Search

Your search keyword '"Kim, Kyu Bong"' showing total 471 results
Start Over Author "Kim, Kyu Bong"
471 results on '"Kim, Kyu Bong"'

6. Negligible Toxicokinetic Differences of Glyphosate by Different Vehicles in Rats

Author

Kim, Yu-Jin, Nitin, Nitin, and Kim, Kyu-Bong

Subjects
Biomedical and Clinical Sciences, Environmental Sciences, Pollution and Contamination, toxicokinetic, glyphosate, polyoxyethylene tallow amine, tween 20, vehicles
Abstract

Glyphosate is a non-selective herbicide. Although glyphosate is not acutely toxic, the intake of glyphosate-based herbicides has caused many accidents. Some studies have suggested that surfactants might be the cause. The purpose of this study was to compare the toxicokinetic (TK) properties of glyphosate according to different vehicles in rats. Glyphosate (1%) was dissolved in distilled water (DW), polyoxyethylene tallow amine (POEA), and Tween 20. After a single oral treatment of glyphosate (50 mg/kg), blood was collected at time intervals, and glyphosate concentrations in the target organ (liver and kidney) were determined 24 h after final blood collection. All samples were analyzed using LC-MS/MS. The TK parameters of glyphosate were similar in the DW and Tween 20 groups. However, there were significant differences in Tmax and volume of distribution (Vd) between the DW and POEA group (p < 0.05). Glyphosate was absorbed about 10 times faster in POEA group rather than DW, and exhibited a higher distribution. However, other important TK parameters of T1/2, AUC, and Cmax were not statistically different among the different vehicle groups. Although glyphosate concentration in the liver was significantly higher in the POEA group than in the DW group, there was no significant difference in the kidney. These results indicate that the toxicokinetics of glyphosate are not significantly affected by POEA. It can be concluded that POEA toxicity itself can be attributed to the acute toxicity of glyphosate-containing products.

Published
2023

22. Para-phenylenediamine, an oxidative hair dye ingredient, increases thymic stromal lymphopoietin and proinflammatory cytokines causing acute dermatitis

Author

Lee, Jae Kwon, Lee, Hye Eun, Yang, Gabsik, Kim, Kyu-Bong, Kwack, Seung Jun, and Lee, Joo Young

Abstract

Due to high consumption of cosmetics in modern society, people are always exposed to the risk of skin damage and complications. Para-phenylenediamine (P-PD), an ingredient of hair dye, has been reported to cause allergic contact dermatitis. However, the mechanism has not been well elucidated. Here, we identify that P-PD causes dermatitis by increasing thymic stromal lymphopoietin (TSLP) and inflammatory cytokines. Topical application of P-PD to mouse ear skin in consecutive 5 days resulted in dermatitis symptoms and increased ear thickness. TSLP production in skin was upregulated by P-PD treatment alone. In addition, P-PD-induced TSLP production was potentiated by MC903, which is an in vivo TSLP inducer. P-PD increased TSLP production in keratinocytes (KCMH-1 cells and phorbol 12-myristate 13-acetate-stimulated PAM212 cells). The production of proinflammatory cytokines such as IL-1β, IL-6, IFN-γ, and CCL2, was upregulated by P-PD treatment together with MC903. The results show that repeated exposure to P-PD causes acute contact dermatitis mediated by increasing the expression of TSLP and proinflammatory cytokines.

Published
2024
Full Text
View/download PDF

37. Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats.

Author

Kim, Woojin, Kim, Eunbin, Lee, Jaewoong, Song, Chang Ho, Jung, Woohyung, Shin, Soyoung, Kim, Kyu-Bong, Shin, Beom Soo, and Kim, Tae Hwan

Subjects
METHENAMINE, ORAL drug administration, LIQUID chromatography-mass spectrometry, URINARY tract infections, INTRAVENOUS injections, FOOD preservatives
Abstract

Hexamethylenetetramine, an aldehyde-releasing agent, is used as a preservative in various food, cosmetics, and medical treatments, such as a treatment for urinary tract infections. It has been reported to be allergenic on contact with the skin, with the additional possibility of causing toxicity once absorbed systemically. Despite its potential toxicity, there are no reports on the in vivo bioavailability of hexamethylenetetramine following oral or dermal administration. In this study, we developed a new simple and sensitive LC–MS/MS method for the determination of hexamethylenetetramine in plasma and applied this method to characterize the toxicokinetics. The developed assay had a sufficient specificity and sensitivity for toxicokinetic characterization, and its accuracy and precision were verified. Following iv injection, the plasma concentration of hexamethylenetetramine showed mono exponential decay, with an elimination half-life of about 1.3 h. Following oral administration, the Tmax reached an average of 0.47 h and bioavailability was estimated as 89.93%. After percutaneous administration, it reached Cmax on average at 2.9–3.6 h. Although the absorption rate was relatively slow, its average bioavailability was calculated as 77.19–78.91%. Overall, most of the orally and percutaneously administered hexamethylenetetramine was absorbed into systemic circulation. The derived results in this study are expected to be utilized as the scientific evidence for further toxicokinetic study and risk assessment. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

42. Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis

Author

Jin, Sun Woo, primary, Im, Jong Seung, additional, Park, Jae Hyeon, additional, Kim, Hyung Gyun, additional, Lee, Gi Ho, additional, Kim, Se Jong, additional, Kwack, Seung Jun, additional, Kim, Kyu-Bong, additional, Chung, Kyu Hyuck, additional, Lee, Byung Mu, additional, Kacew, Sam, additional, Jeong, Hye Gwang, additional, and Kim, Hyung Sik, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results