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1. A Large Open Access Dataset of Brain Metastasis 3D Segmentations with Clinical and Imaging Feature Information

Author

Ramakrishnan, Divya, Jekel, Leon, Chadha, Saahil, Janas, Anastasia, Moy, Harrison, Maleki, Nazanin, Sala, Matthew, Kaur, Manpreet, Petersen, Gabriel Cassinelli, Merkaj, Sara, von Reppert, Marc, Baid, Ujjwal, Bakas, Spyridon, Kirsch, Claudia, Davis, Melissa, Bousabarah, Khaled, Holler, Wolfgang, Lin, MingDe, Westerhoff, Malte, Aneja, Sanjay, Memon, Fatima, and Aboian, Mariam S.

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Resection and whole brain radiotherapy (WBRT) are the standards of care for the treatment of patients with brain metastases (BM) but are often associated with cognitive side effects. Stereotactic radiosurgery (SRS) involves a more targeted treatment approach and has been shown to avoid the side effects associated with WBRT. However, SRS requires precise identification and delineation of BM. While many AI algorithms have been developed for this purpose, their clinical adoption has been limited due to poor model performance in the clinical setting. Major reasons for non-generalizable algorithms are the limitations in the datasets used for training the AI network. The purpose of this study was to create a large, heterogenous, annotated BM dataset for training and validation of AI models to improve generalizability. We present a BM dataset of 200 patients with pretreatment T1, T1 post-contrast, T2, and FLAIR MR images. The dataset includes contrast-enhancing and necrotic 3D segmentations on T1 post-contrast and whole tumor (including peritumoral edema) 3D segmentations on FLAIR. Our dataset contains 975 contrast-enhancing lesions, many of which are sub centimeter, along with clinical and imaging feature information. We used a streamlined approach to database-building leveraging a PACS-integrated segmentation workflow., Comment: 12 pages, 2 figures, 1 table

Published
2023

2. A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information

Author

Ramakrishnan, Divya, Jekel, Leon, Chadha, Saahil, Janas, Anastasia, Moy, Harrison, Maleki, Nazanin, Sala, Matthew, Kaur, Manpreet, Petersen, Gabriel Cassinelli, Merkaj, Sara, von Reppert, Marc, Baid, Ujjwal, Bakas, Spyridon, Kirsch, Claudia, Davis, Melissa, Bousabarah, Khaled, Holler, Wolfgang, Lin, MingDe, Westerhoff, Malte, Aneja, Sanjay, Memon, Fatima, and Aboian, Mariam S.

Published
2024
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3. Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: RTOG Foundation 3504

Author

Gillison, Maura L, Ferris, Robert L, Harris, Jonathan, Colevas, A Dimitrios, Mell, Loren K, Kong, Christina, Jordan, Richard C, Moore, Kevin L, Truong, Minh-Tam, Kirsch, Claudia, Chakravarti, Arnab, Blakaj, Dukagjin M, Clump, David A, Ohr, James P, Deeken, John F, Gensheimer, Michael F, Saba, Nabil F, Dorth, Jennifer A, Rosenthal, David I, Leidner, Rom S, Kimple, Randall J, Machtay, Mitchell, Curran, Walter J, Torres-Saavedra, Pedro, and Le, Quynh Thu

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Digestive Diseases, Clinical Trials and Supportive Activities, Rare Diseases, Immunotherapy, Radiation Oncology, Dental/Oral and Craniofacial Disease, Cancer, Orphan Drug, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Squamous Cell Carcinoma of Head and Neck, Nivolumab, Cisplatin, Carcinoma, Squamous Cell, Mucositis, Neoplasm Recurrence, Local, Head and Neck Neoplasms, Fatigue, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeProgrammed death-1 immune checkpoint blockade improves survival of patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), but the benefits of addition to (chemo)radiation for newly diagnosed patients with HNSCC remain unknown.Methods and materialsWe evaluated the safety of nivolumab concomitant with 70 Gy intensity modulated radiation therapy and weekly cisplatin (arm 1), every 3-week cisplatin (arm 2), cetuximab (arm 3), or alone for platinum-ineligible patients (arm 4) in newly diagnosed intermediate- or high-risk locoregionally advanced HNSCC. Patients received nivolumab from 2 weeks prior to radiation therapy until 3 months post-radiation therapy. The primary endpoint was dose-limiting toxicity (DLT). If ≤2 of the first 8 evaluable patients experienced a DLT, an arm was considered safe. Secondary endpoints included toxicity and feasibility of adjuvant nivolumab to 1 year, defined as all 7 additional doses received by ≥4 of the first 8 evaluable patients across arms.ResultsOf 39 patients (10 in arms 1, 3, 4 and 9 in arm 2), 72% had T3-4 tumors, 85% had N2-3 nodal disease, and 67% had >10 pack-years of smoking. There were no DLTs in arms 1 and 2, 1 in arm 3 (mucositis), and 2 in arm 4 (lipase elevation and mucositis in 1 and fatigue in another). The most common grade ≥3 nivolumab-related adverse events were lipase increase, mucositis, diarrhea, lymphopenia, hyponatremia, leukopenia, fatigue, and serum amylase increase. Adjuvant nivolumab was feasible as defined in the protocol.ConclusionsConcomitant nivolumab with the 4 tested regimens was safe for patients with intermediate- and high-risk HNSCC, and subsequent adjuvant nivolumab was feasible as defined (NCT02764593).

Published
2023

15. ACR Appropriateness Criteria® Neck Mass-Adenopathy

Author

Aulino, Joseph M., Kirsch, Claudia F.E., Burns, Judah, Busse, Paul M., Chakraborty, Santanu, Choudhri, Asim F., Conley, David B., Jones, Christopher U., Lee, Ryan K., Luttrull, Michael D., Moritani, Toshio, Policeni, Bruno, Ryan, Maura E., Shah, Lubdha M., Sharma, Aseem, Shih, Robert Y., Subramaniam, Rathan M., Symko, Sophia C., and Bykowski, Julie

Published
2019
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17. ACR Appropriateness Criteria® Cervical Neck Pain or Cervical Radiculopathy

Author

McDonald, Marin A., Kirsch, Claudia F.E., Amin, Beejal Y., Aulino, Joseph M., Bell, Angela M., Cassidy, R. Carter, Chakraborty, Santanu, Choudhri, Asim F., Gemme, Seth, Lee, Ryan K., Luttrull, Michael D., Metter, Darlene F., Moritani, Toshio, Reitman, Charles, Shah, Lubdha M., Sharma, Aseem, Shih, Robert Y., Snyder, Laura A., Symko, Sophia C., Thiele, Ralf, and Bykowski, Julie

Published
2019
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18. ACR Appropriateness Criteria® Suspected Spine Trauma

Author

Beckmann, Nicholas M., West, O. Clark, Nunez, Diego, Jr., Kirsch, Claudia F.E., Aulino, Joseph M., Broder, Joshua S., Cassidy, R. Carter, Czuczman, Gregory J., Demertzis, Jennifer L., Johnson, Michele M., Motamedi, Kambiz, Reitman, Charles, Shah, Lubdha M., Than, Khoi, Ying-Kou Yung, Elizabeth, Beaman, Francesca D., Kransdorf, Mark J., and Bykowski, Julie

Published
2019
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19. MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis

Author

Awad, Hamdy, Bratasz, Anna, Nuovo, Gerard, Burry, Richard, Meng, Xiaomei, Kelani, Hesham, Brown, Melissa, Ramadan, Mohamed E., Williams, Jim, Bouhliqah, Lamia, Popovich, Phillip G., Guan, Zhen, Mcallister, Cynthia, Corcoran, Sarah E., Kaspar, Brian, Michele Basso, D., Otero, José J., Kirsch, Claudia, Davis, Ian C., Croce, Carlo Maria, Michaille, Jean-Jacques, and Tili, Esmerina

Published
2018
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22. Life-Threatening Hematuria as Initial Presentation of a Complicated Transplant Renal Artery Pseudoaneurysm.

Author

Miyara, Santiago J., Becker, Lance B., Guevara, Sara, Lau, Lawrence, Nair, Vinay V., Jandovitz, Nicholas, Fahmy, Ahmed E., Grodstein, Elliot, Winnick, Aaron M., Kirsch, Claudia, Rolston, Daniel M., Bhaskaran, Madhu C., Hayashida, Kei, Shinozaki, Koichiro, Takegawa, Ryosuke, Cho, Young Min, Cagliani, Joaquin A., Isa, Arton, Al-Roubaie, Mustafa, and Krishnasastry, K. V.

Published
2023
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23. Skull Base Registries: Building Consensus

Author

Parikh, Kara A., additional, Mustafa, Motiwala, additional, Rangarajan, Sanjeet V., additional, Pacione, Donato R., additional, McKean, Erin, additional, Kshettry, Varun, additional, Beer-Furlan, Andre, additional, Kirsch, Claudia, additional, Michael, L. Madison, additional, and Sorenson, Jeffrey, additional

Published
2023
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24. Radiologists staunchly support patient safety and autonomy, in opposition to the SCOTUS decision to overturn Roe v Wade

Author

Karandikar, Aditya, primary, Solberg, Agnieszka, additional, Fung, Alice, additional, Lee, Amie Y., additional, Farooq, Amina, additional, Taylor, Amy C., additional, Oliveira, Amy, additional, Narayan, Anand, additional, Senter, Andi, additional, Majid, Aneesa, additional, Tong, Angela, additional, McGrath, Anika L., additional, Malik, Anjali, additional, Brown, Ann Leylek, additional, Roberts, Anne, additional, Fleischer, Arthur, additional, Vettiyil, Beth, additional, Zigmund, Beth, additional, Park, Brian, additional, Curran, Bruce, additional, Henry, Cameron, additional, Jaimes, Camilo, additional, Connolly, Cara, additional, Robson, Caroline, additional, Meltzer, Carolyn C., additional, Phillips, Catherine H., additional, Dove, Christine, additional, Glastonbury, Christine, additional, Pomeranz, Christy, additional, Kirsch, Claudia F.E., additional, Burgan, Constantine M., additional, Scher, Courtney, additional, Tomblinson, Courtney, additional, Fuss, Cristina, additional, Santillan, Cynthia, additional, Daye, Dania, additional, Brown, Daniel B., additional, Young, Daniel J., additional, Kopans, Daniel, additional, Vargas, Daniel, additional, Martin, Dann, additional, Thompson, David, additional, Jordan, David W., additional, Shatzkes, Deborah, additional, Sun, Derek, additional, Mastrodicasa, Domenico, additional, Smith, Elainea, additional, Korngold, Elena, additional, Dibble, Elizabeth H., additional, Arleo, Elizabeth K., additional, Hecht, Elizabeth M., additional, Morris, Elizabeth, additional, Maltin, Elizabeth P., additional, Cooke, Erin A., additional, Schwartz, Erin Simon, additional, Lehrman, Evan, additional, Sodagari, Faezeh, additional, Shah, Faisal, additional, Doo, Florence X., additional, Rigiroli, Francesca, additional, Vilanilam, George K., additional, Landinez, Gina, additional, Kim, Grace Gwe-Ya, additional, Rahbar, Habib, additional, Choi, Hailey, additional, Bandesha, Harmanpreet, additional, Ojeda-Fournier, Haydee, additional, Ikuta, Ichiro, additional, Dragojevic, Irena, additional, Schroeder, Jamie Lee Twist, additional, Ivanidze, Jana, additional, Katzen, Janine T., additional, Chiang, Jason, additional, Nguyen, Jeffers, additional, Robinson, Jeffrey D., additional, Broder, Jennifer C., additional, Kemp, Jennifer, additional, Weaver, Jennifer S., additional, Conyers, Jesse M., additional, Robbins, Jessica B., additional, Leschied, Jessica R., additional, Wen, Jessica, additional, Park, Jocelyn, additional, Mongan, John, additional, Perchik, Jordan, additional, Barbero, José Pablo Martínez, additional, Jacob, Jubin, additional, Ledbetter, Karyn, additional, Macura, Katarzyna J., additional, Maturen, Katherine E., additional, Frederick-Dyer, Katherine, additional, Dodelzon, Katia, additional, Cort, Kayla, additional, Kisling, Kelly, additional, Babagbemi, Kemi, additional, McGill, Kevin C., additional, Chang, Kevin J., additional, Feigin, Kimberly, additional, Winsor, Kimberly S., additional, Seifert, Kimberly, additional, Patel, Kirang, additional, Porter, Kristin K., additional, Foley, Kristin M., additional, Patel-Lippmann, Krupa, additional, McIntosh, Lacey J., additional, Padilla, Laura, additional, Groner, Lauren, additional, Harry, Lauren M., additional, Ladd, Lauren M., additional, Wang, Lisa, additional, Spalluto, Lucy B., additional, Mahesh, M., additional, Marx, M. Victoria, additional, Sugi, Mark D., additional, Sammer, Marla B.K., additional, Sun, Maryellen, additional, Barkovich, Matthew J., additional, Miller, Matthew J., additional, Vella, Maya, additional, Davis, Melissa A., additional, Englander, Meridith J., additional, Durst, Michael, additional, Oumano, Michael, additional, Wood, Monica J., additional, McBee, Morgan P., additional, Fischbein, Nancy J., additional, Kovalchuk, Nataliya, additional, Lall, Neil, additional, Eclov, Neville, additional, Madhuripan, Nikhil, additional, Ariaratnam, Nikki S., additional, Vincoff, Nina S., additional, Kothary, Nishita, additional, Yahyavi-Firouz-Abadi, Noushin, additional, Brook, Olga R., additional, Glenn, Orit A., additional, Woodard, Pamela K., additional, Mazaheri, Parisa, additional, Rhyner, Patricia, additional, Eby, Peter R., additional, Raghu, Preethi, additional, Gerson, Rachel F., additional, Patel, Rina, additional, Gutierrez, Robert L., additional, Gebhard, Robyn, additional, Andreotti, Rochelle F., additional, Masum, Rukya, additional, Woods, Ryan, additional, Mandava, Sabala, additional, Harrington, Samantha G., additional, Parikh, Samir, additional, Chu, Sammy, additional, Arora, Sandeep S., additional, Meyers, Sandra M., additional, Prabhu, Sanjay, additional, Shams, Sara, additional, Pittman, Sarah, additional, Patel, Sejal N., additional, Payne, Shelby, additional, Hetts, Steven W., additional, Hijaz, Tarek A., additional, Chapman, Teresa, additional, Loehfelm, Thomas W., additional, Juang, Titania, additional, Clark, Toshimasa J., additional, Potigailo, Valeria, additional, Shah, Vinil, additional, Planz, Virginia, additional, Kalia, Vivek, additional, DeMartini, Wendy, additional, Dillon, William P., additional, Gupta, Yasha, additional, Koethe, Yilun, additional, Hartley-Blossom, Zachary, additional, Wang, Zhen Jane, additional, McGinty, Geraldine, additional, Haramati, Adina, additional, Allen, Laveil M., additional, and Germaine, Pauline, additional

Published
2023
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25. ACR Appropriateness Criteria Head Trauma

Author

Shetty, Vilaas S., Reis, Martin N., Aulino, Joseph M., Berger, Kevin L., Broder, Joshua, Choudhri, Asim F., Kendi, A. Tuba, Kessler, Marcus M., Kirsch, Claudia F., Luttrull, Michael D., Mechtler, Laszlo L., Prall, J. Adair, Raksin, Patricia B., Roth, Christopher J., Sharma, Aseem, West, O. Clark, Wintermark, Max, Cornelius, Rebecca S., and Bykowski, Julie

Published
2016
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26. ACR Appropriateness Criteria Myelopathy

Author

Roth, Christopher J., Angevine, Peter D., Aulino, Joseph M., Berger, Kevin L., Choudhri, Asim F., Fries, Ian Blair, Holly, Langston T., Kendi, Ayse Tuba Karaqulle, Kessler, Marcus M., Kirsch, Claudia F., Luttrull, Michael D., Mechtler, Laszlo L., O’Toole, John E., Sharma, Aseem, Shetty, Vilaas S., West, O. Clark, Cornelius, Rebecca S., and Bykowski, Julie

Published
2016
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27. Erratum: Skull Base Registries: A Roadmap

Author

Parikh, Kara P., additional, Motiwala, Mustafa, additional, Beer-Furlan, Andre, additional, Michael, L. Madison, additional, Rangarajan, Sanjeet V., additional, Choby, Garret W., additional, Kshettry, Varun R., additional, Saleh, Sara, additional, Mukherjee, Debraj, additional, Kirsch, Claudia, additional, McKean, Erin, additional, and Sorenson, Jeffrey M., additional

Published
2022
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28. Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: Radiation Therapy Oncology Group Foundation 3504

Author

Gillison, Maura L., primary, Ferris, Robert L., additional, Harris, Jonathan, additional, Colevas, A. Dimitrios, additional, Mell, Loren K., additional, Kong, Christina, additional, Jordan, Richard C., additional, Moore, Kevin L., additional, Truong, Minh-Tam, additional, Kirsch, Claudia, additional, Chakravarti, Arnab, additional, Blakaj, Dukagjin M., additional, Clump, David A., additional, Ohr, James P., additional, Deeken, John F., additional, Gensheimer, Michael F., additional, Saba, Nabil F., additional, Dorth, Jennifer A., additional, Rosenthal, David I., additional, Leidner, Rom S., additional, Kimple, Randall J., additional, Machtay, Mitchell, additional, Curran, Walter J., additional, Torres-Saavedra, Pedro, additional, and Le, Quynh Thu, additional

Published
2022
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30. Skull Base Registries: A Roadmap

Author

Parikh, Kara P., additional, Motiwala, Mustafa, additional, Beer-Furlan, Andre, additional, Michael, L. Madison, additional, Rangarajan, Sanjeet V., additional, Choby, Garret W., additional, Kshettry, Varun R., additional, Saleh, Sara, additional, Mukherjee, Debraj, additional, Kirsch, Claudia, additional, McKean, Erin, additional, and Sorenson, Jeffrey M., additional

Published
2022
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33. Semi-automated Segmentation and Quantification of Perivascular Spaces at 7 Tesla in COVID-19

Author

Langan, Mackenzie T., primary, Smith, Derek A., additional, Verma, Gaurav, additional, Khegai, Oleksandr, additional, Saju, Sera, additional, Rashid, Shams, additional, Ranti, Daniel, additional, Markowitz, Matthew, additional, Belani, Puneet, additional, Jette, Nathalie, additional, Mathew, Brian, additional, Goldstein, Jonathan, additional, Kirsch, Claudia F. E., additional, Morris, Laurel S., additional, Becker, Jacqueline H., additional, Delman, Bradley N., additional, and Balchandani, Priti, additional

Published
2022
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34. Bilateral Spontaneous Pneumothorax in a COVID-19 and HIV-Positive Patient: A Case Report

Author

Cho, Young Min, primary, Guevara, Sara, additional, Aronsohn, Judith, additional, Mumford, James M., additional, Shore-Lesserson, Linda, additional, Miyara, Santiago J., additional, Herrera, Martin, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Zafeiropoulos, Stefanos, additional, Giannis, Dimitrios, additional, McCann-Molmenti, Alexia, additional, Hayashida, Kei, additional, Shinozaki, Koichiro, additional, Shoaib, Muhammad, additional, Choudhary, Rishabh C., additional, Aranalde, Gabriel I., additional, Becker, Lance B., additional, Molmenti, Ernesto P., additional, Kruer, James, additional, and Hatoum, Anthony, additional

Published
2021
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35. Drug safety for nursing-home residents

Author

Junius-Walker, Ulrike, primary, Krause, Olaf, additional, Thürmann, Petra, additional, Bernhard, Simone, additional, Fuchs, Angela, additional, Sparenberg, Lisa, additional, Wollny, Anja, additional, Stolz, Regina, additional, Haumann, Hannah, additional, Freytag, Antje, additional, Kirsch, Claudia, additional, Usacheva, Svetlana, additional, Wilm, Stefan, additional, and Wiese, Birgitt, additional

Published
2021
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36. EEG Abnormalities and Their Radiographic Correlates in a COVID-19 Inpatient Cohort

Author

Hwang, Sean T., primary, Ballout, Ahmad A., additional, Sonti, Anup N., additional, Kapyur, Amitha, additional, Kirsch, Claudia, additional, Singh, Neeraj, additional, Markowitz, Noah, additional, Leung, Tung Ming, additional, Chong, Derek J., additional, Temes, Richard, additional, Pacia, Steven V., additional, Kuzniecky, Ruben I., additional, and Najjar, Souhel, additional

Published
2021
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39. Right Ventricle Embolization of IVC Filter Fragments: An Incidental Finding

Author

Miyara, Santiago J., additional, Guevara, Sara, additional, Shore-Lesserson, Linda, additional, Shoaib, Muhammad, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Nair, Vinay, additional, Lau, Lawrence, additional, Choudhary, Rishabh C., additional, McCann-Molmenti, Alexia, additional, Baez, Anthony M., additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shinozaki, Koichiro, additional, Aoki, Tomoaki, additional, Nishikimi, Mitsuaki, additional, Cho, Young Min, additional, Morell, Alexis, additional, Zafeiropoulos, Stefanos, additional, Zanos, Stavros, additional, Watt, Stacey, additional, Montorfano, Lisandro, additional, Bartoc, Cristian D., additional, Lumermann, Claudio M., additional, Aronsohn, Judith, additional, Becker, Lance B., additional, and Molmenti, Ernesto P., additional

Published
2021
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41. Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York

Author

Miyara, Santiago J., primary, Becker, Lance B., additional, Guevara, Sara, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Shoaib, Muhammad, additional, Grodstein, Elliot, additional, Nair, Vinay V., additional, Jandovitz, Nicholas, additional, McCann-Molmenti, Alexia, additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shinozaki, Koichiro, additional, Yagi, Tsukasa, additional, Aoki, Tomoaki, additional, Nishikimi, Mitsuaki, additional, Choudhary, Rishabh C., additional, Cho, Young Min, additional, Zanos, Stavros, additional, Zafeiropoulos, Stefanos, additional, Hoffman, Hannah B., additional, Watt, Stacey, additional, Lumermann, Claudio M., additional, Aronsohn, Judith, additional, Shore-Lesserson, Linda, additional, and Molmenti, Ernesto P., additional

Published
2021
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