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2. Open-label, randomized study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin or cisplatin in patients with advanced non-small-cell lung cancer (NSCLC)

Author

Joerger, M., von Pawel, J., Kraff, S., Fischer, J.R., Eberhardt, W., Gauler, T.C., Mueller, L., Reinmuth, N., Reck, M., Kimmich, M., Mayer, F., Kopp, H.-G., Behringer, D.M., Ko, Y.-D., Hilger, R.A., Roessler, M., Kloft, C., Henrich, A., Moritz, B., Miller, M.C., Salamone, S.J., and Jaehde, U.

Published
2016
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3. MA06.08 Long-term Survival and Competing Risks of Death in the ESPATUE Randomized Phase-III Trial in Stage III NSCLC

Author

Eberhardt, W.E.E., primary, Poettgen, C., additional, Gauler, T.C., additional, Schulte, C., additional, Friedel, G., additional, Kopp, H.-G., additional, Fischer, B., additional, Schmidberger, H., additional, Kimmich, M., additional, Budach, W., additional, Cordes, S., additional, Metzenmacher, M., additional, de Los Rios, R. Hepp, additional, Spengler, W., additional, De Ruysscher, D., additional, Belka, C., additional, Welter, S., additional, Brintrup, D. Luetke, additional, Guberina, M., additional, Oezkan, F., additional, Darwiche, K., additional, Schuler, M., additional, Jöckel, K.-H., additional, Aigner, C., additional, Stamatis, G., additional, and Stuschke, M., additional

Published
2022
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4. 1021P DURATION - a phase II randomized trial in older / frail patients (pts) with advanced non-small cell lung cancer (NSCLC) comparing chemotherapy (CTX, 4 cycles) with CTX (2 cycles) and consecutive durvalumab (D): Top-line early efficacy endpoints

Author

Kuon, J.B., primary, Blasi, M., additional, Kokowski, K., additional, Faehling, M., additional, Schuette, W., additional, Christoph, D.C.C., additional, Kimmich, M., additional, Engel-Riedel, W., additional, Fischer, J., additional, Lehmann, M., additional, Ulmer, M., additional, Schuett, P., additional, Moosmann, N., additional, Meyer zum Bueschenfelde, C., additional, Griesinger, F., additional, Schneider, M., additional, Behnisch, R., additional, Stenzinger, A., additional, Christopoulos, P., additional, and Thomas, M., additional

Published
2022
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5. OA02.03 Amivantamab Plus Lazertinib vs Osimertinib in First-line EGFR-mutant Advanced NSCLC: Longer Follow-up of the MARIPOSA Study

Author

Gadgeel, S., Cho, B.C., Lu, S., Felip, E., Hayashi, H., Spira, A.I., Besse, B., Thomas, M., Owen, S., Kim, Y.J., Lee, S.-H., Mourão Dias, J., Lee, Y.-G., Zhao, Y., Fang, Y., Girard, N., Liu, Z., Sun, P., Oliveira, S.C. Sousa, Shen, H., Paz-Ares, L., Matsumoto, S., Tanaka, H., Ahmad, A.R., Andabekov, T., Sunpaweravong, P., Ozyilkan, O., Yang, J.C.-H., Gottfried, M., Hernandez, O., Kimmich, M., Cortinovis, D., Kaen, D.L., Montes, L.V. García, Popat, S., Newsom-Davis, T., Xie, J., Sun, T., Fennema, E., Daksh, M., Ennis, M., Sethi, S., Bauml, J.M., and Nguyen, D.

Published
2024
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6. Long-term Survival and Competing Risks of Death in the ESPATUE Randomized Phase-III Trial in Stage III NSCLC

Author

Eberhardt, Wilfried, Pöttgen, Christoph, Gauler, Thomas, Schulte, C, Friedel, G., Kopp, H.-G., Fischer, B., Schmidberger, H., Kimmich, M., Budach, W., Cordes, S., Metzenmacher, M., de Los Rios, R. Hepp, Spengler, W., De Ruysscher, D., Belka, C., Welter, S., Brintrup, D. Luetke, Guberina, M., Oezkan, F., Darwiche, Kaid, Schuler, Martin, Jöckel, Karl-Heinz, Aigner, Clemens, Stamatis, Georgios, and Stuschke, Martin

Subjects
Medizin
Published
2022

8. 1442P DURATION: A multicenter randomized phase II trial investigating sequential mono- (mCTX) or doublet-chemotherapy (dCTX) followed by durvalumab (D) in older or frail patients with advanced non-small cell lung cancer (NSCLC)

Author

Kuon, J.B., Blasi, M., Kokowski, K., Faehling, M., Schuette, W., Christoph, D.C.C., Kimmich, M., Engel-Riedel, W., Fischer, J.R., Lehmann, M., Ulmer, M., Schuett, P., Moosmann, N., Meyer zum Büschenfelde, C., Griesinger, F., Schneider, M., Behnisch, R., Stenzinger, A., Christopoulos, P., and Thomas, M.

Published
2023
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9. 1246P Hybrid capture-based assays in primary diagnostics of NSCLC patients: Results from the NEOlung study

Author

Jori, B., primary, Gautschi, O., additional, Kimmich, M., additional, Beaucaire Danel, S., additional, Reinmuth, N., additional, Garrido Lopez, P., additional, Cappuzzo, F., additional, Forster, M., additional, Patel, K., additional, Grohe, C., additional, Müller, A., additional, Wesseler, C., additional, Menon, R., additional, Müller, J., additional, Mariotti, E., additional, Brinkmann, J., additional, Heukamp, L., additional, and Griesinger, F., additional

Published
2020
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11. Therapy of the 5q-syndrome: 976

Author

Giagounidis, A. A.N., Haase, S., Germing, U., Grips, K., Wysk, J., Burstedde, V., Grabenhorst, U., Lipke, J., Kimmich, M., Oborilova, A., Fetscher, S., Lange, W., Stark, U., Schmidt, M., Schlegelberger, B., Kreipe, H. H., Ganser, A., and Aul, C.

Published
2002

13. Strategien zur Überwindung der erworbenen EGFR-TKI-Resistenz durch T790M spezifische Substanzen am Beispiel von Osimertinib

Author

Griesinger, F., additional, Radke, S., additional, Lüers, A., additional, Deschler-Baier, B., additional, Kimmich, M., additional, Sebastian, M., additional, Schulz, C., additional, Brugger, W., additional, Wiewrodt, R., additional, Pirker, R., additional, Früh, M., additional, Gautschi, O., additional, and Wolf, J., additional

Published
2018
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14. Strategies to Overcome Acquired Resistance to EGFR-TKI Therapy Based on T790M Specific Substances using Osimertinib as an Example

Author

Griesinger, F., Radke, S., Lueers, A., Deschler-Baier, B., Kimmich, M., Sebastian, M., Schulz, C., Brugger, W., Wiewrodt, R., Pirker, R., Fruh, M., Gautschi, O., Wolf, J., Griesinger, F., Radke, S., Lueers, A., Deschler-Baier, B., Kimmich, M., Sebastian, M., Schulz, C., Brugger, W., Wiewrodt, R., Pirker, R., Fruh, M., Gautschi, O., and Wolf, J.

Abstract

Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) are widely used in non-small cell lung cancer patients harboring activating EGFR mutations. However, resistance mechanisms, particularly the T790M mutation, hamper longer-term therapeutic success of first and second generation EGFR-TKIs. To address this unmet medical need, EGFR-TKIs of the third generation are under clinical development. Relevant clinical efficacy with mainly mild to moderate class-specific side effects has been shown for third-generation EGFR-TKIs. Molecular testing is of major importance in deciding for treatment with third generation EGFR-TKIs. This article elucidates the developmental state of third generation EGFR-TKIs with its focus on Osimertinib, the first and currently the only compound in this class which is approved in Germany. Additionally, the medical importance of molecular diagnosis using tumor tissue and circulating tumor DNA is discussed.

Published
2018

15. Nivolumab-Induced Rapid Tumor Remission of Pulmonary Adenocarcinoma

Author

German Ott, Kimmich M, M Wohlleber, Bode-Erdmann S, M Kohlhäufl, R. F. Falkenstern-Ge, and Godehard Friedel

Subjects
Oncology, medicine.medical_specialty, Metastatic melanoma, business.industry, Melanoma, Fda approval, Pulmonary adenocarcinoma, medicine.disease, Immune checkpoint, Internal medicine, Immunology, Medicine, Anaplastic lymphoma kinase, Non small cell, Nivolumab, business
Abstract

We The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. Nivolumab received FDA approval for the treatment of melanoma in December 2014. On 24 April 2015, the Committee for Medical Products for Human Use of the European Medicine Agency recommended approval of Nivolumab for metastatic melanoma as a monotherapy. In March 2015, the US FDA approved it for the treatment of squamous non-small cell lung cancer. This case reports about a patient with metastatical pulmonary adenocarcinoma who benefited from the therapy with nivolumab. Already after 10 weeks of treatment with nivolumab, we registered rapid tumor remission.

Published
2017
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17. Cryo-Recanalization of Huge Endobronchial Pulmonary Adenocarcinoma

Author

Biwer As, M Wohlleber, R. F. Falkenstern-Ge, Godehard Friedel, Kimmich M, and Alscher M

Subjects
medicine.medical_specialty, Bronchoscopy, medicine.diagnostic_test, business.industry, Pulmonary adenocarcinoma, medicine, Adenocarcinoma, Lumen (anatomy), Right upper lobe, Radiology, business, medicine.disease, Lung cancer
Abstract

We were able to recanalize the major lumen of the right main bronchial branch, which was completely blocked because of huge tumor mass from the right upper lobe. With the cryo-therapy, we could freeze and remove the major portion of this huge tumor mass.

Published
2017
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18. An expanded access program of osimertinib (Tagrisso) in patients with advanced non-small cell lung cancer: data report from Germany

Author

Stratmann, J. A., Hornetz, S., Griesinger, F., Wolf, J., Christoph, D. C., Sackmann, S., Spengler, W., Bischoff, H., Schaefer, M., Alt, J., Mlueller, A., Laack, E., Kimmich, M., Sebastian, M., Stratmann, J. A., Hornetz, S., Griesinger, F., Wolf, J., Christoph, D. C., Sackmann, S., Spengler, W., Bischoff, H., Schaefer, M., Alt, J., Mlueller, A., Laack, E., Kimmich, M., and Sebastian, M.

Published
2017

21. The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Rosenberg, M, Tomulescu, V, Huang, J, Foroulis, C, Lang Lazdunski, L, Billè, A, Maessen, Jg, Keijzers, M, van Veer, H, Wright, C, Marino, M, Facciolo, F, Palmieri, G, Buonerba, C, Ferguson, M, Marulli, G, Lucchi, M, Loehrer, P, Kalkat, M, Rohrberg, K, Daugaard, G, Toker, A, Erus, S, Kimmich, M, Brunelli, A, Refai, M, Nicholson, A, Lim, E, Park, Ik, Wagner, J, Tieu, B, Fang, W, Zhang, J, Yu, Z, Han, Y, Li, Y, Chen, K, Chen, G, Okumura, M, Fujii, Y, Asamura, H, Nagai, K, Nakajima, J, Ikeda, N, Haraguchi, S, Onuki, T, Suzuki, K, Yoshino, I, Tsuchida, M, Takahashi, S, Yokoi, K, Hanyuda, M, Niwa, H, Date, H, Maniwa, Y, Miyoshi, S, Kondo, K, Iwasaki, A, Okamoto, T, Nagayasu, T, Tanaka, F, Suzuki, M, Yoshida, K, Okuma, Y, Horio, H, Matsumura, A, Higashiyama, M, Suehisa, H, Sano, Y, Al Kattan, K, Cerfolio, R, Gebitekin, C, de Antonio, D, Kernstine, Kh, Altorki, N, Novoa, N, Ruffini, E, Filosso, Pl, Saita, S, Scarci, M, Voltolini, L, Weder, W, Zurek, W, Arame, A, Casadio, C, Carbognani, P, Donati, G, Keshavjee, S, Klepetko, W, Moser, B, Lequaglie, C, Liberman, M, Mancuso, M, Nosotti, M, Spaggiari, L, Thomas, Pa, Rendina, Erino Angelo, Venuta, Federico, Anile, Marco, Schützner, J, Rocco, G, Crowley, J, Detterbeck, F, Falkson, C, Filosso, L, Giaccone, G, Giroux, D, Kim, J, Marom, Em, Nicholson, Ag, Brompton, R, Van Schil, P, Stratton, K., University of Zurich, Detterbeck, Frank C, Eberhardt, Wilfried (Beitragende*r), Prognostic Factors Comm, Advisory Boards, and Participating Inst Thymic Domain

Subjects
Pulmonary and Respiratory Medicine, Stage classification, Oncology, medicine.medical_specialty, Pathology, Staging, Thymoma, Evidence-based practice, 10255 Clinic for Thoracic Surgery, Medizin, 610 Medicine & health, Metastasis, Thymic carcinoma, Cohort Studies, Neoplasms, Internal medicine, medicine, Humans, Neoplasms, Glandular and Epithelial, Stage (cooking), Lung cancer, Neoplasm Staging, Retrospective Studies, Evidence-Based Medicine, business.industry, Glandular and Epithelial, Cancer, Thymus Neoplasms, Prognosis, medicine.disease, 2740 Pulmonary and Respiratory Medicine, 2730 Oncology, Human medicine, business
Abstract

A universal and consistent stage classification system, which describes the anatomic extent of a cancer, provides a foundation for communication and collaboration. Thymic epithelial malignancies have seen little progress, in part because of the lack of an official system. The International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group assembled a large retrospective database, a multispecialty international committee and carried out extensive analysis to develop proposals for the 8th edition of the stage classification manuals. This tumor, node, metastasis (TNM)-based system is applicable to all types of thymic epithelial malignancies. This article summarizes the proposed definitions of the T, N, and M components and describes how these are combined into stage groups. This represents a major step forward for thymic malignancies.

Published
2014
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22. Metachrone multiple Tumore

Author

Falkenstern-Ge, R, additional, Kimmich, M, additional, Wohlleber, M, additional, Bode-Erdmann, S, additional, Huettle, K, additional, Grabner, A, additional, Friedel, G, additional, Ott, G, additional, and Kohlhäufl, M, additional

Published
2017
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23. Explorative Subgruppenanalysen von Patienten, die refraktär auf eine Erstlinientherapie waren, sowie von Patienten mit Pemetrexed (PEM) als Erstlinientherapie aus der REVEL Studie: Randomisierte Phase III Studie zur Therapie mit Docetaxel (DOC) plus Ramucirumab (RAM) oder plus Plazebo (PL) bei nichtkleinzelligem Lungenkarzinom (NSCLC) nach Progression mit platinbasierter Therapie im Stadium IV

Author

Reck, M, additional, Kimmich, M, additional, Schütte, W, additional, Schumann, C, additional, Garon, EB, additional, Pérol, M, additional, Alexandris, E, additional, Zimmermann, AH, additional, and Lee, P, additional

Published
2017
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25. The IASLC/ITMIG thymic malignancies staging project: development of a stage classification for thymic malignancies

Author

Detterbeck, Fc1, Asamura, H, Crowley, J, Falkson, C, Giaccone, G, Giroux, D, Huang, J, Kim, J, Kondo, K, Lucchi, M, Marino, M, Marom, Em, Nicholson, A, Okumura, M, Ruffini, E, van Schil, P, Stratton, K, Staging, Prognostic Factors Committee, Members of the Advisory Boards, Goldstraw P, Participating Institutions of the Thymic D. o. m. a. i. n., Rami Porta, R, Ball, D, Beer, D, Beyruti, R, Bolejack, V, Chansky, K, Detterbeck, F, Eberhardt, W, Edwards, J, Galateau Sallé, F, Gleeson, F, Groome, P, Kennedy, C, Kim, Y, Kingsbury, L, Kondo, H, Krasnik, M, Kubota, K, Lerut, A, Lyons, G, Marom, E, van Meerbeeck, J, Mitchell, A, Nakano, T, Newman, J, Nowak, A, Peake, M, Rice, T, Rosenzweig, K, Rusch, V, Sculier, Jp, Suzuki, K, Tachimori, Y, Thomas CF Jr, Travis, W, Tsao, M, Turrisi, A, Vansteenkiste, J, Watanabe, H, Wu, Yi, Zielinski, M, Filosso, L, Baas, P, Erasmus, J, Hasegawa, S, Inai, K, Kernstine, K, Kindler, H, Krug, L, Nackaerts, K, Pass, H, Rice, D, Blackstone, E, Call Caja, S, Ahmad, U, Girard, N, Haam, Sj, Bae, Mk, Gomez, Dr, Ströbel, P, Marx, A, Saita, S, Wakelee, H, Bertolaccini, L, Vallieres, E, Scott, W, Su, S, Park, B, Marks, J, Khella, S, Shen, R, Rosenberg, M, Aires, B, Tomulescu, V, Foroulis, C, Lang Lazdunski, L, Billè, A, Maessen, Jg, Keijzers, M, van Veer, H, Wright, C, Palmieri, G, Buonerba, C, Ferguson, M, Marulli, G, Loehrer, P, Kalkat, M, Rohrberg, K, Daugaard, G, Toker, A, Erus, S, Kimmich, M, Brunelli, A, Refai, M, Lim, E, Park, Ik, Wagner, J, Tieu, B, Fang, W, Zhang, J, Yu, Z, Han, Y, Li, Y, Chen, K, Chen, G, Fujii, Y, Nagai, K, Nakajima, J, Ikeda, N, Haraguchi, S, Onuki, T, Yoshino, I, Tsuchida, M, Takahashi, S, Yokoi, K, Hanyuda, M, Niwa, H, Date, H, Maniwa, Y, Miyoshi, S, Iwasaki, A, Okamoto, T, Nagayasu, T, Tanaka, F, Suzuki, M, Yoshida, K, Okuma, Y, Horio, H, Matsumura, A, Higashiyama, M, Suehisa, H, Sano, Y, Kattan, K, Cerfolio, R, Gebitekin, C, de Antonio, D, Kernstine, Kh, Altorki, N, Novoa, N, Filosso, Pl, Scarci, M, Voltolini, L, Weder, W, Zurek, W, Arame, A, Casadio, C, Toracica, C, Carbognani, P, Donati, G, Keshavjee, S, Klepetko, W, Moser, B, Lequaglie, C, Liberman, M, Mancuso, M, Nosotti, M, Spaggiari, L, Thomas, Pa, Rendina, Erino Angelo, Venuta, F, Anile, M, Schützner, J, Rocco, G., Staging Prognostic Factors Comm, University of Zurich, Detterbeck, Frank C, and Eberhardt, Wilfried (Beitragende*r)

Subjects
Pulmonary and Respiratory Medicine, Oncology, Stage classification, medicine.medical_specialty, Pathology, Lung Neoplasms, Thymoma, 10255 Clinic for Thoracic Surgery, Medizin, 610 Medicine & health, Thymic carcinoma, Internal medicine, medicine, Humans, Project management, Program Development, Lung cancer, Neoplasm Staging, business.industry, International Agencies, Thymus Neoplasms, Staging of stage classification, medicine.disease, 2740 Pulmonary and Respiratory Medicine, Interest group, 2730 Oncology, Program development, Human medicine, business
Abstract

The lack of an official-stage classification system for thymic malignancies is an issue that hampers progress in this rare disease. A collaborative effort by the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group is underway to develop proposals for such a system. A database of more than 10,000 cases worldwide has been assembled to provide a solid basis for analysis. This report outlines the structure of the effort and the process that has been designed.

Published
2014

26. Pulmonary Adenocarcinoma Occurring 5 Years after Resection of a Primary Pancreatic Adenocarcinoma: A Relevant Differential Diagnosis

Author

Falkenstern-Ge, R. F., Wohlleber, M., Kimmich, M., Huettl, K., Friedel, G., Ott, G., and Kohlhäufl, M.

Subjects
Article Subject
Abstract

Ductal adenocarcinoma of the pancreas is a lethal disease. Surgical extirpation only offers the slim chance for long-term survival in localized disease. We report on a 73 year old female patient who initially underwent successful resection of pancreatic adenocarcinoma in May 2005. She was treated with adjuvant chemotherapy with gemcitabine. In October 2010 the patient noticed increasing dyspnea with haemoptysis. She was soon referred to our center. After the diagnosis of pulmonary adenocarcinoma with widespread metastasis, she was treated with systemic chemotherapy. For a period of next three years, she was treated with different chemotherapy regimens due to repeated episodes of tumor progression. To the best of our knowledge after reviewing the literature, this case represents an unusually clinical course with metachronous pulmonary adenocarcinoma arising after treatment of a primary pancreatic cancer after a long latency period.

Published
2014
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27. Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment

Author

Falkenstern-Ge, R. F., Kimmich, M., Wohlleber, M., Grabner, A., Friedel, G., Ott, G., Leuschner, I., and Kohlhäufl, M.

Subjects
Article Subject, respiratory system
Abstract

A 30-year old woman was referred to our center because of suspicion of a primary lung tumor of the right upper lobe. Histological examination of the lung lesion revealed lung metastasis of a previously treated alveolar soft part sarcoma of the musculus vastus medialis of the right femur, which was resected 20 years ago. Alveolar soft-part sarcoma is a rare malignant tumor that occurs most often in the soft tissue of lower limbs. It is a slow-growing malignant soft tissue tumor arising in muscle tissue, usually in young adults. Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. Late metastases from previously treated alveolar part sarcoma should be considered in patients with suspicious lung lesions even if surgical treatment was performed a long time ago.

Published
2013
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28. Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation

Author

Falkenstern-Ge, R. F., Kimmich, M., Bode-Erdmann, S., Friedel, G., Ott, G., and Kohlhäufl, M.

Subjects
Article Subject, respiratory system, neoplasms, respiratory tract diseases
Abstract

Introduction. Pleural mesothelioma with metastasis to the subcutaneous tissue of the abdominal wall at first diagnosis and without penetration into the peritoneum is an extremely rare clinical presentation. Methods. Patients with pleural mesothelioma have low survival rate. Usually, the disease at presentation is confined to its site of origin (most often the pleural cavity). A 55-year-old man was referred to our center due to increasing dyspnea and a painful periumbilical mass in the anterior abdominal wall. CT scan revealed both advanced mesothelioma of the pleura and a tumor mass confined to the subcutaneous fatty tissue without penetration through the peritoneum. Results. Video-assisted thoracoscopy confirmed the diagnosis of epithelioid pleural mesothelioma, which was also confirmed by a biopsy of the periumbilical mass. Systemic chemotherapy with cisplatin and pemetrexed was initiated. Under the ongoing systemic chemotherapy, the evaluation revealed partial remission of pleura mesothelioma and its subcutaneous manifestation of the abdominal wall. Conclusion. Mesothelioma of the pleura with a simultaneous metastasis to the subcutaneous fatty tissue of the abdominal wall at presentation without penetration of peritoneum is a rare clinical presentation of mesothelioma disease. The knowledge of its natural history is very limited. This is the first ever clinical documentation of a patient with pleura mesothelioma and simultaneous subcutaneous manifestation of abdominal wall.

Published
2013
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29. Open-label, randomized study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin in advanced Non-Small Cell Lung Cancer (NSCLC) patient

Author

Pawel, J von, primary, Kraff, S, additional, Fischer, JR, additional, Eberhardt, W, additional, Gauler, T, additional, Müller, L, additional, Reinmuth, N, additional, Reck, M, additional, Kimmich, M, additional, Mayer, F, additional, Kopp, HG, additional, Behringer, DM, additional, Ko, YD, additional, Frueh, M, additional, Hilger, RA, additional, Roessler, M, additional, Moritz, B, additional, Jaehde, U, additional, and Joerger, M, additional

Published
2016
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32. 3066 Pharmacokinetically (PK)-guided dosing of paclitaxel in combination with carboplatin in advanced non-small cell lung cancer (NSCLC) is gender dependent: Updated results of the randomized CEPAC-TDM study

Author

Joerger, M., primary, Von Pawel, J., additional, Kraff, S., additional, Fischer, J.R., additional, Gauler, T., additional, Mueller, L., additional, Reinmuth, N., additional, Reck, M., additional, Kimmich, M., additional, Frank, M., additional, Kopp, H.G., additional, Behringer, D., additional, Ko, Y.D., additional, Ralf, H., additional, Roessler, M., additional, Kloft, C., additional, Henrich, A., additional, Moritz, B., additional, and Jaehde, U., additional

Published
2015
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33. Update REVEL: Eine randomisierte, doppelblinde Phase III Studie von Docetaxel (DOC) und Ramucirumab (RAM; IMC-1121B) versus DOC und Placebo (PL) in der Zweitlinienbehandlung des Nicht-Kleinzelligen Lungenkarzinoms im Stadium IV nach Progression der Erkrankung nach einer Platin-basierten Vortherapie

Author

Reck, M, primary, Thomas, M, additional, Schuette, W, additional, Kimmich, M, additional, Rittmeyer, A, additional, Heinrich, B, additional, Yurasov, S, additional, Zimmermann, A, additional, Carter, GC, additional, Garon, EB, additional, and Pérol, M, additional

Published
2015
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34. Phase III study of surgery (S) versus definitive concurrent chemoradiotherapy boost (def ccCRTx-BOx) in patients (pts) with operable (OP+) stage IIIA(N2)/selected IIIb (sel IIIB) non-small cell lung cancer (NSCLC) following induction (IND) chemotherapy (CTx) and concurrent CRTx (ESPATUE)

Author

Eberhardt, Wilfried, Gauler, Thomas, Pöttgen, Christoph, Friedel, G., Veit, S., Heinrich, V., Welter, Stefan, Spengler, W., Kimmich, M., Fischer, B., Schmidberger, H., Gkika, E., Cordes, S., Hepp, R., Luetke-Brintrup, D., Lehmann, Nils, Schuler, Martin, Jöckel, Karl-Heinz, Stamatis, Georgios, Stuschke, Martin, and ESPATUE AIO ARO Clinical Trials

Subjects
Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Medizin, non-small cell lung cancer (NSCLC), medicine.disease, Concurrent chemoradiotherapy, Surgery, Oncology, medicine, In patient, Stage IIIa, business
Abstract

7510 Background: Def ccCRTx or ccCRTx + S are accepted therapies (Tx) for OP+ stage IIIA(N2) NSCLC (Albain 2009). Our multicenter phase-II showed efficacy of CTx + ccCRTx + S in IIIA(N2) / sel IIIB...

Published
2014
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37. Bronchiale Aspergillosen

Author

Dobbertin, I., primary, Friedel, G., additional, Jaki, R., additional, Michl, M., additional, Kimmich, M., additional, Hofmann, A., additional, Eulenbruch, H.-P., additional, Weber, J., additional, Spengler, W., additional, Ott, G., additional, and Kohlhäufl, M., additional

Published
2010
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44. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Kondo, K., Schil, P., Detterbeck, F. C., Okumura, M., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Pier Luigi Filosso, Giaccone, G., Huang, J., Kim, J., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Ruffini, E., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Stratton, K., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Filosso, P. L., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

45. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Kondo, K., Schil, P., Detterbeck, F. C., Okumura, M., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giuseppe Giaccone, Huang, J., Kim, J., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Ruffini, E., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Stratton, K., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

46. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Nicholson, A. G., Detterbeck, F. C., Marino, M., Kim, J., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kondo, K., Lucchi, M., Marom, E. M., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., William Travis, Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

47. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Nicholson, A. G., Detterbeck, F. C., Marino, M., Kim, J., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kondo, K., Lucchi, M., Marom, E. M., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Federico Venuta, Anile, M., Schützner, J., and Rocco, G.

48. The IASLC/ITMIG thymic epithelial tumors staging project: Proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Detterbeck, F. C., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Frazier, A. A., Giaccone, G., Huang, J., Kim, J., Kondo, K., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Anna Nowak, Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

49. The IASLC/ITMIG thymic epithelial tumors staging project: Proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Detterbeck, F. C., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Frazier, A. A., Giaccone, G., Huang, J., Kim, J., Kondo, K., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Federico Venuta, Anile, M., Schützner, J., and Rocco, G.

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