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193 results on '"Kingsmore D"'

3. The impact of surgical management on outcome from breast cancer

Author

Kingsmore, D. B.

Subjects
618.19059
Abstract

This thesis aimed to determine the causes of the better survival of women treated for breast cancer by specialist surgeons. Two separate studies were performed. Firstly, a geographically defined database of pathology and mortality data from 1980-88 was updated to 1996. Secondly, a retrospective cohort study was performed of 2762 (94% of total) case-records of women diagnosed during 1986 to 1991. Women treated by specialists, even in the screening time-period, had a long-term survival advantage. Inadequate compared to adequate treatment was associated with double the risk of recurrence independent of other factors. The case-mix for non-specialists was more often unknown. Specialists were more exact in the treatment given: a preoperative diagnosis and mammography were obtained twice as frequently; staging was more selective; breast conserving surgery was performed with equal frequency, but when performed by non-specialists was inadequate twice as frequently and was four times more likely to be due to more than one error. Non-specialists omitted axillary staging three times more often and inadequately treated the axilla ten times more often. Overall, inadequate loco-regional treatment was twice as likely if treated by a non-specialist. Specialists prescribed chemotherapy twice as often, but the prescription of systemic therapy to those at highest risk was the same. The loco-regional recurrence for non-specialists was twice that of specialists after accounting for pathology and treatment. Specialists had a 26% lower risk of death after allowing for demographic, prognostic and treatment variables. This was negated if adequacy of treatment was included as an independent variable. There was poor correlation between caseload and adequacy of treatment. Adequacy of loco-regional treatment correlated with death from breast cancer.

Published
2005

12. A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function

Author

Wlodek, E., primary, Kirkpatrick, R. B., additional, Andrews, S., additional, Noble, R., additional, Schroyer, R., additional, Scott, J., additional, Watson, C. J. E., additional, Clatworthy, M., additional, Harrison, E. M., additional, Wigmore, S. J., additional, Stevenson, K., additional, Kingsmore, D., additional, Sheerin, N. S., additional, Bestard, O., additional, Stirnadel-Farrant, H. A., additional, Abberley, L., additional, Busz, M., additional, DeWall, S., additional, Birchler, M., additional, Krull, D., additional, Thorneloe, K. S., additional, Weber, A., additional, and Devey, L., additional

Published
2021
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28. The Effects of Creatine Supplementation on Cardiovascular, Metabolic, and Thermoregulatory Responses During Exercise in the Heat in Endurance-Trained Humans.

Author

Kilduff, L. P., Georgiades, E., James, N., Minnion, R. H., Mitchell, M., Kingsmore, D., Hadjicharlambous, M., and Pitsiladis, Y. P.

Subjects
EXERCISE tests, CREATINE, BODY temperature regulation, METABOLISM, HEAT
Abstract

The effects of creatine (Cr) supplementation on cardiovascular, metabolic, and thermoregulatory responses, and on the capacity of trained humans to perform prolonged exercise in the heat was examined. Endurance-trained males (n = 21) performed 2 constant-load exercise tests to exhaustion at 63 ± 5 % VO[sub2max] in the heat (ambient temperature: 30.3 ± 0.5 °C) before and after 7 d of Cr (20 g ⋅ d[sup-1] Cr + 140 g ⋅ d[sup-1] glucose polymer) or placebo. Cr increased intracellular water and reduced thermoregulatory and cardiovascular responses (e.g., heart rate, rectal temperature, sweat rate) but did not significantly increase time to exhaustion (47.0 ± 4.7 min vs. 49.7 ± 7.5 min, P = 0.095). Time to exhaustion was increased significantly in subjects whose estimated intramuscular Cr levels were substantially increased ("responders": 47.3 ± 4.9 min vs. 51.7 ± 7.4 min, P = 0.031). Cr-induced hyperhydration can result in a more efficient thermoregulatory response during prolonged exercise in the heat. [ABSTRACT FROM AUTHOR]

Published
2004
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34. Elite Kenyan Endurance Runners are Hydrated Day-To-Day with Ad Libitum Fluid Intake

Author

Fudge, B.W., Fudge, B.W., Easton, C., Kingsmore, D., Kiplamai, F.K., Onywera, V.O., Westerterp, K.R., Kayser, B., Noakes, T.D., Pitsiladis, Y.P., Fudge, B.W., Fudge, B.W., Easton, C., Kingsmore, D., Kiplamai, F.K., Onywera, V.O., Westerterp, K.R., Kayser, B., Noakes, T.D., and Pitsiladis, Y.P.

Abstract

Previous studies of elite Kenyan endurance runners reported that athletes did not consume liquids before or during training and infrequently consumed modest amounts of liquids after training that contributed to low daily fluid intake. PURPOSE:: To assess hydration status of elite Kenyan endurance runners during an important training period. METHODS:: Hydration status was monitored in fourteen elite Kenyan endurance runners over a 5-d training period 1 wk prior to the Kenyan national trials for the 2005 IAAF Athletics World Championships by measuring body mass, urine osmolality, total body water, and daily fluid intake. Dietary sodium (Na) intake was estimated using a 5-d nutritional diary and biochemical analysis, whilst [Na] was determined in urine and sweat. Intestinal temperature was monitored continuously during training sessions. RESULTS:: Daily fluid intake was consistent with previous observations. There was a significant body mass loss during the morning, interval, and afternoon training sessions (P < 0.05). Nevertheless, mean total body water and pretraining body mass were well maintained day-to-day throughout the 5-d recording period (P = 0.194 and P = 0.302, respectively). Furthermore, there was no significant difference between the osmolality of the morning urine sample and the evening sample (P = 0.685). Mean Na intake was not significantly different to Na loss in sweat and urine (P = 0.975). No athlete showed signs or symptoms of heat strain at any time. CONCLUSIONS:: These results demonstrate that elite Kenyan endurance runners remain well hydrated day-to-day with an ad libitum fluid intake; a pattern and volume of fluid intake that is consistent with previous observations of elite Kenyan endurance runners.

Published
2008

48. Mycotic pseudoaneurysm in intravenous drug users: current insights

Author

Stevenson RP, Tolias C, Hussey K, and Kingsmore DB

Subjects
mycotic, pseudoaneurysm, false, IVDU, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Richard P Stevenson,1 Christos Tolias,1 Keith Hussey,2 David B Kingsmore2 1Department of Surgery, Glasgow Royal Infirmary, Glasgow G4 0SF, UK; 2Department of Vascular Surgery, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK Abstract: Mycotic pseudoaneurysms are rare, but potentially life threatening. They are challenging both from a diagnostic and surgical perspective. It is an area lacking in robust trial data, and current knowledge and evidence is represented only by retrospective case series. This review will summarize the current literature with regard to mycotic pseudoaneurysms consequent to illicit drug misuse. Keywords: IVDU, mycotic, pseudoaneurysm

Published
2019

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