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49 results on '"Kimoto, Kenichi"'

2. Successful Treatment of Hemi-Retinal Vein Occlusion with Macular Edema following Spinal Surgery Using Intravitreal Aflibercept and Retinal Photocoagulation: A Case Report.

Author

Nakatake, Shunji, Sato, Yoshiki, Itotani, Maho, Kimoto, Kenichi, Kubota, Toshiaki, and Takeda, Atsunobu

Subjects
RETINAL vein occlusion, RETINAL surgery, LASER photocoagulation, SPINAL surgery, MACULAR edema, TREATMENT effectiveness, AFLIBERCEPT, LIGHT coagulation
Abstract

Introduction: Perioperative visual loss (POVL) owing to hemi-retinal vein occlusion (HRVO) following prone positioning during spinal surgery is rare. Here, we report a case of HRVO with macular edema (ME) after spinal surgery that was successfully treated with intravitreal aflibercept (IVA) injections and retinal photocoagulation (RP). Case Presentation: A 63-year-old Japanese man underwent spinal surgery for lumbar spinal canal stenosis. Surgery was performed with the patient in the prone position under general anesthesia; the operation time was 305 min. No complications were associated with intraoperative anesthesia. On postoperative day 4, the patient noticed decreased visual acuity in his left eye and visited the Department of Ophthalmology on postoperative day 9. The best-corrected visual acuity (BCVA) in the left eye was 0.1. Fundus and optical coherence tomography revealed HRVO and ME in the left eye. IVA injections and RP were performed in the eye, which substantially decreased the ME and improved the patient's BCVA to 0.8. Conclusions: HRVO can cause POVL after prone positioning during spinal surgery. This is the first case of HRVO with ME after spinal surgery, which was successfully treated with IVA injections and RP. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Associations of Diabetic Retinopathy Severity With High Ambulatory Blood Pressure and Suppressed Serum Renin Levels

Author

Sada, Kentaro, primary, Yoshida, Yuichi, additional, Shibuta, Kanako, additional, Kimoto, Kenichi, additional, Miyamoto, Shotaro, additional, Ozeki, Yoshinori, additional, Okamoto, Mitsuhiro, additional, Gotoh, Koro, additional, Masaki, Takayuki, additional, Yokoyama, Katsuhiko, additional, Kubota, Toshiaki, additional, and Shibata, Hirotaka, additional

Published
2023
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11. Palliative Radiation Therapy for Choroidal Metastases: A Report of Three Cases

Author

Kiyota, Takashige, primary, Takata, Shoko, additional, Matsumoto, Akira, additional, Otsuka, Makoto, additional, Itotani, Maho, additional, Adachi, Toru, additional, Oki, Ryoko, additional, Kimoto, Kenichi, additional, Osoegawa, Atsushi, additional, Sugio, Kenji, additional, Nishikawa, Kazuo, additional, Nishida, Haruto, additional, Daa, Tsutomu, additional, and Asayama, Yoshiki, additional

Published
2022
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18. Corrigendum to “Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish”

Author

Yatsuka, Hiroyuki, primary, Hada, Kazumasa, additional, Shiraishi, Hiroshi, additional, Umeda, Ryohei, additional, Morisaki, Ikuko, additional, Urushibata, Hirotaro, additional, Shimizu, Nobuyuki, additional, Sebastian, Wulan Apridita, additional, Hikida, Takatoshi, additional, Ishitani, Tohru, additional, Hanada, Reiko, additional, Shimada, Tatsuo, additional, Kimoto, Kenichi, additional, Kubota, Toshiaki, additional, and Hanada, Toshikatsu, additional

Published
2021
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22. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish

Author

Yatsuka, Hiroyuki, primary, Hada, Kazumasa, additional, Shiraishi, Hiroshi, additional, Umeda, Ryohei, additional, Morisaki, Ikuko, additional, Urushibata, Hirotaro, additional, Shimizu, Nobuyuki, additional, Sebastian, Wulan Apridita, additional, Hikida, Takatoshi, additional, Ishitani, Tohru, additional, Hanada, Reiko, additional, Shimada, Tatsuo, additional, Kimoto, Kenichi, additional, Kubota, Toshiaki, additional, and Hanada, Toshikatsu, additional

Published
2020
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30. One-Year Outcomes following Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in Japanese Patients: The APOLLO Study

Author

Oshima, Yuji, primary, Kimoto, Kenichi, additional, Yoshida, Noriko, additional, Fujisawa, Kimihiko, additional, Sonoda, Shozo, additional, Kubota, Toshiaki, additional, Murata, Toshinori, additional, Sakamoto, Taiji, additional, Yoshida, Shigeo, additional, Sonoda, Koh-hei, additional, Ishibashi, Tatsuro, additional, and Oshima, Yuji, additional

Published
2017
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31. Three cases of pigmented cosmetic dermatitis-like eruptions associated with primary Sjögren's syndrome or anti-SSA antibody

Author

Takeo, Naoko, primary, Sakai, Takashi, additional, Saito-Shono, Tomoko, additional, Ishikawa, Kazushi, additional, Hatano, Yutaka, additional, Katagiri, Kazumoto, additional, Takahashi, Yoshihiro, additional, Kawano, Kenji, additional, Kimoto, Kenichi, additional, Kubota, Toshiaki, additional, Eshima, Nobuoki, additional, Kojima, Hiroto, additional, and Fujiwara, Sakuhei, additional

Published
2016
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33. 大学でできる再使用型ロケット実験(その6)

Author

Yonemoto, Koichi, Sagara, Shinichi, Matsumoto, Takaaki, Nagata, Harunori, Ochi, Yoshimasa, Ishimoto, Shinji, Mugitani, Takashi, Makino, Takashi, and Kimoto, Kenichi

Abstract

平成24年度宇宙輸送シンポジウム (2013年1月17日-1月18日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)), 相模原市, 神奈川県, Space Transportation FY2012 (January 17-18, 2013. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 九州工業大学では、2005年より有翼ロケットによる無人のサブオービタル飛行システムの研究を進めてきた。航法誘導制御システム、推進システム、回収システムや複合材構造設計技術等の個別要素研究を進める一方、それらの技術実証を目的とした小型有翼ロケット実験機を用いた飛行実験を行ってきた。2010年からは、北海道大学、防衛大学大学校およびJAXA宇宙輸送ミッション本部や航空宇宙機メーカー等と連携し、高々度飛行を目指す有翼ロケット実験機の開発を進めている。これまでに行ってきた飛行実験結果を紹介し、サブオービタル飛行を目指す将来計画についても報告する。, 形態: カラー図版あり, 形態: PDF, Physical characteristics: Original contains color illustrations, Physical characteristics: PDF, Translation title: Experiment of reusable rocket performable in the university (part 5), 資料番号: AA0061856056, レポート番号: STCP-2012-056

Published
2013

34. Anti-VEGF Agents for Ocular Angiogenesis and Vascular Permeability

Author

Kimoto, Kenichi and Kubota, Toshiaki

Subjects
genetic structures, Article Subject, sense organs, eye diseases
Abstract

We review articles describing intravitreal injection of anti-VEGF drug trials, while discussing the mechanisms of the action of anti-VEGF antibodies, and also evaluating their outcomes. Intraocular injections of anti-VEGF drug are considered to be an effective treatment for macular edema after retinal vein occlusion, however, recurrent/persistent edema is common. The recent reports may lead to a shift in treatment paradigm for DME, from laser photocoagulation, to newer approaches using anti-VEGF drugs. There have been several well-publicized prospective, randomized studies that demonstrated the efficacy of intravitreal injection of anti-VEGF drugs for patients with AMD. Adjuvant bevacizumab for neovascular glaucoma may prevent further PAS formation, and it is likely to open up a therapeutic window for a panretinal photocoagulation and trabeculectomy. Intravitreal injection of bevacizumab (IVB) results in a substantial decrease in bleeding from the retinal vessels or new vessels during a standard vitrectomy. IVB has also been reported to be effective for inducing the regression of new vessels in proliferative diabetic retinopathy. The use of bevacizumab in stage 4 or 5 retinopahty of permaturity (ROP) is to reduce the plus sign to help reduce hemorrhage during the subsequent vitrectomy. Some authors reported cases of resolution of stage 4 A ROP after bevacizumab injection.

Published
2012
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48. ULTRA-WIDE FIELD FUNDUS AUTOFLUORESCENCE IMAGING OF EYES WITH STICKLER SYNDROME.

Author

Fujimoto K, Nagata T, Matsushita I, Oku K, Imagawa M, Kuniyoshi K, Hayashi T, Kimoto K, Ohji M, Kusaka S, and Kondo H

Subjects
Adolescent, Adult, Arthritis physiopathology, Child, Child, Preschool, Connective Tissue Diseases physiopathology, Female, Follow-Up Studies, Fundus Oculi, Hearing Loss, Sensorineural physiopathology, Humans, Male, Middle Aged, Retinal Detachment physiopathology, Retrospective Studies, Young Adult, Arthritis diagnosis, Connective Tissue Diseases diagnosis, Fluorescein Angiography methods, Hearing Loss, Sensorineural diagnosis, Optical Imaging, Retinal Detachment diagnosis, Tomography, Optical Coherence methods, Visual Acuity, Visual Fields physiology
Abstract

Purpose: To determine the characteristics of fundus autofluorescence (FAF) images and visual functions in eyes with Stickler syndrome using ultra-widefield FAF images., Methods: Forty-six eyes of 26 patients with mutations in the COL2A1 gene underwent ultra-widefield FAF imaging. The eyes were categorized into three types; no signs of abnormal AF, predominantly hyperfluorescent AF (hyper-AF), and predominantly hypofluorescent AF (hypo-AF). Goldmann perimetry was performed on 34 eyes, and line-scan images of the abnormal AF lesions were obtained by swept-source optical coherence tomography in 4 eyes., Results: Abnormal AF lesions were found in 37 eyes of 21 (80.7%) of the 26 patients. Hyper-AF was found in 15 eyes and hypo-AF was found in 22 eyes. The FAF changes corresponded with the funduscopically observed radial paravascular retinal degeneration. The average age at the examination was significantly younger in patients who had eyes with hyper-AF or no abnormal AF than in those with hypo-AF (12.8 vs. 28.4 years; P = 0.009). Abnormal AF-associated visual field defects were found in 5/10 (50%) eyes with hyper-AF and 17/18 (94%) eyes with hypo-AF. Hyper-AF changes tended to appear before retinal changes were detectable by fluorescein angiography. An absence of the ellipsoid zone and the outer nuclear layer and a thinning of the overall retinal thickness were found corresponding to the hypo-AF lesions in the swept source optical coherence tomography images., Conclusion: Abnormal FAF is characteristic of eyes with Stickler syndrome. Age-related alterations of the FAF was associated with visual field defects and disruption of the photoreceptors and retinal pigment epithelial cells., (Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc.)

Published
2021
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49. p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19.

Author

Kimoto K, Nakatsuka K, Matsuo N, and Yoshioka H

Subjects
Cells, Cultured, Collagen biosynthesis, Collagen Type I biosynthesis, Collagen Type I, alpha 1 Chain, Enzyme Inhibitors pharmacology, Humans, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinases antagonists & inhibitors, Peptide Fragments metabolism, Pigment Epithelium of Eye metabolism, Plasmids, Procollagen metabolism, Reverse Transcriptase Polymerase Chain Reaction, Transforming Growth Factor beta2, p38 Mitogen-Activated Protein Kinases, Collagen genetics, Collagen Type I genetics, MAP Kinase Signaling System drug effects, Mitogen-Activated Protein Kinases metabolism, Pigment Epithelium of Eye drug effects, RNA, Messenger biosynthesis, Transforming Growth Factor beta pharmacology
Abstract

Purpose: Transforming growth factor (TGF)-beta has been implicated as the key mediator of proliferative vitreoretinopathy, but the cellular mechanisms by which TGF-beta induces extracellular matrix protein (ECM) synthesis are not fully understood. The current study was conducted to examine whether the mitogen-activated protein kinase (MAPK) pathway is involved in TGF-beta 2-induced collagen expression in retinal pigment epithelial cells., Methods: Human retinal pigment epithelial cells ARPE-19 were cultured and stimulated with various concentrations of TGF-beta 2. The type I collagen gene (COL1A1, COL1A2) expression induced by TGF-beta 2 was evaluated by real-time RT-PCR. Synthesis of type I collagen was evaluated by the concentration of the C-terminal propeptide of type I (PICP) in the medium. The activation of MAPK pathways by TGF-beta 2 was assessed by immunoblot with anti-phospho-p38 and anti-phospho-extracellular signal-regulated kinase (ERK)1/2 antibodies. The role of MAPK was assessed using biochemical inhibitors. To examine the transcriptional activities of COL1A1 and COL1A2, luciferase reporter assays were also performed., Results: mRNA expression of COL1A1 and COL1A2 and type I collagen synthesis were activated by TGF-beta 2. Both ERK and p38 MAPK pathways were also activated by TGF-beta 2. The biochemical blockade of p38 MAPK activation, but not ERK activation, inhibited TGF-beta 2-induced type I collagen mRNA expression and type I collagen synthesis. Moreover, blockade of the p38 MAPK pathway inhibited the increase in both COL1A1 and COL1A2 promoter activities when induced by TGF-beta 2., Conclusions: TGF-beta 2 activates p38 MAPK and p38 MAPK plays a role in relaying the TGF-beta 2 signal to type I collagen production in the retinal pigment epithelium.

Published
2004
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