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48 results on '"Kim, Seong Muk"'

11. Amyloid Against Amyloid: Dimeric Amyloid Fragment Ameliorates Cognitive Impairments by Direct Clearance of Oligomers and Plaques

Author

Lee, Hee Yang, primary, Baek, Seungyeop, additional, Cha, Minhae, additional, Yang, Seung‐Hoon, additional, Cho, Illhwan, additional, Shin, Heewon, additional, Lee, Sejin, additional, Kim, Hye Yun, additional, Lee, Songmin, additional, Shin, Jisu, additional, Lee, Donghee, additional, Kim, Kyeonghwan, additional, Park, InWook, additional, Yoon, Soljee, additional, Kim, Jiyoon, additional, Park, Seong Jeong, additional, Kim, Seong Muk, additional, Kim, Ko Eun, additional, Kim, Hye Ju, additional, Oh, Min‐Seok, additional, Lee, Gwan‐Ho, additional, Yu, Byung‐Yong, additional, Kannan, Priyadharshini, additional, Park, Keunwan, additional, and Kim, YoungSoo, additional

Published
2023
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22. In vivo near-infrared imaging for the tracking of systemically delivered mesenchymal stem cells: tropism for brain tumors and biodistribution

Author

Kim,Seong Muk, Jeong,Chang Hyun, Woo,Ji Sun, Ryu,Chung Heon, Lee,Jeong-Hwa, Jeun,Sin-Soo, Kim,Seong Muk, Jeong,Chang Hyun, Woo,Ji Sun, Ryu,Chung Heon, Lee,Jeong-Hwa, and Jeun,Sin-Soo

Abstract

Seong Muk Kim,1 Chang Hyun Jeong,2 Ji Sun Woo,2 Chung Heon Ryu,1 Jeong-Hwa Lee,3 Sin-Soo Jeun1,21Postech-Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Neurosurgery, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea; 3Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, KoreaAbstract: Mesenchymal stem cell (MSC)-based gene therapy is a promising tool for the treatment of various neurological diseases, including brain tumors. However, the tracking of in vivo stem cell migration, distribution, and survival need to be defined for their clinical application. The systemic routes of stem cell delivery must be determined because direct intracerebral injection as a cure for brain tumors is an invasive method. In this study, we show for the first time that near-infrared (NIR) imaging can reveal the distribution and tumor tropism of intravenously injected MSCs in an intracranial xenograft glioma model. MSCs were labeled with NIR fluorescent nanoparticles, and the effects of the NIR dye on cell proliferation and migratory capacity were evaluated in vitro. We investigated the tumor-targeting properties and tissue distribution of labeled MSCs introduced by intravenous injection and followed by in vivo imaging analysis, histological analysis, and real-time quantitative polymerase chain reaction. We observed no cytotoxicity or change in the overall growth rate and characteristics of labeled MSCs compared with control MSCs. NIR fluorescent imaging showed the organ distribution and targeted tumor tropism of systemically injected human MSCs. A significant number of MSCs accumulated specifically at the tumor site in the mouse brain. These results suggest that NIR-based cell tracking is a potentially useful imaging technique to visualize cell survival, migration, and distribution for the application of MSC-mediated therapies i

Published
2015

35. Neural Differentiation of Brain-Derived Neurotrophic Factor-Expressing Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Culture via TrkB-Mediated ERK and β-Catenin Phosphorylation and following Transplantation into the Developing Brain

Author

Lim, Jung Yeon, primary, Park, Sang In, additional, Kim, Seong Muk, additional, Jun, Jin Ae, additional, Oh, Ji Hyeon, additional, Ryu, Chung Hun, additional, Jeong, Chang Hyun, additional, Park, Sun Hwa, additional, Park, Soon A., additional, Oh, Wonil, additional, Chang, Jong Wook, additional, and Jeun, Sin-Soo, additional

Published
2011
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38. Irradiation Enhances the Tumor Tropism and Therapeutic Potential of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Glioma Therapy

Author

Kim, Seong Muk, primary, Oh, Ji Hyeon, additional, Park, Soon A, additional, Ryu, Chung Heon, additional, Lim, Jung Yeon, additional, Kim, Dal-Soo, additional, Chang, Jong Wook, additional, Oh, Wonil, additional, and Jeun, Sin-Soo, additional

Published
2010
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40. The Investigator Initiated Clinical Trial in Japan

Author

Ahn, Byung-Jin, primary, Lim, Chi-Yeon, additional, Nagata, Ryuji, additional, Choi, Min-Joung, additional, Kim, Hee-Jung, additional, Lee, Jongtae, additional, Yim, Hyeon Woo, additional, Kim, Seong Muk, additional, and Jeun, Sin-Soo, additional

Published
2010
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43. Brain‐derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood‐derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt‐dependent signaling pathways

Author

Lim, Jung Yeon, primary, Park, Sang In, additional, Oh, Ji Hyeon, additional, Kim, Seong Muk, additional, Jeong, Chang Hyun, additional, Jun, Jin Ae, additional, Lee, Kwan‐Sung, additional, Oh, Wonil, additional, Lee, Jae‐Kwon, additional, and Jeun, Sin‐Soo, additional

Published
2008
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47. Gene therapy of multiple sclerosis using interferon β-secreting human bone marrow mesenchymal stem cells.

Author

Ryu CH, Park KY, Hou Y, Jeong CH, Kim SM, and Jeun SS

Subjects
Animals, Bone Marrow Cells metabolism, Gene Transfer Techniques, Genetic Vectors, Humans, Interferon-beta administration & dosage, Interferon-beta genetics, Interferon-gamma metabolism, Interleukin-10 metabolism, Interleukin-4 metabolism, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells cytology, Mice, Multiple Sclerosis genetics, Multiple Sclerosis pathology, Tumor Necrosis Factor-alpha metabolism, Genetic Therapy, Interferon-beta metabolism, Mesenchymal Stem Cells metabolism, Multiple Sclerosis drug therapy
Abstract

Interferon-beta (IFN- β ), a well-established standard treatment for multiple sclerosis (MS), has proved to exhibit clinical efficacy. In this study, we first evaluated the therapeutic effects for MS using human bone marrow-derived mesenchymal stem cells (hBM-MSCs) as delivery vehicles with lesion-targeting capability and IFN- β as therapeutic gene. We also engineered hBM-MSCs to secret IFN- β (MSCs-IFN β ) via adenoviral transduction and confirmed the secretory capacity of MSCs-IFN β by an ELISA assay. MSCs-IFN β -treated mice showed inhibition of experimental autoimmune encephalomyelitis (EAE) onset, and the maximum and average score for all animals in each group was significantly lower in the MSCs-IFN β -treated EAE mice when compared with the MSCs-GFP-treated EAE mice. Inflammatory infiltration and demyelination in the lumbar spinal cord also significantly decreased in the MSCs-IFN β -treated EAE mice compared to PBS- or MSCs-GFP-treated EAE mice. Moreover, MSCs-IFN β treatment enhanced the immunomodulatory effects, which suppressed proinflammatory cytokines (IFN-γ and TNF-α) and conversely increased anti-inflammatory cytokines (IL-4 and IL-10). Importantly, injected MSCs-IFN β migrated into inflamed CNS and significantly reduced further injury of blood-brain barrier (BBB) permeability in EAE mice. Thus, our results provide the rationale for designing novel experimental protocols to enhance the therapeutic effects for MS using hBM-MSCs as an effective gene vehicle to deliver the therapeutic cytokines.

Published
2013
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48. CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas.

Author

Park SA, Ryu CH, Kim SM, Lim JY, Park SI, Jeong CH, Jun JA, Oh JH, Park SH, Oh W, and Jeun SS

Subjects
Animals, Brain Neoplasms metabolism, Brain Neoplasms pathology, Cell Movement physiology, Cells, Cultured, Fetal Blood cytology, Fetal Blood metabolism, Glioma metabolism, Glioma pathology, Humans, Mesenchymal Stem Cells metabolism, Mesenchymal Stem Cells pathology, Mice, Mice, Nude, Receptors, CXCR4 metabolism, Signal Transduction, Transfection, Brain Neoplasms genetics, Fetal Blood physiology, Glioma genetics, Mesenchymal Stem Cells physiology, Receptors, CXCR4 genetics
Abstract

Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, stromal cell-derived factor-1α (SDF-1α) has been identified as a key molecule related to the tropism of MSC in many cancers containing gliomas. In this study, we found that overexpression of the SDF-1α receptor, CXCR4, on human umbilical cord blood-derived MSCs (hUCB-MSCs) enhanced the migratory capacity of MSCs toward gliomas. We showed that hUCB-MSCs have the migration ability toward the glioma cell lines and primary glioma cells. SDF-1α treatment increased the migration capacity of hUCB-MSCs in a dose-dependent manner and inhibition of SDF-1α or CXCR4 by treatment with the anti-SDF-1α or the CXCR4 antagonist AMD3100 blocked the migration capacity of hUCB-MSCs toward glioma cells. Furthermore, CXCR4-overexpressed hUCB-MSCs (hMSCs-CXCR4) showed a stronger migration capacity toward glioma cells in vitro compared with control MSCs, and also exhibited enhanced migration to glioma cells in an intracranial human malignant glioma xenograft model. These results indicate that SDF-1α/CXCR4 could be involved in recruitment of hUCB-MSCs to glioma cells and that overexpression of CXCR4 may be a useful tool for stem cell-based glioma therapy.

Published
2011

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