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824 results on '"Kim, Seong-Kyu"'

6. Risk of cardiovascular disease associated with long-term use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis.

Author

Kim, Ji-Won, Yoon, Jun Sik, Park, Sojeong, Kim, Hasung, Kim, Bo young, Lee, Hwajeong, Park, Sung-Hoon, Kim, Seong-Kyu, and Choe, Jung-Yoon

Subjects
ANKYLOSING spondylitis, NONSTEROIDAL anti-inflammatory agents, RISK assessment, ANTI-inflammatory agents, MYOCARDIAL ischemia, BODY mass index, HYPERLIPIDEMIA, RESEARCH funding, STATISTICAL sampling, SEX distribution, SMOKING, HYPERTENSION, TREATMENT duration, CARDIOVASCULAR diseases risk factors, RANDOMIZED controlled trials, DESCRIPTIVE statistics, HEART failure, AGE distribution, LONGITUDINAL method, CASE-control method, COMPARATIVE studies, STROKE, CONFIDENCE intervals, SOCIAL classes, DIABETES, DISEASE incidence
Abstract

Objective To examine the risk of cardiovascular disease associated with long-term use of NSAIDs in a large real-world AS cohort. Methods This nationwide population-based cohort study used data from the Korean National Health Insurance Database. Patients aged ≥18 years old who were newly diagnosed with AS without prior cardiovascular disease between January 2010 and December 2018 were included in this study. Controls without AS were randomly selected by age, sex and index year. The primary outcome was cardiovascular disease, a composite outcome of ischaemic heart disease, stroke or congestive heart failure. Long-term use of NSAIDs was defined as use of NSAIDs for >365 cumulative defined daily doses. The association between long-term use of NSAIDs and incident cardiovascular disease was examined in both AS and non-AS populations. Results Among 19 775 patients with AS and 59 325 matched controls without AS, there were 1663 and 4308 incident cases of cardiovascular disease, showing an incidence of 16.9 and 13.8 per 1000 person-years, respectively. Long-term use of NSAIDs was associated with increased risk of cardiovascular disease in non-AS controls [adjusted hazard ratio (aHR) 1.64; 95% CI 1.48–1.82]. In contrast, long-term use of NSAIDs did not increase the risk of cardiovascular disease in AS patients (aHR 1.06; 95% CI 0.94–1.20; adjusted for age, sex, socioeconomic status, BMI, smoking status, hypertension, diabetes, hyperlipidemia and TNF inhibitor use). Conclusion Prolonged NSAID treatment in AS patients may not be as harmful as in the general population regarding cardiovascular risk. [ABSTRACT FROM AUTHOR]

Published
2025
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8. Artificial Intelligence Based Electronic Healthcare Solution

Author

Kim, Seong-Kyu, Huh, Jun-Ho, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Park, James J., editor, Fong, Simon James, editor, Pan, Yi, editor, and Sung, Yunsick, editor

Published
2021
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9. Interleukin-37 Inhibits Interleukin-1β-Induced Articular Chondrocyte Apoptosis by Suppressing Reactive Oxygen Species.

Author

Kim, Seong-Kyu, Kim, Boyoung, Choe, Jung-Yoon, Kim, Ji-Won, and Park, Ki-Yeun

Subjects
CELL analysis, EXTRACELLULAR matrix, CELL cycle, REACTIVE oxygen species, CARTILAGE cells, CELL death
Abstract

Objective: Chondrocyte apoptosis has been considered a crucial mechanism that is responsible for cartilage destruction in osteoarthritis (OA). The mechanism of interleukin-37 (IL-37) on chondrocyte apoptosis has not been clearly determined in the pathogenesis of OA. Here, we explored the role of IL-37 in the regulation of cellular apoptosis in rat chondrocytes stimulated by IL-1β. Methods: Rat chondrocytes were used in in vitro study, and were stimulated with IL-1β (10 ng/mL) and/or recombinant IL-37 (rIL-37; 100 ng/mL) after cytotoxicity assessments using these cytokines were conducted. After rIL-37 treatment of chondrocytes stimulated with IL-1β, the cell proliferation assay, apoptosis assays, including expression of mitochondrial apoptosis-related markers, flow cytometry analysis of annexin V-FITC/propidium iodide (PI), cell cycle analysis, and Hoechst 33342 staining, and reactive oxygen species (ROS) measurement were used. Results: IL-1β induced expression of inflammatory cytokines and triggered degradation of the extracellular matrix of rat chondrocytes, but this effect was significantly attenuated by rIL-37 treatment. Enhanced ROS generation following IL-1β stimulation was reduced in a dose-dependent manner after stimulation with rIL-37. IL-1β induced pro-apoptotic markers and suppressed anti-apoptotic markers in rat chondrocytes. Flow cytometry using annexin V-FITC/PI revealed that IL-1β increased the apoptosis rate of rat chondrocytes, and that this effect was markedly reversed by treatment with rIL-37. Conclusions: IL-37 potently attenuated IL-1β-mediated apoptosis of rat chondrocytes by blocking ROS production. This study suggests that IL-37 can serve as a novel anti-cytokine therapy in OA by blocking chondrocyte apoptosis. [ABSTRACT FROM AUTHOR]

Published
2024
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11. A Study on Application Method for Automation Solution Using Blockchain dApp Platform

Author

Kim, Seong-Kyu, Kwon, Hyun-Taek, Kim, Young-Kun, Park, Yong-Pil, Keum, Dae-Won, Kim, Ung-Mo, Barbosa, Simone Diniz Junqueira, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Ghosh, Ashish, Series Editor, Park, Jong Hyuk, editor, Shen, Hong, editor, Sung, Yunsick, editor, and Tian, Hui, editor

Published
2019
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12. A Study on the LMS Platform Performance and Performance Improvement of K-MOOCs Platform from Learner’s Perspective

Author

Kim, Seong-kyu, Huh, Jun-Ho, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Park, James J., editor, Loia, Vincenzo, editor, Choo, Kim-Kwang Raymond, editor, and Yi, Gangman, editor

Published
2019
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13. A Study on the Rainbowchain Certificate in Order to Overcome Existing Certification System

Author

Kim, Seong-kyu, Huh, Jun-Ho, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Park, James J., editor, Loia, Vincenzo, editor, Choo, Kim-Kwang Raymond, editor, and Yi, Gangman, editor

Published
2019
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14. A Study on the Security Performance Improvement in BoT Perspective in Order to Overcome Security Weaknesses of IoT Devices

Author

Kim, Seong-kyu, Huh, Jun-Ho, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Park, James J., editor, Loia, Vincenzo, editor, Choo, Kim-Kwang Raymond, editor, and Yi, Gangman, editor

Published
2019
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15. A Study on the RFID and 2D Barcode, and NFC and Performance Improvement

Author

Kim, Seong-kyu, Huh, Jun-Ho, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Park, James J., editor, Loia, Vincenzo, editor, Choo, Kim-Kwang Raymond, editor, and Yi, Gangman, editor

Published
2019
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19. Anti-Inflammatory Effect of Atorvastatin and Rosuvastatin on Monosodium Urate-Induced Inflammation through IL-37/Smad3-Complex Activation in an In Vitro Study Using THP-1 Macrophages.

Author

Kim, Seong-Kyu, Choe, Jung-Yoon, Kim, Ji-Won, Park, Ki-Yeun, and Kim, Boyoung

Subjects
*INTERLEUKIN-37, *GENE expression, *POLYMERASE chain reaction, *REDUCTASE inhibitors, *CASPASES
Abstract

Objective: The pleiotropic effect of hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) is responsible for potent defense against inflammatory response. This study evaluated the inhibitory effects of HMG-CoA reductase inhibitors on the monosodium urate (MSU)-induced inflammatory response through the regulation of interleukin-37 (IL-37) expression. Methods: Serum was collected from patients with gout (n = 40) and from healthy controls (n = 30). The mRNA and protein expression of the target molecules IL-1β, IL-37, caspase-1, and Smad3 were measured in THP-1 macrophages stimulated with MSU, atorvastatin, or rosuvastatin using a real-time quantitative polymerase chain reaction and Western blot assay. Transfection with IL-1β or Smad3 siRNA in THP-1 macrophages was used to verify the pharmaceutical effect of statins in uric-acid-induced inflammation. Results: Serum IL-37 levels in gout patients were significantly higher than in controls (p < 0.001) and was associated with the serum uric acid level (r = 0.382, p = 0.008). THP-1 cells stimulated with MSU markedly induced IL-37 mRNA expression and the transition of IL-37 from the cytoplasm to the nucleus. Recombinant IL-37 treatment dose-dependently inhibited activation of caspase-1 and IL-1β in MSU-induced inflammation. Atorvastatin and rosuvastatin attenuated caspase-1 activation and mature IL-1β expression but augmented translocation of IL-37 from the cytoplasm to the nucleus. Atorvastatin and rosuvastatin induced phosphorylation of Smad3 in THP-1 cells treated with MSU crystals. Statins potently attenuated translocation of IL-37 from the cytoplasm to the nucleus in THP-1 macrophages transfected with Smad3 siRNA compared to cells with negative control siRNA. Conclusions: This study revealed that statins inhibit the MSU-induced inflammatory response through phosphorylated Smad3-mediated IL-37 expression in THP-1 macrophages. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Korean treatment recommendations for patients with axial spondyloarthritis

Author

Seo, Mi Ryoung, primary, Yeo, Jina, additional, Park, Jun Won, additional, Lee, Yeon-Ah, additional, Lee, Ju Ho, additional, Kang, Eun Ha, additional, Ji, Seon Mi, additional, Kwon, Seong-Ryul, additional, Kim, Seong-Kyu, additional, Kim, Tae-Jong, additional, Kim, Tae-Hwan, additional, Kim, Hye Won, additional, Park, Min-Chan, additional, Shin, Kichul, additional, Lee, Sang-Hoon, additional, Lee, Eun Young, additional, Cha, Hoon Suk, additional, Shim, Seung Cheol, additional, Yoon, Youngim, additional, Lee, Seung Ho, additional, Lim, Jun Hong, additional, and Baek, Han Joo, additional

Published
2023
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42. Comparative effectiveness of treatment options after conventional DMARDs failure in rheumatoid arthritis

Author

Sung, Yoon-Kyoung, Cho, Soo-Kyung, Kim, Dam, Choi, Chan-Bum, Won, Soyoung, Bang, So-Young, Cha, Hoon-Suk, Choe, Jung-Yoon, Chung, Won Tae, Hong, Seung-Jae, Jun, Jae-Bum, Kim, Hyoun Ah, Kim, Jinseok, Kim, Seong-Kyu, Kim, Tae-Hwan, Lee, Hye-Soon, Lee, Jaejoon, Lee, Jisoo, Lee, Shin-Seok, Lee, Sung Won, Lee, Yeon-Ah, Nah, Seong-Su, Suh, Chang-Hee, Yoo, Dae-Hyun, Yoon, Bo Young, Bae, Sang Cheol, and For the BIOPSY and KORONA investigators

Published
2017
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