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5. Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis

Author

Shin, Min-Jeong, primary, Kim, Hyun-Sun, additional, Lee, Pyeongan, additional, Yang, Na-Gyeong, additional, Kim, Jae-Yun, additional, Eun, Yun-Su, additional, Lee, Whiin, additional, Kim, Doyeon, additional, Lee, Young, additional, Jung, Kyung-Eun, additional, Hong, Dongkyun, additional, Shin, Jung-Min, additional, Lee, Sul-Hee, additional, Lee, Sung-Yul, additional, Kim, Chang-Deok, additional, and Kim, Jung-Eun, additional

Published
2023
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7. Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.

Author

Shin, Min-Jeong, Kim, Hyun-Sun, Lee, Pyeongan, Yang, Na-Gyeong, Kim, Jae-Yun, Eun, Yun-Su, Lee, Whiin, Kim, Doyeon, Lee, Young, Jung, Kyung-Eun, Hong, Dongkyun, Shin, Jung-Min, Lee, Sul-Hee, Lee, Sung-Yul, Kim, Chang-Deok, and Kim, Jung-Eun

Subjects
*TUMOR suppressor proteins, *SKIN inflammation, *REVERSE transcriptase polymerase chain reaction, *OXIDOREDUCTASES, *PROTEIN kinase C, *NF-kappa B, *TUMOR suppressor genes, KERATINOCYTE differentiation
Abstract

Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, aberrant differentiation of keratinocytes, and dysregulated immune responses. WW domain-containing oxidoreductase (WWOX) is a non-classical tumor suppressor gene that regulates multiple cellular processes, including proliferation, apoptosis, and migration. This study aimed to explore the possible role of WWOX in the pathogenesis of psoriasis. Immunohistochemical analysis showed that the expression of WWOX was increased in epidermal keratinocytes of both human psoriatic lesions and imiquimod-induced mice psoriatic model. Immortalized human epidermal keratinocytes were transduced with a recombinant adenovirus expressing microRNA specific for WWOX to downregulate its expression. Inflammatory responses were detected using Western blotting, real-time quantitative reverse transcription polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay. In human epidermal keratinocytes, WWOX knockdown reduced nuclear factor-kappa B signaling and levels of proinflammatory cytokines induced by polyinosinic: polycytidylic acid [(poly(I:C)] in vitro. Furthermore, calcium chelator and protein kinase C (PKC) inhibitors significantly reduced poly(I:C)-induced inflammatory reactions. WWOX plays a role in the inflammatory reaction of epidermal keratinocytes by regulating calcium and PKC signaling. Targeting WWOX could be a novel therapeutic approach for psoriasis in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Development and effects of a non‐face‐to‐face forest therapy program for nurses during the COVID‐19 pandemic.

Author

Kang, Mi‐Jung, Kim, Hyun‐Sun, and Kim, Ji‐Yeon

Subjects
*EVALUATION of human services programs, *HAPPINESS, *ANALYSIS of variance, *CONFIDENCE intervals, *MENTAL health, *HEALTH outcome assessment, *FISHER exact test, *RANDOMIZED controlled trials, *PRE-tests & post-tests, *PSYCHOLOGICAL tests, *COMPARATIVE studies, *T-test (Statistics), *HOSPITAL nursing staff, *STRESS management, *QUESTIONNAIRES, *CHI-squared test, *REPEATED measures design, *DESCRIPTIVE statistics, *RESEARCH funding, *ALTERNATIVE medicine, *NATURE, *STATISTICAL sampling, *NURSE practitioners, *SOCIODEMOGRAPHIC factors, *DATA analysis software, *VIDEO recording, *COVID-19 pandemic, *PSYCHOLOGICAL stress, *HEALTH promotion
Abstract

Aim: In this study, we developed a non‐face‐to‐face forest therapy program using videos and applied it to nurses working in hospitals during the prolonged COVID‐19 situation to confirm the effect on their mental health. Method: This study was a randomized control group pretest‐posttest, and 27 clinical nurses in the experimental group and 28 clinical nurses in the control group participated. The program developed forest therapy videos and three city videos each. The experimental group watched the forest therapy video and the control group watched the city video and stress and happiness were measured through pre‐test and post‐test. Results: The stress level of clinical nurses who applied the non‐face‐to‐face forest therapy program had a significant reduction effect compared to the control group on day 2 (t = −2.239 P =.026) and day 3 (t = −3.188, P =.003). On the other hand, there was no significant effect in happiness in both groups. In addition, repeated measures analysis of variance statistical analysis confirmed that the stress level of the experimental group significantly decreased over time (F = 10.578, P <.001). Conclusion: The non‐face‐to‐face forest therapy program is significant in that it had a positive effect on relieving stress by conducting a randomized controlled study targeting clinical nurses working in various hospitals. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Methane emission estimation from landfills in Korea (1978-2004): quantitative assessment of a new approach

Author

Kim, Hyun-Sun and Yi, Seung-Muk

Subjects
Methane -- Measurement -- Environmental aspects -- Methods, Greenhouse gases -- Measurement -- Environmental aspects -- Methods, Estimation theory -- Methods -- Measurement -- Environmental aspects, Emissions (Pollution) -- Measurement -- Methods -- Environmental aspects, Research -- Environmental aspects -- Measurement -- Methods, Sanitary landfills -- Environmental aspects -- Measurement -- Methods, Environmental services industry, Environmental issues, Science and technology
Abstract

ABSTRACT Quantifying methane emission from landfills is important to evaluating measures for reduction of greenhouse gas (GHG) emissions. To quantify GHG emissions and identify sensitive parameters for their measurement, a [...]

Published
2009

32. Life and Work of Korean War Widows during the 1950s

Author

Kim Hyun Sun

Subjects
Cultural Studies, Human rights, media_common.quotation_subject, Opposition (politics), General Social Sciences, Gender studies, Livelihood, Value systems, Oral history, Arts and Humanities (miscellaneous), Public arena, Sociology, Life history, Consciousness, media_common
Abstract

This paper examines the realities of life and work for women during the 1950s through life history interviews with Korean War widows. The 1950s was a time when many women began to enter the public arena in South Korea. This period witnessed, at the level of social discourse, radical discussions on women’s economic activities in relation to the goal of women’s liberation. What characterized the dominant discourse of the day was an activist thrust that defended women’s entry into jobs outside the home as a natural outcome of the changed conditions of the era, as a matter of women’s human rights, or as a prerequisite for the reconstruction of Korean society. On the other hand, however, the realities of war widows’ lives in the 1950s show glaring discrepancies from what the discourse produced by contemporary journals portrayed. Most war widows spent their lives playing the role of family head, caring for children, and supporting their in-laws. It is hard to find signs of the changing status of widows in the family corresponding to their expanded economic responsibilities. Most war widows maintained their daughterin-law roles while also assuming the role of breadwinner for the family. In short, there was a gap between the image of modern women produced by intellectuals and the actual life stories of war widows. A major reason for this divergence is the fact that women began their economic activities to secure the livelihood of their families following their husbands’ deaths. For war widows having a job often meant becoming even more bound up in the framework of traditional value systems and family institutions, rather than a process of achieving their own individual rights. In the cases of war widows who sought to work not for family reasons but of their own volition, we find that opposition from the family often thwarted their desires. Although ending in failure, the life courses of this latter group reveal much about how, during the 1950s, a radical and modern consciousness was forged while the traditional family system and pre-modern consciousness persisted.

Published
2009

40. Effect of Repeated MSG Administration on Cognitive Ability and Anxiety of Juvenile Rats

Author

Lee, Hae-Nim, primary, Choo, Gang-Sik, additional, Shin, Seong-Ah, additional, Park, Jung-Joon, additional, Lee, Se-Geun, additional, Kim, Se-Woon, additional, Kim, Hyun-Sun, additional, Lee, Song-Hee, additional, Lim, Jeong-Min, additional, Kim, Hyeong-Jin, additional, Park, Young-Seok, additional, Kim, Sang-Ki, additional, Park, Byung-Kwon, additional, Kim, Byeong-Soo, additional, and Jung, Ji-Youn, additional

Published
2015
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43. Prx I Suppresses K-ras-Driven Lung Tumorigenesis by Opposing Redox-Sensitive ERK/Cyclin D1 Pathway

Author

Park, Young-Ho, primary, Kim, Sun-Uk, additional, Lee, Bo-Kyoung, additional, Kim, Hyun-Sun, additional, Song, In-Sung, additional, Shin, Hye-Jun, additional, Han, Ying-Hao, additional, Chang, Kyu-Tae, additional, Kim, Jin-Man, additional, Lee, Dong-Seok, additional, Kim, Yeul-Hong, additional, Choi, Chang-Min, additional, Kim, Bo-Yeon, additional, and Yu, Dae-Yeul, additional

Published
2013
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46. Electrical control of terahertz nano antennas on VO_2 thin film

Author

Jeong, Young-Gyun, primary, Bernien, Hannes, additional, Kyoung, Ji-Soo, additional, Park, Hyeong-Ryeol, additional, Kim, Hyun‑Sun, additional, Choi, Jae-Wook, additional, Kim, Bong-Jun, additional, Kim, Hyun-Tak, additional, Ahn, Kwang Jun, additional, and Kim, Dai-Sik, additional

Published
2011
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