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1. StaccaToe: A Single-Leg Robot that Mimics the Human Leg and Toe

Author

Perera, Nisal, Yu, Shangqun, Marew, Daniel, Tang, Mack, Suzuki, Ken, McCormack, Aidan, Zhu, Shifan, Kim, Yong-Jae, and Kim, Donghyun

Subjects
Computer Science - Robotics
Abstract

We introduce StaccaToe, a human-scale, electric motor-powered single-leg robot designed to rival the agility of human locomotion through two distinctive attributes: an actuated toe and a co-actuation configuration inspired by the human leg. Leveraging the foundational design of HyperLeg's lower leg mechanism, we develop a stand-alone robot by incorporating new link designs, custom-designed power electronics, and a refined control system. Unlike previous jumping robots that rely on either special mechanisms (e.g., springs and clutches) or hydraulic/pneumatic actuators, StaccaToe employs electric motors without energy storage mechanisms. This choice underscores our ultimate goal of developing a practical, high-performance humanoid robot capable of human-like, stable walking as well as explosive dynamic movements. In this paper, we aim to empirically evaluate the balance capability and the exertion of explosive ground reaction forces of our toe and co-actuation mechanisms. Throughout extensive hardware and controller development, StaccaToe showcases its control fidelity by demonstrating a balanced tip-toe stance and dynamic jump. This study is significant for three key reasons: 1) StaccaToe represents the first human-scale, electric motor-driven single-leg robot to execute dynamic maneuvers without relying on specialized mechanisms; 2) our research provides empirical evidence of the benefits of replicating critical human leg attributes in robotic design; and 3) we explain the design process for creating agile legged robots, the details that have been scantily covered in academic literature., Comment: Submitted to 2024 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2024)

Published
2024

14. More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL <70 mg/dL After a Stroke

Author

Amarenco, Pierre, Lavallée, Philippa C., Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, Kim, Jong S, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Pico, Fernando, Touzé, Emmanuel, Ducrocq, Gregory, Abtan, Jérémy, Varenne, Olivier, Touboul, Pierre-Jean, Kemmel, Agnes, Syana, Fausta, Ledra, Manele, Nagasara, Tharani, Ledjeroud, Mervette, Samia, Bahous, Hadia, Hafirassou, Hazare, Benyoub, Jaghouni, Ikrame El, Yelles, Nessima, Zemouri, Sofia, Ladjeroud, Mervette, Kerai, Salim, In, YunJeong, Hobeanu, Cristina, Guidoux, Celine, Cabrejo, Lucie, Lapergue, Bertrand, Sabben, Candice, Gonzalez-Valcarcel, Jaime, Rigual, Ricardo, Sirimarco, Gaia, Martin-Bechet, Anna, Viedma, Elena, Avram, Ioan, Samson, Yves, Rosso, Charlotte, Crozier, Sophie, Leder, Sara, Léger, Anne, Deltour, Sandrine, Mutlu, Gurkan, Yger, Marion, Zavanone, Chiara, Baronnet, Flore, Pires, Christine, Lapergue, Bertrand, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Bourdain, Frédéric, Lopez, Delphine, Pico, Fernando, de la Tour, Laetitia Bayon, Chadenat, Marie-Laure, Duong, Duc Long, Genty, Solène, Hirel, Catherine, Mutlu, Gurkan, Nifle, Chantal, Servan, Jérôme, Stanciu, Daniela, Sudacevschi, Veronica, Tir, Mélissa, Troussière, Anne-Cécile, Yeung, Jennifer, Zeghoudi, Anne-Céline, Tidafi-Bayou, Ikram, Lachaud, Sylvain, Cho, Tae-Hee, Mechtouff, Laura, Ritzenthaller, Thomas, Derex, Laurent, Albanesi, Carlo, Ong, Elodie, Benoit, Amandine, Berhoune, Nadia, Felix, Sandra, Esteban-Mader, Maud, Sibon, Igor, Kazadi, Annabelle, Rouanet, François, Renou, Pauline, Debruxelles, Sabrina, Poli, Mathilde, Sagnier, Sharmila, Mas, Jean-Louis, Domigo, Valérie, Lamy, Catherine, Bodiguel, Eric, Grimaud, Jérôme, Bohotin, Valentin, Obadia, Michael, Sabben, Candice, Morvan, Erwan, Rodier, Gilles, Vadot, Wilfried, Hénon, Hilde, Cordonnier, Charlotte, Dumont, Frédéric, Bodenant, Marie, Lucas, Christian, Moulin, Solène, Dequatre, Nelly, Alamowitch, Sonia, Muresan, Jean-Paul, Drouet, Thomas, Gallea, Magalie, Dalloz, Marie-Amélie, Delorme, Stephen, Yger, Marion, Béjot, Yannick, Loisel, Philippe, Bonnin, Carine, Bernigal, Virginie, Osseby, Guy Victor, Hervieu-BègueMarsac, Marie, Garnier, Pierre, Accassat, Sandrine, Epinat, Magali, Varvat, Jérôme, Marinescu, Doïna, Triquenot-Bagan, Aude, Ozkul- Wermester, Ozlem, Philippeau, Frédéric, Olaru, Angel, Vieillart, Anne, Lannuzel, Annie, Demoly, Alice, Wolff, Valérie, Diaconu, Mihaela, Bataillard, Marc, Montoro, Francisco Macian, Faugeras, Frédéric, Gimenez, Laeticia, Abdallah-Lebeau, Françoise, Timsit, Serge, Viakhireva-Dovganyuk, Irina, Tirel-Badets, Anne, Merrien, François-Mathias, Goas, Philippe, Rouhart, François, Jourdain, Aurore, Guillon, Benoit, Hérissson, Fanny, Sevin-Allouet, Mathieu, Nasr, Nathalie, Olivot, Jean-Marc, Lecluse, Alderic, Marc, Guillaume, Touzé, Emmanuel, de la Sayette, Vincent, Apoil, Marion, Lin, Li, Cogez, Julien, Guettier, Sophie, Godefroy, Olivier, Lamy, Chantal, Bugnicourt, Jean-Marc, Taurin, Grégory, Mérienne, Marc, Gere, Julien, Chessak, Anne-Marie, Habet, Tarik, Ferrier, Anna, Bourgois, Nathalie, Minier, Dominique, Caillier-Minier, Marie, Contégal- Callier, Fabienne, Vion, Philippe, Vaschalde, Yvan, Amrani, Mohammed El, Emilie, Zuber, Mathieu, Bruandet, Marie, Join- Lambert, Claire, Garcia, Pierre-Yves, Serre, Isabelle, Faucheux, Jean-Marc, Radji, Fatia, Leca-Radu, Elena, Debroucker, Thomas, Cumurcuc, Rodica, Cakmak, Serkan, Peysson, Stéphane, Ellie, Emmanuel, Bernady, Patricia, Moulin, Thierry, Montiel, Paola, Revenco, Eugeniu, Decavel, Pierre, Medeiros, Elisabeth, Bouveret, Myriam, Louchart, Pierre, Vaduva, Claudia, Couvreur, Grégory, Sartori, Eric, Carpentier, Alnajar, Levasseur, Michèle, Louchart, Pierre, Faucheux, Jean-Marc, Neau, Philippe, Vandamme, Xavier, Meresse, Isabelle, Stantescu, Bataillard, Marc, Ozsancak, Canan, Beauvais, Katell, Auzou, Pascal, Amevigbe, Joséphine, Vuillemet, Francis, Dugay-Arentz, Marie-Hélène, Carelli, Gabriela, Martinez, Mikel, Maillet-Vioud, Marcel, Escaillas, Jean-Pierre, Chapuis, Stéphane, Tardy, Jean, Manchon, Eric, Varnet, Olivier, Kim, Yong-Jae, Chang, Yoonkyung, Song, Tae-Jin, Kim, Jong Sung, Han, Jung-Hoon, Noh, Kyung Chul, Lee, Eun-Jae, Kang, Dong-Wha, Kwon, Sun Uck, Kwon, Boseoung, Park, Seongho, Lee, Dongwhane, Kwon, Hyuk Sung, Jeong, Daeun, Lee, MinHwan, Kim, Joonggoo, Lee, Hanbin, Nam, Hyo Jung, Lee, Sang Hun, Kim, Bum Joon, Cha, Jae-kwan, Kim, DaeHyun, Kim, Rae Young, Sohn, Sang Wuk, Shim, Dong-Hyun, Lee, Hyungjin, Nah, Hyun-Wook, Sung, Sang Min, Lee, Kyung Bok, Yoon Lee, Jeong, Yoon, Jee Eun, Kim, Eung-Gyu, Seo, Jung Hwa, Kim, Yong-Won, Hwang, Yangha, Park, Man Seok, Kim, Joon-Tae, Choi, Kang-Ho, Nam, Hyo Suk, Heo, Ji Hoe, Kim, Young Dae, Hwang, In Gun, Park, Hyung Jong, Kim, Kyoung Sub, Baek, Jang Hyun, Song, Dong Beom, Yoo, Joon Sang, Park, Jong-Moo, Kwon, Ohyun, Lee, Woong-Woo, Lee, Jung-Ju, Kang, Kyusik, Kim, Byung Kun, Lim, Jae-Sung, Oh, Mi Sun, Yu, Kyung-Ho, Hong, Bora, Jang, Mihoon, Jang, Seyoung, Jin, Jung Eun, Kim, Jei, Jeong, Hye Seon, Hong, Keun Sik, Park, Hong Kyun, Cho, Yong Jin, Bang, Oh Young, Seo, Woo-Keun, and Chung, Jongwon

Published
2023
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19. Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity

Author

Kim, Gihyeon, Yoon, Youngmin, Park, Jin Ho, Park, Jae Won, Noh, Myung-guin, Kim, Hyun, Park, Changho, Kwon, Hyuktae, Park, Jeong-hyeon, Kim, Yena, Sohn, Jinyoung, Park, Shinyoung, Kim, Hyeonhui, Im, Sun-Kyoung, Kim, Yeongmin, Chung, Ha Yung, Nam, Myung Hee, Kwon, Jee Young, Kim, Il Yong, Kim, Yong Jae, Baek, Ji Hyeon, Kim, Hak Su, Weinstock, George M., Cho, Belong, Lee, Charles, Fang, Sungsoon, Park, Hansoo, and Seong, Je Kyung

Published
2022
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21. Mitigating the Effects of 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on Gastrointestinal Acute Radiation Syndrome after Total-Body Irradiation in Mice.

Author

Jeong, Jinseon, Sun, Sojung, Kim, Yong-Jae, Sohn, Ki-Young, Kim, Jae Wha, and Lee, Jae Sam

Abstract

Total-body irradiation (TBI) with gamma rays can damage organisms in various unexpected ways and trigger several organ dysfunction syndromes, such as acute radiation syndrome (ARS). Hematopoietic cells and enterocytes are particularly sensitive to radiation due to their self-renewal ability and rapid division, which leads to hematopoietic ARS (H-ARS) and gastrointestinal ARS (GI-ARS). We previously showed that a lipid-based small molecule, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG), improved 30-day survival and alleviated H-ARS symptoms in BALB/c mice after a lethal dose (LD70/30) of gamma-ray TBI. In this study, we investigated the mitigating effects of PLAG on radiation-induced GI damage that occurs under the same conditions as H-ARS in BALB/c mice. Our study showed that PLAG facilitated the structural restoration of intestinal tissues by increasing villus height, crypt depth, crypt number, mucin-producing goblet cells, and proliferating cell nuclear antigen (PCNA)-positive crypt cells. PLAG significantly improved intestinal absorptive capacity and reduced intestinal injury-induced bacterial translocation. In addition, PLAG effectively inhibited radiation-induced necroptosis signaling activation in the intestinal crypt cells, which was responsible for sustained tissue damage and the release of high mobility group box 1 (HMGB1), a typical damage-associated molecular pattern. Overall, our findings support the radiation-mitigating potential of PLAG against GI-ARS after accidental radiation exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial–Stromal Interplay in Cancer Development.

Author

Karunasagara, Shanika, Taghizadeh, Ali, Kim, Sang‐Hyun, Kim, So Jung, Kim, Yong‐Jae, Taghizadeh, Mohsen, Kim, Moon‐Young, Oh, Kyu‐Young, Lee, Jung‐Hwan, Kim, Hye Sung, Hyun, Jeongeun, and Kim, Hae‐Won

Subjects
EPITHELIAL-mesenchymal transition, HEDGEHOG signaling proteins, EXTRACELLULAR matrix proteins, TISSUE mechanics, EPITHELIAL cells
Abstract

Epithelial‐stromal interplay through chemomechanical cues from cells and matrix propels cancer progression. Elevated tissue stiffness in potentially malignant tissues suggests a link between matrix stiffness and enhanced tumor growth. In this study, employing chronic oral/esophageal injury and cancer models, it is demonstrated that epithelial–stromal interplay through matrix stiffness and Hedgehog (Hh) signaling is key in compounding cancer development. Epithelial cells actively interact with fibroblasts, exchanging mechanoresponsive signals during the precancerous stage. Specifically, epithelial cells release Sonic Hh, activating fibroblasts to produce matrix proteins and remodeling enzymes, resulting in tissue stiffening. Subsequently, basal epithelial cells adjacent to the stiffened tissue become proliferative and undergo epithelial‐to‐mesenchymal transition, acquiring migratory and invasive properties, thereby promoting invasive tumor growth. Notably, transcriptomic programs of oncogenic GLI2, mechano‐activated by actin cytoskeletal tension, govern this process, elucidating the crucial role of non‐canonical GLI2 activation in orchestrating the proliferation and mesenchymal transition of epithelial cells. Furthermore, pharmacological intervention targeting tissue stiffening proves highly effective in slowing cancer progression. These findings underscore the impact of epithelial‐stromal interplay through chemo‐mechanical (Hh‐stiffness) signaling in cancer development, and suggest that targeting tissue stiffness holds promise as a strategy to disrupt chemo‐mechanical feedback, enabling effective cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

Author

Shin, Seung Jae, primary, Bayarkhangai, Buuvee, additional, Tsogtbaataar, Khaliunsarnai, additional, Yuxuan, Meng, additional, Kim, Sang-Hyun, additional, Kim, Yong-Jae, additional, Kim, Daesan, additional, Kim, Dong-Hwee, additional, Lee, Jung Hwan, additional, Hyun, Jeongeun, additional, and Kim, Hae-Won, additional

Published
2024
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31. Genetic Prediction of Smoking Cessation Medication Side Effects : A Genome‐Wide Investigation of Abnormal Dreams on Varenicline

Author

Chenoweth, Meghan J., Kim, Yong Jae, Nollen, Nikki L., Hawk, Larry W., Mahoney, Martin C., Lerman, Caryn, Knight, Jo, Tyndale, Rachel F., Chenoweth, Meghan J., Kim, Yong Jae, Nollen, Nikki L., Hawk, Larry W., Mahoney, Martin C., Lerman, Caryn, Knight, Jo, and Tyndale, Rachel F.

Abstract

Varenicline, the most efficacious smoking cessation monotherapy, produces abnormal dreams. Although genetic contributions to varenicline-associated nausea and cessation have been identified, the role of genetics in abnormal dreams is unknown. We conducted a genomewide association study (GWAS) of abnormal dreams in 188 European ancestry smokers treated with varenicline (NCT01314001). Additive genetic models examined the likelihood of experiencing abnormal dreams 2 weeks following varenicline initiation. For the top locus, we tested for selectivity to varenicline, effects on cessation, replication, and generalizability to African ancestry (AA) individuals. The top GWAS variant associated with abnormal dreams was rs901886, mapping to intron 2 of ICAM5 on chromosome 19. The prevalence of abnormal dreams in those with rs901886 CC, CT, and TT genotypes was 15%, 36%, and 62%, respectively (odds ratio = 2.94 for T vs. C, 95% confidence interval = 1.92-4.55, P = 2.03e ; T allele frequency = 52%). This rs901886 association was selective to varenicline (P values > 0.05 on nicotine patch and placebo). There were also positive associations for rs901886 T (vs. C allele, P = 0.03) and for abnormal dreams (P = 0.06) with varenicline-aided cessation. Neither rs901886 (P = 0.40) nor abnormal dreams (P = 0.24) were associated with adherence. A similar direction of effect of rs901886 on abnormal dreams was observed in a second varenicline trial (NCT01836276). In AA individuals (n = 137), rs901886 was not associated with abnormal dreams (P = 0.41), but there was an association for a variant located ~ 74.4 kb 5' of ICAM5 (P = 2.56e ). Variation in ICAM5 may influence abnormal dreams and cessation on varenicline. These findings provide additional support for genetically optimized smoking cessation approaches. [Abstract copyright: © 2024 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeut

Published
2024

34. Corrigendum to “D-dimer to fibrinogen ratio predicts early neurological deterioration in ischemic stroke with atrial fibrillation” [Thromb. Res. 229 (2023) 219–224]

Author

Nam, Ki-Woong, primary, Kim, Chi Kyung, additional, Yu, Sungwook, additional, Oh, Kyungmi, additional, Chung, Jong-Won, additional, Oh, Young Bang, additional, Kim, Gyeong-Moon, additional, Jung, Jin-Man, additional, Song, Tae-Jin, additional, Kim, Yong-Jae, additional, Kim, Bum Joon, additional, Heo, Sung Hyuk, additional, Park, Kwang-Yeol, additional, Kim, Jeong-Min, additional, Park, Jong-Ho, additional, Choi, Jay Chol, additional, Park, Man-Seok, additional, Kim, Joon-Tae, additional, Choi, Kang-Ho, additional, Hwang, Yang Ha, additional, and Seo, Woo-Keun, additional

Published
2024
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42. Interpretable machine learning for early neurological deterioration prediction in atrial fibrillation-related stroke

Author

Kim, Seong-Hwan, Jeon, Eun-Tae, Yu, Sungwook, Oh, Kyungmi, Kim, Chi Kyung, Song, Tae-Jin, Kim, Yong-Jae, Heo, Sung Hyuk, Park, Kwang-Yeol, Kim, Jeong-Min, Park, Jong-Ho, Choi, Jay Chol, Park, Man-Seok, Kim, Joon-Tae, Choi, Kang-Ho, Hwang, Yang Ha, Kim, Bum Joon, Chung, Jong-Won, Bang, Oh Young, Kim, Gyeongmoon, Seo, Woo-Keun, and Jung, Jin-Man

Published
2021
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46. Prediction of hemorrhagic transformation in patients with mild atrial fibrillation-associated stroke treated with early anticoagulation: post hoc analysis of the Triple AXEL Trial

Author

Lee, Sang Hun, Hong, Keun-Sik, Lee, Ji Sung, Kim, Yong-Jae, Song, Tae-Jin, Kim, Young Dae, Park, Man-Seok, Kim, Eung-Gyu, Cha, Jae-Kwan, Sung, Sang Min, Yoon, Byung-Woo, Bang, Oh Young, Seo, Woo-Keun, Hwang, Yang-Ha, Ahn, Seong Hwan, Kang, Dong-Wha, Kang, Hyun Goo, Yu, Kyung-Ho, and Kwon, Sun U.

Published
2018
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48. The usefulness of quantitative 99mTc-HMPAO WBC SPECT/CT for predicting lower extremity amputation in diabetic foot infection.

Author

Park, Soo Bin, Lim, Chae Hong, Chun, Dong-il, Kim, Yong Jae, Kim, Tae Hyong, and Park, Jung Mi

Abstract

We investigated the usefulness of quantitative 99mTc-white blood cell (WBC) single photon emission computed tomography (SPECT)/computed tomography (CT) for predicting lower extremity amputation in diabetic foot infection (DFI). A total of 93 feet of 83 consecutive patients with DFI who underwent WBC SPECT/CT for treatment planning were retrospectively analysed. The clinical and SPECT/CT parameters were collected along with the measurements of the maximum standardized uptake value (SUVmax) at DFI. Statistical logistic regression analysis was performed to explore the predictors of LEA and receiver operating characteristic (ROC) curve was analysed to assess the predictive value of SPECT/CT. The independent predictors of amputation were previous amputation (OR 11.9), numbers of SPECT/CT lesions (OR 2.1), and SUVmax of DFI; either continuous SUVmax (1-increase) (OR 1.3) or categorical SUVmax > 1.1 (OR 21.6). However, the conventional SPECT/CT interpretation failed to predict amputation. In ROC analysis, the SUVmax yielded a fair predictor (area under the curve (AUC) 0.782) of amputation. The model developed from these independent predictors yielded an excellent performance for predicting amputation (AUC 0.873). Quantitative WBC SPECT/CT can provide new information useful for predicting the outcomes and guiding treatment for patients with DFI. [ABSTRACT FROM AUTHOR]

Published
2024
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50. The Quality Control Method in the Laboratory Analysis of Aquatic Ecosystem Health Monitoring and Assessment: Permanent Mounting Slides Tool Development Using Benthic Attached Diatoms

Author

Shin, Jae-Ki, primary, Kim, Nan-Young, additional, Park, Yongeun, additional, Lee, Kyung-Lak, additional, Kim, Baik-Ho, additional, Kim, Yong-Jae, additional, Kim, Han-Soon, additional, Lee, Jung Ho, additional, Lee, Hak Young, additional, and Hwang, Soon-Jin, additional

Published
2023
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