Search

Your search keyword '"Kim, Yong-Sun"' showing total 1,159 results
Start Over Author "Kim, Yong-Sun"
1,159 results on '"Kim, Yong-Sun"'

11. Human papillomavirus and Merkel cell polyomavirus in Korean patients with nonsmall cell lung cancer: Evaluation and genetic variability of the noncoding control region.

Author

Jin, Hyoung‐Tae, Kim, Yong‐Sun, and Choi, Eun‐Kyoung

Subjects
NON-small-cell lung carcinoma, HUMAN papillomavirus, MERKEL cells, KOREANS, MERKEL cell carcinoma
Abstract

Human papillomavirus (HPV) is an important causative factor of cervical cancer and is associated with nonsmall cell lung cancer (NSCLC). Merkel cell polyomavirus (MCPyV) is a rare and highly fatal cutaneous virus that can cause Merkel cell carcinoma (MCC). Although coinfection with oncogenic HPV and MCPyV may increase cancer risk, a definitive etiological link has not been established. Recently, genomic variation and genetic diversity in the MCPyV noncoding control region (NCCR) among ethnic groups has been reported. The current study aimed to provide accurate prevalence information on HPV and MCPyV infection/coinfection in NSCLC patients and to evaluate and confirm Korean MCPyV NCCR variant genotypes and sequences. DNA from 150 NSCLC tissues and 150 adjacent control tissues was assessed via polymerase chain reaction (PCR) targeting regions of the large T antigen (LT‐ag), viral capsid protein 1 (VP1), and NCCR. MCPyV was detected in 22.7% (34 of 150) of NSCLC tissues and 8.0% (12 of 150) of adjacent tissues from Korean patients. The incidence rates of HPV with and without MCPyV were 26.5% (nine of 34) and 12.9% (15 of 116). The MCPyV NCCR genotype prevalence in Korean patients was 21.3% (32 of 150) for subtype I and 6% (nine of 150) for subtype IIc. Subtype I, a predominant East Asian strain containing 25 bp tandem repeats, was most common in the MCPyV NCCR data set. Our results confirm that coinfection with other tumor‐associated viruses is not associated with NSCLC. Although the role of NCCR rearrangements in MCPyV infection remains unknown, future studies are warranted to determine the associations of MCPyV NCCR sequence rearrangements with specific diseases. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Impact of Target Arterial Residual Stenosis on Outcome After Endovascular Revascularization.

Author

Hwang, Yang-Ha, Kim, Yong-Won, Kang, Dong-Hun, Kim, Yong-Sun, and Liebeskind, David

Subjects
angiography, middle cerebral artery occlusion, prevalence, reperfusion, stroke, Aged, Cerebral Angiography, Combined Modality Therapy, Computed Tomography Angiography, Diagnosis, Differential, Endovascular Procedures, Female, Humans, Infarction, Middle Cerebral Artery, Intracranial Arteriosclerosis, Magnetic Resonance Angiography, Male, Middle Aged, Prevalence, Recurrence, Retrospective Studies, Risk Factors, Smoking, Thrombectomy, Tirofiban, Treatment Outcome, Tyrosine, Vasospasm, Intracranial
Abstract

BACKGROUND AND PURPOSE: Acute intracranial occlusion can be associated with in situ thrombo-occlusion in relation to preexisting intracranial atherosclerotic disease. We aimed to assess residual stenosis at the site of a target arterial lesion (TAL) to determine whether residual stenosis at the TAL is associated with underlying intracranial atherosclerotic disease. METHODS: One hundred and sixty-three patients who underwent endovascular therapy for M1 middle cerebral artery occlusion and achieved angiographic reperfusion were selected for analysis. The presence of residual stenosis at the TAL was classified using the Arterial Occlusive Lesion (AOL) scale at postprocedural angiography, and the severity of stenosis was grouped into none, mild (

Published
2016

19. AlterVerse: A Framework for Interactive Virtual Altering of Physical Objects in Extended Reality Environments

Author

Seo, Byung-Kuk, Park, Hye Sun, Kim, Yong Sun, and Potel, Mike

Abstract

This article presents AlterVerse, a framework that provides users with novel experiences through visual illusions of interactively altering physical objects in extended reality environments. In the AlterVerse framework, physical objects are seamlessly virtualized by aligning their 3-D virtual replicas with them. It enables users to manipulate (move or rotate) and reshape (deform the shapes or transform the styles of) the physical objects virtually. Simultaneously, the physical objects are visually removed from a physical environment, creating the perception that the altering occurs directly on the physical objects. As a promising application of the AlterVerse framework, the article demonstrates interactive virtual altering of home furniture in interior design or decoration scenarios without physically altering existing furniture.

Published
2024
Full Text
View/download PDF

22. In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation

Author

Wang, Zerui, Yuan, Jue, Shen, Pingping, Abskharon, Romany, Lang, Yue, Dang, Johnny, Adornato, Alise, Xu, Ling, Chen, Jiafeng, Feng, Jiachun, Moudjou, Mohammed, Kitamoto, Tetsuyuki, Lee, Hyoung-gon, Kim, Yong-Sun, Langeveld, Jan, Appleby, Brian, Ma, Jiyan, Kong, Qingzhong, Petersen, Robert B., Zou, Wen-Quan, and Cui, Li

Published
2019
Full Text
View/download PDF

26. Intuitive Pointing Position Estimation for Large Scale Display Interaction in Top-View Depth Images

Author

Kim, Hye-mi, Kim, Daehwan, Kim, Yong Sun, Kim, Ki-Hong, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Chen, Chu-Song, editor, Lu, Jiwen, editor, and Ma, Kai-Kuang, editor

Published
2017
Full Text
View/download PDF

33. A mouse xenograft long‐term replication yields a SARS‐CoV‐2 Delta mutant with increased lethality.

Author

Kim, Dongbum, Kim, Minyoung, Kim, Jinsoo, Baek, Kyeongbin, Park, Heedo, Park, Sangkyu, Kang, Bo Min, Kim, Suyeon, Kim, Mo‐Jong, Mostafa, Mohd Najib, Maharjan, Sony, Shin, Ha‐Eun, Lee, Myeong‐Heon, Il Kim, Jin, Park, Man‐Seong, Kim, Yong‐Sun, Choi, Eun‐Kyoung, Lee, Younghee, and Kwon, Hyung‐Joo

Abstract

We recently established a long‐term SARS‐CoV‐2 infection model using lung‐cancer xenograft mice and identified mutations that arose in the SARS‐CoV‐2 genome during long‐term propagation. Here, we applied our model to the SARS‐CoV‐2 Delta variant, which has increased transmissibility and immune escape compared with ancestral SARS‐CoV‐2. We observed limited mutations in SARS‐CoV‐2 Delta during long‐term propagation, including two predominant mutations: R682W in the spike protein and L330W in the nucleocapsid protein. We analyzed two representative isolates, Delta‐10 and Delta‐12, with both predominant mutations and some additional mutations. Delta‐10 and Delta‐12 showed lower replication capacity compared with SARS‐CoV‐2 Delta in cultured cells; however, Delta‐12 was more lethal in K18‐hACE2 mice compared with SARS‐CoV‐2 Delta and Delta‐10. Mice infected with Delta‐12 had higher viral titers, more severe histopathology in the lungs, higher chemokine expression, increased astrocyte and microglia activation, and extensive neutrophil infiltration in the brain. Brain tissue hemorrhage and mild vacuolation were also observed, suggesting that the high lethality of Delta‐12 was associated with lung and brain pathology. Our long‐term infection model can provide mutant viruses derived from SARS‐CoV‐2 Delta and knowledge about the possible contributions of emergent mutations to the properties of new variants. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

34. Balloon Guide Catheter Is Beneficial in Endovascular Treatment Regardless of Mechanical Recanalization Modality

Author

Baek, Jang-Hyun, Kim, Byung Moon, Kang, Dong-Hun, Heo, Ji Hoe, Nam, Hyo Suk, Kim, Young Dae, Hwang, Yang-Ha, Kim, Yong-Won, Kim, Yong-Sun, Kim, Dong Joon, Kwak, Hyo Sung, Roh, Hong Gee, Lee, Young-Jun, Kim, Sang Heum, Baik, Seung Kug, Jeon, Pyoung, Yoo, Joonsang, Suh, Sang Hyun, Kim, Byungjun, Kim, Jin Woo, Suh, Sangil, and Jeon, Hong-Jun

Published
2019
Full Text
View/download PDF

44. Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues.

Author

Kim, Dong Hwan, Kim, Jaehyeon, Lee, Hakmin, Lee, Dongyun, Im, So Myoung, Kim, Ye Eun, Yoo, Miryeong, Cheon, Yong-Pil, Bartz, Jason C., Son, Young-Jin, Choi, Eun-Kyoung, Kim, Yong-Sun, Jeon, Jae-Ho, Kim, Hyo Shin, Lee, Sungeun, Ryou, Chongsuk, and Nam, Tae-gyu

Subjects
PRIONS, PRION diseases, ATOMIC force microscopy, SMALL molecules, CREUTZFELDT-Jakob disease, GEL electrophoresis
Abstract

Prions are infectious protein particles known to cause prion diseases. The biochemical entity of the pathogen is the misfolded prion protein (PrPSc) that forms insoluble amyloids to impair brain function. PrPSc interacts with the non-pathogenic, cellular prion protein (PrPC) and facilitates conversion into a nascent misfolded isoform. Several small molecules have been reported to inhibit the aggregation of PrPSc but no pharmacological intervention was well established thus far. We, here, report that acylthiosemicarbazides inhibit the prion aggregation. Compounds 7x and 7y showed almost perfect inhibition (EC50 = 5 µM) in prion aggregation formation assay. The activity was further confirmed by atomic force microscopy, semi-denaturing detergent agarose gel electrophoresis and real-time quaking induced conversion assay (EC50 = 0.9 and 2.8 µM, respectively). These compounds also disaggregated pre-existing aggregates in vitro and one of them decreased the level of PrPSc in cultured cells with permanent prion infection, suggesting their potential as a treatment platform. In conclusion, hydroxy-2-naphthoylthiosemicarbazides can be an excellent scaffold for the discovery of anti-prion therapeutics. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results