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40 results on '"Kitahara, Nobuo"'

25. SURGICAL APPROACH TO THE NASAL VALVE STENOSIS

Author

ICHIMURA, KEIICHI, primary, NIBU, KENICHI, additional, SHIMAZAKI, YUICHI, additional, KASE, YASUHIRO, additional, TANAKA, TOSHIYOSHI, additional, OGAWA, KEIKO, additional, KITAHARA, NOBUO, additional, and HORIUCHI, YASUHARU, additional

Published
1993
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29. 血痕における6-フォスフォグルコン酸脱水素酵素型の安定性

Author

Komatsu, Nori, Ose, Yukiko, Kido, Akira, Oya, Masakazu, and Kitahara, Nobuo

Subjects
PGD型, PGD phenotypes, Grouping of bloodstains, 酵素多型, 血痕からの型判定, 安定性試験, Polymorphism, Stability study
Abstract

The possibility of determination of 6-phosphogluconate dehydrogenase (PGD) types from bloodstains made on filter paper was examined by starch gel electrophoresis. Addition of NADP to the gel and cathodal butfers yielded a rather better visualization of isoenzyme bands. The time limits of determination of PGD types were: at 4℃ 6 weeks, at room temperature 4 weeks, at 37℃ less than 1 Week.

Published
1987

30. 赤血球酸性フォスファターゼの多型:山梨県における集団調査および血痕からの型判定

Author

Oya, Masakazu, Komatsu, Nori, Ose, Yukiko, Kido, Akira, and Kitahara, Nobuo

Subjects
Typenbestimmung aus Blutspuren, 酵素多型, saure Erythrocyten-Phosphatase, 血痕からの型判定, Enzympolymorphismus, Populations-studie in Yamanashi-ken, 山梨県における集団調査, 赤血球酸性フォスファターゼ
Abstract

Zusammenfassung: Bei 1254 in Yamanashi-ken lebenden, nicht verwandten japanischen Individuen wurde die Typenverteilung der sauren Erythrocyten-Phosphatase (SEP) untersucht. Neben den drel haeufigen Phaenotypen (A, BA, B) wurden eine Probe des Typs CA und eine Probe des Typs CB beobachtet. Die Allelfrequenzen betrugen: Pa=0,2109, Pb= 0,7883 und Pc=0,0008. Ferner wurde die Nachweisbarkeit der SEP-Typen aus auf Filterpapier angelegten Blutspuren ueberprueft. Die drel haeutigen Phaenotypen konnten bei 37℃ bis zu 3 Wochen, bei Zimmertemperatur bis zu 9 Wochen und bei 4℃ ueiber 16 Wochen nach Beginn der Lagerung nachgewiesen werden.

Published
1987

31. Chldren's sinusitis seen by waters' view.

Author

IINUMA, TOSHITAKA, primary, KASE, YASUHIRO, additional, SHIONO, HIROMI, additional, KITAHARA, NOBUO, additional, HIROTA, YOSHIHARU, additional, SHIMIZU, YAYOI, additional, and FUKUDA, MASAHIRO, additional

Published
1988
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35. Nippon Jibiinkoka Gakkai Kaiho

Author

KUMAKAWA, KOHZOH, primary, MATSUMOTO, KAZUHIKO, additional, KITAHARA, NOBUO, additional, FUNAI, HIROAKI, additional, and FUNASAKA, SOTARO, additional

Published
1983
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37. AUDIOLOGY JAPAN

Author

Funai, Hiroaki, primary, Watanabe, Shigeru, additional, Kitahara, Nobuo, additional, and Funasaka, Sotaro, additional

Published
1984
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40. Identification of tonsillar CD4+CD25−LAG3+ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.

Author

Sumitomo, Shuji, Nakachi, Shinichiro, Okamura, Tomohisa, Tsuchida, Yumi, Kato, Rika, Shoda, Hirofumi, Furukawa, Asayo, Kitahara, Nobuo, Kondo, Kenji, Yamasoba, Tatsuya, Yamamoto, Kazuhiko, and Fujio, Keishi

Subjects
*CD4 antigen, *LYMPHOID tissue, *T cells, *IMMUNOSUPPRESSION, *IMMUNOREGULATION
Abstract

IL-10-producing regulatory T cells (IL-10-producing Tregs) are one of the regulatory T cell subsets characterized by the production of high amounts of IL-10, the lack of FOXP3 expression and the strong immunosuppressive capabilities. IL-10-producing Tregs have been primarily reported as induced populations thus far, in part because identifying naturally occurring IL-10-producing Tregs was difficult due to the lack of definitive surface markers. Lymphocyte-activation gene 3 (LAG3) is a CD4 homologue that we have identified as being expressed on IL-10 producing Tregs. In human PBMC, LAG3 combined with CD49b efficiently identifies IL-10-producing Tregs. However, naturally occurring IL-10-producing Tregs in human secondary lymphoid tissue have not been described. In this report, we identified CD4 + CD25 − LAG3 + T cells in human tonsil. This T cell subset produced high amounts of IL-10 and expressed low levels of FOXP3. Surface markers and microarray analysis revealed that this is a distinct tonsillar CD4 + T cell subset. CD4 + CD25 − LAG3 + T cells expressed interleukin 10 (IL10), PR/SET domain 1 (PRDM1), and CD274 at high levels and chemokine receptor 5 (CXCR5) at low levels. CD4 + CD25 − LAG3 + T cells suppressed antibody production more efficiently than CD4 + CD25 + T cells, and CD4 + CD25 − LAG3 + T cells induced B cell apoptosis. Moreover, analysis of humanized mice revealed that this cell subset suppressed a graft-versus-host disease (GVHD) reaction in vivo . Our study reveals the existence of naturally occurring IL-10-producing Tregs in human secondary lymphoid tissue and their function in immune regulation. [ABSTRACT FROM AUTHOR]

Published
2017
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