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31 results on '"Kiyozawa, Daisuke"'

3. Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer

Author

Tanoue, Kenro, Ohmura, Hirofumi, Uehara, Koki, Ito, Mamoru, Yamaguchi, Kyoko, Tsuchihashi, Kenji, Shinohara, Yudai, Lu, Peng, Tamura, Shingo, Shimokawa, Hozumi, Isobe, Taichi, Ariyama, Hiroshi, Shibata, Yoshihiro, Tanaka, Risa, Kusaba, Hitoshi, Esaki, Taito, Mitsugi, Kenji, Kiyozawa, Daisuke, Iwasaki, Takeshi, Yamamoto, Hidetaka, Oda, Yoshinao, Akashi, Koichi, and Baba, Eishi

Published
2024
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5. Giant cranial angiolipoma with arteriovenous fistula: A case report.

Author

Hatae, Ryusuke, Mizoguchi, Masahiro, Arimura, Koichi, Kiyozawa, Daisuke, Shimogawa, Takafumi, Sangatsuda, Yuhei, Nishimura, Ataru, Ono, Kotaro, Oda, Yoshinao, and Yoshimoto, Koji

Subjects
Angiolipomas, Arteriovenous fistula, Epilepsy, Hemorrhage, Skull tumor
Abstract

BACKGROUND: Angiolipomas are benign mesenchymal tumors comprising mature adipocytes and abnormal blood vessels, commonly found in the subcutaneous tissue of the trunk and rarely in the skull. Furthermore, sporadic cases of angiolipoma with arteriovenous fistula (AVF) have been reported. CASE DESCRIPTION: We reported the case of a 72-year-old woman who presented with head swelling, seizures, and cognitive dysfunction. Computed tomography and magnetic resonance imaging revealed a right frontal bone tumor exceeding a sagittal suture of up to 10.7 cm. Angiography revealed AVF and varices formation. Endovascular embolization was performed to treat the AVF and reduce blood loss during surgical resection. Two days after the embolization, a craniotomy was performed; however, uncontrollable bleeding was observed at the time of tumor resection. Postoperatively, the patient was symptom-free and has been stable for 2 years without recurrence. CONCLUSION: Despite careful preoperative evaluation and treatment planning, the patient in this case report was difficult to treat. Such cases require adequate preparation.

Published
2022

8. Expression of SATB2, RUNX2, and SOX9 and possible osteoblastic and chondroblastic differentiation in chondroblastoma

Author

Toda, Yu, Yamamoto, Hidetaka, Iwasaki, Takeshi, Ishihara, Shin, Ito, Yoshihiro, Susuki, Yosuke, Kawaguchi, Kengo, Kinoshita, Izumi, Kiyozawa, Daisuke, Yamada, Yuichi, Kohashi, Kenichi, Kimura, Atsushi, Fujiwara, Toshifumi, Setsu, Nokitaka, Endo, Makoto, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Mawatari, Masaaki, and Oda, Yoshinao

Published
2023
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9. Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases

Author

Yamada, Yuichi, Kinoshita, Izumi, Miyazaki, Yoshiko, Tateishi, Yuki, Kuboyama, Yusuke, Iwasaki, Takeshi, Kohashi, Kenichi, Yamamoto, Hidetaka, Ishihara, Shin, Toda, Yu, Ito, Yoshihiro, Susuki, Yosuke, Kawaguchi, Kengo, Hashisako, Mikiko, Yamada-Nozaki, Yui, Kiyozawa, Daisuke, Mori, Taro, Yamamoto, Takeo, Tsuchihashi, Kenji, Kuriwaki, Kazumi, Mukai, Munenori, Kawai, Masataka, Suzuki, Keiko, Nishimura, Hirotake, Bando, Kenji, Masumoto, Junya, Fukushima, Mana, Motoshita, Junichi, Mori, Hiroki, Shiose, Akira, and Oda, Yoshinao

Published
2022
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10. Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer.

Author

Tanoue, Kenro, Ohmura, Hirofumi, Uehara, Koki, Ito, Mamoru, Yamaguchi, Kyoko, Tsuchihashi, Kenji, Shinohara, Yudai, Lu, Peng, Tamura, Shingo, Shimokawa, Hozumi, Isobe, Taichi, Ariyama, Hiroshi, Shibata, Yoshihiro, Tanaka, Risa, Kusaba, Hitoshi, Esaki, Taito, Mitsugi, Kenji, Kiyozawa, Daisuke, Iwasaki, Takeshi, and Yamamoto, Hidetaka

Subjects
SQUAMOUS cell carcinoma, T cells, CELL populations, IMMUNE checkpoint proteins, LYMPHOID tissue
Abstract

Despite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear. Here, imaging mass cytometry of tumor tissues from ICB-treated patients identifies a distinct cell population of CD39+PD-1+CD8+ T cells, specifically the TCF1+ subset, precursor exhausted T (CD39+ Tpex) cells, which positively correlate with ICB benefit. CD39+ Tpex cells are predominantly in the stroma, while differentiated CD39+ exhausted T cells are abundantly and proximally within the parenchyma. Notably, CD39+ Tpex cells are concentrated within and around tertiary lymphoid structure (TLS). Accordingly, tumors harboring TLSs have more of these cells in tumor areas than tumors lacking TLSs, suggesting Tpex cell recruitment from TLSs to tumors. In addition, circulating CD39+ Tpex cells are also increased in responders following ICB therapy. Our findings show that this unique subpopulation of CD39+PD-1+CD8+ T cells is crucial for ICB benefit, and suggest a key role in TLS-mediated immune responses against tumors. Immune checkpoint blockade (ICB) benefits esophageal squamous cell cancer, but the immune cell mediators remain unclear. Here the author show, by imaging mass cytometry, that CD39+CD8+ exhausted cells are present abundantly in both tertiary lymphoid tissue and tumor and correlate with responses to ICB. [ABSTRACT FROM AUTHOR]

Published
2024
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11. The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma

Author

Ishihara, Shin, Iwasaki, Takeshi, Kohashi, Kenichi, Yamada, Yuichi, Toda, Yu, Ito, Yoshihiro, Susuki, Yousuke, Kawaguchi, Kengo, Takamatsu, Dai, Kawatoko, Shinichiro, Kiyozawa, Daisuke, Mori, Taro, Kinoshita, Izumi, Yamamoto, Hidetaka, Fujiwara, Toshifumi, Setsu, Nokitaka, Endo, Makoto, Matsumoto, Yoshihiro, Nakashima, Yasuharu, and Oda, Yoshinao

Published
2021
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12. Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment

Author

Toda, Yu, Kohashi, Kenichi, Yamamoto, Hidetaka, Ishihara, Shin, Ito, Yoshihiro, Susuki, Yosuke, Kawaguchi, Kengo, Kiyozawa, Daisuke, Takamatsu, Dai, Kinoshita, Izumi, Yamada, Yuichi, Maehara, Junki, Kimura, Atsushi, Tamiya, Sadafumi, Taguchi, Kenichi, Matsunobu, Tomoya, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Mawatari, Masaaki, and Oda, Yoshinao

Published
2021
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15. Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death

Author

Yamada, Yuichi, Kohashi, Kenichi, Kinoshita, Izumi, Yamamoto, Hidetaka, Iwasaki, Takeshi, Yoshimoto, Masato, Ishihara, Shin, Toda, Yu, Itou, Yoshihiro, Koga, Yutaka, Hashisako, Mikiko, Nozaki, Yui, Kiyozawa, Daisuke, Kitahara, Daichi, Inoue, Takeshi, Mukai, Munenori, Honda, Yumi, Toyokawa, Gouji, Tsuchihashi, Kenji, Matsushita, Yoshifumi, Fushimi, Fumiyoshi, Taguchi, Kenichi, Tamiya, Sadafumi, Oshiro, Yumi, Furue, Masutaka, Nakashima, Yasuharu, Suzuki, Satoshi, Iwaki, Toru, and Oda, Yoshinao

Published
2019
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16. Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer

Author

Onoyama, Ichiro, primary, Kawakami, Minoru, additional, Hachisuga, Kazuhisa, additional, Maenohara, Shoji, additional, Kodama, Keisuke, additional, Yagi, Hiroshi, additional, Yasunaga, Masafumi, additional, Ohgami, Tatsuhiro, additional, Asanoma, Kazuo, additional, Yahata, Hideaki, additional, Kitamura, Yuya, additional, Sakamoto, Ryuichi, additional, Kiyozawa, Daisuke, additional, and Kato, Kiyoko, additional

Published
2023
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17. Comparative analyses of tumour immune microenvironment between collecting duct carcinoma and fumarate hydratase-deficient renal cell carcinoma

Author

Kiyozawa, Daisuke, Kohashi, Kenichi, Takamatsu, Dai, Umekita, Shinya, Eto, Masatoshi, Kinjo, Mitsuru, Nishiyama, Kenichi, Taguchi, Kenichi, Oshiro, Yumi, Kuboyama, Yusuke, and Oda, Yoshinao

Abstract

AimsCollecting duct carcinoma (CDC) and fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) have similar histological morphologies and both show a poor prognosis. Programmed death ligand 1 (PD-L1) inhibitor has been approved for the treatment of RCC. However, tumour-infiltrating neutrophils stimulated by interleukin-8 (IL-8) interfere with PD-L1 inhibitors. Here, we retrospectively analysed PD-L1 and IL-8 expression, and examined its relationship with infiltrating immune cells.MethodsNine cases of CDC and seven cases of FH-deficient RCC were selected. We defined PD-L1 and IL-8 expression by the Tumour Proportion Score and Combined Positive Score (CPS). We counted the numbers of CD8+, CXCR2+, CD11b+, CD66b+and CD33+immune cells located in the tumour components.ResultsA number of CXCR2+(p=0.0058), CD11b+(p=0.0070) and CD66b+(p=0.0067) immune cells infiltrating into CDC were significantly higher than those infiltrating into FH-deficient RCC. In CDC, PD-L1 expression was correlated with a high density of CD8+lymphocytes (p=0.0389), but was not in FH-deficient RCC (p=0.6985). IL-8 CPS was significantly higher in CDC than in FH-deficient RCC (p=0.0069). In addition, among the CDC cases, IL-8 CPS showed significant positive correlations with CXCR2+, CD11b+and CD66b+immune cell densities (p=0.0250, p=0.0104 and p=0.0374, respectively), whereas FH-deficient RCC showed no significant correlations between IL-8 CPS and immune cell densities.ConclusionsOur results suggest the difference of each tumour microenvironment between CDC and FH-deficient RCC, and IL-8 is a potential therapeutic target for treating CDC, but not FH-deficient RCC.

Published
2024
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18. Comparative analyses of tumour immune microenvironment between collecting duct carcinoma and fumarate hydratase-deficient renal cell carcinoma

Author

Kiyozawa, Daisuke, primary, Kohashi, Kenichi, additional, Takamatsu, Dai, additional, Umekita, Shinya, additional, Eto, Masatoshi, additional, Kinjo, Mitsuru, additional, Nishiyama, Kenichi, additional, Taguchi, Kenichi, additional, Oshiro, Yumi, additional, Kuboyama, Yusuke, additional, and Oda, Yoshinao, additional

Published
2022
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20. Approach for reclassification of collecting duct carcinoma and comparative histopathological analysis with SMARCB1/INI1-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma

Author

Kiyozawa, Daisuke, primary, Kohashi, Kenichi, additional, Takamatsu, Dai, additional, Iwasaki, Takeshi, additional, Shibata, Daiki, additional, Tomonaga, Takumi, additional, Tateishi, Yuki, additional, Eto, Masatoshi, additional, Kinjo, Mitsuru, additional, Nishiyama, Kenichi, additional, Taguchi, Kenichi, additional, Oshiro, Yumi, additional, Kuboyama, Yusuke, additional, Furuya, Mitsuko, additional, and Oda, Yoshinao, additional

Published
2022
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21. Prognostic implication of desmoplastic stroma in synovial sarcoma: A histological review

Author

Toda, Yu, primary, Yamada, Yuichi, additional, Kohashi, Kenichi, additional, Ishihara, Shin, additional, Ito, Yoshihiro, additional, Susuki, Yosuke, additional, Kawaguchi, Kengo, additional, Kinoshita, Izumi, additional, Kiyozawa, Daisuke, additional, Mori, Taro, additional, Kuboyama, Yusuke, additional, Tateishi, Yuki, additional, Yamamoto, Hidetaka, additional, Fujiwara, Toshifumi, additional, Setsu, Nokitaka, additional, Endo, Makoto, additional, Matsumoto, Yoshihiro, additional, Nakashima, Yasuharu, additional, Mawatari, Masaaki, additional, and Oda, Yoshinao, additional

Published
2021
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22. Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution

Author

Tateishi, Yuki, primary, Yamada, Yuichi, additional, Katsuki, Masato, additional, Nagata, Takuya, additional, Yamamoto, Hidetaka, additional, Kohashi, Kenichi, additional, Koga, Yutaka, additional, Hashisako, Mikiko, additional, Kiyozawa, Daisuke, additional, Mori, Taro, additional, Kuboyama, Yusuke, additional, Kakinokizono, Ayumi, additional, Miyazaki, Yoshiko, additional, Yamaguchi, Aina, additional, Tsutsui, Hiroyuki, additional, Ninomiya, Toshiharu, additional, Naiki, Hironobu, additional, and Oda, Yoshinao, additional

Published
2021
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23. Morphological, immunohistochemical, and genomic analyses of papillary renal neoplasm with reverse polarity

Author

Kiyozawa, Daisuke, primary, Kohashi, Kenichi, additional, Takamatsu, Dai, additional, Yamamoto, Takeo, additional, Eto, Masatoshi, additional, Iwasaki, Takeshi, additional, Motoshita, Junichi, additional, Shimokama, Tatsuro, additional, Kinjo, Mitsuru, additional, Oshiro, Yumi, additional, Yonemasu, Hirotoshi, additional, and Oda, Yoshinao, additional

Published
2021
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24. Histological background of dedifferentiated solitary fibrous tumour

Author

Yamada, Yuichi, primary, Kohashi, Kenichi, additional, Kinoshita, Izumi, additional, Yamamoto, Hidetaka, additional, Iwasaki, Takeshi, additional, Yoshimoto, Masato, additional, Ishihara, Shin, additional, Toda, Yu, additional, Ito, Yoshihiro, additional, Kuma, Yuki, additional, Yamada-Nozaki, Yui, additional, Koga, Yutaka, additional, Hashisako, Mikiko, additional, Kiyozawa, Daisuke, additional, Kitahara, Daichi, additional, Narutomi, Fumiya, additional, Kuboyama, Yusuke, additional, Nakamura, Takahito, additional, Inoue, Takeshi, additional, Mukai, Munenori, additional, Honda, Yumi, additional, Toyokawa, Gouji, additional, Tsuchihashi, Kenji, additional, Fushimi, Fumiyoshi, additional, Taguchi, Kenichi, additional, Nishiyama, Kenichi, additional, Tamiya, Sadafumi, additional, Oshiro, Yumi, additional, Furue, Masutaka, additional, Nakashima, Yasuharu, additional, Suzuki, Satoshi, additional, Iwaki, Toru, additional, and Oda, Yoshinao, additional

Published
2021
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25. Copy number gain of CMTM6 increases the expression of PD-L1 in undifferentiated pleomorphic sarcoma

Author

Ishihara, Shin, primary, Iwasaki, Takeshi, additional, Kohashi, Kenichi, additional, Yamada, Yuichi, additional, Toda, Yu, additional, Ito, Yoshihiro, additional, Susuki, Yousuke, additional, Kawaguchi, Kengo, additional, Takamatsu, Dai, additional, Kawatoko, Shinichiro, additional, Kiyozawa, Daisuke, additional, Mori, Taro, additional, Kinoshita, Izumi, additional, Yamamoto, Hidetaka, additional, Fujiwara, Toshifumi, additional, Setsu, Nokitaka, additional, Endo, Makoto, additional, Matsumoto, Yoshihiro, additional, Nakashima, Yasuharu, additional, and Oda, Yoshinao, additional

Published
2021
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28. Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion: A potential diagnostic pitfall

Author

Yorita, Kenji, primary, Togashi, Yuki, additional, Nakagawa, Hideyuki, additional, Miyazaki, Katsushi, additional, Sakata, Seiji, additional, Baba, Satoko, additional, Takeuchi, Kengo, additional, Hayashi, Yoshihiro, additional, Murakami, Ichiro, additional, Kuroda, Naoto, additional, Oda, Yoshinao, additional, Kohashi, Kenichi, additional, Yamada, Yuichi, additional, Kiyozawa, Daisuke, additional, Michal, Michael, additional, and Michal, Michal, additional

Published
2019
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29. Histological background of dedifferentiated solitary fibrous tumour

Author

Yamada, Yuichi, Kohashi, Kenichi, Kinoshita, Izumi, Yamamoto, Hidetaka, Iwasaki, Takeshi, Yoshimoto, Masato, Ishihara, Shin, Toda, Yu, Ito, Yoshihiro, Kuma, Yuki, Yamada-Nozaki, Yui, Koga, Yutaka, Hashisako, Mikiko, Kiyozawa, Daisuke, Kitahara, Daichi, Narutomi, Fumiya, Kuboyama, Yusuke, Nakamura, Takahito, Inoue, Takeshi, Mukai, Munenori, Honda, Yumi, Toyokawa, Gouji, Tsuchihashi, Kenji, Fushimi, Fumiyoshi, Taguchi, Kenichi, Nishiyama, Kenichi, Tamiya, Sadafumi, Oshiro, Yumi, Furue, Masutaka, Nakashima, Yasuharu, Suzuki, Satoshi, Iwaki, Toru, and Oda, Yoshinao

Abstract

AimsDedifferentiation is a histological phenomenon characterised by abrupt transition of histology to a sarcomatous component with high-grade malignant potential in solitary fibrous tumour (SFT). The authors histologically reviewed SFT cases to reveal the histological background of dedifferentiated SFTs.MethodsClinicopathological and histopathological findings of 145 SFT cases were reviewed. Immunohistochemical staining and genetic analysis were also performed.ResultsThe non-dedifferentiated components showed a cellular component in 45 of 145 (31%), high mitotic rate (≥4/10 high-powered field) in 12 of 145 (8.2%) tumours, necrosis in 7 of 145 (4.8%) tumours, multinodular growth pattern in 39 of 132 (29.5%) available tumours and intratumoural fibrous septa in 37 of 131 (28.2%). Immunohistochemically, the non-dedifferentiated components were positive for CD34 in 128 of 141 (90.7%), bcl-2 in 101 of 133 (75.9%), nuclear pattern of β-catenin in 64 of 127 (50.3%) and p16 in 22 of 140 (15.7%). Loss of Rb protein expression was detected in 17 of 110 (15.4%) cases. Statistically, cellular component, multinodular structure, p16 overexpression and Rb protein loss were significantly associated with dedifferentiation. Moreover, cellular component and multinodular structure were significantly associated with p16 overexpression and Rb protein loss. All the non-deddifferentiated components showed wild type of p53 expression. The dedifferentiated components of all 10 dedifferentiated tumours presented positivity for p16 in 9 of 10 (90%) and mutational type of p53 in 5 of 10 (50%). Loss of Rb protein expression was detected in 6 of 10 (60%).ConclusionsThe authors propose that cellular or multinodular transformation may be associated with dedifferentiation. They also suggest that cellular and multinodular transformation may be associated with p16 overexpression and Rb downregulation.

Published
2022
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30. Prognostic implication of desmoplastic stroma in synovial sarcoma: A histological review.

Author

Toda Y, Yamada Y, Kohashi K, Ishihara S, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Kiyozawa D, Mori T, Kuboyama Y, Tateishi Y, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Mawatari M, and Oda Y

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Collagen, Extracellular Matrix pathology, Female, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Sclerosis pathology, Young Adult, Sarcoma, Synovial pathology, Soft Tissue Neoplasms pathology
Abstract

Synovial sarcoma (SS) is a malignant soft tissue neoplasm harboring SS18-SSX fusion gene and is histologically characterized by spindle cells and epithelial components. Some investigations have demonstrated that desmoplastic reaction (DR) is an independent prognostic factor of cancers. However, it remains unknown whether DR is of predictive value for the prognosis of synovial sarcoma patients. Here, we reviewed the clinical and histological findings of 88 patients with SS. We defined DR as hyalinized collagenous structures and classified the degree of DR as follows: none, mild, moderate, and severe. Overall, 23 SS cases (24%) showed moderate or severe DR histologically. Statistically, the cases with moderate or severe degree of DR showed poorer prognosis than those with no or mild DR (local recurrence: P = 0.0059, distant metastasis: P = 0.0002, tumor death: P = 0.0382). The findings of the study suggest that the DR of synovial sarcoma could be an important prognostic factor., (Copyright © 2021 Elsevier GmbH. All rights reserved.)

Published
2021
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31. Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution.

Author

Tateishi Y, Yamada Y, Katsuki M, Nagata T, Yamamoto H, Kohashi K, Koga Y, Hashisako M, Kiyozawa D, Mori T, Kuboyama Y, Kakinokizono A, Miyazaki Y, Yamaguchi A, Tsutsui H, Ninomiya T, Naiki H, and Oda Y

Subjects
Adult, Aged, Aged, 80 and over, Amyloid Neuropathies, Familial immunology, Amyloid Neuropathies, Familial pathology, Amyloidosis immunology, Autopsy, Biomarkers analysis, Cardiomyopathies immunology, Female, Humans, Immunoglobulin Light-chain Amyloidosis immunology, Immunoglobulin Light-chain Amyloidosis pathology, Immunoglobulin kappa-Chains analysis, Immunoglobulin lambda-Chains analysis, Japan, Male, Middle Aged, Myocardium immunology, Prealbumin analysis, Predictive Value of Tests, Young Adult, beta 2-Microglobulin analysis, Amyloidosis pathology, Cardiomyopathies pathology, Immunohistochemistry, Myocardium pathology
Abstract

Aim: Amyloidosis is a systemic or localized disease of protein deposition characterized by amorphous eosinophilic morphology and positivity of Congo Red staining. The typing of amyloidosis is becoming increasingly important because therapeutic agents for each amyloidosis type have been developed. Herein, the authors review the autopsy cases at an institution to reveal the putative Japanese characteristics of each amyloidosis type and evaluate the clinicopathological significance of each type., Materials and Methods: A total of 131 autopsy cases of systemic and localized amyloidosis were retrieved for classification by immunohistochemistry. Immunohistochemistry for transthyretin, amyloid A (AA), immunoglobulin light-chain kappa and lambda, and β2-microglobulin was performed for all cases., Results: The 131 amyloidosis cases were classified as follows: 71 cases (54.2%) of transthyretin amyloidosis, 32 cases (24.4%) of AA amyloidosis, 8 cases (6.1%) of light-chain amyloidosis, and 5 cases (3.8%) of β2-microglobulin amyloidosis, along with 15 equivocal cases (11.5%). All cases showed myocardial involvement of amyloidosis. Histopathologically, the transthyretin type was significantly associated with the interstitial and nodular patterns, and with the absence of the perivascular and endocardial patterns. The AA type was significantly associated with the perivascular and endocardial patterns, and with the absence of the nodular pattern., Conclusion: The authors revealed the putative characteristics of cardiac amyloidosis in Japan by using autopsy cases. About 90% of amyloidosis cases were successfully classified using only commercially available antibodies., (Copyright © 2021 Elsevier GmbH. All rights reserved.)

Published
2021
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