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4. Historical Credibility for Movie Reviews and Its Application to Weakly Supervised Classification

Author

Kim, Min-Seon, Lim, Bo-Young, Shin, Han-Sub, and Kwon, Hyuk-Yoon

Subjects
Computer Science - Information Retrieval
Abstract

In this study, we deal with the problem of judging the credibility of movie reviews. The problem is challenging because even experts cannot clearly and efficiently judge the credibility of a movie review and the number of movie reviews is very large. To tackle this problem, we propose historical credibility that judges the credibility of reviews based on the historical ratings and textual reviews written by each reviewer. For this, we present three kinds of criteria that can clearly classify the reviews into trusted or distrusted ones. We validate the effectiveness of the proposed historical credibility through extensive analysis. Specifically, we show that characteristics between the trusted or distrusted reviews are quite distinguishable in terms of three viewpoints: 1) distribution, 2) statistics, and 3) correlation. Then, we apply historical credibility to a weakly supervised model to classify a given review as a trusted or distrusted one. First, we show that it is significantly efficient because the entire data set is annotated according to the predefined criteria. Indeed, it can annotate 6,400 movie reviews only in 0.093 seconds, which occupy only 0.55%~1.88% of the total learning time when we use LSTM and SVM as the learning model. Second, we show that the historical credibility-based classification model clearly outperforms the textual review-based classification model. Specifically, the classification accuracy of the former outperforms that of the latter by up to 11.7%~13.4%. In addition, we clearly confirm that our classification model shows higher accuracy as the data size increases.

Published
2020

8. Stomach clusterin as a gut-derived feeding regulator

Author

NamKoong, Cherl, primary, Kim, Bohye, additional, Yu, Ji Hee, additional, Youn, Byung Soo, additional, Kim, Hanbin, additional, Kim, Evonne, additional, Gil, So Young, additional, Kang, Gil Myoung, additional, Lee, Chan Hee, additional, Kim, Young-Bum, additional, Park, Kyeong-Han, additional, Kim, Min-Seon, additional, and Kwon, Obin, additional

Published
2024
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17. Hypothalamic astrocyte NAD+ salvage pathway mediates the coupling of dietary fat overconsumption in a mouse model of obesity.

Author

Park, Jae Woo, Park, Se Eun, Koh, Wuhyun, Jang, Won Hee, Choi, Jong Han, Roh, Eun, Kang, Gil Myoung, Kim, Seong Jun, Lim, Hyo Sun, Park, Chae Beom, Jeong, So Yeon, Moon, Sang Yun, Lee, Chan Hee, Kim, Sang Yeob, Choi, Hyung Jin, Min, Se Hee, Lee, C. Justin, and Kim, Min-Seon

Abstract

Nicotinamide adenine dinucleotide (NAD)+ serves as a crucial coenzyme in numerous essential biological reactions, and its cellular availability relies on the activity of the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed salvage pathway. Here we show that treatment with saturated fatty acids activates the NAD+ salvage pathway in hypothalamic astrocytes. Furthermore, inhibition of this pathway mitigates hypothalamic inflammation and attenuates the development of obesity in male mice fed a high-fat diet (HFD). Mechanistically, CD38 functions downstream of the NAD+ salvage pathway in hypothalamic astrocytes burdened with excess fat. The activation of the astrocytic NAMPT–NAD+–CD38 axis in response to fat overload induces proinflammatory responses in the hypothalamus. It also leads to aberrantly activated basal Ca2+ signals and compromised Ca2+ responses to metabolic hormones such as insulin, leptin, and glucagon-like peptide 1, ultimately resulting in dysfunctional hypothalamic astrocytes. Our findings highlight the significant contribution of the hypothalamic astrocytic NAD+ salvage pathway, along with its downstream CD38, to HFD-induced obesity.The cellular levels of the critical coenzyme nicotinamide adenine dinucleotide (NAD)+ depend on its salvage pathway. Here, the authors show that the NAD+ salvage pathway in hypothalamic astrocytes is activated to promote obesity in high fat diet-fed mice. [ABSTRACT FROM AUTHOR]

Published
2024
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19. LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus

Author

Uner, Aaron Aykut, primary, Yang, Won-Mo, additional, Kang, Min-Cheol, additional, Rodrigues, Kellen Cristina da Cruz, additional, Aydogan, Ahmet, additional, Seo, Ji A, additional, Mendes, Natalia F., additional, Kim, Min-Seon, additional, Timzoura, Fatima Ezzahra, additional, Holtzman, Michael J., additional, Lehtinen, Maria, additional, Prevot, Vincent, additional, and Kim, Young-Bum, additional

Published
2023
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21. Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Author

Huang, Hu, Lee, Seung-Hwan, Sousa-Lima, Ines, Kim, Sang Soo, Hwang, Won Min, Dagon, Yossi, Yang, Won-Mo, Cho, Sungman, Kang, Min-Cheol, Seo, Ji A., Shibata, Munehiko, Cho, Hyunsoo, Belew, Getachew Debas, Bhin, Jinhyuk, Desai, Bhavna N., Ryu, Min Jeong, Shong, Minho, Li, Peixin, Meng, Hua, Chung, Byung-Hong, Hwang, Daehee, Kim, Min Seon, Park, Kyong Soo, Macedo, Maria Paula, White, Morris, Jones, John, and Kim, Young-Bum

Subjects
Obesity -- Complications and side effects -- Genetic aspects, Fatty liver -- Risk factors -- Genetic aspects, Cellular signal transduction -- Research, Gene expression -- Research, Hepatocellular carcinoma, Insulin resistance, Carcinoma, Insulin, Liver diseases, Genes, Liver cirrhosis, Hyperglycemia, Type 2 diabetes, Biochemistry, Health care industry
Abstract

Obesity is a major risk factor for developing nonalcoholic fatty liver disease (NAFLD). NAFLD is the most common form of chronic liver disease and is closely associated with insulin resistance, ultimately leading to cirrhosis and hepatocellular carcinoma. However, knowledge of the intracellular regulators of obesity-linked fatty liver disease remains incomplete. Here we showed that hepatic Rho-kinase 1 (ROCK1) drives obesity-induced steatosis in mice through stimulation of de novo lipogenesis. Mice lacking ROCK1 in the liver were resistant to diet-induced obesity owing to increased energy expenditure and thermogenic gene expression. Constitutive expression of hepatic ROCK1 was sufficient to promote adiposity, insulin resistance, and hepatic lipid accumulation in mice fed a high-fat diet. Correspondingly, liver-specific ROCK1 deletion prevented the development of severe hepatic steatosis and reduced hyperglycemia in obese diabetic (ob/ob) mice. Of pathophysiological significance, hepatic ROCK1 was markedly upregulated in humans with fatty liver disease and correlated with risk factors clustering around NAFLD and insulin resistance. Mechanistically, we found that hepatic ROCK1 suppresses AMPK activity and a ROCK1/AMPK pathway is necessary to mediate cannabinoid-induced lipogenesis in the liver. Furthermore, treatment with metformin, the most widely used antidiabetes drug, reduced hepatic lipid accumulation by inactivating ROCK1, resulting in activation of AMPK downstream signaling. Taken together, our findings establish a ROCK1/AMPK signaling axis that regulates de novo lipogenesis, providing a unique target for treating obesity-related metabolic disorders such as NAFLD., IntroductionObesity has reached epidemic proportions in the United States and worldwide, and is associated with increased risk for type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), atherosclerotic disease, sleep apnea, [...]

Published
2018
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30. Prediabetes is not a risk factor for subclinical coronary atherosclerosis

Author

Park, Gyung-Min, Cho, Young-Rak, Lee, Seung-Whan, Yun, Sung-Cheol, Won, Ki-Bum, Ann, Soe Hee, Kim, Yong-Giun, Kim, Shin-Jae, Roh, Jae-Hyung, Kim, Young-Hak, Yang, Dong Hyun, Kang, Joon-Won, Lim, Tae-Hwan, Jung, Chang Hee, Koh, Eun Hee, Lee, Woo Je, Kim, Min-Seon, Lee, Ki-Up, Park, Joong-Yeol, Kim, Hong-Kyu, Choe, Jaewon, and Lee, Sang-Gon

Published
2017
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32. Author Correction: Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

Author

Seo, Ji A., Kang, Min-Cheol, Yang, Won-Mo, Hwang, Won Min, Kim, Sang Soo, Hong, Soo Hyun, Heo, Jee-In, Vijyakumar, Achana, de Moura, Leandro Pereira, Uner, Aykut, Huang, Hu, Lee, Seung Hwan, Lima, Inês S., Park, Kyong Soo, Kim, Min Seon, Dagon, Yossi, Willnow, Thomas E., Aroda, Vanita, Ciaraldi, Theodore P., Henry, Robert R., and Kim, Young-Bum

Published
2020
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41. Comparison of Coronary Computed Tomographic Angiographic Findings in Asymptomatic Subjects With Versus Without Diabetes Mellitus

Author

Park, Gyung-Min, Lee, Jae-Hwan, Lee, Seung-Whan, Yun, Sung-Cheol, Kim, Young-Hak, Cho, Young-Rak, Gil, Eun Ha, Kim, Tae-Seok, Kim, Chan Joon, Cho, Jung Sun, Park, Mahn-Won, Her, Sung Ho, Yang, Dong Hyun, Kang, Joon-Won, Lim, Tae-Hwan, Koh, Eun Hee, Lee, Woo Je, Kim, Min-Seon, Lee, Ki-Up, Kim, Hong-Kyu, Choe, Jaewon, and Park, Joong-Yeol

Published
2015
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50. Coronary Computed Tomographic Angiographic Findings in Asymptomatic Patients With Type 2 Diabetes Mellitus

Author

Park, Gyung-Min, Lee, Seung-Whan, Cho, Young-Rak, Kim, Chan Joon, Cho, Jung Sun, Park, Mahn-Won, Her, Sung Ho, Ahn, Jung-Min, Lee, Jong-Young, Park, Duk-Woo, Kang, Soo-Jin, Kim, Young-Hak, Lee, Cheol Whan, Koh, Eun Hee, Lee, Woo Je, Kim, Min-Seon, Lee, Ki-Up, Kang, Joon-Won, Lim, Tae-Hwan, Park, Seong-Wook, Park, Seung-Jung, and Park, Joong-Yeol

Published
2014
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