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A major flaw in autism spectrum disorder (ASD) management is late diagnosis. Activity-dependent neuroprotective protein (ADNP) is a most frequent de novo mutated ASD-related gene. Functionally, ADNP protects nerve cells against electrical blockade. In mice, complete Adnp deficiency results in dysregulation of over 400 genes and failure to form a brain. Adnp haploinsufficiency results in cognitive and social deficiencies coupled to sex- and age-dependent deficits in the key microtubule and ion channel pathways. Here, collaborating with parents/caregivers globally, we discovered premature tooth eruption as a potential early diagnostic biomarker for ADNP mutation. The parents of 44/54 ADNP-mutated children reported an almost full erupted dentition by 1 year of age, including molars and only 10 of the children had teeth within the normal developmental time range. Looking at Adnp-deficient mice, by computed tomography, showed significantly smaller dental sacs and tooth buds at 5 days of age in the deficient mice compared to littermate controls. There was only trending at 2 days, implicating age-dependent dysregulation of teething in Adnp-deficient mice. Allen Atlas analysis showed Adnp expression in the jaw area. RNA sequencing (RNAseq) and gene array analysis of human ADNP-mutated lymphoblastoids, whole-mouse embryos and mouse brains identified dysregulation of bone/nervous system-controlling genes resulting from ADNP mutation/deficiency (for example, BMP1 and BMP4). AKAP6, discovered here as a major gene regulated by ADNP, also links cognition and bone maintenance. To the best of our knowledge, this is the first time that early primary (deciduous) teething is related to the ADNP syndrome, providing for early/simple diagnosis and paving the path to early intervention/specialized treatment plan.

Substitution of Gd 3+ for Eu 2+ ions in EuTe leads to the introduction of Gd 5d electrons to the conduction band and antiferromagnetic order of EuTe (Heisenberg magnetic semiconductor) can be replaced by ferromagnetic state due to RKKY interaction. The layers were grown by MBE method on BaF 2 (1 1 1) substrate. Layer of Te deposited on top of (EuGd)Te protects surface of oxidation. Heating in 320 °C leads to Te atoms desorption and to improvement of the layer electronic structure. Additional Gd atoms were sequentially deposited on the layer of (PbGd)Te and set of Fano resonance curves were observed for ions of Gd. The Fano type photoemission resonance corresponding to the 4d–4f transitions were studied for Eu and Gd.

The electronic structure of Ge0.4 Mn0.5 Eu0.1 Te has been investigated by means of resonant photoemission spectroscopy. The spectra were acquired for the photon energy ranges of 130–155 and 40–60 eV corresponding to the Eu 4d → 4f and Mn 3p → 3d resonances, respectively. The features related to Eu 4f and Mn 3d states were revealed in the emission from the valence band. It was shown that europium ions occur as Eu2+. The Mn2+ 3d states contribute to the whole valence band with a maximum of the Mn 3d distribution at 3.9 eV.

Agradecimentos: The authors thank J. Morais and M. F. Carazzolle for their help and FAPESP, LNLS, CNPq, and FINEP of Brazil for support Abstract: MVV spectra of Rh, Pd, and Ag were measured with and without ionization of their L3 levels. Extra (MMMVV) structure corresponds to the M45M45 ? M45VV transition following the L3M45M45 transition. We interpret the MMMVV structure for Pd as quasiatomic in nature from its similarity to the corresponding Ag spectral shape and from its agreement with atomic calculations. The Pd quasiatomic MMMVV spectrum arises from a two final-state hole bound state in the Pd d band filled by screening of the core holes. These findings represent the first unambiguous observation of the influence of complete screening on spectral features FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ FINANCIADORA DE ESTUDOS E PROJETOS - FINEP Fechado