, Wong, Lawrence K S, Yu, Sungwook, Heo, Sung Hyuk, and Ahn, Sung Hwan

Published
2018
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42. Neurological Deterioration in Patients with Acute Ischemic Stroke or Transient Ischemic Attack

Author

Park, Tai Hwan, Lee, Jeong-Kon, Park, Moo-Seok, Park, Sang-Soon, Hong, Keun-Sik, Ryu, Wi-Sun, Kim, Dong-Eog, Park, Man Seok, Choi, Kang-Ho, Kim, Joon-Tae, Kang, Jihoon, Kim, Beom Joon, Han, Moon-Ku, Lee, Jun, Cha, Jae-Kwan, Kim, Dae-Hyun, Kim, Jae Guk, Lee, Soo Joo, Cho, Yong-Jin, Kwon, Jee-Hyun, Shin, Dong-Ick, Yeo, Min-Ju, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Ji Sung, Choi, Jay Chol, Kim, Wook-Joo, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi-Sun, Park, Jong-Moo, Kang, Kyusik, Lee, Kyung Bok, Lee, Juneyoung, Gorelick, Philip B., and Bae, Hee-Joon

Published
2020
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43. Three-month modified Rankin Scale as a determinant of 5-year cumulative costs after ischemic stroke: An analysis of 11,136 patients in Korea

Author

Kim, Seong-Eun, Lee, Heeyoung, Kim, Jun Yup, Lee, Keon-Joo, Kang, Jihoon, Kim, Beom Joon, Han, Moon-Ku, Choi, Kang-Ho, Kim, Joon-Tae, Shin, Dong-Ick, Yeo, Min-Ju, Cha, Jae-Kwan, Kim, Dae-Hyun, Nah, Hyun-Wook, Kim, Dong-Eog, Ryu, Wi-Sun, Park, Jong-Moo, Kang, Kyusik, Kim, Jae Guk, Lee, Soo Joo, Oh, Mi-Sun, Yu, Kyung-Ho, Lee, Byung-Chul, Park, Hong-Kyun, Hong, Keun-Sik, Cho, Yong-Jin, Choi, Jay Chol, Sohn, Sung Il, Hong, Jeong-Ho, Park, Moo-Seok, Park, Tai Hwan, Park, Sang-Soon, Lee, Kyung Bok, Kwon, Jee-Hyun, Kim, Wook-Joo, Lee, Jun, Lee, Ji Sung, Lee, Juneyoung, Meretoja, Atte, Gorelick, Philip B., and Bae, Hee-Joon

Published
2020
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44. Effect of Heart Rate on Stroke Recurrence and Mortality in Acute Ischemic Stroke With Atrial Fibrillation

Author

Lee, Keon-Joo, Kim, Beom Joon, Han, Moon-Ku, Kim, Joon-Tae, Choi, Kang-Ho, Shin, Dong-Ick, Yeo, Min-Ju, Cha, Jae-Kwan, Kim, Dae-Hyun, Nah, Hyun-Wook, Kim, Dong-Eog, Ryu, Wi-Sun, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Oh, Mi-Sun, Yu, Kyung-Ho, Lee, Byung-Chul, Hong, Keun-Sik, Cho, Yong-Jin, Choi, Jay Chol, Park, Tai Hwan, Park, Sang-Soon, Kwon, Jee-Hyun, Kim, Wook-Joo, Lee, Jun, Lee, Ji Sung, Lee, Juneyoung, Gorelick, Philip B., and Bae, Hee-Joon

Published
2019
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45. Deep learning algorithms for automatic segmentation of acute cerebral infarcts on diffusion-weighted images: Effects of training data sample size, transfer learning, and data features

Author

Noh, Yoon-Gon, primary, Ryu, Wi-Sun, additional, Schellingerhout, Dawid, additional, Park, Jonghyeok, additional, Chung, Jinyong, additional, Jeong, Sang-Wuk, additional, Gwak, Dong-Seok, additional, Kim, Beom Joon, additional, Kim, Joon-Tae, additional, Hong, Keun-Sik, additional, Lee, Kyung Bok, additional, Park, Tai Hwan, additional, Park, Sang-Soon, additional, Park, Jong-Moo, additional, Kang, Kyusik, additional, Cho, Yong-Jin, additional, Park, Hong-Kyun, additional, Lee, Byung-Chul, additional, Yu, Kyung-Ho, additional, Oh, Mi Sun, additional, Lee, Soo Joo, additional, Kim, Jae Guk, additional, Cha, Jae-Kwan, additional, Kim, Dae-Hyun, additional, Lee, Jun, additional, Park, Man Seok, additional, Kim, Dongmin, additional, Bang, Oh Young, additional, Kim, Eung Yeop, additional, Sohn, Chul-Ho, additional, Kim, Hosung, additional, Bae, Hee-Joon, additional, and Kim, Dong-Eog, additional

Published
2023
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46. Secular Trends in Outcomes and Impact of Novel Oral Anticoagulants in Atrial Fibrillation–Related Acute Ischemic Stroke

Author

Lee, Minwoo, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi-Sun, Kim, Beom Joon, Kim, Jun Yup, Kang, Jihoon, Lee, Keon-Joo, Kim, Do Yeon, Park, Jong-Moo, Kang, Kyusik, Park, Tai Hwan, Lee, Kyung Bok, Hong, Keun-Sik, Park, Hong-Kyun, Cho, Yong-Jin, Kim, Dong-Eog, Lee, Soo Joo, Kim, Jae Guk, Lee, Jun, Cha, Jae-Kwan, Kim, Dae-Hyun, Kim, Joon-Tae, Choi, Kang-Ho, Choi, Jay Chol, Sohn, Sung-il, Hong, Jeong-Ho, Lee, Sang-hwa, Kim, Chulho, Shin, Dong-Ick, Yum, Kyu Sun, Lee, Juneyoung, Lee, Ji Sung, Gorelick, Philip B., and Bae, Hee-Joon

Published
2024
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47. Utility of Items of Baseline National Institutes of Health Stroke Scale as Predictors of Functional Outcomes at Three Months after Mild Ischemic Stroke

Author

Choi, Jay Chol, Kim, Beom Joon, Han, Moon-Ku, Lee, Soo Joo, Kang, Kyusik, Park, Jong-Moo, Park, Sang-Soon, Park, Tai Hwan, Cho, Yong-Jin, Hong, Keun-Sik, Lee, Kyung Bok, Lee, Jun, Ryu, Wi-Sun, Kim, Dong-Eog, Nah, Hyun-Wook, Kim, Dae-Hyun, Cha, Jae-Kwan, Kim, Joon-Tae, Choi, Kang-Ho, Oh, Mi Sun, Yu, Kyung-Ho, Lee, Byung-Chul, Jang, Myung Suk, Lee, Ji Sung, Lee, Juneyoung, and Bae, Hee-Joon

Published
2017
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48. Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study

Author

Kim, Jong S, Lee, Eun-Jae, Chang, Dae-Il, Park, Jong-Ho, Ahn, Seong Hwan, Cha, Jae-Kwan, Heo, Ji Hoe, Sohn, Sung-Il, Lee, Byung-Chul, Kim, Dong-Eog, Kim, Hahn Young, Kim, Seongheon, Kwon, Do-Young, Kim, Jei, Seo, Woo-Keun, Lee, Jun, Park, Sang-Won, Koh, Seong-Ho, Kim, Jin Young, and Choi-Kwon, Smi

Published
2017
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50. Futile reperfusion and predicted therapeutic benefits after successful endovascular treatment according to initial stroke severity

Author

Lee, Sang-Hwa, Kim, Beom Joon, Han, Moon-Ku, Park, Tai Hwan, Lee, Kyung Bok, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Cha, Jae Kwan, Kim, Dae-Hyun, Nah, Hyun-Wook, Lee, Jun, Lee, Soo Joo, Kim, Jae Guk, Park, Jong-Moo, Kang, Kyusik, Cho, Yong-Jin, Hong, Keun-Sik, Park, Hong-Kyun, Choi, Jay Chol, Kim, Joon-Tae, Choi, Kangho, Kim, Dong-Eog, Ryu, Wi-Sun, Kim, Wook-Joo, Shin, Dong-Ick, Yeo, Minju, Sohn, Sung-Il, Hong, Jeong-Ho, Lee, Juneyoung, Lee, Ji Sung, Khatri, Pooja, and Bae, Hee-Joon

Published
2019
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