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18. Tumor Microenvironment Prognostic Risk and Its Association With MUC5AC in Ampullary Carcinoma

Author

Jun, Sun-Young, Lee, Eui-Jin, Kim, Sang-Il, and An, Soyeon

Subjects
Medical research, Medicine, Experimental, Colorectal cancer -- Development and progression -- Prognosis, Carcinoma -- Prognosis -- Development and progression, Cancer -- Prognosis -- Development and progression, Mucins, Health
Abstract

Context.--The tumor-host interaction in the tumor microenvironment (TME) affects the prognosis of patients with malignant tumors. TME assessed via tumor budding (BD) and tumor-infiltrating lymphocyte (TIL) had a prognostic impact in patients with nonampullary small intestinal and colorectal carcinomas. In ampullary carcinoma (AC), MUC5AC was recently revealed as a significant prognosticator, but studies about the TME have not been conducted. Objective.--To assess TME-based prognostic risk in AC. Design.--We generated a collective TME risk index based on high-grade BD at the invasive front (BD3) and high density of stromal-TIL (>5%) in 64 surgically resected ACs. We evaluated its predictive values for overall survival (OS) and recurrence-free survival (RFS). We also investigated the relationship of TME to MUC5AC expression. Results.--TME prognostic risk index was classified into low-risk ([BD.sup.Low]/[TIL.sup.High]; 26 of 64; 41%), intermediate-risk ([BD.sup.Low]/[TIL.sup.Low] or [BD.sup.High]/[TIL.sup.High]; 23; 36%), and high-risk ([BD.sup.High]/[TIL.sup.Low]; 15; 23%) groups. Higher TME prognostic risk was associated with higher tumor grade (P = .03), lymphovascular invasion (P = .05), and MUC5AC immunopositivity (P = .02). TME prognostic risk index displayed better predictive ability for both OS (53.9 versus 46.1 versus 42.2) and RFS (24.8 versus 16.9 versus 15.3) than BD or TIL alone. In multivariate analysis, TME prognostic risk index was an independent prognosticator for OS (P = .003) and RFS (P = .03). Conclusions.--TME risk index in combination with BD and TIL was a stronger predictor of prognostic risk stratification than either BD or TIL alone for both OS and RFS in patients with AC. MUC5AC may modulate the interaction between tumor cells and immunity toward enhancing invasiveness in TME., Ampullary carcinoma (AC) is a rare cancer, constituting less than 0.5% of all gastrointestinal (GI) cancers. (1,2) The ampulla has an anatomically complex structure; it is located at the junction [...]

Published
2023
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48. Current-driven dynamics and inhibition of the skyrmion Hall effect of ferrimagnetic skyrmions in GdFeCo films

Author

Woo, Seonghoon, Song, Kyung Mee, Zhang, Xichao, Zhou, Yan, Ezawa, Motohiko, Liu, Xiaoxi, Finizio, S., Raabe, J., Lee, Nyun Jong, Kim, Sang-Il, Park, Seung-Young, Kim, Younghak, Kim, Jae-Young, Lee, Dongjoon, Lee, OukJae, Choi, Jun Woo, Min, Byoung-Chul, Koo, Hyun Cheol, and Chang, Joonyeon

Subjects
Condensed Matter - Materials Science
Abstract

Magnetic skyrmions are swirling magnetic textures with novel characteristics suitable for future spintronic and topological applications. Recent studies confirmed the room-temperature stabilization of skyrmions in ultrathin ferromagnets. However, such ferromagnetic skyrmions show undesirable topological effect, the skyrmion Hall effect, which leads to their current-driven motion towards device edges, where skyrmions could easily be annihilated by topographic defects. Recent theoretical studies have predicted enhanced current-driven behaviour for antiferromagnetically exchange-coupled skyrmions. Here we present the stabilization of these skyrmions and their current-driven dynamics in ferrimagnetic GdFeCo films. By utilizing element-specific X-ray imaging, we find that the skyrmions in the Gd and FeCo sublayers are antiferromagnetically exchange-coupled. We further confirm that ferrimagnetic skyrmions can move at a velocity of ~50 m s-1 with reduced skyrmion Hall angle, {\theta}SkHE ~20{\deg}. Our findings open the door to ferrimagnetic and antiferromagnetic skyrmionics while providing key experimental evidences of recent theoretical studies., Comment: 24 pages, 3 figures

Published
2017
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