1. A cross-sectional study on fatigue, anxiety, and symptoms of depression and their relation with medical status in adult patients with Marfan syndrome. Psychological consequences in Marfan syndrome
- Author
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Mitzi M. van Andel, Kim Graaumans, Maarten Groenink, Aeilko H. Zwinderman, Roland R. J. van Kimmenade, Arthur J. H. A. Scholte, Maarten P. van den Berg, Michael G. Dickinson, Hans Knoop, Jos A. Bosch, Barbara J. M. Mulder, Vivian de Waard, Floor Bennebroek Evertsz', Graduate School, Medical Biochemistry, ACS - Atherosclerosis & ischemic syndromes, Cardiology, ACS - Heart failure & arrhythmias, Epidemiology and Data Science, APH - Methodology, Medical Psychology, APH - Mental Health, APH - Aging & Later Life, APH - Personalized Medicine, APH - Quality of Care, Cardiovascular Centre (CVC), and Klinische Psychologie (Psychologie, FMG)
- Subjects
Marfan syndrome ,Cross-Sectional Studies ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,depression ,Genetics ,Humans ,fatigue ,Chronic Pain ,anxiety ,Genetics (clinical) - Abstract
Contains fulltext : 283508.pdf (Publisher’s version ) (Open Access) Marfan syndrome (MFS) is a connective tissue disorder affecting the cardiovascular, ocular, and skeletal system, which may be accompanied by psychological features. This study aimed to determine the prevalence of fatigue, anxiety, and symptoms of depression in MFS patients, and to assess the degree to which sociodemographic and clinical variables are associated with fatigue and psychological aspects. The prevalence of fatigue, anxiety, and symptoms of depression were assessed in two cohorts of MFS patients and compared with healthy controls. The checklist individual strength (CIS), and hospital anxiety and depression scale (HADS) questionnaires were utilized. Medical status was assessed (family history of MFS, aortic root dilatation >40 mm, previous aortic surgery, aortic dissection, chronic pain, skeletal involvement, and scoliosis). Severe fatigue was experienced by 37% of the total MFS cohort (n = 155). MFS patients scored significantly higher on the CIS questionnaire, concerning severe fatigue, as compared with the general Dutch population (p
- Published
- 2022