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Supplemental material, sj-docx-1-chl-10.1177_17475198221143738 for Photophysical properties of furan-bridged dimeric boron-dipyrromethene derivatives (BODIPYs) by Galam Jung, Namdoo Kim and Se Won Bae in Journal of Chemical Research

The U.S. Department of Energy’s (DOE) Vehicle Technologies Office (VTO) supports research, development (R&D), and deployment of efficient and sustainable transportation technologies that will improve energy efficiency, fuel economy, and enable America to use less petroleum. To accelerate the development and adoption of new technologies, VTO has developed specific targets for a wide range of powertrain technologies (e.g., engine, battery, electric machine, lightweighting, etc.). The objective of the paper is to quantify the impact of VTO R&D on vehicle energy consumption and cost compared to expected historical improvements across vehicle classes, powertrains, component technologies and timeframes. A large scale simulation process was used to develop and simulate tens of thousands of vehicles on US standard driving cycles using Autonomie. Results demonstrate significant additional reduction in both cost and energy consumption due to VTO R&D targets compared to historical predicted trends.

The U.S. Department of Energy’s (DOE) Hydrogen & Fuel Cell Technologies Office (HFTO) supports research, development (R&D), and deployment of efficient and sustainable transportation technologies that will improve energy efficiency, fuel economy, and enable America to use less petroleum. To accelerate the development and adoption of new technologies, both HFTO and the Vehicle Technologies Office (VTO) has developed specific targets for a wide range of powertrain technologies (e.g., fuel cell system, hydrogen storage, engine, battery, electric machine, lightweighting, etc.). The objective of the paper is to quantify the impact of HFTO R&D on vehicle energy consumption and cost compared to expected historical improvements across vehicle classes, powertrains, component technologies and timeframes with specific focus on fuel cell vehicles. A large scale simulation process was used to develop and simulate tens of thousands of vehicles on US standard driving cycles using Autonomie. Results demonstrate significant additional reduction in both cost and energy consumption due to HFTO R&D targets compared to historical predicted trends.

Various amyloidogenic proteins have been suggested to be involved in the onset and progression of neurodegenerative diseases (ND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Particularly, the aggregation of misfolded amyloid-β and hyperphosphorylated tau and α-synuclein are linked to the pathogenesis of AD and PD, respectively. In order to care the diseases, multiple small molecules have been developed to regulate the aggregation pathways of these amyloid proteins. In addition to controlling the aggregation of amyloidogenic proteins, maintaining the levels of the proteins in the brain by amyloid degrading enzymes (ADE; neprilysin (NEP), insulin-degrading enzyme (IDE), asparagine endopeptidase (AEP), and ADAM10) is also essential to cure AD and PD. Therefore, numerous biological molecules and chemical agents have been investigated as either inducer or inhibitor against the levels and activities of ADE. Although the side effect of enhancing the activity of ADE could occur, the removal of amyloidogenic proteins could result in a relatively good strategy to treat AD and PD. Furthermore, since the causes of ND are diverse, various multifunctional (multitarget) chemical agents have been designed to control the actions of multiple risk factors of ND, including amyloidogenic proteins, metal ions, and reactive oxygen species. Many of them, however, were invented without considerations of regulating ADE levels and actions. Incorporation of previously created molecules with the chemical agents handling ADE could be a promising way to treat AD and PD. This review introduces the ADE and molecules capable of modulating the activity and expression of ADE.