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1,039 results on '"Kim Raymond J"'

2. Automated Quality Controlled Analysis of 2D Phase Contrast Cardiovascular Magnetic Resonance Imaging

Author

Chan, Emily, O'Hanlon, Ciaran, Marquez, Carlota Asegurado, Petalcorin, Marwenie, Mariscal-Harana, Jorge, Gu, Haotian, Kim, Raymond J., Judd, Robert M., Chowienczyk, Phil, Schnabel, Julia A., Razavi, Reza, King, Andrew P., Ruijsink, Bram, and Puyol-Antón, Esther

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Flow analysis carried out using phase contrast cardiac magnetic resonance imaging (PC-CMR) enables the quantification of important parameters that are used in the assessment of cardiovascular function. An essential part of this analysis is the identification of the correct CMR views and quality control (QC) to detect artefacts that could affect the flow quantification. We propose a novel deep learning based framework for the fully-automated analysis of flow from full CMR scans that first carries out these view selection and QC steps using two sequential convolutional neural networks, followed by automatic aorta and pulmonary artery segmentation to enable the quantification of key flow parameters. Accuracy values of 0.958 and 0.914 were obtained for view classification and QC, respectively. For segmentation, Dice scores were $>$0.969 and the Bland-Altman plots indicated excellent agreement between manual and automatic peak flow values. In addition, we tested our pipeline on an external validation data set, with results indicating good robustness of the pipeline. This work was carried out using multivendor clinical data consisting of 986 cases, indicating the potential for the use of this pipeline in a clinical setting., Comment: STACOM 2022 workshop

Published
2022

3. An AI tool for automated analysis of large-scale unstructured clinical cine CMR databases

Author

Mariscal-Harana, Jorge, Asher, Clint, Vergani, Vittoria, Rizvi, Maleeha, Keehn, Louise, Kim, Raymond J., Judd, Robert M., Petersen, Steffen E., Razavi, Reza, King, Andrew, Ruijsink, Bram, and Puyol-Antón, Esther

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods
Abstract

Artificial intelligence (AI) techniques have been proposed for automating analysis of short axis (SAX) cine cardiac magnetic resonance (CMR), but no CMR analysis tool exists to automatically analyse large (unstructured) clinical CMR datasets. We develop and validate a robust AI tool for start-to-end automatic quantification of cardiac function from SAX cine CMR in large clinical databases. Our pipeline for processing and analysing CMR databases includes automated steps to identify the correct data, robust image pre-processing, an AI algorithm for biventricular segmentation of SAX CMR and estimation of functional biomarkers, and automated post-analysis quality control to detect and correct errors. The segmentation algorithm was trained on 2793 CMR scans from two NHS hospitals and validated on additional cases from this dataset (n=414) and five external datasets (n=6888), including scans of patients with a range of diseases acquired at 12 different centres using CMR scanners from all major vendors. Median absolute errors in cardiac biomarkers were within the range of inter-observer variability: <8.4mL (left ventricle volume), <9.2mL (right ventricle volume), <13.3g (left ventricular mass), and <5.9% (ejection fraction) across all datasets. Stratification of cases according to phenotypes of cardiac disease and scanner vendors showed good performance across all groups. We show that our proposed tool, which combines image pre-processing steps, a domain-generalisable AI algorithm trained on a large-scale multi-domain CMR dataset and quality control steps, allows robust analysis of (clinical or research) databases from multiple centres, vendors, and cardiac diseases. This enables translation of our tool for use in fully-automated processing of large multi-centre databases., Comment: Accepted at EHJ Digital Health; Bram Ruijsink and Esther Puyol-Ant\'on are shared last authors

Published
2022

4. Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study

Author

Villar-Calle, Pablo, Kochav, Jonathan D., Vadaketh, Krista, Chiu, Caitlin, Tak, Katherine, Agoglia, Hannah, Liberman, Nicole, Nguyen, Kenny L., Vizcarra-Tellez, Abdier, Wu, Alan, RoyChoudhury, Arindam, Khalique, Omar K., Judd, Robert M., Kim, Raymond J., Shah, Dipan J., Heitner, John F., Farzaneh-Far, Afshin, Shenoy, Chetan, Owyang, Clark G., Mukherjee, Monica, Horn, Evelyn M., Weinsaft, Jonathan W., and Kim, Jiwon

Published
2024
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13. The ferumoxytol in renal insufficiency study (FiRST)

Author

Vemulapalli Sreekanth, Abboud Lucien, Duran Cassidy, Klem Igor, Kim Han W, Crowley Anna, Quinones Miguel A, Nabi Faisal, Middleton John P, Zoghbi William A, Kim Raymond J, and Shah Dipan J

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2013
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35. Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols

Author

Kim Raymond J, Flamm Scott D, Barkhausen Jorg, Kramer Christopher M, and Nagel Eike

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Index 1. General techniques 1.1. Stress and safety equipment 1.2. Left ventricular (LV) structure and function module 1.3. Right ventricular (RV) structure and function module 1.4. Gadolinium dosing module. 1.5. First pass perfusion 1.6. Late gadolinium enhancement (LGE) 2. Disease specific protocols 2.1. Ischemic heart disease 2.1.1. Acute myocardial infarction (MI) 2.1.2. Chronic ischemic heart disease and viability 2.1.3. Dobutamine stress 2.1.4. Adenosine stress perfusion 2.2. Angiography: 2.2.1. Peripheral magnetic resonance angiography (MRA) 2.2.2. Thoracic MRA 2.2.3. Anomalous coronary arteries 2.2.4. Pulmonary vein evaluation 2.3. Other 2.3.1. Non-ischemic cardiomyopathy 2.3.2. Arrhythmogenic right ventricular cardiomyopathy (ARVC) 2.3.3. Congenital heart disease 2.3.4. Valvular heart disease 2.3.5. Pericardial disease 2.3.6. Masses

Published
2008
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36. Diastolic Dysfunction in Patients With Human Immunodeficiency Virus Receiving Antiretroviral Therapy: Results From the CHART Study

Author

Butler, Javed, Greene, Stephen J, Shah, Svati H, Shah, Sanjiv J, Anstrom, Kevin J, Kim, Raymond J, Kalogeropoulos, Andreas P, Velazquez, Eric J, Hernandez, Adrian F, Desvigne-Nickens, Patrice, Scherzer, Rebecca, Hsue, Priscilla Y, and Braunwald, Eugene

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, HIV/AIDS, Cardiovascular, Infectious Diseases, Clinical Research, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Cardiomyopathies, Case-Control Studies, Cross-Sectional Studies, HIV, HIV Infections, Heart Atria, Heart Failure, Humans, Quality of Life, Ventricular Dysfunction, Left, Antiretroviral therapy, diastolic dysfunction, human immunodeficiency virus, myocardial fibrosis, Cardiorespiratory Medicine and Haematology, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundDiastolic dysfunction (DD) is common and occurs at an earlier age among human immunodeficiency virus-infected (HIV+) individuals, but the mechanisms and consequences of DD among HIV+ individuals are unclear.Methods and resultsThe Characterization of Heart Function on Antiretroviral Therapy (CHART) study was a multicenter cross-sectional case-control study of treated and virally suppressed HIV+ individuals with (DD+) and without DD (DD-). All patients had normal ejection fraction (>50%), no significant valvular disease, and no history of coronary revascularization or persistent atrial fibrillation. Overall, 94 DD+ and 101 DD- patients were included. DD+ patients were older with higher body mass index (BMI) and more likely to have hypertension, renal dysfunction, and dyslipidemia. Groups were similar with respect to sex, race, CD4 count, and HIV RNA copies. N-terminal pro-B-type natriuretic peptide levels (median 36 [23, 85] vs 26 [12, 49] pg/mL, P < .01) and high-sensitivity troponin I (3.6 [2.6, 5.1] vs 2.5 [1.8, 3.5] pg/mL, P < .01) were higher among DD+ patients. The latter had similar left atrial size, but increased stiffness (conduit strain: 23.5 [17.5, 36.9] vs 30.0 [22.9, 37.0], P < .01) and impaired relaxation (reservoir strain: 39.7 [32.0, 58.0] vs 45.9 [37.0, 60.6], P = .04). On cardiac magnetic resonance, the prevalence of focal fibrosis was higher among DD+ patients (19.0% vs 5.3%, P < .01). DD+ patients demonstrated higher levels of carboxyl-terminal telopeptide of collagen type I (P = .04), and trends toward higher interleukin-6 and oxidized low-density lipoprotein levels (P ≤ .08). Kansas City Cardiomyopathy Questionnaire physical limitation (87.1±21.4 vs 93.1±18.1, P = .01) and symptom frequency scores were lower among DD+ patients (86.0±21.5 vs 92.5±16.8, P = .01).ConclusionsIn this contemporary HIV+ population receiving antiretroviral therapy, DD was associated with multiple alterations in cardiac structure and function, including myocardial fibrosis and left atrial abnormalities, and worse quality of life. Further studies are needed to assess longitudinal changes in these parameters and their potential as therapeutic targets to prevent progressive cardiac remodeling and dysfunction in HIV.

Published
2020

40. Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance

Author

Kochav, Jonathan D., Kim, Jiwon, Judd, Robert, Tak, Katherine A., Janjua, Emmad, Maciejewski, Abigail J., Kim, Han W., Klem, Igor, Heitner, John, Shah, Dipan, Zoghbi, William A., Shenoy, Chetan, Farzaneh-Far, Afshin, Polsani, Venkateshwar, Villar-Calle, Pablo, Parker, Michele, Judd, Kevin M., Khalique, Omar K., Leon, Martin B., Devereux, Richard B., Levine, Robert A., Kim, Raymond J., and Weinsaft, Jonathan W.

Published
2022
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41. Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study

Author

Butler, Javed, Kalogeropoulos, Andreas P, Anstrom, Kevin J, Hsue, Priscilla Y, Kim, Raymond J, Scherzer, Rebecca, Shah, Sanjiv J, Shah, Svati H, Velazquez, Eric J, Hernandez, Adrian F, Desvigne-Nickens, Patrice, and Braunwald, Eugene

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Cardiovascular, HIV/AIDS, Clinical Research, Heart Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Anti-Retroviral Agents, Global Health, HIV, HIV Infections, Heart Failure, Diastolic, Humans, Incidence, Prognosis, Stroke Volume, Ventricular Function, Left, Human immunodeficiency virus, diastolic dysfunction, heart failure, pathophysiology, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Antiretroviral therapy (ART) has been associated with a shift in the epidemiology of human immunodeficiency virus (HIV)-associated cardiomyopathy from a phenotype of primarily left ventricular (LV) systolic dysfunction to LV diastolic dysfunction (DD). Patients with HIV receiving ART have higher rates of DD compared with age-matched control subjects and develop DD at a younger age. However, little is known about the natural history and pathogenesis of DD in virally suppressed HIV-infected patients. Current evidence suggests that immune processes modulate the risk for cardiac involvement in HIV-infected persons. Ongoing inflammation appears to have myocardial effects, and accelerated myocardial fibrosis appears to be a key mediator of HIV-induced DD. The Characterizing Heart Function on Antiretroviral Therapy (CHART) study aims to systematically investigate determinants, mechanisms, and consequences of DD in HIV-infected patients. We will compare ART-treated virally suppressed HIV-infected individuals with and without DD and HIV- individuals with DD regarding (1) systemic inflammation, myocardial stress, and subclinical myocardial necrosis as indicated by circulating biomarkers; (2) immune system activation as indicated by cell surface receptors; (3) myocardial fibrosis according to cardiac magnetic resonance examination; (4) markers of fibrosis and remodeling, oxidative stress, and hypercoagulability; (5) left atrial function according to echocardiographic examination; (6) myocardial stress and subclinical necrosis as indicated by circulating biomarkers; (7) proteomic and metabolic profiles; and (8) phenotype signatures derived from clinical, biomarker, and imaging data.

Published
2018

44. Abstract 13857: Reduction of Infarct Size in Anterior ST Segment Elevation Myocardial Infarction (STEMI) With LAD Occlusion and LV Unloading Using a Micro-Axial Pump for 30 Minutes Before PCI: A Per Protocol Analysis of the STEMI DTU Pilot Study

Author

Kapur, Navin K, Moses, Jeffrey, FARAZ, HAROON, George, Zachary, Iyer, Vijay S, Kaki, Amir, Karas, Richard, Kimmelstiel, Carey, Koenig, Gerald, Madder, Ryan D, Meraj, Perwaiz M, MORELAND, Jason A, Kim, Raymond J, schreiber, theodore, wohns, david, Udelson, James E, Stone, Gregg, and OʼNeill, William

Published
2022
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45. Automated Quality Controlled Analysis of 2D Phase Contrast Cardiovascular Magnetic Resonance Imaging

Author

Chan, Emily, primary, O’Hanlon, Ciaran, additional, Marquez, Carlota Asegurado, additional, Petalcorin, Marwenie, additional, Mariscal-Harana, Jorge, additional, Gu, Haotian, additional, Kim, Raymond J., additional, Judd, Robert M., additional, Chowienczyk, Phil, additional, Schnabel, Julia A., additional, Razavi, Reza, additional, King, Andrew P., additional, Ruijsink, Bram, additional, and Puyol-Antón, Esther, additional

Published
2022
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47. Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction—Results of the Chymase Inhibitor in Adverse Remodeling after Myocardial Infarction (CHIARA MIA) 2 trial

Author

Podpera, Ivo, Linkova, Hana, Hajek, Petr, Bauersachs, Johann, Menck, Niels, Fuisting, Jan, Oumbe Tiam, Sadrack, Martinez Selles, Manuel, Miro Palau, Vicente, Roque, Mercedes, Ibanez, Borja, Arbel, Yaron, Nikolsky, Eugenia, Nodari, Savina, Silvio Marenzi, Gian Carlo, Achilli, Felice, Reimers, Bernhard, Duengen, Hans-Dirk, Kim, Raymond J., Zahger, Doron, Orvin, Katia, Kornowski, Ran, Admon, Dan, Kettner, Jiri, Shimony, Avraham, Otto, Christiane, Becka, Michael, Kanefendt, Friederike, Romo, Andres Iniguez, Hasin, Tal, Ostadal, Petr, Rojas, Gonzalo Calvo, and Senni, Michele

Published
2020
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48. Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial

Author

Butler, Javed, Khan, Muhammad Shahzeb, Anker, Stefan D., Fonarow, Gregg C., Kim, Raymond J., Nodari, Savina, O'Connor, Christopher M., Pieske, Burkert, Pieske-Kraigher, Elisabeth, Sabbah, Hani N., Senni, Michele, Voors, Adriaan A., Udelson, James E., Carr, Jim, Gheorghiade, Mihai, and Filippatos, Gerasimos

Published
2020
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50. Cardiovascular magnetic resonance accurately detects obstructive coronary artery disease in suspected non-ST elevation myocardial infarction: a sub-analysis of the CARMENTA Trial

Author

van Cauteren, Yvonne J. M., Smulders, Martijn W., Theunissen, Ralph A. L. J., Gerretsen, Suzanne C., Adriaans, Bouke P., Bijvoet, Geertruida P., Mingels, Alma M. A., van Kuijk, Sander M. J., Schalla, Simon, Crijns, Harry J. G. M., Kim, Raymond J., Wildberger, Joachim E., Heijman, Jordi, and Bekkers, Sebastiaan C. A. M.

Published
2021
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