1. Effect of High-Carbohydrate Diet on Lipid Metabolism in Young Type I Diabetics: Transient Changes in High-Density Lipoprotein2and Lipoprotein Lipase
- Author
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Charles A. Bradley, Akiyo Miyao, Kohtaro Asayama, Rodney A. Lorenz, Ian M. Burr, and Kiyohoko Kato
- Subjects
Lipoprotein lipase ,medicine.medical_specialty ,Very low-density lipoprotein ,Triglyceride ,business.industry ,Cholesterol ,medicine.medical_treatment ,Reverse cholesterol transport ,chemistry.chemical_compound ,High-density lipoprotein ,Endocrinology ,Diabetic diet ,chemistry ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Medicine ,lipids (amino acids, peptides, and proteins) ,business ,Lipoprotein - Abstract
The short-term effect of a high-carbohydrate, low-fat diet on lipoprotein metabolism was evaluated in eight young patients with type I diabetes mellitus. An isocaloric exchange diet containing 60% carbohydrate and 20% fat was administered for four weeks and serum lipid, high-density lipoprotein and subfraction cholesterol, and the activity of the lipolytic enzymes in postheparin plasma were monitored. The assay methods for lipase activity and cholesterol concentration in high-density lipoprotein subfractions were described previously. There were no appreciable changes in diabetic control, serum triglyceride and total cholesterol levels. The high-density lipoprotein2 cholesterol level decreased significantly after two weeks on the diet and returned toward baseline levels thereafter. There was a significant correlation between high-density lipoprotein2 cholesterol level and lipoprotein lipase activity. The high carbohydrate diet did not affect the glycemic control but induced a transient decrease in high-density lipoprotein2 cholesterol mediated by the decrease in lipoprotein lipase activity.
- Published
- 1986
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