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203 results on '"Kim, Wooki"'

4. Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation

Author

Kang, Eun Young, primary, Kim, Do‐Young, additional, Kim, Hyun Kyung, additional, Kim, Tae Hoon, additional, Kim, Wooki, additional, Lei, Cao, additional, Lee, Sang‐gil, additional, Gang, Gyoungok, additional, Shin, Minhye, additional, Kim, Jun‐Mo, additional, and Go, Gwang‐woong, additional

Published
2023
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11. Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice

Author

Jia, Qian, primary, Lupton, Joanne R., primary, Smith, Roger, primary, Weeks, Brad R., primary, Callaway, Evelyn, primary, Davidson, Laurie A., primary, Kim, Wooki, primary, Fan, Yang-Yi, primary, Yang, Peiying, primary, Newman, Robert A., primary, Kang, Jing X., primary, McMurray, David N., primary, and Chapkin, Robert S., primary

Published
2023
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29. Dietary curcumin and limonin suppress [CD4.sup.+] T-Cell proliferation and interleukin-2 production in mice

Author

Kim, Wooki, Fan, Yang-Yi, Smith, Roger, Patil, Bhimanagouda, Jayaprakasha, K. Guddadarangavvanahally, McMurray, David N., and Chapkin, Robert S.

Subjects
Turmeric -- Physiological aspects, Turmeric -- Health aspects, Phytochemicals -- Physiological aspects, Phytochemicals -- Health aspects, T cell proliferation -- Prevention, Food/cooking/nutrition
Abstract

Phytochemicals may reduce chronic inflammation and cancer risk in part by modulating T-cell nuclear factor-[kappa]B (NF-[kappa]B) activation. Therefore, we examined the effects of curcumin (Cur) and limonin (Lim) feeding on NF-[kappa]B-dependent [CD4.sup.+] T-cell proliferation. DO11.10 transgenic mice (n = 5-7) were fed diets containing 1% Cur or 0.02% Lim combined with either (n-6) PUFA [5% corn oil (CO)] or (n-3) PUFA [4% fish oil +1% corn oil (FO)] for 2 wk, followed by splenic [CD4.sup.+] T-cell isolation and stimulation with ovalbumin peptide 323-339 (OVA) and antigen-presenting cells from mice fed a conventional nonpurified rodent diet. Both Cur and Lim diets suppressed (P < 0.05) NF-[kappa]B p65 nuclear translocation in activated [CD4.sup.+] T-cells. In contrast, activator protein-1 (c-Jun) and nuclear factor of activated T-cells c1 were not affected compared with the CO control diet (no Cur or Lim). [CD4.sup.+] T-cell proliferation in response to either mitogenic anti-CD3/28 monoclonal antibodies (mAb) or antigenic stimulation by OVA was also suppressed (P < 0.05) by Cur as assessed by carboxyfluorescein succinimidyl ester staining. In contrast, interleukin-2 production was not directly associated with NF-[kappa]B status. Interestingly, dietary combination with FO enhanced the suppressive effects (P < 0.05) of Cur or Lim with respect to [CD4.sup.+] T-cell proliferation in response to anti-CD3/28 mAb. These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate [CD4.sup.+] T-cell-mediated inflammation.

Published
2009

31. Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansion

Author

Zhang, Ping, Kim, Wooki, Zhou, Lan, Wang, Naisyin, Ly, Lan H., McMurray, David N., and Chapkin, Robert S.

Subjects
Fish oils -- Research, Fish oils -- Nutritional aspects, Cell research, Food/cooking/nutrition
Abstract

To determine the mechanisms by which dietary fish oil (FO) affects antigen-stimulated Th1 cell development, DO11.10 Rag [2.sup.-/-] T cell receptor transgenic mice were fed a control diet (5% corn oil (CO) or a FO diet (1% CO + 4% FO, (n-3) PUFA) for 2 wk. CD[4.sup.+] T cells were cultured under neutral or Th1 polarizing conditions. FO feeding suppressed (P < 0.05) ovalbumin peptide--induced proliferation of nonpolarized CD[4.sup.+] T cells. Differentiation in vitro to Th1 cells was not affected by dietary FO, as evidenced by similar percentages of KJ1-[26.sup.+], IFN-[[gamma].sup.+], IL-[4.sup.-] Th1 cells in cultures from CO-fed (99%) and FO-fed (97%) mice. However, the absolute number of viable Th1 cells in polarized cultures from FO-fed mice was less than half that observed in CO-fed mice (P< 0.05), indicating that FO inhibits in vitro Th1 clonal expansion. The reduced number of Th1 cells in FO cultures was not a result of increased apoptosis, because similar percentages of apoptotic Th1 cells were observed in cultures from FO-and CO-fed mice. IL-2-induced cell proliferation was significantly decreased in polarized Th1 cells from the FO group; however, the suppressed proliferation was not linked to reduced CD25 surface expression on antigen-stimulated CD[4.sup.+] T cells. Adoptively transferred CFSE-labeled DO11.10 CD[4.sup.+] cells into immunized mice (Th1 polarizing agents) showed that dietary FO reduced (P < 0.05) the number of cell divisions in vivo. These studies suggest that the attenuated inflammatory response which accompanies FO feeding may be explained, at least in part, by suppression of Th1 clonal expansion.

Published
2006

48. Increased Intestinal Permeability Secondary To Junctional Adhesion Molecule‐A Deficiency Results In Impaired Macrophage‐Dependent Neutrophil Recruitment In A Zymosan Peritonitis Model

Author

Luissint, Anny Claude, primary, Williams, Holly C, additional, Kim, Wooki, additional, Hilgarth, Roland S, additional, O'Leary, Monique, additional, Flemming, Sven, additional, Reed, Michelle, additional, Denning, Timothy L, additional, Nusrat, Asma, additional, and Parkos, Charles A, additional

Published
2017
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