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508 results on '"King, Wendy C."'

1. Characteristics of Older Patients With Immunotolerant Chronic Hepatitis B Virus Infection

Author

Feld, Jordan J, King, Wendy C, Ghany, Marc G, Chang, Kyong-Mi, Terrault, Norah, Perrillo, Robert P, Khalili, Mandana, Hinerman, Amanda S, LA. Janssen, Harry, Lok, Anna S, and Network, Hepatitis B Research

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Hepatitis - B, Prevention, Hepatitis, Chronic Liver Disease and Cirrhosis, Infectious Diseases, Clinical Trials and Supportive Activities, Clinical Research, Liver Disease, Good Health and Well Being, Adult, Male, Humans, Aged, Female, Hepatitis B, Chronic, Hepatitis B virus, Hepatitis B e Antigens, Cohort Studies, Cross-Sectional Studies, Hepatitis B Surface Antigens, Alanine Transaminase, DNA, Viral, Immune Tolerance, Chronic HBV Infection, Immune Active, Immunotolerant, Phase Transition, Hepatitis B Research Network, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsMost patients in the immunotolerant (IT) phase of chronic hepatitis B (CHB) transition to the immune active (IA-hepatitis B surface antigen [HBeAg]+) phase by early adulthood. We examined characteristics of adults in the IT vs IA-HBeAg+ phase and rate of transition from IT to other phases of CHB, with a focus on those ≥40 years.MethodsDemographic, clinical, and virologic characteristics of participants in the Hepatitis B Research Network adult cohort study with IT CHB (alanine aminotransferase ≤1.5 × upper limit of normal, hepatitis B virus DNA >107 IU/mL) were compared by age category, and to those with IA-HBeAg+ CHB in cross-sectional analysis. This study received institutional review board approval at all participating centers.ResultsOf 107 adult IT participants, 52 (48%) were

Published
2023

3. REPLY: The exact predictive value of HBcrAg and HBV RNA in serological status and disease activity in CHB

Author

Ghany, Marc G., primary, King, Wendy C., additional, Hinerman, Amanda S., additional, Lok, Anna S.F., additional, Lisker-Melman, Mauricio, additional, Chung, Raymond T., additional, Terrault, Norah, additional, Janssen, Harry L.A., additional, Khalili, Mandana, additional, Lee, William M., additional, Lau, Daryl T.Y., additional, Cloherty, Gavin A., additional, and Sterling, Richard K., additional

Published
2024
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8. Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B

Author

Di Bisceglie, Adrian M, King, Wendy C, Lisker‐Melman, Mauricio, Khalili, Mandana, Belle, Steven H, Feld, Jordan J, Ghany, Marc G, Janssen, Harry LA, Lau, Daryl, Lee, William M, Ling, Simon C, Cooper, Stewart, Rosenthal, Philip, Schwarz, Kathleen B, Sterling, Richard K, Teckman, Jeffrey H, Terrault, Norah, and Network, the Hepatitis B Research

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Hepatitis, Hepatitis - B, Genetics, Clinical Research, Digestive Diseases, Infectious Diseases, Liver Disease, 4.2 Evaluation of markers and technologies, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, Aetiology, Infection, Good Health and Well Being, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, DNA, Viral, Female, Genotype, Hepatitis B e Antigens, Hepatitis B virus, Hepatitis B, Chronic, Humans, Infant, Male, Middle Aged, Population Groups, Public Health Surveillance, Seroepidemiologic Studies, Viral Load, Young Adult, e antigen, hepatitis B, natural history, Hepatitis B Research Network, Microbiology, Medical Microbiology, Gastroenterology & Hepatology, Clinical sciences, Medical microbiology
Abstract

Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viraemia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analysed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross-sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2241 enrolled participants who met criteria for this analysis, 825 (37%) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85% among those up to 10 years of age to only 12% among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; the prevalence of HBeAg was significantly higher among Asians > 10-30 years old vs Whites or Blacks who were >10 to 30 years old and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and precore variants was associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy.

Published
2019

13. Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study

Author

Berk, Paul D., Bessler, Marc, Daud, Amna, Lobdell, Harrison, IV, Mwelu, Jemela, Schrope, Beth, Ude, Akuezunkpa, Honohan, Jamie, Capasso, Michelle, Costa, Ricardo, Dakin, Greg, Ebel, Faith, Gagner, Michel, Hsieh, Jane, Pomp, Alfons, Strain, Gladys, Bowden, Rita, Chapman, William, Cundiff, Blair, Ball, Mallory, Cunningham, Emily, Dohm, Lynis, Pender, John, Pories, Walter, Barker, Jennifer, Howell, Michael, Garcia, Luis, Lancaster, Kathy, Lovaas, Erika, Mitchell, James E., Monson, Tim, Cassady, Chelsea, Coburn, Emily, Moher, Emily, Deveney, Clifford, Elder, Katherine, Greene, Stefanie, Purnell, Jonathan, O’Rourke, Robert, Sorenson, Chad, Wolfe, Bruce M., Patterson, Emma, Raum, William, VanDerWerff, Lisa, Kwiatkowski, Jason, Courcoulas, Anita P., Gourash, William, McCloskey, Carol A., Ramanathan, Ramesh, Kalarchian, Melissa, Marcus, Marsha, Shirley, Eleanor, Turo, Angela, Flum, David R., Dellinger, E. Patchen, Khandelwal, Saurabh, Stewart, Skye D., Cooley, Morgan M., Blissell, Rebecca, Miller, Megan J., Thirlby, Richard, Chang, Lily, Hunter, Jeffrey, Moonka, Ravi, Ng, Debbie, Belle, Steven H., King, Wendy C., Martin, Debbie, Mercurio, Rocco, Wahed, Abdus, Averbach, Frani, Horlick, Mary, Miles, Carolyn W., Staten, Myrlene A., Yanovski, Susan Z., Kleiner, David E., Fischer, Laura E., Fino, Nora, Elman, Miriam R., Pories, Walter J., Purnell, Jonathan Q., and Patti, Mary-Elizabeth

Published
2021
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22. Urinary Incontinence Before and After Bariatric Surgery

Author

Subak, Leslee L, King, Wendy C, Belle, Steven H, Chen, Jia-Yuh, Courcoulas, Anita P, Ebel, Faith E, Flum, David R, Khandelwal, Saurabh, Pender, John R, Pierson, Sheila K, Pories, Walter J, Steffen, Kristine J, Strain, Gladys W, Wolfe, Bruce M, and Huang, Alison J

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Nutrition, Obesity, Urologic Diseases, Clinical Research, Clinical Trials and Supportive Activities, Oral and gastrointestinal, Renal and urogenital, Adolescent, Adult, Age Factors, Aged, Bariatric Surgery, Body Mass Index, Cohort Studies, Comorbidity, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Prevalence, Treatment Outcome, Urinary Incontinence, Stress, Urinary Incontinence, Urge, Weight Loss, Young Adult, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Clinical sciences, Health services and systems
Abstract

ImportanceAmong women and men with severe obesity, evidence for improvement in urinary incontinence beyond the first year after bariatric surgery-induced weight loss is lacking.ObjectivesTo examine change in urinary incontinence before and after bariatric surgery and to identify factors associated with improvement and remission among women and men in the first 3 years after bariatric surgery.Design, setting, and participantsThe Longitudinal Assessment of Bariatric Surgery 2 is an observational cohort study at 10 US hospitals in 6 geographically diverse clinical centers. Participants were recruited between February 21, 2005, and February 17, 2009. Adults undergoing first-time bariatric surgical procedures as part of clinical care by participating surgeons between March 14, 2006, and April 24, 2009, were followed up for 3 years (through October 24, 2012).InterventionParticipants undergoing bariatric surgery completed research assessments before the procedure and annually thereafter.Main outcomes and measuresThe frequency and type of urinary incontinence episodes in the past 3 months were assessed using a validated questionnaire. Prevalent urinary incontinence was defined as at least weekly urinary incontinence episodes, and remission was defined as change from prevalent urinary incontinence at baseline to less than weekly urinary incontinence episodes at follow-up.ResultsOf 2458 participants, 1987 (80.8%) completed baseline and follow-up assessments. At baseline, the median age was 47 years (age range, 18-78 years), the median body mass index was 46 kg/m2 (range, 34-94 kg/m2), and 1565 of 1987 (78.8%) were women. Urinary incontinence was more prevalent among women (49.3%; 95% CI, 46.9%-51.9%) than men (21.8%; 95% CI, 18.2%-26.1%) (P

Published
2015

36. Human immunodeficiency virus coinfection differentially impacts hepatitis B virus viral markers based on hepatitis Be antigen status in patients with suppressed viremia

Author

Lisker‐Melman, Mauricio, primary, King, Wendy C., additional, Ghany, Marc G., additional, Chung, Raymond T., additional, Hinerman, Amanda S., additional, Cloherty, Gavin A., additional, Khalili, Mandana, additional, Jain, Mamta K., additional, Sulkowski, Mark, additional, and Sterling, Richard K., additional

Published
2023
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39. SARS-CoV-2 control on a large urban college campus without mass testing

Author

O’Donnell, Christopher, primary, Brownlee, Katherine, additional, Martin, Elise, additional, Suyama, Joe, additional, Albert, Steve, additional, Anderson, Steven, additional, Bhatte, Sai, additional, Bonner, Kenyon, additional, Burton, Chad, additional, Corn, Micaela, additional, Eng, Heather, additional, Flage, Bethany, additional, Frerotte, Jay, additional, Balasubramani, Goundappa K., additional, Haggerty, Catherine, additional, Haight, Joel, additional, Harrison, Lee H., additional, Hartman, Amy, additional, Hitter, Thomas, additional, King, Wendy C., additional, Ledger, Kate, additional, Marsh, Jane W., additional, McDonald, Margaret C., additional, Miga, Bethany, additional, Moses, Kimberly, additional, Newman, Anne, additional, Ringler, Meg, additional, Roberts, Mark, additional, Sax, Theresa, additional, Shekhar, Anantha, additional, Sterne, Matthew, additional, Tenney, Tyler, additional, Vanek, Marian, additional, Wells, Alan, additional, Wenzel, Sally, additional, and Williams, John, additional

Published
2023
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41. Reply

Author

Feld, Jordan J., primary, King, Wendy C., additional, and Lok, Anna S., additional

Published
2022
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50. HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy

Author

Lisker‐Melman, Mauricio, primary, Wahed, Abdus S., additional, Ghany, Marc G., additional, Chung, Raymond T., additional, King, Wendy C., additional, Kleiner, David E., additional, Bhan, Atul K., additional, Khalili, Mandana, additional, Jain, Mamta K., additional, Sulkowski, Mark, additional, Wong, David K., additional, Cloherty, Gavin, additional, and Sterling, Richard K., additional

Published
2022
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