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3 results on '"Kipelainen, TO"'

1. Domestic Heating Transitions: A Literature Review

Author

McCarthy, Lindsey, Ambrose, Aimee, Jiglau, George, Palm, Jenny, Pelsmakers, Sofie, Shaw, Becky, Shahzad, Sally, Kipelainen, Sarah, von Platten, Jenny, Vornicu, Andreea, McCarthy, Lindsey, Ambrose, Aimee, Jiglau, George, Palm, Jenny, Pelsmakers, Sofie, Shaw, Becky, Shahzad, Sally, Kipelainen, Sarah, von Platten, Jenny, and Vornicu, Andreea

Published
2023

2. Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection : A Case Report

Author

Massanella, Marta, Martin-Urda, Anabel, Mateu, Lourdes, Marín, Toni, Aldas Criado, Irene, Riveira-Muñoz, Eva, Kipelainen, Athina, Jiménez-Moyano, Esther, Rodriguez de la Concepción, Maria Luisa, Avila-Nieto, Carlos, Trinité, Benjamin, Pradenas, Edwards, Rodon, Jordi, Marfil, Silvia, Parera, Mariona, Carrillo, Jorge, Blanco, Julià, Prado, Julia G., Ballana, Ester, Vergara-Alert, Júlia, Segalés Coma, Joaquim, Noguera-Julian, Marc, Masabeu, Àngels, Clotet Sala, Bonaventura, Toda, Maria de la Roca, Paredes, Roger, Universitat Autònoma de Barcelona. Departament de Medicina, Producció Animal, and Sanitat Animal

Subjects
0301 basic medicine, Cellular immunity, life, Secondary infection, viruses, CoV, threatening COVID, Immune responses, medicine.disease_cause, Virus, reinfection, Life threatening COVID-19, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunity, secondary infection, medicine, Novel ID Cases, 030212 general & internal medicine, Coronavirus, Virus quantification, SARS, biology, business.industry, SARS-CoV-2, life-threatening COVID19, immune responses, 030104 developmental biology, Infectious Diseases, AcademicSubjects/MED00290, Oncology, Reinfection, Immunology, biology.protein, Antibody, business
Abstract

BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections have been reported; however, most cases are milder than the primary infection. We report the first case of a life-threatening critical presentation of a SARS-CoV-2 reinfection.MethodsA 62-year-old man from Palamós (Spain) suffered a first mild coronavirus disease 2019 (COVID-19) episode in March 2020, confirmed by 2 independent SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) assays and a normal radiograph. He recovered completely and tested negative on 2 consecutive PCRs. In August 2020, the patient developed a second SARS-CoV-2 infection with life-threatening bilateral pneumonia and Acute respiratory distress syndrome criteria, requiring COVID-19–specific treatment (remdesivir + dexamethasone) plus high-flow oxygen therapy. Nasopharyngeal swabs from the second episode were obtained for virus quantification by real-time PCR, for virus outgrowth and sequencing. In addition, plasma and peripheral blood mononuclear cells during the hospitalization period were used to determine SARS-CoV-2–specific humoral and T-cell responses.ResultsGenomic analysis of SARS-CoV-2 showed that the virus had probably originated shortly before symptom onset. When the reinfection occurred, the subject showed a weak immune response, with marginal humoral and specific T-cell responses against SARS-CoV-2. All antibody isotypes tested as well as SARS-CoV-2 neutralizing antibodies increased sharply after day 8 postsymptoms. A slight increase of T-cell responses was observed at day 19 after symptom onset.ConclusionsThe reinfection was firmly documented and occurred in the absence of robust preexisting humoral and cellular immunity. SARS-CoV-2 immunity in some subjects is unprotective and/or short-lived; therefore, SARS-CoV-2 vaccine schedules inducing long-term immunity will be required to bring the pandemic under control.

Published
2021

3. Early growth genetics C. New loci associated with birgh weight identify genetic links between intrauterine growth and adult height and metabolism

Author

Horikoshi, M, Yaghootkar, H, Mook, Dennis, Sovio, U, Taal, Rob, Hennig, BJ, Bradfield, JP, St Pourcain, B, Evans, DM, Charoen, P, Kaakinen, M, Cousminer, DL, Lehtimaki, T, Kreiner-Moller, E, Warrington, NM, Bustamante, M, Feenstra, B, Berry, DJ, Thiering, E, Pfab, T, Barton, SJ, Shields, BM, Kerkhof, M, Leeuwen, Elisa, Fulford, AJ, Kutalik, Z, Zhao, JH, den Hoed, M, Mahajan, A, Lindi, V, Goh, LK, Hottenga, JJ (Jouke Jan), Wu, Fenny, Raitakari, OT, Harder, M, Meirhaeghe, A, Ntalla, I, Salem, RM, Jameson, KA, Zhou, K, Monies, D, Lagou, V, Kirin, M, Heikkinen, J, Adair, LS, Alkuraya, FS, Al-Odaib, A, Amouyel, P, Andersson, EAS, Bennett, AJ, Blakemore, AIF, Buxton, JL, Dallongeville, J, Das, Suman, de Geus, EJC, Estivill, X, Flexeder, C, Froguel, P, Geller, F, Godfrey, KM, Gottrand, F, Groves, CJ, Hansen, T, Hirschhorn, JN, Hofman, Bert, Hollegaard, MV, Hougaard, DM, Hypponen, E, Inskip, H, Isaacs, Aaron, Jorgensen, T, Kanaka-Gentenbein, C, Kemp, JP, Kiess, W, Kipelainen, TO, Klopp, N, Knight, BA, Kuzawa, CW, McMahon, G, Newnham, JP, Niinikoski, H, Oostra, Ben, Pedersen, L, Postma, DS, Ring, SM, Rivadeneira, Fernando, Robertson, NR, Sebert, S, Simell, O, Slowinski, T, Tiesler, CMT, Tonjes, A, Vaag, A, Viikari, JS, Vink, JM, Vissing, NH, Wareham, NJ, Willemsen, G, Witte, DR, Zhang, H, Zhao, J, Wilson, JF, Stumvoll, M, Prentice, AM, Meyer, BF, Pearson, ER, Boreham, CA, Cooper, C, Gilman, MW, Dedoussis, GV, Moreno, LA, Pedersen, O, Saarinen, M, Mohlke, KL, Boomsma, DI, Saw, SM, Lakka, TA, Korner, A, Loos, RJ, Ong, KK, Vollenweider, P, Duijn, Cornelia, Koppelman, GH, Hattersley, AT, Holloway, JW, Hocher, B, Heinrich, J, Power, C, Melbye, M, Guxens Junyent, Monica, Pennell, CE, Bonnelykke, K, Bisgaard, H, Eriksson, JG, Widen, E, Hakonarson, H, Uitterlinden, André, Pouta, A, Lawlor, DA, Smith, GD, Frayling, TM, McCarthy, M, Grant, SFA, Jaddoe, Vincent, Jarvelin, MR, Timpson, NJ, Prokopenko, I, Freathy, RM, Erasmus MC other, Epidemiology, Medical Microbiology & Infectious Diseases, Clinical Genetics, Internal Medicine, and Hematology

Published
2013

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