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21 results on '"Kizlaitienė, Rasa"'

6. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author

Achiron, Anat, Achtnichts, Lutz, Agan, Kadriye, Akman-Demir, Gulsen, Allen, Alison B, Antel, Jack P, Antiguedad, Alfredo Rodriguez, Apperson, Michelle, Applebee, Angela M, Ayuso, Guillermo Izquierdo, Baba, Masayuki, Bajenaru, Ovidiu, Balasa, Rodica, Balci, Belgin Petek, Barnett, Michael, Bass, Ann, Becker, Veit U, Bejinariu, Mihaela, Bergh, Florian Then, Bergmann, Arnfin, Bernitsas, Evanthia, Berthele, Achim, Bhan, Virender, Bischof, Felix, Bjork, Randall John, Blevins, Gregg, Boehringer, Matthias, Boerner, Thomas, Bonek, Robert, Bowen, James D, Bowling, Allen, Boyko, Alexey N, Boz, Cavit, Bracknies, Vera, Braune, Stefan, Brescia Morra, Vincenzo, Brochet, Bruno, Brola, Waldemar, Brownstone, Paul Kenneth, Brozman, Miroslav, Brunet, Donald, Buraga, Ioan, Burnett, Margaret, Buttmann, Mathias, Butzkueven, Helmut, Cahill, Jonathan, Calkwood, Jonathan C, Camu, William, Cascione, Mark, Castelnovo, Giovani, Centonze, Diego, Cerqueira, Joao, Chan, Andrew, Cimprichova, Andrea, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cooper, Joanna A, Corboy, John, Correale, Jorge, Costell, Brian, Cottrell, David A, Coyle, Patricia K, Craner, Matthew, Cui, Liying, Cunha, Luis, Czlonkowska, Anna, da Silva, Ana Martins, de Sa, Joao, de Seze, Jérôme, Debouverie, Marc, Debruyne, Jan, Decoo, Danny, Defer, Gilles, Derfuss, Tobias, Deri, Norma H, Dihenia, Bhupesh, Dioszeghy, Peter, Donath, Vladimir, Dubois, Benedicte, Duddy, Martin, Duquette, Pierre, Edan, Gilles, Efendi, Husnu, Elias, Stanton, Emrich, Peter J, Estruch, Bonaventura Casanova, Evdoshenko, Evgeniy P, Faiss, Juergen, Fedyanin, Alexander S, Feneberg, Wolfgang, Fermont, Jiske, Fernandez, Oscar Fernandez, Ferrer, Francisco Coret, Fink, Katharina, Ford, Helen, Ford, Corey, Francia, Ada, Freedman, Mark, Frishberg, Benjamin, Galgani, Simonetta, Garmany, George P, Gehring, Klaus, Gitt, Jeffrey, Gobbi, Claudio, Goldstick, Lawrence P, Gonzalez, Rafael Arroyo, Grandmaison, Francois, Grigoriadis, Nikolaos, Grigorova, Olga, Grimaldi, Luigi Maria Edoardo, Gross, Jeffrey, Gross-Paju, Katrin, Gudesblatt, Mark, Guillaume, Daniel, Haas, Judith, Hancinova, Viera, Hancu, Anca, Hardiman, Orla, Harmjanz, Arndt, Heidenreich, Fedor R, Hengstman, G J D, Herbert, Joseph, Herring, Mark, Hodgkinson, Suzanne, Hoffmann, Olaf M, Hofmann, Werner E, Honeycutt, William D, Hua, Le Hanh, Huang, Dehui, Huang, Yining, Huang, DeRen, Hupperts, Raymond, Imre, Piroska, Jacobs, Alan Keith, Jakab, Gabor, Jasinska, Elzbieta, Kaida, Kenichi, Kalnina, Jolanta, Kaprelyan, Ara, Karelis, Guntis, Karussis, Dimitrios, Katz, Amos, Khabirov, Farit A, Khatri, Bhupendra, Kimura, Takashi, Kister, Ilya, Kizlaitiene, Rasa, Klimova, Eleonora, Koehler, Juergen, Komatineni, Aparna, Kornhuber, Anselm, Kovacs, Krisztina, Koves, Agnes, Kozubski, Wojciech, Krastev, Georgi, Krupp, Lauren B, Kurca, Egon, Lassek, Christoph, Laureys, Guy, Lee, Liesly, Lensch, Eckart, Leutmezer, Fritz, Li, Hongzeng, Linker, Ralf A, Linnebank, Michael, Liskova, Petra, Llanera, Cristina, Lu, Jiahong, Lutterotti, Andreas, Lycke, Jan, Macdonell, Richard, Maciejowski, Maciej, Maeurer, Mathias, Magzhanov, Rim V, Maida, Eva-Maria, Malciene, Lina, Mao-Draayer, Yang, Marfia, Girolama Alessandra, Markowitz, Clyde, Mastorodimos, Vasileios, Matyas, Klotild, Meca-Lallana, Jose, Merino, Juan Antonio Garcia, Mihetiu, Ioan Gheorghe, Milanov, Ivan, Miller, Aaron E, Millers, Andrejs, Mirabella, Massimiliano, Mizuno, Masanori, Montalban, Xavier, Montoya, Lilina, Mori, Masahiro, Mueller, Stefanie, Nakahara, Jin, Nakatsuji, Yuji, Newsome, Scott, Nicholas, Richard, Nielsen, A Scott, Nikfekr, Esmaeil, Nocentini, Ugo, Nohara, Chiyoko, Nomura, Kyoichi, Odinak, Miroslav M, Olsson, Tomas, van Oosten, B W, Oreja-Guevara, Celia, Oschmann, Patrick, Overell, James, Pachner, Andrew, Panczel, Gyula, Pandolfo, Massimo, Papeix, Caroline, Patrucco, Liliana, Pelletier, Jean, Piedrabuena, Raul, Pless, Misha, Polzer, Udo, Pozsegovits, Krisztian, Rastenyte, Daiva, Rauer, Sebastian, Reifschneider, Gerd, Rey, Roberto, Rizvi, Syed A, Robertson, Derrick, Rodriguez, Jose Martinez, Rog, David, Roshanisefat, Homayoun, Rowe, Vernon, Rozsa, Csilla, Rubin, Susan, Rusek, Stanislaw, Saccà, Francesco, Saida, Takahiko, Salgado, Antonio Vasco, Sanchez, Victoria Eugenia Fernandez, Sanders, Kalina, Satori, Maria, Sazonov, Denis V, Scarpini, Elio Angelo, Schlegel, Eugen, Schluep, Myriam, Schmidt, Stephan, Scholz, Erich, Schrijver, H M, Schwab, Matthias, Schwartz, Raymond, Scott, James, Selmaj, Krzysztof, Shafer, Stuart, Sharrack, Basil, Shchukin, Ivan A, Shimizu, Yuko, Shotekov, Penko, Siever, Arno, Sigel, Karl-Otto, Silliman, Scott, Simo, Magdolna, Simu, Mihaela, Sinay, Vladimiro, Siquier, Antonio Escartin, Siva, Aksel, Skoda, Ondrej, Solomon, Andrew, Stangel, Martin, Stefoski, Dusan, Steingo, Brian, Stolyarov, Igor D, Stourac, Pavel, Strassburger-Krogias, Katrin, Strauss, Erik, Stuve, Olaf, Tarnev, Ivaylo, Tavernarakis, Antonios, Tello, Cristina Ramo, Terzi, Murat, Ticha, Veronika, Ticmeanu, Marina, Tiel-Wilck, Klaus, Toomsoo, Toomas, Tubridy, Niall, Tullman, Mark J, Tumani, Hayrettin, Turcani, Peter, Turner, Ben, Uccelli, Antonio, Urtaza, Francisco Javier Olascoaga, Vachova, Marta, Valikovics, Attila, Walter, Silke, Van Wijmeersch, Bart, Vanopdenbosch, Ludo, Weber, Joerg R, Weiss, Sara, Weissert, Robert, Vermersch, Patrick, West, Timothy, Wiendl, Heinz, Wiertlewski, Sandrine, Wildemann, Brigitte, Willekens, Barbara, Visser, L H, Vorobeychik, Galina, Xu, Xianhao, Yamamura, Takashi, Yang, Yi N, Yelamos, Sergio Martinez, Yeung, Michael, Zacharias, Alan, Zelkowitz, Marvin, Zettl, Uwe, Zhang, Meini, Zhou, Hongyu, Zieman, Ulf, Ziemssen, Tjalf, Kappos, Ludwig, Bar-Or, Amit, Cree, Bruce A C, Fox, Robert J, Giovannoni, Gavin, Gold, Ralf, Arnold, Douglas L, Arnould, Sophie, Scherz, Tatiana, Wolf, Christian, Wallström, Erik, and Dahlke, Frank

Published
2018
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7. Differences in temporal gait parameters between multiple sclerosis and healthy people

Author

Daunoravičienė, Kristina, Apanskienė, Vigita, Žižienė, Jurgita, Ovčinikova, Agnė, Kizlaitienė, Rasa, Sereikė, Ieva, Kaubrys, Gintaras, Lukšys, Donatas, Griškevičius, Julius, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, and Badnjevic, Almir, editor

Published
2017
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9. Cirkadinio ritmo ypatumų ir chronotipų ryšys su išsėtine skleroze: literatūros apžvalga

Author

Jonušaitė, Ieva, Sakalauskaitė-Juodeikienė, Eglė, Mameniškienė, Rūta, and Kizlaitienė, Rasa

Subjects
circadian rhythm, chronotype, multiple sclerosis, melatonin, oxidative stress
Abstract

Circadian rhythm disorder is described as discrepancy between person’s sleep habits and usual, generally accepted sleep model during 24-hour period. Circadian rhythm disorders affect not only person’s working capacity during the day but also may reduce quality of life. The term chronotype refers to a specific circadian rhythm manifestation – person’s preference to sleep and to be awake at some point of 24-hour period. Both circadian rhythm disorders and increased serum levels of proinflammatory cytokines are considered as factors negatively affecting sleep homeostasis among patients with multiple sclerosis. It is important to recognize and manage circadian rhythm variations and associated sleep disorders among patients with multiple sclerosis in order to reduce fatigue, improve cognitive functions and mood, and general quality of life. In this review article, we describe mechanism of action of circadian rhythm, its imbalances, objective and subjective evaluation methods of circadian rhythm and chronotypes, as well as relationship between circadian rhythm characteristics, chronotypes, melatonin concentration, oxidative stress, and multiple sclerosis.

Published
2021

10. Išsėtinės sklerozės gydymo ligos eigą modifikuojančiais vaistais rekomendacijos COVID-19 pandemijos metu

Author

Kizlaitienė, Rasa, Giedraitienė, Nataša, Sereikė, Ieva, Liutkienė, Justina, Leščinskienė, Loreta Meilutė, and Kaubrys, Gintaras Ferdinandas

Subjects
COVID-19 pandemic, multiple sclerosis, disease-modifying therapies
Abstract

The novel coronavirus 2019 (COVID-19) and the subsequent pandemic present a challenge to neurologists treating patients with multiple sclerosis (MS) worldwide. Many national professional bodies have responded rapidly by issuing guidelines for the COVID-19 pandemic, primarily focused on MS disease-modifying therapies (DMTs). In this article, we review implications of COVID-19 for people with MS, including general health advice, the risk of respiratory infections, basic recommendations for relapse management, MS treatment, including disease-modifying therapies, and medical services for MS patients during the COVID-19 pandemic.

Published
2020

11. Multiple sclerosis: overview of orally administrated disease-modifying drugs. Do genetics influence the success of treatment?

Author

Ovčinikova, Agnė and Kizlaitienė, Rasa

Subjects
multiple sclerosis, orally administrated drugs, fingolimod, dimethyl fumarate, teriflunamide, human leukocite antigen
Abstract

Multiple sclerosis (MS) is the main cause of acquired neurological disability in the young people. In MS treatment, disease modifying therapies (DMTs) are essential to reduce disease progression by suppressing the inflammatory response responsible for promoting lesion formation. Injectable (Interferons and Glatiramer acetate) and infusion (Natalizumab, Alemtuzumab) therapies are both effective however rather exhausting for patients. Recently, in addition to the injectable and infusion DMTs, new orally administered drugs have been approved for MS therapy: fingolimode, dimethyl fumarate, and teriflunomide. These drugs act with different mechanisms on the immune system and are more comfortable for MS patients. In this review we provide a systematic description of the new oral drugs fingolimod, dimethyl fumarate and teriflunomide and also introduce the influence of polymorphic gene variants in the Human Leukocyte Antigen region on the risk of developing MS and its progression and effectiveness of DMTs.

Published
2019

16. Kognityvinių funkcijų sutrikimai sergant išsėtine skleroze, jų ryšys su demografiniais klinikiniais rodikliais ir pakitimais magnetinio rezonanso tomografijos tyrime

Author

Kizlaitienė, Rasa, TUTKUVIENĖ, JANINA, VALEVIČIENĖ, NOMEDA, VAITKUS, ANTANAS, MACKEVIČIENĖ, DALIA, JATUŽIS, DALIUS, ULOZIENĖ, INGRIDA, MAMENIŠKIENĖ, RŪTA, and Vilnius University

Subjects
Multiple sclerosis, Magnetic resonance imaging, Cognitive dysfunction, Kognityvinės funkcijos, Magnetnio rezonanso tomografija, Medicine, Išsėtinė sklerozė
Abstract

Išsėtinė sklerozė (IS) – demielinizuojanti uždegiminė neurologinė liga, kylanti dažniausiai jauniems žmonėms. Svarbi ne tik IS fizinė negalia, bet ne mažiau svarbi ir kognityvinė negalia, kuri reiškiasi kognityvinių funkcijų sutrikimu (KFS). Nors KFS simptomai gali būti labai įvairūs, dažniausiai nukenčia išmokimas, atmintis, dėmesys, informacijos apdorojimo greitis, vizualiniai konstrukciniai gebėjimai ir valdomosios funkcijos. Darbo tikslas buvo įvertinti demografinių ir klinikinių ligos rodiklių bei pakitimų magnetinio rezonanso tomografijos tyrime įtaką išsėtine skleroze sergančių ligonių kognityvinėms funkcijoms (KF). Ištyrėme 120 IS sergančių ligonių ir 40 sveikų asmenų. Įvertinome fizinę negalią, subjektyvius nusiskundimus atmintimi ir nuovargiu, objektyvų nuovargį, depresiją ir nerimą. Kognityvinių funkcijų vertinimui buvo atlikta vienuolikos kognityvinių testų rinkinys. Galvos smegenų magnetinio rezonanso tomografijos (MRT) tyrimuose įvertintas demielinizacijos židinių skaičius, tiesiniai atrofijos matmenys ir jų santykiai. Sergančių IS KF buvo blogesnės nei sveikų asmenų, priklausė nuo ligos eigos, objektyvi depresija blogino KF rezultatus. IS subjektyvūs skundai atmintimi ir nuovargiu neturėjo ryšio su KF. IS sergančiųjų KFS ir galvos smegenų atrofija buvo labiau išreikšti sergant antrinės progresuojančios (AP) negu recidyvuojančios remituojančios (RR) eigos IS. MRT židinių skaičiaus įtaka KF testų rezultatams labiau atsispindėjo IS pradžioje. Sergančiuosius RR ir... [toliau žr. visą tekstą] Multiple sclerosis (MS) is a chronic demyelinating inflammatory neurological disease in young adults. Cognitive dysfunction (CD) contributes significantly to patient’s disability status. Although almost all kind of CD can be observed in MS, the typical profile is the impairment of information processing speed, memory, attention and often executive skills. The aim of the study was to investigate the influence of different demographic and clinical markers of the disease and changes in MRI tomography on cognitive functions in MS patients. The study involved 120 patients with MS and 40 healthy controls. Neurological examination, complaints of memory and fatigue, objective depression, anxiety and objective fatigue were evaluated. Cognitive functions (CF) were tested using battery of 11 cognitive tests. Brain MRI was performed to evaluate focal demyelinised lesions and to calculate regional linear markers of brain atrophy. The impairment of CF was much more expressed in MS patients as compared to controls. CF were negatively affected by objective depression and disease course. Subjective memory complaints and subjective fatigue in MS patients did not correlate with CF however they did correlate with objective fatigue. Self reported memory impairment worsened with the progression of disease. CD and brain atrophy reflected by MRI linear parameters were more expressed in secondary progressive (SP) MS as compared to relapsing remitting (RR) MS. Number of demyelinated lesions were... [to full text]

Published
2012

18. Estimation of temporal gait parameters of multiple sclerosis patients in clinical setting using inertial sensors.

Author

Griškevičius, Julius, Apanskienė, Vigita, Žižienė, Jurgita, Daunoravičienė, Kristina, Ovčinikova, Agnė, Kizlaitienė, Rasa, Sereikė, Ieva, Kaubrys, Gintaras, Pauk, Jolanta, and Idźkowski, Adam

Subjects
MULTIPLE sclerosis, GAIT in humans, WALKING, NEUROLOGICAL disorders, YOUNG adults
Abstract

Multiple sclerosis (MS) is the most frequent neurological disease causing permanent disability in young adults. Subtle walking difficulties, such as reduced walking speed, step length, cadence and increased step width can be detected at an early stage of the disease. Main goal of this research is by using non-invasive wireless inertial sensors measure gait of MS patients in clinical setting and extract temporal biomechanical parameters that would allow objectively evaluate level of disability in MS patients. Analysis of 25-Foot walk showed that the duration of stance phase is approximately 1.6 times greater in MS group than in healthy control group, while the duration of swing phase in MS group is 1.3 times longer. In general, the MS patients are walking approximately 1.6 times slower. [ABSTRACT FROM AUTHOR]

Published
2016
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19. COMPREHENSIVE AND UNINTERRUPTIBLE PATIENT MONITORING USING MULTIPLE SCLEROSIS REGISTRY IN LITHUANIA.

Author

Kizlaitienė, Rasa

Subjects
*MEDICAL care, *PATIENT monitoring, *RESOURCE allocation, *MULTIPLE sclerosis, *CLINICAL trials
Abstract

The discussion about the benefits of a robust evidence base derived from clinical trial and real world is becoming important during the last decade. Real world data collection in the clinic and the potential impacts on MS clinical practice allow us to think about the main innovation in the patient care-to provide the information from doctors to doctors. Real world populations may differ from populations studied in age (elderly, paediatrics), ethnicity, co-morbidities, concomitant medications, lifestyle (smoking, diet) and compliance. To improve quality and delivery of medical care, to improve patient outcomes, to optimise allocation of resources, as well as personalised therapy decisions, prediction of individual treatment response for different DMTs we use comprehensive and uninterruptible patient monitoring cloud based multicentre Multiple Sclerosis Registry in Lithuania. From the monitoring point of view, the assessment of relapses, disability progression, evaluation of MRI lesion load and brain atrophy, evoked potentials and retinal changes measured by OCT is really a key aspect. Real world evidence has to become as a new standard of the 21st century in the aim to fill the knowledge gap between clinical trials and clinical practice. [ABSTRACT FROM AUTHOR]

Published
2018

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