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3. Completion of JT-60SA construction and contribution to ITER

Author

Kamada Y., Di Pietro E., Hanada M., Barabaschi P., Ide S., Davis S., Yoshida M., Giruzzi G., Sozzi C., Abdel Maksoud W., Abe H., Aiba N., Akiyama T., Ayllon-Guerola J., Arai T., Artaud J. -F., Asakura N., Ashikawa N., Balbinot L., Bando T., Baulaigue O., Belonohy E., Bin W., Bombarda F., Bolzonella T., Bonne F., Bonotto M., Botija J., Cabrera-Perez S., Cardella A., Carraro L., Cavalier J., Chernyshova M., Chiba S., Clement-Lorenzo S., Cocilovo V., Coda S., Coelho R., Coffey I., Collin B., Corato V., Cucchiaro A., Czarski T., Dairaku M., Day C., de la Luna E., De Tommasi G., Decool P., Di Pace L., Dibon M., Disset G., Ejiri A., Endo Y., Ezumi N., Falchetto G., Fassina A., Fejoz P., Ferro A., Fietz W., Figini L., Fornal T., Frello G., Fujita T., Fukuda T., Fukui K., Fukumoto M., Furukawa M., Futatani S., Gabellieri L., Gaio E., Galazka K., Garcia J., Garcia-Dominguez J., Garcia-Lopez J., Garcia-Munoz M., Garzotti L., Gasparini F., Gharafi S., Giacomelli L., Ginoulhiac G., Giudicotti L., Guillen Gonzalez R., Hajnal N., Hall S., Hamada K., Hanada K., Hasegawa K., Hatae T., Hatakeyama S., Hauer V., Hayashi N., Hayashi T., Heller R., Higashijima S., Hinata J., Hiranai S., Hiratsuka J., Hiwatari R., Hoa C., Homma H., Honda A., Honda M., Horiike H., Hoshino K., Hurzlmeier H., Iafrati M., Ibano K., Ichige H., Ichikawa M., Ichimura M., Ida K., Idei H., Iijima T., Iio S., Ikeda R., Ikeda Y., Imai T., Imazawa R., Inagaki S., Inomoto M., Inoue S., Isayama A., Ishida S., Ishii Y., Isobe M., Janky F., Joffrin E., Jokinen A., Kado S., Kajita S., Kajiwara K., Kamata I., Kaminaga A., Kamiya K., Kanapienyte D., Kashiwa Y., Kashiwagi M., Katayama K., Kawamata Y., Kawamura G., Kawano K., Kawashima H., Kin F., Kitajima S., Kiyono K., Kizu K., Kobayashi K., Kobayashi M., Kobayashi S., Kobayashi T., Kocsis G., Koide Yo., Koide Yu., Kojima A., Kokusen S., Komuro K., Konishi S., Kovacsik A., Ksiazek I., Kubkowska M., Kuhner G., Kuramochi M., Kurihara K., Kurki-Suonio T., Kurniawan A. B., Kuwata T., Lacroix B., Lamaison V., Lampasi A., Lang P., Lauber P., Lawson K., Louzguiti A., Maekawa R., Maekawa T., Maeyama S., Maffia G., Maget P., Mailloux J., Maione I., Maistrello A., Malinowski K., Marchiori G., Marechal J. -L., Massaut V., Masuzaki S., Matsunaga G., Matsunaga S., Mayri Ch., Mattei M., Medrano M., Mele A., Meyer I., Michel F., Minami T., Miyata Y., Miyazawa J., Miyo Y., Mizuuchi T., Mogaki K., Morales J., Moreau P., Mori M., Morisaki T., Morishima S., Moriyama S., Moro A., Murakami H., Murayama M., Murakami S., Nagasaki K., Naito O., Nakamura S., Nakano T., Nakashima Y., Nardino V., Narita E., Narushima Y., Natsume K., Nemoto S., Neu R., Nicollet S., Nishikawa M., Nishimura S., Nishiura M., Nishiyama T., Nocente M., Nobuta Y., Novello L., Nunio F., Ochoa S., Ogawa T., Ogawa Y., Ohdachi S., Ohmori Y., Ohno N., Ohtani Y., Ohzeki M., Oishi T., Okano F., Okano J., Okano K., Onishi Y., Osakabe M., Oshima T., Ostuni V., Oya M., Oya Y., Oyama N., Ozeki T., Pasqualotto R., Pelli S., Peretti E., Phillips G., Piccinni C., Pigatto L., Pironti A., Pizzuto A., Plockl B., Polli G., Poncet J. -M., Ponsot P., Puiatti M., Radloff D., Raimondi V., Ramos F., Rancsik P., Ricci D., Ricciarini S., Rincon E., Romano A., Rossi P., Roussel P., Rubino G., Saeki H., Sagara A., Sakakibara S., Sakamoto H., Sakamoto M., Sakamoto Y., Sakasai A., Sakata S., Sakuma T., Sakurai S., Salanon B., Salmi A., Sannazzaro G., Sano R., Sanpei A., Sasajima T., Sasaki S., Sasao H., Sato F., Sato M., Sawahata M., Scherber A., Scully S., Seki M., Seki S., Shibama Y., Shibata Y., Shikama T., Shimada K., Shimono M., Shinde J., Shinya T., Shinohara K., Shirai H., Shiraishi J., Soare S., Soleto A., Someya Y., Streciwilk-Kowalska E., Strobel H., Sueoka M., Sukegawa A., Sulistyanintyas D., Sumida S., Sunaoshi H., Suzuki H., Suzuki M., Suzuki S., Suzuki T., Suzuki Y., Svoboda J., Szabolics T., Szepesi T., Takahashi K., Takase Y., Takechi M., Takeda K., Takeiri Y., Takenaga H., Taliercio C., Tamura N., Tanaka H., Tanaka K., Tani K., Tanigawa H., Tardocchi M., Terakado A., Terakado M., Terakado T., Teuchner B., Tilia B., Tobita K., Toi K., Toida N., Tojo H., Tokitani M., Tokuzawa T., Tormarchio V., Tomine M., Torre A., Totsuka T., Tsuchiya K., Tsujii N., Tsuru D., Tsutsui H., Uchida M., Ueda Y., Uno J., Urano H., Usui K., Utoh H., Valisa M., Vallar M., Vallcorba-Carbonell R., Vallet J. -C., Varela J., Vega J., Verrecchia M., Vieillard L., Villone F., Vincenzi P., Wada K., Wada R., Wakatsuki T., Wanner M., Watanabe F., Watanabe K., Wauters T., Wiesen S., Wischmeier M., Yagi M., Yagyu J., Yajima M., Yokooka S., Yokoyama M., Yamamoto S., Yamanaka H., Yamauchi K., Yamauchi Y., Yamazaki H., Yamazaki K., Yamazaki R., Yamoto S., Yanagi S., Yanagihara K., Yoshizawa N., Zani L., Zito P., Kamada, Y., Di Pietro, E., Hanada, M., Barabaschi, P., Ide, S., Davis, S., Yoshida, M., Giruzzi, G., Sozzi, C., Abdel Maksoud, W., Abe, H., Aiba, N., Akiyama, T., Ayllon-Guerola, J., Arai, T., Artaud, J. -F., Asakura, N., Ashikawa, N., Balbinot, L., Bando, T., Baulaigue, O., Belonohy, E., Bin, W., Bombarda, F., Bolzonella, T., Bonne, F., Bonotto, M., Botija, J., Cabrera-Perez, S., Cardella, A., Carraro, L., Cavalier, J., Chernyshova, M., Chiba, S., Clement-Lorenzo, S., Cocilovo, V., Coda, S., Coelho, R., Coffey, I., Collin, B., Corato, V., Cucchiaro, A., Czarski, T., Dairaku, M., Day, C., de la Luna, E., De Tommasi, G., Decool, P., Di Pace, L., Dibon, M., Disset, G., Ejiri, A., Endo, Y., Ezumi, N., Falchetto, G., Fassina, A., Fejoz, P., Ferro, A., Fietz, W., Figini, L., Fornal, T., Frello, G., Fujita, T., Fukuda, T., Fukui, K., Fukumoto, M., Furukawa, M., Futatani, S., Gabellieri, L., Gaio, E., Galazka, K., Garcia, J., Garcia-Dominguez, J., Garcia-Lopez, J., Garcia-Munoz, M., Garzotti, L., Gasparini, F., Gharafi, S., Giacomelli, L., Ginoulhiac, G., Giudicotti, L., Guillen Gonzalez, R., Hajnal, N., Hall, S., Hamada, K., Hanada, K., Hasegawa, K., Hatae, T., Hatakeyama, S., Hauer, V., Hayashi, N., Hayashi, T., Heller, R., Higashijima, S., Hinata, J., Hiranai, S., Hiratsuka, J., Hiwatari, R., Hoa, C., Homma, H., Honda, A., Honda, M., Horiike, H., Hoshino, K., Hurzlmeier, H., Iafrati, M., Ibano, K., Ichige, H., Ichikawa, M., Ichimura, M., Ida, K., Idei, H., Iijima, T., Iio, S., Ikeda, R., Ikeda, Y., Imai, T., Imazawa, R., Inagaki, S., Inomoto, M., Inoue, S., Isayama, A., Ishida, S., Ishii, Y., Isobe, M., Janky, F., Joffrin, E., Jokinen, A., Kado, S., Kajita, S., Kajiwara, K., Kamata, I., Kaminaga, A., Kamiya, K., Kanapienyte, D., Kashiwa, Y., Kashiwagi, M., Katayama, K., Kawamata, Y., Kawamura, G., Kawano, K., Kawashima, H., Kin, F., Kitajima, S., Kiyono, K., Kizu, K., Kobayashi, K., Kobayashi, M., Kobayashi, S., Kobayashi, T., Kocsis, G., Koide, Yo., Koide, Yu., Kojima, A., Kokusen, S., Komuro, K., Konishi, S., Kovacsik, A., Ksiazek, I., Kubkowska, M., Kuhner, G., Kuramochi, M., Kurihara, K., Kurki-Suonio, T., Kurniawan, A. B., Kuwata, T., Lacroix, B., Lamaison, V., Lampasi, A., Lang, P., Lauber, P., Lawson, K., Louzguiti, A., Maekawa, R., Maekawa, T., Maeyama, S., Maffia, G., Maget, P., Mailloux, J., Maione, I., Maistrello, A., Malinowski, K., Marchiori, G., Marechal, J. -L., Massaut, V., Masuzaki, S., Matsunaga, G., Matsunaga, S., Mayri, Ch., Mattei, M., Medrano, M., Mele, A., Meyer, I., Michel, F., Minami, T., Miyata, Y., Miyazawa, J., Miyo, Y., Mizuuchi, T., Mogaki, K., Morales, J., Moreau, P., Mori, M., Morisaki, T., Morishima, S., Moriyama, S., Moro, A., Murakami, H., Murayama, M., Murakami, S., Nagasaki, K., Naito, O., Nakamura, S., Nakano, T., Nakashima, Y., Nardino, V., Narita, E., Narushima, Y., Natsume, K., Nemoto, S., Neu, R., Nicollet, S., Nishikawa, M., Nishimura, S., Nishiura, M., Nishiyama, T., Nocente, M., Nobuta, Y., Novello, L., Nunio, F., Ochoa, S., Ogawa, T., Ogawa, Y., Ohdachi, S., Ohmori, Y., Ohno, N., Ohtani, Y., Ohzeki, M., Oishi, T., Okano, F., Okano, J., Okano, K., Onishi, Y., Osakabe, M., Oshima, T., Ostuni, V., Oya, M., Oya, Y., Oyama, N., Ozeki, T., Pasqualotto, R., Pelli, S., Peretti, E., Phillips, G., Piccinni, C., Pigatto, L., Pironti, A., Pizzuto, A., Plockl, B., Polli, G., Poncet, J. -M., Ponsot, P., Puiatti, M., Radloff, D., Raimondi, V., Ramos, F., Rancsik, P., Ricci, D., Ricciarini, S., Rincon, E., Romano, A., Rossi, P., Roussel, P., Rubino, G., Saeki, H., Sagara, A., Sakakibara, S., Sakamoto, H., Sakamoto, M., Sakamoto, Y., Sakasai, A., Sakata, S., Sakuma, T., Sakurai, S., Salanon, B., Salmi, A., Sannazzaro, G., Sano, R., Sanpei, A., Sasajima, T., Sasaki, S., Sasao, H., Sato, F., Sato, M., Sawahata, M., Scherber, A., Scully, S., Seki, M., Seki, S., Shibama, Y., Shibata, Y., Shikama, T., Shimada, K., Shimono, M., Shinde, J., Shinya, T., Shinohara, K., Shirai, H., Shiraishi, J., Soare, S., Soleto, A., Someya, Y., Streciwilk-Kowalska, E., Strobel, H., Sueoka, M., Sukegawa, A., Sulistyanintyas, D., Sumida, S., Sunaoshi, H., Suzuki, H., Suzuki, M., Suzuki, S., Suzuki, T., Suzuki, Y., Svoboda, J., Szabolics, T., Szepesi, T., Takahashi, K., Takase, Y., Takechi, M., Takeda, K., Takeiri, Y., Takenaga, H., Taliercio, C., Tamura, N., Tanaka, H., Tanaka, K., Tani, K., Tanigawa, H., Tardocchi, M., Terakado, A., Terakado, M., Terakado, T., Teuchner, B., Tilia, B., Tobita, K., Toi, K., Toida, N., Tojo, H., Tokitani, M., Tokuzawa, T., Tormarchio, V., Tomine, M., Torre, A., Totsuka, T., Tsuchiya, K., Tsujii, N., Tsuru, D., Tsutsui, H., Uchida, M., Ueda, Y., Uno, J., Urano, H., Usui, K., Utoh, H., Valisa, M., Vallar, M., Vallcorba-Carbonell, R., Vallet, J. -C., Varela, J., Vega, J., Verrecchia, M., Vieillard, L., Villone, F., Vincenzi, P., Wada, K., Wada, R., Wakatsuki, T., Wanner, M., Watanabe, F., Watanabe, K., Wauters, T., Wiesen, S., Wischmeier, M., Yagi, M., Yagyu, J., Yajima, M., Yokooka, S., Yokoyama, M., Yamamoto, S., Yamanaka, H., Yamauchi, K., Yamauchi, Y., Yamazaki, H., Yamazaki, K., Yamazaki, R., Yamoto, S., Yanagi, S., Yanagihara, K., Yoshizawa, N., Zani, L., and Zito, P.

Subjects
assembly, Cryostat, Nuclear and High Energy Physics, Materials science, Tokamak, Nuclear engineering, Plasma, Condensed Matter Physics, Field coil, ITER risk mitigation, Overcurrent, law.invention, Control theory, law, Electromagnetic coil, research plan, broader approach, Voltage
Abstract

Construction of the JT-60SA tokamak was completed on schedule in March 2020. Manufacture and assembly of all the main tokamak components satisfied technical requirements, including dimensional accuracy and functional performances. Development of the plasma heating systems and diagnostics have also progressed, including the demonstration of the favourable electron cyclotron range of frequency (ECRF) transmission at multiple frequencies and the achievement of long sustainment of a high-energy intense negative ion beam. Development of all the tokamak operation control systems has been completed, together with an improved plasma equilibrium control scheme suitable for superconducting tokamaks including ITER. For preparation of the tokamak operation, plasma discharge scenarios have been established using this advanced equilibrium controller. Individual commissioning of the cryogenic system and the power supply system confirmed that these systems satisfy design requirements including operational schemes contributing directly to ITER, such as active control of heat load fluctuation of the cryoplant, which is essential for dynamic operation in superconducting tokamaks. The integrated commissioning (IC) is started by vacuum pumping of the vacuum vessel and cryostat, and then moved to cool-down of the tokamak and coil excitation tests. Transition to the super-conducting state was confirmed for all the TF, EF and CS coils. The TF coil current successfully reached 25.7 kA, which is the nominal operating current of the TF coil. For this nominal toroidal field of 2.25 T, ECRF was applied and an ECRF plasma was created. The IC was, however, suspended by an incident of over current of one of the superconducting equilibrium field coil and He leakage caused by insufficient voltage holding capability at a terminal joint of the coil. The unique importance of JT-60SA for H-mode and high-β steady-state plasma research has been confirmed using advanced integrated modellings. These experiences of assembly, IC and plasma operation of JT-60SA contribute to ITER risk mitigation and efficient implementation of ITER operation.

Published
2022
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22. Intramedullary injury combined with osteoporosis therapeutics regulates targeted local osteogenesis

Author

Yoko Miyazaki-Asato, Kiyono Koi, Hiroki Fujimoto, Kae Kakura, Hirofumi Kido, Tsukasa Yanagi, and Junro Yamashita

Subjects
Medicine, Science
Abstract

Abstract Bone marrow ablation prompts transient bone formation in nearly the entire medullary cavity before marrow regeneration occurs. Here, we establish a procedure to direct bone formation in a desired particular site within the medullary cavity for support of biomedical devices. Local intramedullary injury was performed in the tibiae of rats and parathyroid hormone (PTH), alendronate, or saline was administered. Newly generated bone in the medulla was assessed by micro-CT and histology. To evaluate the function of newly generated bone, animals received intramedullary injury in tibiae followed by daily PTH. At day-14, implants were placed in the endocortical bone and the bone response to the implants was assessed. The fate of newly generated bone was compared with and without implants. We found that neither intramedullary injury nor medication alone resulted in bone formation. However, when combined, substantial bone was generated locally inside the diaphyseal medulla. Newly formed bone disappeared without implant placement but was retained with implants. Bone was especially retained around and between the implants. This study found that local bone marrow disruption followed by PTH or alendronate generated substantial cancellous bone locally in the diaphyseal medulla. This approach offers promise as a tissue engineering tool in medicine and dentistry.

Published
2021
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23. MODULATION INFLUENCES OF THE VESTIBULAR SYSTEM PERTURBATION ON THE POSTURAL BALANCE IN PHYSICALLY TRAINED HUMANS.

Author

Kolosova, E., Seleznov, I., Popov, A., Kiyono, K., and Kolomiiets, B.

Subjects
VESTIBULAR apparatus, SENSORY deprivation, INNER ear diseases, MALE athletes, VESTIBULO-ocular reflex, MARTIAL arts
Abstract

Medical evaluation of patients with postural balance complaints requires assessment of person's vestibular function. The most common vestibular tests include videonystagmography or the rotary chair test with recording of eye movements under different conditions to investigate inner ear function; the head impulse test that evaluates the vestibulo-ocular reflex. At the same time, stabilometry method is not widely used in clinical research for assessing the vestibular function, although it may provide important information about the contribution of the vestibular system to postural balance. The objective of the research was to evaluate changes in stabilometric indices under the conditions of vestibular system perturbation in physically trained people. Seventeen athletes specialized in coordination sports -- gymnastics and martial arts (11 men and 6 women, 18-28 years of age, Mage=19.7, SD=2.3) took part in the stabilometric study conducted using the force platform equipped with four force transducers. Recording and analysis of the Center of pressure (CoP) oscillations were performed using an NI 6070E interface (National Instruments, USA) and software written on the LabView language. The sampling frequency was 100 Hz. We analysed CoP trajectories measured under conditions of counterclockwise head rotation (HR) performed in suitable rhythm, approximately one time per second. CoP trajectories before and immediately after HR were also analysed. The tests lasting 20 s each were performed in an upright position with eyes open and closed (EO and EC, respectively). To evaluate the influence of the test conditions on the studied indices twofactor analysis of variance with repeated samplings considering two within-subjects factors (vestibular, associated with the presence of HR and visual, associated with the presence of visual deprivation) was carried out using SPSS Statistics 17.0. Both vestibular and visual factors were found to have significant effects on CoP trajectory length values. Vestibular factor also had significant effect on power spectral density (PSD) of anteroposterior (AP) and mediolateral (ML) oscillations. To determine differences of indices groups in specific test conditions their pairwise comparison (post-hoc analysis) based on the Hochberg's test was performed. It was revealed that CoP trajectory length of AP and ML oscillations as well as CoP trajectory length in the force platform plane increased statistically significantly during HR in EO and EC conditions (p<0,05). Besides, AP trajectory length remained greater after HR than before it, with the difference close to significant, in closed eyes conditions. The AP/ML trajectory length ratio also increased significantly during HR in the EO and EC conditions; this might be due to the predominance of forward and backward body sway to maintain postural balance during head rotation. It was also found that PSD of AP and ML oscillations increased significantly during HR in the frequency ranges 0.2-0.5, 0.5-1.0, 1.0-2.0, 2.0-3.0 and 3.0-6.0 Hz for both open and closed eyes conditions, although the head rotation frequency was about 1 Hz. Such data may indicate the complex nature of the transmission of head rotation to the sway of various body regions. In addition, the PSD of AP oscillations remained significantly greater after HR test than before it under closed eyes conditions in the frequency ranges of 0.2-0.5 Hz and 3.0-6.0 Hz, and the PSD of ML oscillations remained greater with a difference close to significant under open eyes conditions in the frequency range of 0,2-0,5 Hz. Obtained data demonstrate the inertial properties of the vestibular system. It is supposed that according to the degree of residual effects it will be possible to assess the level of training or impairment of the vestibular system, as well as to control the process of treatment and rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2022

34. Erratum: Achievement of High Fusion Performance in JT-60U Reversed Shear Discharges [Phys. Rev. Lett.79, 3917 (1997)]

Author

Ishida, S., primary, Fujita, T., additional, Akasaka, H., additional, Akino, N., additional, Annou, K., additional, Aoyagi, T., additional, Arai, T., additional, Arakawa, K., additional, Asakura, N., additional, Azumi, M., additional, Budny, R., additional, Chiba, S., additional, Da Costa, O., additional, Ebisawa, N., additional, Fujii, T., additional, Fukuda, T., additional, Funahashi, A., additional, Grisham, L., additional, Gunji, S., additional, Hamamatsu, K., additional, Hasegawa, Y., additional, Hatae, T., additional, Higashijima, S., additional, Hiratsuka, H., additional, Hirauchi, S., additional, Hirayama, T., additional, Honda, A., additional, Honda, M., additional, Hosogane, N., additional, Ichige, H., additional, Ide, S., additional, Ikeda, Y., additional, Isaka, M., additional, Isayama, A., additional, Isei, N., additional, Ishii, Y., additional, Isozaki, N., additional, Itami, K., additional, Itoh, T., additional, Iwahashi, T., additional, Kamada, Y., additional, Kaminaga, A., additional, Kashiwabara, T., additional, Kawai, M., additional, Kawamata, Y., additional, Kawano, Y., additional, Kazama, D., additional, Kazawa, M., additional, Kikuchi, M., additional, Kimura, H., additional, Kimura, T., additional, Kishimoto, H., additional, Kishimoto, Y., additional, Kitamura, S., additional, Kiyono, K., additional, Kodama, K., additional, Koide, Y., additional, Kokusen, S., additional, Kondoh, T., additional, Konoshima, S., additional, Koog, J., additional, Kramer, G. J., additional, Kubo, H., additional, Kurihara, K., additional, Kurita, G., additional, Kuriyama, M., additional, Kusama, Y., additional, Masaki, K., additional, Matsuda, T., additional, Matsumoto, T., additional, Matukawa, M., additional, Miura, T., additional, Miya, N., additional, Miyachi, K., additional, Miyata, H., additional, Miyo, Y., additional, Mogaki, K., additional, Mori, M., additional, Morimoto, M., additional, Morioka, S., additional, Moriyama, S., additional, Nagami, M., additional, Nagashima, A., additional, Nagashima, K., additional, Nagaya, S., additional, Naito, O., additional, Nakamura, Y., additional, Nemoto, M., additional, Neyatani, Y., additional, Nishitani, T., additional, Ogiwara, N., additional, Ohga, T., additional, Ohsawa, M., additional, Ohshima, T., additional, Oikawa, T., additional, Okabe, T., additional, Okano, J., additional, Omori, K., additional, Omori, S., additional, Omori, Y., additional, Onose, Y., additional, Oohara, H., additional, Ozeki, T., additional, Saidoh, M., additional, Saigusa, M., additional, Saito, N., additional, Sakasai, A., additional, Sakata, S., additional, Sakurai, S., additional, Sasajima, T., additional, Sato, M., additional, Scott, S. D., additional, Seimiya, M., additional, Seiki, H., additional, Seki, M., additional, Shimada, M., additional, Shimizu, K., additional, Shimizu, M., additional, Shimono, M., additional, Shinozaki, S., additional, Shirai, H., additional, Shitomi, M., additional, Suganuma, K., additional, Sugie, T., additional, Sunaoshi, H., additional, Takahashi, M., additional, Takahashi, S., additional, Takeji, S., additional, Takenaga, H., additional, Takizuka, T., additional, Tamai, H., additional, Terakado, M., additional, Terakado, T., additional, Tobita, K., additional, Tokuda, S., additional, Totsuka, T., additional, Toyokawa, Y., additional, Toyoshima, N., additional, Tsuchiya, K., additional, Tsugita, T., additional, Tsukahara, Y., additional, Tuda, T., additional, Uramoto, Y., additional, Ushigusa, K., additional, Usui, K., additional, Yagyu, J., additional, Yamagiwa, M., additional, Yamamoto, M., additional, Yamamoto, T., additional, Yamashita, O., additional, Yokokura, K., additional, Yoshida, H., additional, Yoshida, M., additional, and Yoshino, R., additional

Published
1998
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35. Achievement of High Fusion Performance in JT-60U Reversed Shear Discharges

Author

Ishida, S., primary, Fujita, T., additional, Akasaka, H., additional, Akino, N., additional, Annou, K., additional, Aoyagi, T., additional, Arai, T., additional, Arakawa, K., additional, Asakura, N., additional, Azumi, M., additional, Budny, R., additional, Chiba, S., additional, Da Costa, O., additional, Ebisawa, N., additional, Fujii, T., additional, Fukuda, T., additional, Funahashi, A., additional, Grisham, L., additional, Gunji, S., additional, Hamamatsu, K., additional, Hasegawa, Y., additional, Hatae, T., additional, Higashijima, S., additional, Hiratsuka, H., additional, Hirauchi, S., additional, Hirayama, T., additional, Honda, A., additional, Honda, M., additional, Hosogane, N., additional, Ichige, H., additional, Ide, S., additional, Ikeda, Y., additional, Isaka, M., additional, Isayama, A., additional, Isei, N., additional, Ishii, Y., additional, Isozaki, N., additional, Itami, K., additional, Itoh, T., additional, Iwahashi, T., additional, Kamada, Y., additional, Kaminaga, A., additional, Kashiwabara, T., additional, Kawai, M., additional, Kawamata, Y., additional, Kawano, Y., additional, Kazama, D., additional, Kazawa, M., additional, Kikuchi, M., additional, Kimura, H., additional, Kimura, T., additional, Kishimoto, H., additional, Kishimoto, Y., additional, Kitamura, S., additional, Kiyono, K., additional, Kodama, K., additional, Koide, Y., additional, Kokusen, S., additional, Kondoh, T., additional, Konoshima, S., additional, Koog, J., additional, Kramer, G. J., additional, Kubo, H., additional, Kurihara, K., additional, Kurita, G., additional, Kuriyama, M., additional, Kusama, Y., additional, Masaki, K., additional, Matsuda, T., additional, Matsumoto, T., additional, Matukawa, M., additional, Miura, T., additional, Miya, N., additional, Miyachi, K., additional, Miyata, H., additional, Miyo, Y., additional, Mogaki, K., additional, Mori, M., additional, Morimoto, M., additional, Morioka, S., additional, Moriyama, S., additional, Nagami, M., additional, Nagashima, A., additional, Nagashima, K., additional, Nagaya, S., additional, Naito, O., additional, Nakamura, Y., additional, Nemoto, M., additional, Neyatani, Y., additional, Nishitani, T., additional, Ogiwara, N., additional, Ohga, T., additional, Ohsawa, M., additional, Ohshima, T., additional, Oikawa, T., additional, Okabe, T., additional, Okano, J., additional, Omori, K., additional, Omori, S., additional, Omori, Y., additional, Onose, Y., additional, Oohara, H., additional, Ozeki, T., additional, Saidoh, M., additional, Saigusa, M., additional, Saito, N., additional, Sakasai, A., additional, Sakata, S., additional, Sakurai, S., additional, Sasajima, T., additional, Sato, M., additional, Scott, S. D., additional, Seimiya, M., additional, Seiki, H., additional, Seki, M., additional, Shimada, M., additional, Shimizu, K., additional, Shimizu, M., additional, Shimono, M., additional, Shinozaki, S., additional, Shirai, H., additional, Shitomi, M., additional, Suganuma, K., additional, Sugie, T., additional, Sunaoshi, H., additional, Takahashi, M., additional, Takahashi, S., additional, Takeji, S., additional, Takenaga, H., additional, Takizuka, T., additional, Tamai, H., additional, Terakado, M., additional, Terakado, T., additional, Tobita, K., additional, Tokuda, S., additional, Totsuka, T., additional, Toyokawa, Y., additional, Toyoshima, N., additional, Tsuchiya, K., additional, Tsugita, T., additional, Tsukahara, Y., additional, Tuda, T., additional, Uramoto, Y., additional, Ushigusa, K., additional, Usui, K., additional, Yagyu, J., additional, Yamagiwa, M., additional, Yamamoto, M., additional, Yamamoto, T., additional, Yamashita, O., additional, Yokokura, K., additional, Yoshida, H., additional, Yoshida, M., additional, and Yoshino, R., additional

Published
1997
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40. Ultrasonography of Thymoma with Pathologic Correlation

Author

Sakai, F., primary, Sone, S., additional, Kawai, T., additional, Maruyama, A., additional, Kiyono, K., additional, Morimoto, M., additional, Haniuda, M., additional, Honda, T., additional, Ishi, K., additional, Ikeda, S.-I., additional, Kobayashi, O., additional, and Nishimura, H., additional

Published
1994
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46. Development and operation of JT-60 lhrf launchers

Author

Ikeda, Y., primary, Imai, T., additional, Seki, M., additional, Sakamoto, K., additional, Konishi, K., additional, Kiyono, K., additional, Maebara, S., additional, Nagashima, T., additional, Naito, O., additional, Sawahata, M., additional, Suganuma, N., additional, Suzuki, N., additional, Uehara, K., additional, Ushigusa, K., additional, and Yokokura, M., additional

Published
1991
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47. Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling.

Author

Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe A, Aburatani H, Miyoshi H, Kiyono K, Shirai YT, Suzuki HI, Hirakawa K, Kano MR, Miyazono K, Komuro, Akiyoshi, Yashiro, Masakazu, Iwata, Caname, Morishita, Yasuyuki, and Johansson, Erik

Abstract

Background: Diffuse-type gastric carcinoma is a cancer with poor prognosis that has high levels of transforming growth factor beta (TGF-beta) expression and thick stromal fibrosis. However, the association of TGF-beta signaling with diffuse-type gastric carcinoma has not been investigated in detail.Methods: We used a lentiviral infection system to express a dominant-negative TGF-beta type II receptor (dnTbetaRII) or green fluorescent protein (GFP) as a control in the diffuse-type gastric carcinoma cell lines, OCUM-2MLN and OCUM-12. These infected cells and the corresponding parental control cells were subcutaneously or orthotopically injected into nude mice. Angiogenesis was inhibited by infecting cells with a lentivirus carrying the gene for angiogenic inhibitor thrombospondin-1 or by injecting mice intraperitoneally with the small-molecule angiogenic inhibitor sorafenib or with anti-vascular endothelial growth factor (VEGF) neutralizing antibody (six or eight mice per group). Expression of phospho-Smad2 and thrombospondin-1 was investigated immunologically in human gastric carcinoma tissues from 102 patients. All statistical tests were two-sided.Results: Expression of dnTbetaRII into OCUM-2MLN cells did not affect their proliferation in vitro, but it accelerated the growth of subcutaneously or orthotopically transplanted tumors in vivo (eg, for mean volume of subcutaneous tumors on day 10 relative to that on day 0: dnTbetaRII tumors = 3.49 and GFP tumors = 2.46, difference = 1.02, 95% confidence interval [CI] = 0.21 to 1.84; P = .003). The tumors expressing dnTbetaRII had higher levels of angiogenesis than those expressing GFP because of decreased thrombospondin-1 production. Similar results were obtained with OCUM-12 cells. Expression of thrombospondin-1 in the dnTbetaRII tumor or treatment with sorafenib or anti-VEGF antibody reduced tumor growth, whereas knockdown of thrombospondin-1 expression resulted in more accelerated growth of OCUM-2MLN tumors than of GFP tumors (eg, mean tumor volumes on day 14 relative to those on day 0: thrombospondin-1-knockdown tumors = 4.91 and GFP tumors = 3.79, difference = 1.12, 95% CI = 0.80 to 1.44; P < .001). Positive association between phosphorylated Smad2 and thrombospondin-1 immunostaining was observed in human gastric carcinoma tissues.Conclusions: Disruption of TGF-beta signaling in diffuse-type gastric carcinoma models appeared to accelerate tumor growth, apparently through increased tumor angiogenesis that was induced by decreased expression of thrombospondin-1. [ABSTRACT FROM AUTHOR]

Published
2009
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48. Recent results of LH experiments on the JT-60 tokamak

Author

Akaoka, N, primary, Akasaka, H, additional, Akiba, M, additional, Akino, N, additional, Ando, T, additional, Annou, K, additional, Aoyagi, T, additional, Arai, T, additional, Arakawa, K, additional, Araki, M, additional, Azumi, M, additional, Chiba, S, additional, Dairaku, M, additional, Ebisawa, N, additional, Fujii, T, additional, Fukuda, T, additional, Funahashi, A, additional, Furukawa, H, additional, Gunji, H, additional, Hamamatsu, K, additional, Hanada, M, additional, Hara, M, additional, Haraguchi, K, additional, Hiratsuka, H, additional, Hirayama, T, additional, Hiroki, S, additional, Hiruta, K, additional, Honda, M, additional, Horiike, H, additional, Hosogane, N, additional, Iida, Y, additional, Iijima, T, additional, Ikeda, K, additional, Ikeda, Y, additional, Imai, T, additional, Inoue, T, additional, Isaji, N, additional, Isaka, M, additional, Isei, N, additional, Ishida, S, additional, Itami, K, additional, Itige, N, additional, Ito, T, additional, Kakizaki, T, additional, Kamada, Y, additional, Kaminaga, A, additional, Kaneko, T, additional, Kawai, M, additional, Kawabe, M, additional, Kawamata, Y, additional, Kawano, Y, additional, Kikuchi, K, additional, Kikuchi, M, additional, Kimura, H, additional, Kimura, T, additional, Kishimoto, H, additional, Kitamura, S, additional, Kiyono, K, additional, Kodama, K, additional, Koide, Y, additional, Koide, T, additional, Kobayashi, T, additional, Komata, M, additional, Kondo, I, additional, Kondo, T, additional, Konoshima, S, additional, Kubo, H, additional, Kunieda, S, additional, Kurihara, K, additional, Kuriyama, M, additional, Kusaka, M, additional, Kusama, Y, additional, Kushima, T, additional, Maeno, M, additional, Matoba, T, additional, Matsuda, S, additional, Matsukawa, M, additional, Matsuoka, M, additional, Matsuzaki, Y, additional, Miura, Y, additional, Miya, N, additional, Miyachi, K, additional, Miyake, K, additional, Miyo, Y, additional, Mizuno, M, additional, Mogaki, K, additional, Moriyama, S, additional, Murakami, Y, additional, Muto, M, additional, Nagami, M, additional, Nagashima, A, additional, Nagashima, K, additional, Nagashima, T, additional, Nagaya, S, additional, Nagayama, K, additional, Naito, O, additional, Nakamura, H, additional, Nagafuji, T, additional, Nemoto, H, additional, Nemoto, M, additional, Neyatani, Y, additional, Ninomiya, H, additional, Nishino, N, additional, Nishitani, T, additional, Nobusaka, H, additional, Nomata, H, additional, Oikawa, A, additional, Obara, K, additional, Odajima, K, additional, Ogiwara, N, additional, Ohga, T, additional, Ohara, Y, additional, Oohara, H, additional, Ohshima, T, additional, Ohta, K, additional, Ohta, M, additional, Ohuchi, S, additional, Ohuchi, Y, additional, Okumura, H, additional, Omori, K, additional, Omori, S, additional, Omori, Y, additional, Ozeki, T, additional, Saegusa, M, additional, Saitoh, N, additional, Sakasai, A, additional, Sakata, S, additional, Sakuma, T, additional, Sasajima, T, additional, Satou, K, additional, Satou, M, additional, Sawahata, M, additional, Seimiya, M, additional, Seki, M, additional, Seki, S, additional, Shibanuma, K, additional, Shimada, M, additional, Shimizu, K, additional, Shimizu, M, additional, Shimomura, Y, additional, Shinozaki, S, additional, Shirai, H, additional, Shirakata, H, additional, Shitomi, M, additional, Suganuma, K, additional, Sugawara, T, additional, Sugie, T, additional, Sunaoshi, H, additional, Suzuki, M, additional, Suzuki, N, additional, Suzuki, S, additional, Tachibana, H, additional, Takahashi, M, additional, Takahashi, S, additional, Takahashi, T, additional, Takasaki, M, additional, Takatsu, H, additional, Takeuchi, H, additional, Takeshita, A, additional, Takizuka, T, additional, Tamura, S, additional, Tanaka, S, additional, Tanaka, T, additional, Tanaka, Y, additional, Tani, T, additional, Terakado, M, additional, Terakado, T, additional, Tobita, K, additional, Totsuka, T, additional, Toyoshima, N, additional, Tsugita, T, additional, Tsuji, S, additional, Tsukahara, Y, additional, Tsuneoka, M, additional, Uehara, K, additional, Uramoto, Y, additional, Usami, H, additional, Ushigusa, K, additional, Usui, K, additional, Yagyu, J, additional, Yamagishi, K, additional, Yamagiwa, M, additional, Yamamoto, M, additional, Yamashita, O, additional, Yamazaki, T, additional, Yokokura, K, additional, Yokoyama, K, additional, Yoshida, H, additional, Yoshida, Z, additional, Yoshino, R, additional, Yoshioka, Y, additional, Yonekawa, I, additional, and Watanabe, K, additional

Published
1990
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49. High resolution ultrasound of the chest wall

Author

Sakai, F., primary, Sone, S., additional, Kiyono, K., additional, Imai, S., additional, Izuno, I., additional, Oguchi, M., additional, Okazaki, Y., additional, Kasuga, T., additional, and Ehara, T., additional

Published
1990
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