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2. A genomic view of the sea urchin nervous system

Author

Burke, R.D., Angerer, L.M., Elphick, M.R., Humphrey, G.W., Yaguchi, S., Kiyama, T., Liang, S., Mu, X., and Agca, C.

Subjects
Sea urchins -- Genetic aspects, Nervous system -- Analysis, Biological sciences
Abstract

A study on neural genes examines the genome sequencing of strongylocentrotus purpuratus.

Published
2006

9. P1864Primary predictor of esophageal injury after catheter ablation of atrial fibrillation

Author

Ito, M, primary, Kanazawa, H K, additional, Kaneko, S K, additional, Kanemaru, Y K, additional, Kiyama, T K, additional, Arima, Y A, additional, Takashio, S T, additional, Yamamoto, E Y, additional, Kaikita, K K, additional, Fujisue, K F, additional, Sueta, D S, additional, Usuku, H U, additional, Suzuki, T S, additional, Sakamoto, K S, additional, and Tsujita, K T, additional

Published
2019
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10. P2504Inappropriate dose of direct oral anticoagulants therapy in patients with non-valvular atrial fibrillation

Author

Ito, M, primary, Kaikita, K, additional, Sueta, D, additional, Ishii, M, additional, Oimatsu, Y, additional, Mitsuse, T, additional, Arima, Y, additional, Iwashita, S, additional, Takahashi, A, additional, Kanazawa, H, additional, Kaneko, S, additional, Kanemaru, Y, additional, Kiyama, T, additional, Yamabe, H, additional, and Tsujita, K, additional

Published
2018
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14. General Lectures

Author

Yamaoka, Y., Nagai, T., Furuta, K., Inagawa, T., Sugiya, T., Kai, T., Amamoto, H., Okunara, T., Miyoshi, A., Araya, S., Sometani, T., Ogura, T., Yamato, T., Hirata, S., Hashimoto, T., Hamanaka, Y., Shakudo, Y., Ozaki, T., Noda, S., Kobayashi, K., Sasaki, K., Matsuura, R., Ueno, H., Ito, T., Umayahara, A., Koga, Y., Watanabe, K., Nabeya, K., Shimura, I., Ohyama, O., Komatsuzaki, T., Ogoshi, K., Hara, Y., Hiratsuka, H., Kubo, N., Masuda, H., Inoue, S., Arakawa, H., Koizumi, K., Mukozima, K., Inoue, Y., Hosaka, H., Kikuchi, N., Yoshida, H., Sakumoto, I., Inaba, M., Yokoi, Y., Abei, T., Iwama, S., Shirota, A., Miki, M., Ōkawa, K., Onda, M., Yoshioka, M., Shiba, T., Yamashita, K., Moriyama, Y., Adachi, K., Miyashita, M., Henmi, H., Egami, K., Toi, K., Fukiwake, T., Ito, H., Tamesue, N., Ohsato, K., Nagamitsu, S., Nishimura, M., Yamashita, Y., Yao, T., Mizuno, S., Tanabe, M., Yanase, M., Suzuki, K., Suzuki, K., Hayashi, K., Nishitani, T., Katake, K., Iwasa, N., Nishimura, S., Miyoshi, M., Fukumoto, K., Fujii, H., Inatomi, I., Nakajima, H., Hojo, Y., Tosaka, T., Kaneko, H., Yoshikawa, K., Mori, K., Uematsu, T., Takahashi, T., Morikawa, S., Hashi, M., Sakamoto, T., Kimura, A., Sasagawa, T., Maeda, Y., Matsukawa, M., Aizawa, T., Tabata, I., Munakata, A., Toda, S., Tajima, T., Matsunaga, F., Ogata, T., Nakayama, K., Nakayama, T., Minota, S., Otani, A., Takei, S., Tanaka, M., Miki, H., Hojo, K., Hirota, E., Sano, R., Murashima, Y., Okuuti, Y., Miwa, K., Suga, T., Yaosaka, T., Namiki, M., Kawauti, H., Nakagawa, K., Kasukawa, T., Kobayashi, S., Watanabe, H., Yamagata, S., Narasaka, T., Imai, H., Tsuneoka, T., Watanabe, H., Hoshi, K., Nishiyama, S., Hoshi, K., Fushimi, I., Hirai, T., Katsuda, M., Hirose, M., Yokomori, H., Matsumoto, T., Watanabe, N., Matsuura, K., Ishibashi, T., Nakata, S., Takei, C., Asano, H., Miyoshi, H., Hidaka, T., Dodo, H., Kitada, A., Nakamura, T., Sakata, S., Kitamura, S., Nakamua, T., Sakata, S., Kitamura, S., Agata, E., Aikawa, K., Oshima, A., Fujimoto, I., Kobayashi, T., Asakawa, Y., Kusakari, M., Abe, C., Tarumi, S., Yamashita, T., Takasu, S., Komase, Y., Hamada, H., Shoji, F., Saito, S., Takayama, T., Fujita, R., Kumura, F., Umeda, K., Okamoto, S., Nishio, H., Shintani, Y., Saitoh, K., Tatara, T., Iwamiya, K., Tamura, M., Tamura, K., Nakano, A., Tamura, U., Nakajima, T., Ichioka, G., Takeuchi, Y., Ayada, K., Torisu, R., Kamada, H., Matuoka, R., Turuoka, M., Sagara, Y., Nakamura, S., Sakasita, O., Mashimo, N., Sekiguchi, T., Kobayashi, S., Kishimoto, H., Takeuchi, T., Murakami, S., Koga, S., Ueno, M., Nishizawa, M., Nomoto, K., Kariya, A., Hayashi, M., Kobayashi, S., Mizuno, K., Mayama, S., Shinozuka, T., Maruyama, T., Ogiwara, T., Okui, K., Higurashi, K., Ito, T., Miyata, Y., Tamura, T., Ikeda, S., Nakata, J., Oshima, H., Mori, S., Otsuka, Y., Oki, I., Tasaka, S., Yamahatsu, J., Inaba, E., Sanada, K., Oura, T., Kinoshita, T., Akagi, M., Katsuhisa, F., Misumi, A., Urashima, K., Ninomiya, S., Hukami, M., Mori, T., Matsuo, Y., Seki, A., Kitamura, T., Mori, H., Yokota, R., Kawashima, S., Itoshima, T., Shimada, Y., Itoshima, T., Inoue, T., Fukuhara, J., Kubota, M., Ohta, W., Ohta, W., Kagaya, T., Abe, R., Kai, Y., Katono, S., Komatsu, K., Masuda, H., Inoue, S., Arakawa, H., Hamajima, T., Kitamura, T., Nakagawa, F., Tamura, H., Kiyonaga, G., Inui, H., Asai, H., Hayashi, N., Obata, H., Toki, F., Kakae, U., Yamauchi, D., Hisamitsu, T., Aziki, K., Tamiya, M., Watanabe, S., Kurokawa, K., Takemoto, T., Murakami, S., Kessoku, Y., Kuwana, H., Hino, K., Kato, A., Ito, A., Arakawa, Y., Ohono, Y., Hase, M., Ariga, K., Usui, R., Kutsukake, S., Nagamori, S., Nagano, H., Shimano, K., Ohya, T., Kikuchi, S., Ito, M., Hidano, S., Banno, H., Tomura, A., Kato, K., Koyama, T., Komatsu, T., Takei, T., Tomimura, K., Yamauchi, M., Sato, G., Sato, R., Haga, M., Toyokawa, S., Yamamoto, J., Ohtomi, S., Ishibashi, Y., Fukuda, M., Endo, R., Ueno, Y., Hisamitsu, T., Sasaki, T., Kobayashi, C., Kusakari, T., Yajima, T., Maeda, M., Kotoda, K., Okuda, K., Ariga, H., Takazawa, G., Nakamura, Y., Ohbayashi, A., Mitsui, H., Nakata, K., Suematsu, T., Kashiwagi, T., Hayashi, N., Baba, T., Tobimatsu, Y., Kamada, T., Abe, H., Matsuoka, K., Matsushima, S., Kamisaka, Y., Kitsuki, T., Ohnuki, H., Fujii, M., Inoue, R., Yamamoto, T., Wakisaka, G., Nakagawa, S., Nagata, K., Takebayashi, J., Nagashima, H., Tanaka, N., Kanai, K., Oda, T., Katayama, T., Furukawa, Y., Miyasaki, R., Noguchi, M., Hirose, K., Maezawa, H., Kano, H., Hirano, K., Ogino, M., Nishiwaki, K., Aoki, T., Morishita, T., Funatsu, K., Morita, A., Okazaki, I., Matsuzaki, S., Oda, M., Asakura, H., Kamegaya, K., Tsuchiya, M., Sambe, K., Kawakami, H., Kunimasa, T., Aimitsu, A., Yamashita, S., Miyoshi, A., Enzan, H., Ikehara, K., Shiozaki, Y., Sameshima, Y., Mizuno, T., Sasakawa, M., Nagi, S., Nagata, T., Fuwa, H., Tatsumi, K., Komatsu, K., Ozeki, T., Kaneda, M., Otsuki, M., Tadaki, H., Miura, K., Yamagata, S., Iwamura, K., Yamanaka, I., Sugimoto, E., Yamazaki, Y., Shiraishi, I., Yamanaka, T., Koike, H., Shimura, S., Hirayama, Y., Nishikawa, H., Kawamura, T., Kamiyama, Y., Takeda, H., Kamano, Y., Kitamura, O., Yamaoka, Y., Nanbu, H., Ozawa, K., Takasan, H., Honjo, I., Itakura, H., Akanuma, Y., Kagaya, T., Kaito, I., Sato, S., Sahara, H., Arisue, T., Kashimura, K., Motoyama, W., Hayashi, H., Okuyama, S., Ito, S., Inagaki, T., Kato, Y., Kakumu, S., Kurokawa, S., Yamawaki, T., Kusakabe, A., Hara, T., Funayama, A., Takahashi, T., Furuta, S., Omori, A., Hanaoka, S., Nagata, A., Tsukioka, J., Kiyosawa, K., Akahane, Y., Koike, Y., Oda, M., Tanaka, K., Kojima, M., Kawaguchi, Y., Kimura, A., Osamura, H., Kurihara, N., Okabe, K., Fujisawa, K., Takahashi, T., Kitami, N., Namihisa, T., Yamaguchi, K., Hisauchi, T., Nambu, M., Iijima, K., Rin, K., Kuroda, H., Kobayashi, N., Inami, Y., Shiga, K., Kon, T., Yamada, T., Yamada, T., Mizoguchi, Y., Enomoto, T., Monna, T., Yamamoto, S., Morisawa, S., Imoto, S., Uchita, K., Yamasawa, Y., Hiraide, S., Hikita, G., Takatsuki, K., Okimoto, Y., Nakagawa, J., Ito, K., Hirayama, C., Kawasaki, H., Irisa, T., Arimura, K., Amagase, H., Shibasaki, K., Tashiro, S., Ichida, F., Tozawa, T., Ishii, M., Inoue, E., Ikehara, H., Baba, S., Miyaji, Y., Nakajima, K., Shimizu, T., Shimizu, Y., Ohnishi, S., Sasaki, S., Kinami, Y., Mizukami, T., Nishida, Y., Nakagawa, T., Ojima, T., Takeshita, Y., Yamashita, T., Furuto, T., Ono, T., Yamaguchi, K., Mizuno, S., Tsumori, K., Miyagi, K., Suga, Y., Tatsumi, S., Kitano, A., Makiishi, H., Mitani, E., Mohri, S., Kamata, T., Kobayashi, K., Yamamoto, S., Yoshii, T., Takemoto, T., Suzuki, H., Hiratsuka, H., Takada, K., Maruyama, M., Takemoto, T., Suzuki, H., Katsu, K., Nomura, M., Kiyama, T., Hirabayashi, H., Yamashita, H., Masuyama, S., Takehara, Y., Sato, T., Abe, H., Sugiura, M., Shima, F., Ichihara, S., Yamasaki, Z., Fukuzawa, S., Horiguchi, Y., Takeda, T., Nakano, S., Kitamura, K., Miwa, M., Suzuke, T., Okada, K., Nakamura, T., Kikuchi, T., Mishima, K., Mandai, M., Kondo, H., Yamagata, Y., Uchida, Y., Harada, H., Nishizawa, M., Nomoto, K., Kariya, A., Ueno, M., Hayashi, M., Kobayashi, S., Mizuno, K., Shinozuka, T., Maruyama, T., Ogiwara, T., Okui, K., Miyake, N., Okada, M., Takahashi, K., Koizumi, H., Hayashi, T., Maeda, H., Abe, M., Takahashi, I., Matsumoto, M., Unoura, T., Iwasaki, A., Hattori, T., Tanaka, M., Hara, T., Sato, H., Hirashima, T., Shioda, A., Kawamura, I., Muto, M., Tsuchiya, R., Sato, Y., Ozawa, T., Hatano, T., Arae, H., Sekine, T., Tsukamoto, M., Shiratori, T., Asaki, S., Oba, E., Yamagata, H., Kobiyama, M., Hisamichi, S., Kitagawa, M., Kobayashi, N., Kurosawa, T., Tokimatsu, S., Kawasaki, S., Iwasa, A., Nagashima, K., Kodeki, K., Hoshizawa, T., Murakami, H., Yagi, T., Matsuda, T., Iwazaki, T., Suzuki, Y., Taketomi, H., Akaike, Y., Naramoto, J., Tsuru, T., Inoue, M., Nagase, T., Kato, K., and Kohyama, K.

Published
1973
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15. Abandoned roadways aged up to 50 years observed in Kushiro Coal Mine, Japan

Author

Fujii, Yoshiaki, Sugawara, T., Kodama, J., Ishijima, Y., Kiyama, T., Takada, M., Ishihara, Y., Kumakura, S., Narita, T., Sawada, M., and Nakata, E.

Subjects
lab testing, monitoring, field measurements, nuclear repository, coal mines, case studies
Abstract

12th ISRM International Congress on Rock Mechanics (Beijing, China, 18-21 October 2011), 95 abandoned old roadways up to 50 years old and 300 m deep were observed at Kushiro Coal Mine. Large plastic deformations as roof deflection and/or floor heave closed most roadways although a few roadways were remain open. Such in-situ measurements as Rayleigh wave velocity, permeability etc. were carried out. Rayleigh wave velocity in the closed roadway was approx. half the virgin rock mass. Permeability of closed roadway was 40 times greater than that for virgin rock mass. This suggests that 1/40 sealability can be expected even a rock cavern in clastic rocks completely collapsed. This would be much better than rock cavern in crystalline rocks in which much less sealability is expected when completely collapsed.

Published
2011

16. The importance of venous Doppler velocimetry for evaluation of intrauterine growth restriction

Author

Adonakis G, Arata K, Georgios Decavalas, Harada T, Iwabe T, Kaponis A, Kiyama T, Makrydimas G, Stefos T, and Tsapanos V

Subjects
Umbilical Arteries/*physiopathology/*ultrasonography, Predictive Value of Tests, Pregnancy, Fetal Growth Retardation/*physiopathology/*ultrasonography, Pregnancy Outcome, Animals, Humans, Ultrasonography, Prenatal/*methods, Female, Ultrasonography, Doppler/*methods, Placenta/blood supply/ultrasonography, Blood Flow Velocity, Rheology/methods
Abstract

The management of growth-restricted fetuses requires accurate diagnosis to optimize the timing of delivery. Doppler velocimetry is the only noninvasive method for assessing the fetoplacental hemodynamic status. This review will give a critical overview of the current knowledge on fetal venous blood flow in pregnancies complicated by in-trauterine growth-restricted fetuses. Adaptation of the circulation in intrauterine growth-restricted fetuses is described. Normal and abnormal venous Doppler waveforms are presented. Correlations of abnormal waveforms with the presence of acidemia and perinatal outcomes are emphasized. Limitations of venous Doppler velocimetry for optimizing the time for delivery and the perinatal outcome are also presented. J Ultrasound Med

Published
2011

19. Regulation of ipRGCs by Tbr2

Author

Mao, C.-A., primary, Li, H., additional, Zhang, Z., additional, Kiyama, T., additional, Panda, S., additional, Hattar, S., additional, Ribelayga, C., additional, Mills, S., additional, and Wang, S., additional

Published
2013
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20. Abandoned roadways aged up to 50 years observed in Kushiro Coal Mine, Japan

Author

1000070192309, Fujii, Yoshiaki, Sugawara, T., Kodama, J., Ishijima, Y., Kiyama, T., Takada, M., Ishihara, Y., Kumakura, S., Narita, T., Sawada, M., Nakata, E., 1000070192309, Fujii, Yoshiaki, Sugawara, T., Kodama, J., Ishijima, Y., Kiyama, T., Takada, M., Ishihara, Y., Kumakura, S., Narita, T., Sawada, M., and Nakata, E.

Abstract

12th ISRM International Congress on Rock Mechanics (Beijing, China, 18-21 October 2011), 95 abandoned old roadways up to 50 years old and 300 m deep were observed at Kushiro Coal Mine. Large plastic deformations as roof deflection and/or floor heave closed most roadways although a few roadways were remain open. Such in-situ measurements as Rayleigh wave velocity, permeability etc. were carried out. Rayleigh wave velocity in the closed roadway was approx. half the virgin rock mass. Permeability of closed roadway was 40 times greater than that for virgin rock mass. This suggests that 1/40 sealability can be expected even a rock cavern in clastic rocks completely collapsed. This would be much better than rock cavern in crystalline rocks in which much less sealability is expected when completely collapsed.

Published
2011

21. A genomic view of the sea urchin nervous system

Author

Burke, R D, Angerer, L M, Elphick, M R, Humphrey, G W, Yaguchi, S, Kiyama, T, Liang, S, Mu, X, Agca, C, Klein, W H, Brandhorst, B P, Rowe, M, Wilson, K, Churcher, A M, Taylor, J S, Chen, N, Murray, G, Wang, D, Mellott, D, Olinski, R, Hallböök, Finn, Thorndyke, M C, Burke, R D, Angerer, L M, Elphick, M R, Humphrey, G W, Yaguchi, S, Kiyama, T, Liang, S, Mu, X, Agca, C, Klein, W H, Brandhorst, B P, Rowe, M, Wilson, K, Churcher, A M, Taylor, J S, Chen, N, Murray, G, Wang, D, Mellott, D, Olinski, R, Hallböök, Finn, and Thorndyke, M C

Abstract

The sequencing of the Strongylocentrotus purpuratus genome provides a unique opportunity to investigate the function and evolution of neural genes. The neurobiology of sea urchins is of particular interest because they have a close phylogenetic relationship with chordates, yet a distinctive pentaradiate body plan and unusual neural organization. Orthologues of transcription factors that regulate neurogenesis in other animals have been identified and several are expressed in neurogenic domains before gastrulation indicating that they may operate near the top of a conserved neural gene regulatory network. A family of genes encoding voltage-gated ion channels is present but, surprisingly, genes encoding gap junction proteins (connexins and pannexins) appear to be absent. Genes required for synapse formation and function have been identified and genes for synthesis and transport of neurotransmitters are present. There is a large family of G-protein-coupled receptors, including 874 rhodopsin-type receptors, 28 metabotropic glutamate-like receptors and a remarkably expanded group of 161 secretin receptor-like proteins. Absence of cannabinoid, lysophospholipid and melanocortin receptors indicates that this group may be unique to chordates. There are at least 37 putative G-protein-coupled peptide receptors and precursors for several neuropeptides and peptide hormones have been identified, including SALMFamides, NGFFFamide, a vasotocin-like peptide, glycoprotein hormones and insulin/insulin-like growth factors. Identification of a neurotrophin-like gene and Trk receptor in sea urchin indicates that this neural signaling system is not unique to chordates. Several hundred chemoreceptor genes have been predicted using several approaches, a number similar to that for other animals. Intriguingly, genes encoding homologues of rhodopsin, Pax6 and several other key mammalian retinal transcription factors are expressed in tube feet, suggesting tube feet function as photosensory organ

Published
2006
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27. Dynamic cis-regulatory evolution in the spec gene family involves the acquisition of a transcriptional enhancer and evidence of stabilizing selection

Author

Villinski, J.V., Dayal, S., Kiyama, T., Liang, S., and Klein, W.H.

Subjects
Zoology and wildlife conservation
Abstract

The evolution of genetic regulatory interactions is considered a driving force in generating evolutionary novelty because alterations to the regulatory milieu can lead to new gene expression patterns. Consistent with this view, homologous genes with highly conserved expression patterns can have conserved aspects of regulation, even in cross-species comparisons. The Spec gene family in sea urchins presents an intriguing counterpoint, genes with a highly conserved expression pattern but profound enhancer divergence. Promoter regions are completely dissimilar between the Strongylocentrotus purpuratus Spec2a gene and its homolog in Lytechinus pictus, species which diverged ~40 million years ago. One conspicuous difference is a repeat sequence, termed the RSR enhancer element, which contributes to transcriptional control of at least 3 S. purpuratus Spec genes but is absent in L. pictus, which presumably has the ancestral regulatory control. Here we further dissect the evolutionary history of the Spec regulatory region by determining (i) the phylogenetic expansion of the Spec gene family and (ii) the emergence and proliferation of the RSR element, as inferred by cloning these sequences from phylogenetic intermediates of S. purpuratus and L. pictus. Our results indicate a complicated history of gene family proliferation and RSR functionality, however there is evidence for correlated evolution of Spec orthologs and the RSR regulatory cassette, which first became associated at least ~17 million years ago.

Published
2003

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