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13. ODP505 Polymorphisms of ITM2A rs1751094 on×Chromosome Is Associated with intractable Graves’ disease in Korean Children

Author

Ahn, Moonbae, primary, Cho, Kyoung Soon, additional, Ho Jung, Min, additional, Suh, Byung-Kyu, additional, Kim, Sung Eun, additional, Cho, Won Kyoung, additional, Kim, Mirae, additional, Baek, In-Cheol, additional, Kim, Tai-Gyu, additional, Shin, Chungwoo, additional, Jeong Jang, Min, additional, Ju Choi, Young, additional, Lee, Na Yeong, additional, Kim, Seul K, additional, and Kim, Shin Hee, additional

Published
2022
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14. Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes

Author

Suh, Jin-Soon, Kim, Shin-Hee, Cho, Kyoung Soon, Jung, In-Ah, Cho, Won Kyoung, Jeon, Yeon Jin, Jung, Min Ho, and Suh, Byoung Kyu

Subjects
Type 1 diabetes -- Research -- Risk factors -- Care and treatment, Diabetic nephropathies -- Research -- Diagnosis -- Patient outcomes -- Care and treatment, Health
Abstract

Background The aim of this study was to evaluate the association of a urinary tubular marker, liver-type fatty acid binding protein (L-FABP) and an inflammatory marker, serum/urinary YKL-40, with albuminuria in patients with childhood-onset type 1 diabetes (T1D). Methods Twenty-nine patients with childhood-onset T1D and 32 controls were enrolled. Serum and urinary concentrations of YKL-40 and urinary concentrations of L-FABP were measured. Results The serum levels of YKL-40 were not significantly different between the control group and the patient groups. However, the levels of urinary YKL-40/creatinine (Cr) were higher in the patients, even those with normoalbuminuria than in the controls (p < 0.001). The levels of urinary L-FABP/Cr were not different between the control group and the patient groups. However, the level of urinary L-FABP/Cr in the microalbuminuria group was higher than that in the normoalbuminuria group (p = 0.03). There were no associations between the levels of urinary albumin-to-creatinine ratio and urinary L-FABP/Cr or YKL-40/Cr. However, the urinary L-FABP/Cr level was significantly correlated with the hemoglobin A1C level (p = 0.005) and the urinary YKL-40/Cr level (p = 0.043). Conclusions Urinary L-FABP/Cr and YKL-40/Cr may reflect renal injury in early stages of nephropathy in patients with childhood-onset T1D, even in the normoalbuminuric state., Author(s): Jin-Soon Suh[sup.1] , Shin-Hee Kim[sup.1] , Kyoung Soon Cho[sup.1] , In-Ah Jung[sup.1] , Won Kyoung Cho[sup.1] , Yeon Jin Jeon[sup.1] , Min Ho Jung[sup.1] , Byoung Kyu Suh[sup.1] Author [...]

Published
2016
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15. LBODP081 The Relationship Between Body Mass Index Changes And Bone Age Progression During Gonadotropin-releasing Hormone Agonist Treatment In Girls With Idiopathic Central Precocious Puberty

Author

Seulki Kim, Chungwoo Shin, Young J Choi, Min Jeong Jang, Sungeun Kim, Moon Bae Ahn, Kim Shin Hee, Won Kyung Cho, Kyung Soon Cho, Min H Jung, and Byung-Kyu Suh

Subjects
Endocrinology, Diabetes and Metabolism
Abstract

Purpose To analyze the relationship between body mass index change and bone age progression during gonadotropin-releasing hormone agonist(GnRHa) treatment in girls with idiopathic central precocious puberty Methods: 65 girls with idiopathic central precocious puberty who are treated with GnRHa more than 2 years were retrospectively reviewed. Height, weight, Tanner stage, bone age were measured every 6 months from the start of treatment. The degree of obesity was evaluated using the body mass index (BMI) standard deviation score (SDS), and the relationship between the change in obesity and the progression of bone age was analyzed. Overweight was defined as a BMI greater than or equal to the 85th percentile. The chronological age at the start and the end of treatment was 7. 00±0. 00 years and 10.63±0.50 years in the overweight group (16 patients), and 6.86±0.35 years and 10.71±0.54 years in the other group (49 patients), respectively. Results There was no difference in bone age between the normal weight group and the overweight group at the start of treatment (9.85±0.57 years vs 10. 04±0.73 years, P=0.263). Bone age was higher in the overweight group, but after 1 year of treatment, 2 years of treatment, and at the end of treatment, the overweight group had a higher bone age than the normal weight group (10.47±0.56 years vs 10.87±0.57 years, P=0. 02; 11. 06±0.47 years vs 11.46±0.51 years, P=0. 004; 11.70±0.46 years vs 12. 01±0.52 years, P=0. 03). Bone age at the end of treatment was related to overweight at the start of treatment (r=0.265, P=0. 03) and the increase in BMI SDS from normal to overweight during treatment (r=0.285, P=0. 02). There were 11 children (17%) whose BMI SDS increased from normal to overweight during treatment, compared with the other patients, there was no difference in bone age during 2 years of treatment, but bone age at the end of treatment was higher (12. 09±0.60 years vs 11.71±0.47 years, P=0. 02), and the difference in bone age before and after treatment was also greater (2.31±0.68 years vs 1.79±0.52 years, P=0. 01). Linear regression analysis demonstrated that the increase in BMI SDS from normal to overweight during treatment had a positive correlation with bone age at the end of treatment (β=0.31, R2=0. 07, P=0. 03). Conclusion In girls with central precocious puberty, an increase in obesity from normal to overweight during GnRHa treatment does not affect bone age progression until 2 years from the start of treatment, but might be a risk factor for bone age progression at the end of treatment. Presentation: No date and time listed

Published
2022

27. Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines

Author

Kim, Shin-Hee, Kim, Shin-Hee, Samal, Siba K., Kim, Shin-Hee, Kim, Shin-Hee, and Samal, Siba K.

Abstract

Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses and NDV. These vaccines have been generated by inserting the hemagglutinin (HA) gene of avian influenza virus into NDV genomes. In laboratory settings, several experimental NDV-vectored vaccines have protected specific pathogen-free chickens from mortality, clinical signs, and virus shedding against H5 and H7 HPAI viruses and NDV challenges. NDV-vectored H5 vaccines have been licensed for poultry vaccination in China and Mexico. Recently, an antigenically chimeric NDV vector has been generated to overcome pre-existing immunity to NDV in poultry and to provide early protection of poultry in the field. Prime immunization of one-day-old poults with a chimeric NDV vector followed by boosting with a conventional NDV vector has shown to protect broiler chickens against H5 HPAI viruses and a highly virulent NDV. This novel vaccination approach can provide efficient control of HPAI viruses in the field and facilitate poultry vaccination.

Published
2019

50. Towards a people-centered theory of translation

Author

Kim, Shin-Hee

Subjects
Translating and interpreting -- Study and teaching, Translating and interpreting -- Practice, Translating and interpreting -- Social aspects, Language and culture -- Research, Sociolinguistics -- Research, Languages and linguistics
Abstract

Translation has become a metaphor for contemporary life, and thus translation theories demand a paradigm shift from binary opposition between 'self and other', or between 'original and target', towards negotiation and dialogic interaction. This article argues that translation as dialogue in the 'in-between space'--or what Mary Louise Pratt termed a 'contact zone'--involves a new model of language use that can incorporate both cultures and languages without prioritizing any. Anna Wierzbicka's concept of linguistic universals and Eva Hoffman's experiences of integrating bilingual and bicultural aspects are elicited to illustrate the tentative translation strategies for 'translation as a dialogue'. The article proposes the importance of understanding and empathy, or, at least, a will to believe in translatability. It also maintains, drawing on Edward Sapir's insight that language is the index to culture, that translation should be not only about content but also about relation between 'self and other', and that translators should realize the importance of learning vocabularies as a sensitive index to a culture. These requirements ask translators to be more attentive to what people are and what people do, thus proposing a more people-oriented translation theory. Keywords: contact zone; transcultural understanding; dialogue; translatability; vocabulary; Hoffman; Wierzbicka DOI: 10.1080/09076760903407384

Published
2009

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