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9. Comparison of antibody response to coronavirus disease 2019 vaccination between patients with solid or hematologic cancer patients undergoing chemotherapy.

Author

Lim, Sung Hee, Choi, Seong Hyeok, Ji, Young Sok, Kim, Se Hyung, Kim, Chan Kyu, Yun, Jina, and Park, Seong Kyu

Subjects
SARS-CoV-2, COVID-19, HEMATOLOGIC malignancies, COVID-19 pandemic, NEUTRALIZATION tests, MACROPHAGE inflammatory proteins, CORONAVIRUS diseases
Abstract

Aim: This study examined the serum antibody response of coronavirus disease 2019 (COVID‐19) vaccines in solid and hematologic cancer patients undergoing chemotherapy. Levels of various inflammatory cytokines/chemokines after full vaccination were analyzed. Methods: Forty‐eight patients with solid cancer and 37 with hematologic malignancy who got fully vaccinated either with severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) or vector vaccines or their combination were included. After consecutively collecting blood, immunogenicity was assessed by surrogate virus neutralization test (sVNT), and cytokine/chemokines were evaluated by Meso Scale Discovery assay. Results: Seropositivity and protective immune response were lower in patients with hematologic cancer compared to those with solid cancers, regardless of vaccine type. Significantly lower sVNT inhibition was observed in patients with hematologic cancer (mean [SD] 45.30 [40.27] %) than in those with solid cancer (mean [SD] 61.78 [34.79] %) (p = 0.047). Heterologous vector/mRNA vaccination was independently and most markedly associated with a higher sVNT inhibition score (p < 0.05), followed by homologous mRNA vaccination. The mean serum levels of tumor necrosis factor α, macrophage inflammatory protein (MIP)‐1α, and MIP‐1β were significantly higher in patients with hematologic cancers compared to those with solid cancers after the full vaccination. In 36 patients who received an additional booster shot, 29 demonstrated increased antibody titer in terms of mean sVNT (%) (40.80 and 75.21, respectively, before and after the additional dose, p < 0.001). Conclusion: Hematologic cancer patients receiving chemotherapy tended to respond poorly to both COVID‐19 mRNA and vector vaccines and had a significantly lower antibody titer compared to those with solid cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Fundamental elements for successful performance of CT colonography (virtual colonoscopy).

Author

Park, Seong Ho, Yee, Judy, Kim, Se Hyung, and Kim, Young Hoon

Subjects
Feces, Humans, Colonic Polyps, Carbon Dioxide, Cathartics, Contrast Media, Diagnosis, Computer-Assisted, Colonography, Computed Tomographic, Imaging, Three-Dimensional, Insufflation, computed tomography, colonography, CTC, virtual colonoscopy, review, Colonography, Computed Tomographic, Diagnosis, Computer-Assisted, Imaging, Three-Dimensional, Clinical Sciences, Other Medical and Health Sciences, Nuclear Medicine & Medical Imaging
Abstract

There are many factors affecting the successful performance of CT colonography (CTC). Adequate colonic cleansing and distention, the optimal CT technique and interpretation with using the newest CTC software by a trained reader will help ensure high accuracy for lesion detection. Fecal and fluid tagging may improve the diagnostic accuracy and allow for reduced bowel preparation. Automated carbon dioxide insufflation is more efficient and may be safer for colonic distention as compared to manual room air insufflation. CT scanning should use thin collimation of < or =3 mm with a reconstruction interval of < or =1.5 mm and a low radiation dose. There is not any one correct method for the interpretation of CTC; therefore, readers should be well-versed with both the primary 3D and 2D reviews. Polyps detected at CTC should be measured accurately and reported following the "polyp size-based" patient management system. The time-intensive nature of CTC and the limited resources for training radiologists appear to be the major barriers for implementing CTC in Korea.

Published
2007

49. Effects of Omicron Infection and Changes in Serum Antibody Response to Wild-Type, Delta, and Omicron After a Booster Dose With BNT163b2 Vaccine in Korean Healthcare Workers

Author

Lim, Sung Hee, primary, Kim, Han Jo, additional, Kim, Se Hyung, additional, Choi, Seong Hyeok, additional, Kim, Bora, additional, Kim, Ji Youn, additional, Ji, Young Sok, additional, Kim, Tark, additional, Choo, Eun Ju, additional, Jung, Jung Chan, additional, Moon, Ji Eun, additional, Kim, Chan Kyu, additional, Park, Seong Kyu, additional, and Yun, Jina, additional

Published
2023
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