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28 results on '"Kim, Hyo-Sop"'

3. Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis Research.

Author

Yun, Chawon, Kim, Sou Hyun, Kim, Kyung Mok, Yang, Min Hye, Byun, Mi Ran, Kim, Joung-Hee, Kwon, Doyoung, Pham, Huyen T. M., Kim, Hyo-Sop, Kim, Jae-Ho, and Jung, Young-Suk

Subjects
CELL culture, BONE growth, HOMEOSTASIS, OSTEOGENESIS imperfecta, DRUG development, RICKETS, BONE regeneration
Abstract

Bone differentiation is crucial for skeletal development and maintenance. Its dysfunction can cause various pathological conditions such as rickets, osteoporosis, osteogenesis imperfecta, or Paget's disease. Although traditional two-dimensional cell culture systems have contributed significantly to our understanding of bone biology, they fail to replicate the intricate biotic environment of bone tissue. Three-dimensional (3D) spheroid cell cultures have gained widespread popularity for addressing bone defects. This review highlights the advantages of employing 3D culture systems to investigate bone differentiation. It highlights their capacity to mimic the complex in vivo environment and crucial cellular interactions pivotal to bone homeostasis. The exploration of 3D culture models in bone research offers enhanced physiological relevance, improved predictive capabilities, and reduced reliance on animal models, which have contributed to the advancement of safer and more effective strategies for drug development. Studies have highlighted the transformative potential of 3D culture systems for expanding our understanding of bone biology and developing targeted therapeutic interventions for bone-related disorders. This review explores how 3D culture systems have demonstrated promise in unraveling the intricate mechanisms governing bone homeostasis and responses to pharmacological agents. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Enhancement of anti-inflammatory and immunomodulatory effects of adipose-derived human mesenchymal stem cells by making uniform spheroid on the new nano-patterned plates

Author

Lee, Sangho, primary, Kim, Hyo-Sop, additional, Min, Byoung-Hoon, additional, Kim, Byoung Geun, additional, Kim, Shin Ae, additional, Nam, Hyeyoung, additional, Lee, Minsuk, additional, Kim, Minsun, additional, Hwang, Hye Yeon, additional, Leesong, Alex Inkeun, additional, Leesong, Margaret Minsun, additional, Kim, Jae-Ho, additional, and Shin, Jun-Seop, additional

Published
2021
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27. Optical investigation on plasmonic effect of the nanostructured surface plasmon resonance sensor chips fabricated by Langmuir-Blodgett technique

Author

Yeon, Chanmi, Sung, So-Hee, Kim, Hyo-Sop, and Kim, Jae-Ho

Abstract

We used the Langmuir-Blodgett (LB) method for preparation of defect-free and large-area silica-nanoparticlesmonolayer as a template for the fabrication of Au nanostructures on an Au-thinfilm for surface plasmon resonance (SPR). The dimensions of trigonal pyramid Au nanostructures were controlled by changing the particle size of the silica LB template. The nanostructured SPR chips provide the enhancement of sensitivity in SPR analysis compared to a conventional SPR chip when 20 % ethanol solution was used as an analyte. We took a theoretical approach by evaluating optical properties of the Au-nanostructures and nanostructured SPR chips in the view of plasmonic effect.

Published
2011
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28. Hexagonally close packed Langmuir-Blodgett films from monodispersed silica nanoparticles.

Author

Kim JH, Kim HS, Lee JH, Choi SW, Cho YJ, and Kim JH

Abstract

This report demonstrates a novel procedure to produce hexagonally close packed nanoparticle film using the Langmuir-Blodgett (LB) technique. The LB technique has advantages over previously reported techniques, such as high reproducibility, formation of large area films with low-cost capable of producing a large number of hexagonally close packed nanoparticle films at a single process. In this method, a monolayer of mono-dispersed silica nanoparticles was spread on the surface of water and then transferred it onto a gold sputtered glass substrate or silicon wafer. The silica particles used for fabrication of LB films were synthesized by the modified Stöber method. In present work, we synthesized 300 +/- 5 nm sized silica particles. A large area of hexagonally close packed nanoparticle films fabricated by the LB technique was confirmed by AFM and FE-SEM. Furthermore, we demonstrate fabrication of over 34 hexagonally close packed nanoparticle LB films on glass substrates with area of 18 x 18 mm2 from a single process.

Published
2009
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