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398 results on '"Kitadai Y"'

16. Re-Treatment with Proton-Pump Inhibitor, Amoxicillin and Metronidazole is effective for Eradicating Failure of H. pylori in Japan

Author

Kamada, T., Haruma, K., Ito, M., Kitadai, Y., Yoshihara, M., Chayama, K., and Kawamura, Y.

Subjects
Gastrointestinal diseases -- Research, Health, Research
Abstract

T. Kamada [1] K. Haruma [1] M. Ito [1] Y. Kitadai [1] M. Yoshihara [1] K. Chayama [1] Y. Kawamura [2] [15/41] Re-Treatment with Proton-Pump Inhibitor, Amoxicillin and Metronidazole is [...]

Published
2001

17. Influence of Helicobacter pylori Infection on Cell Proliferation of Gastric Cancer

Author

Sasaki, A., Haruma, K., Kitadai, Y., Kamada, T., Masuda, H., Tanaka, S., Yoshihara, M., Chayama, K., Inoue, K., and Uemura, N.

Subjects
Gastrointestinal diseases -- Research, Health, Research
Abstract

[10/19] Influence of Helicobacter pylori Infection on Cell Proliferation of Gastric Cancer Background/Objectives: Helicobacter pylori (Hp) is now accepted as a major cause of peptic ulcer disease and gastric cancer [...]

Published
2001

18. Cetraxate, a Mucosal Protective Agent, increases Gastric Mucosal Blood Flow and the Gastric Clarithromycin Concentration in Nicotine-treated Rats

Author

Kamada, T., Haruma, K., Ito, M., Masuda, H., Kitadai, Y., Yoshihara, M., and Chayama, K.

Subjects
Gastrointestinal diseases -- Research, Health, Research
Abstract

[8/18] Cetraxate, a Mucosal Protective Agent, increases Gastric Mucosal Blood Flow and the Gastric Clarithromycin Concentration in Nicotine-treated Rats First Dept. of hiternal Medicine Background: Combination treatment with cetraxate plus [...]

Published
2001

19. Serological Comparison of anti-Parietal Cell Antibody Expression between Japanese and German Patients

Author

Ito, M., Haruma, K., Kaya, S., Kamada, T., Sasaki, A., Miyamoto, M., Hiyama, T., Kitadai, Y., Sumii, M., Tanaka, S., Yoshihara, M., Chayama, K., and Wagner, S.

Subjects
Helicobacter infections -- Research, Helicobacter pylori -- Research, Gastrointestinal diseases -- Research, Health, Research
Abstract

M. Ito [1] K. Haruma [1] S. Kaya [2] T. Kamada [1] A. Sasaki [1] M. Miyamoto [1] T. Hiyama [1] Y. Kitadai [1] M. Sumii [1] S. Tanaka [1] [...]

Published
2001

22. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer

Author

Niitsu, H, primary, Hinoi, T, additional, Kawaguchi, Y, additional, Sentani, K, additional, Yuge, R, additional, Kitadai, Y, additional, Sotomaru, Y, additional, Adachi, T, additional, Saito, Y, additional, Miguchi, M, additional, Kochi, M, additional, Sada, H, additional, Shimomura, M, additional, Oue, N, additional, Yasui, W, additional, and Ohdan, H, additional

Published
2016
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23. 110 Combination therapy using molecular-targeted drugs inhibiting platelet-derived growth factor receptors in the tumor microenvironment of renal cell carcinoma

Author

Kitano, H., primary, Teishima, J., additional, Yuge, R., additional, Shinmei, S., additional, Nagamatsu, H., additional, Goto, K., additional, Syoji, K., additional, Inoue, S., additional, Hayashi, T., additional, Sentani, K., additional, Kitadai, Y., additional, Yasui, W., additional, and Matsubara, A., additional

Published
2016
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24. Expression of interleukin-8 correlates with vascularity in human gastric carcinomas

Author

Kitadai, Y., Haruma, K., Sumii, K., Yamamoto, S., Ue, T., Hiroshi Yokozaki, Yasui, W., Ohmoto, Y., Kajiyama, G., Fidler, I. J., and Tahara, E.

Subjects
Adult, Male, Epidermal Growth Factor, Carcinoma, Interleukin-8, Middle Aged, Transforming Growth Factor alpha, Stomach Neoplasms, Tumor Cells, Cultured, Blood Vessels, Humans, Female, Tissue Distribution, RNA, Messenger, Cell Division, Research Article, Aged, Interleukin-1
Abstract

Interleukin (IL)-8 is a multifunctional cytokine that can stimulate the division of endothelial cells. We examined the expression of IL-8 mRNA using Northern blot analysis and in situ mRNA hybridization (ISH) and protein production using enzyme-linked immunosorbent assay and immunohistochemistry in 8 human gastric carcinoma cell lines and 39 gastric carcinomas and corresponding normal mucosa (34 surgical specimens and 5 biopsy specimens). Of the 8 human gastric carcinoma cell lines, 6 expressed 1.8-kb IL-8 mRNA and secreted various levels of IL-8 protein. The expression of IL-8 by TMK-1 cells was induced by exposure to IL-1 alpha, epidermal growth factor, and transforming growth factor-alpha, shown previously to be autocrine growth stimulators for human gastric carcinoma cells. In tumor tissues, most of the tumors (28 of 34 surgical specimens and 4 of 5 biopsy specimens) expressed IL-8 at higher levels than the corresponding normal mucosa. ISH and immunohistochemical analyses revealed that IL-8 mRNA and protein were localized in the cytoplasm of tumor cells. The number of blood vessels in the gastric carcinomas was determined by using antibodies against CD34. The level of IL-8 mRNA in the neoplasms strongly correlated with vascularization (Spearman correlation, r = 0.812; P = 0.001). The data suggest that IL-8 produced by tumor cells may regulate neovascularization and, hence, the growth and spread of human gastric carcinoma.

Published
1998

25. A low 13C-urea breath test value is associated with increased risk of gastric cancer.

Author

Chen X, Haruma K, Kamada T, Hattori N, Yoshihara M, Kitadai Y, Tanaka S, Sumii K, Chayama K, Chen, X, Haruma, K, Kamada, T, Hartori, N, Yoshihara, M, Kitadai, Y, Tanaka, S, Sumii, K, and Chayama, K

Abstract

Purpose: The 13C-urea breath test (UBT) is considered to be the most accurate way of diagnosing Helicobacter pylori infection. Values are affected by H. pylori infection and by the severity of atrophic gastritis. Our objective was to determine the association of UBT values with gastric cancer, and to evaluate the risk of gastric cancer in terms of UBT values.Methods: Our study involved 413 consecutive patients who had undergone esophagogastroduodenal examination and the UBT test.Results: Of the 398 patients with positive UBT results, atrophy and intestinal metaplasia scores in both antrum and corpus were significantly higher in patients with gastric cancer than in those with gastritis, duodenal ulcer, and gastric ulcer. The UBT value related to gastric cancer (22.01 +/- 1.89%o) was significantly lower than that for gastritis (35.19 +/- 1.53%o; P < 0.01), duodenal ulcer (29.01 +/- 1.97%; P < 0.05), or gastric ulcer (30.79 +/- 2.83%; P < 0.05). When the UBT values were less than 20%, increases in the risk of gastric cancer correlated with decreasing UBT values. CONCLUSIONS; These findings indicate that the UBT value related to gastric cancer is significantly lower than that for gastritis, duodenal ulcer, or gastric ulcer in H. pylori-positive patients. Low UBT values were associated with the risk of gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2001
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26. Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma

Author

Kitadai, Y., Ellis, L. M., Tucker, S. L., Greene, G. F., Bucana, C. D., Cleary, K. R., Takahashi, Y., Tahara, E., and Fidler, I. J.

Subjects
Predictive Value of Tests, Recurrence, Carcinoma, Colonic Neoplasms, Humans, RNA, Messenger, RNA, Neoplasm, In Situ Hybridization, Research Article
Abstract

We examined the expression level of several genes that regulate different steps of metastasis in formalin-fixed, paraffin-embedded archival specimens of primary human colon carcinomas from patients with at least 5 years of follow-up. The expression of epidermal growth factor receptor, basic fibroblast growth factor, type IV collagenase, E-cadherin, and multidrug resistance (mdr-1) was examined by a colorimetric in situ mRNA hybridization technique concentrating on reactivity at the periphery of the neoplasms. The in situ hybridization technique revealed inter- and intratumor heterogeneity for expression of the metastasis-related genes. The expression of basic fibroblast growth factor, collagenase type IV, epidermal growth factor receptor, and mdr-1 mRNA was higher in Dukes's stage D than in Dukes' stage B tumors. Among the 22 Dukes' stage B neoplasms, 5 specimens exhibited a high expression level of epidermal growth factor receptor, basic fibroblast growth factor, and collagenase type IV. Clinical outcome data (5-year follow-up) revealed that all 5 patients with Dukes' stage B tumors developed distant metastasis (recurrent disease), whereas the other 17 patients with Dukes' stage B tumors expressing low levels of the metastasis-related genes were disease-free. Multivariate analysis identified high levels of expression of collagenase type IV and low levels of expression of E-cadherin as independent factors significantly associated with metastasis or recurrent disease. More specifically, metastatic or recurrent disease was associated with a high ratio (> 1.35) of expression of collagenase type IV to E-cadherin (specificity of 95%). Collectively, the data show that multiparametric in situ hybridization analysis for several metastasis-related genes may predict the metastatic potential, and hence the clinical outcome, of individual lymph-node-negative human colon cancers.

Published
1996

37. Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells.

Author

Takahashi Y, Bucana CD, Liu W, Yoneda J, Kitadai Y, Cleary KR, Ellis LM, Takahashi, Y, Bucana, C D, Liu, W, Yoneda, J, Kitadai, Y, Cleary, K R, and Ellis, L M

Abstract

Background: Development of new blood vessels is essential for tumor growth and metastasis and depends on the production of angiogenic factors by tumor and/or infiltrating cells. We previously showed that vascular endothelial growth factor (VEGF) expression and vessel count correlate with metastasis in human colon cancer. Although most tumors with high vessel counts express high levels of VEGF, some do not. Recently, platelet-derived endothelial cell growth factor (PD-ECGF), another potent angiogenic factor, has been reported to be expressed in colon cancer.Purpose: In this study, we examined the role of PD-ECGF in colon cancer angiogenesis and whether PD-ECGF is derived from the tumor or infiltrating cells.Methods: Immunostaining for PD-ECGF was performed on 96 colon cancer specimens, some of which were previously stained for VEGF and factor VIII, a marker that is specific for endothelial cells. Double staining was done by using antibodies to PD-ECGF and to CD68 (macrophage specific) or CD3 (lymphocyte specific) to confirm which infiltrating cells produce PD-ECGF. Northern blot analysis for PD-ECGF messenger RNA (mRNA) was performed on four colon cancer specimens and corresponding normal colon mucosae (same patients) and four human colon cancer cell lines (KM12SM, SW620, HT29, and NCI-H508) to determine whether colon cancer epithelium expresses PD-ECGF.Results: Immunohistochemical analysis demonstrated that PD-ECGF was expressed in infiltrating cells in most of the colon cancer specimens (80 [83%] of 96) but rarely in tumor epithelium (five [5%] of 96). Double staining demonstrated that infiltrating cells staining positive for both PD-ECGF and CD68 were more predominant than those staining positive for both PD-ECGF and CD3. The intensity of staining for PD-ECGF in infiltrating cells correlated with vessel counts (Spearman's rank correlation coefficient (R) = .29; P = .004), but did not correlate with the intensity of VEGF staining (R = .176, P = .086) or metastasis (Mann-Whitney U test, P = .253). PD-ECGF staining intensity was higher in specimens with a high vessel count (> 50 at high magnification) and low VEGF-staining intensity (< or = 2+) than in specimens with a high vessel count (again, > 50) and high VEGF-staining intensity (3+). Northern blot analysis revealed that colon cancer specimens and normal mucosae expressed relatively high levels of PD-ECGF mRNA, whereas PD-ECGF mRNA transcripts were not detectable in colon cancer cell lines.Conclusions and Implications: PD-ECGF expression in human colon cancer specimens is associated with vessel count and may be responsible for tumor vascularity in those tumors with low VEGF expression. Infiltrating cells expressing PD-ECGF may contribute to angiogenesis, thus providing an additional mechanism for tumor neovascularization. [ABSTRACT FROM AUTHOR]

Published
1996
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42. Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability

Author

Hiyama, T., primary, Haruma, K., additional, Kitadai, Y., additional, Ito, M., additional, Masuda, H., additional, Miyamoto, M., additional, Tanaka, S., additional, Yoshihara, M., additional, Sumii, K., additional, Shimamoto, F., additional, and Chayama, K., additional

Published
2001
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