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1. Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

Author

Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, and Robba, Chiara

Published
2024
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2. Medical concerns & military thinking : how medical considerations influenced military planning and combat action in the British, French, and German armies during the First World War

Author

Klein, Sam, O'Brien, Phillips Payson, and Strachan, Hew

Subjects
940.3, Military history, Medical history, First World War, Strategic studies, Combat tactics
Abstract

Medical Concerns & Military Thinking investigates in how far and in which ways medical considerations influenced operational planning and combat action in the First World War. The study focuses on the Western Front and centres on the three main forces that were active on this theatre: the British Army, the French Armée de terre, and the German Heer. The dissertation follows on a two-step process. First, it investigates whether medical features did have an influence on decision making processes of combatant officers. It then inquires in how far battlefield reality allowed for these decisions to be implemented. The study shows that combatant officers did consider medical factors in several aspects of their work. In order to reduce wastage, officers had to take medical aspects of the war seriously; Otherwise, they risked that their formations might become inoperable due to high casualty rates. Medical factors were, however, not always compatible with military considerations. In such cases, officers had to weigh medical and military factors in order to decide which considerations should be given precedence in a specific situation. The study shows that defensive and offensive aspects were sometimes compromised in an effort to reduce wastage in the long run. The dissertation follows a chronological structure and lays special emphasis on the year 1916 and the Battles of Verdun and the Somme. While the dissertation embodies a wide range of primary sources, it is primarily based on operation plans, battle reports, and meeting minutes of the three Armies that are currently held at The National Archives, London (GBR), the Service Historique de la Défense, Paris (FRA), and the Bundesarchiv—Abteilung Militärarchiv, Freiburg im Breisgau (GER).

Published
2020
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3. Pleiotropic Roles of VEGF in the Microenvironment of the Developing Thymus

Author

de Barros, Stephanie C, Suterwala, Batul T, He, Chongbin, Ge, Shundi, Chick, Brent, Blumberg, Garrett K, Kim, Kenneth, Klein, Sam, Zhu, Yuhua, Wang, Xiaoyan, Casero, David, and Crooks, Gay M

Subjects
Pediatric, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Animals, Cell Adhesion, Cell Movement, Endothelium, Mesoderm, Mice, Mice, Inbred C57BL, Neovascularization, Pathologic, Pericytes, Thymocytes, Thymus Gland, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-2, Immunology
Abstract

Neonatal life marks the apogee of murine thymic growth. Over the first few days after birth, growth slows and the murine thymus switches from fetal to adult morphology and function; little is known about the cues driving this dramatic transition. In this study, we show for the first time (to our knowledge) the critical role of vascular endothelial growth factor (VEGF) on thymic morphogenesis beyond its well-known role in angiogenesis. During a brief window a few days after birth, VEGF inhibition induced rapid and profound remodeling of the endothelial, mesenchymal and epithelial thymic stromal compartments, mimicking changes seen during early adult maturation. Rapid transcriptional changes were seen in each compartment after VEGF inhibition, including genes involved in migration, chemotaxis, and cell adhesion as well as induction of a proinflammatory and proadipogenic signature in endothelium, pericytes, and mesenchyme. Thymocyte numbers fell subsequent to the stromal changes. Expression patterns and functional blockade of the receptors VEGFR2 and NRP1 demonstrated that VEGF mediates its pleiotropic effects through distinct receptors on each microenvironmental compartment of the developing mouse thymus.

Published
2020

5. Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

Author

Picetti, E, Demetriades, A, Catena, F, Aarabi, B, Abu-Zidan, F, Alves, O, Ansaloni, L, Armonda, R, Badenes, R, Bala, M, Balogh, Z, Barbanera, A, Bertuccio, A, Biffl, W, Bouzat, P, Buki, A, Castano-Leon, A, Cerasti, D, Citerio, G, Coccolini, F, Coimbra, R, Coniglio, C, Costa, F, De Iure, F, Depreitere, B, Fainardi, E, Fehlings, M, Gabrovsky, N, Godoy, D, Gruen, P, Gupta, D, Hawryluk, G, Helbok, R, Hossain, I, Hutchinson, P, Iaccarino, C, Inaba, K, Ivanov, M, Kaprovoy, S, Kirkpatrick, A, Klein, S, Kolias, A, Konovalov, N, Lagares, A, Lippa, L, Loza-Gomez, A, Luoto, T, Maas, A, Maciejczak, A, Maier, R, Marklund, N, Martin, M, Melloni, I, Mendoza-Lattes, S, Meyfroidt, G, Munari, M, Napolitano, L, Okonkwo, D, Otomo, Y, Papadopoulos, M, Petr, O, Peul, W, Pudkrong, A, Qasim, Z, Rasulo, F, Reizinho, C, Ringel, F, Rizoli, S, Rostami, E, Rubiano, A, Russo, E, Sarwal, A, Schwab, J, Servadei, F, Sharma, D, Sharif, S, Shiban, E, Shutter, L, Stahel, P, Taccone, F, Terpolilli, N, Thomé, C, Toth, P, Tsitsopoulos, P, Udy, A, Vaccaro, A, Varon, A, Vavilala, M, Younsi, A, Zackova, M, Zoerle, T, Robba, C, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, Robba, Chiara, Picetti, E, Demetriades, A, Catena, F, Aarabi, B, Abu-Zidan, F, Alves, O, Ansaloni, L, Armonda, R, Badenes, R, Bala, M, Balogh, Z, Barbanera, A, Bertuccio, A, Biffl, W, Bouzat, P, Buki, A, Castano-Leon, A, Cerasti, D, Citerio, G, Coccolini, F, Coimbra, R, Coniglio, C, Costa, F, De Iure, F, Depreitere, B, Fainardi, E, Fehlings, M, Gabrovsky, N, Godoy, D, Gruen, P, Gupta, D, Hawryluk, G, Helbok, R, Hossain, I, Hutchinson, P, Iaccarino, C, Inaba, K, Ivanov, M, Kaprovoy, S, Kirkpatrick, A, Klein, S, Kolias, A, Konovalov, N, Lagares, A, Lippa, L, Loza-Gomez, A, Luoto, T, Maas, A, Maciejczak, A, Maier, R, Marklund, N, Martin, M, Melloni, I, Mendoza-Lattes, S, Meyfroidt, G, Munari, M, Napolitano, L, Okonkwo, D, Otomo, Y, Papadopoulos, M, Petr, O, Peul, W, Pudkrong, A, Qasim, Z, Rasulo, F, Reizinho, C, Ringel, F, Rizoli, S, Rostami, E, Rubiano, A, Russo, E, Sarwal, A, Schwab, J, Servadei, F, Sharma, D, Sharif, S, Shiban, E, Shutter, L, Stahel, P, Taccone, F, Terpolilli, N, Thomé, C, Toth, P, Tsitsopoulos, P, Udy, A, Vaccaro, A, Varon, A, Vavilala, M, Younsi, A, Zackova, M, Zoerle, T, Robba, C, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, and Robba, Chiara

Abstract

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients.

Published
2024

6. Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo

Author

Chung, Brile, Montel‐Hagen, Amélie, Ge, Shundi, Blumberg, Garrett, Kim, Kenneth, Klein, Sam, Zhu, Yuhua, Parekh, Chintan, Balamurugan, Arumugam, Yang, Otto O, and Crooks, Gay M

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Stem Cell Research - Nonembryonic - Human, Transplantation, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Stem Cell Research, Biotechnology, Aetiology, 5.2 Cellular and gene therapies, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Underpinning research, Animals, Cell Proliferation, Cellular Microenvironment, Gene Expression, Humans, Lymphopoiesis, Mice, Mice, Inbred NOD, Mice, SCID, Thymus Gland, Tissue Engineering, Vascular Endothelial Growth Factor A, Thymus, Thymic microenvironment, T-cell development, Thymus transplantation, Vascular endothelial growth factor, Tissue engineering, Biological Sciences, Technology, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences
Abstract

A system that allows manipulation of the human thymic microenvironment is needed both to elucidate the extrinsic mechanisms that control human thymopoiesis and to develop potential cell therapies for thymic insufficiency. In this report, we developed an implantable thymic microenvironment composed of two human thymic stroma populations critical for thymopoiesis; thymic epithelial cells (TECs) and thymic mesenchyme (TM). TECs and TM from postnatal human thymi were cultured in specific conditions, allowing cell expansion and manipulation of gene expression, before reaggregation into a functional thymic unit. Human CD34+ hematopoietic stem and progenitor cells (HSPC) differentiated into T cells in the aggregates in vitro and in vivo following inguinal implantation of aggregates in immune deficient mice. Cord blood HSPC previously engrafted into murine bone marrow (BM), migrated to implants, and differentiated into human T cells with a broad T cell receptor repertoire. Furthermore, lentiviral-mediated expression of vascular endothelial growth factor in TM enhanced implant size and function and significantly increased thymocyte production. These results demonstrate an in vivo system for the generation of T cells from human HSPC and represent the first model to allow manipulation of gene expression and cell composition in the microenvironment of the human thymus.

Published
2014

9. Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

Author

Khan, Mona, primary, Clijsters, Marnick, additional, Choi, Sumin, additional, Backaert, Wout, additional, Claerhout, Michiel, additional, Couvreur, Floor, additional, Van Breda, Laure, additional, Bourgeois, Florence, additional, Speleman, Kato, additional, Klein, Sam, additional, Van Laethem, Johan, additional, Verstappen, Gill, additional, Dereli, Ayse Sumeyra, additional, Yoo, Seung-Jun, additional, Zhou, Hai, additional, Dan Do, Thuc Nguyen, additional, Jochmans, Dirk, additional, Laenen, Lies, additional, Debaveye, Yves, additional, De Munter, Paul, additional, Gunst, Jan, additional, Jorissen, Mark, additional, Lagrou, Katrien, additional, Meersseman, Philippe, additional, Neyts, Johan, additional, Thal, Dietmar Rudolf, additional, Topsakal, Vedat, additional, Vandenbriele, Christophe, additional, Wauters, Joost, additional, Mombaerts, Peter, additional, and Van Gerven, Laura, additional

Published
2022
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11. International Workshop on Knowledge Graphs

Author

Ding, Ying, primary, Sheth, Amit, additional, Janowicz, Krzysztof W., additional, Baranzini, Sergio, additional, Israni, Sharat, additional, Altintas, Ilkay, additional, Yeghiazarian, Lilit, additional, Young, Ellie, additional, and Klein, Sam, additional

Published
2022
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13. The 2019 James W. Freston Conference: Food at the Intersection of Gut Health and Disease

Author

Mullin, Gerard E., primary, Chey, William D., additional, Crowe, Sheila E., additional, Ananthakrishan, Ashwin, additional, Garcia-Bailo, Bibiana, additional, Dellon, Evan S., additional, DiBaise, John, additional, Fasano, Alessio, additional, Haller, Emily, additional, Hamilton, Matthew J., additional, Klein, Sam, additional, Lebwohl, Benjamin, additional, Leung, John, additional, Lewis, James, additional, Nguyen, Linda, additional, Pandolfino, John, additional, Parrish, Carol Rees, additional, Scarlata, Kate, additional, Tack, Jan, additional, Frye, Jeanetta, additional, Harer, Kimberely, additional, Zevallos, Victor, additional, Srinivasan, Sachin, additional, Verma, Sandeep, additional, Jansson-Knodell, Claire, additional, Dia, Vermont, additional, Rifkin, Samara, additional, and Pace, Laura, additional

Published
2020
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14. Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans

Author

Das, Sai Krupa, Roberts, Susan B., Bhapkar, Manjushri V., Villareal, Dennis T., Fontana, Luigi, Martin, Corby K., Racette, Susan B., Fuss, Paul J., Kraus, William E., Wong, William W., Saltzman, Edward, Pieper, Carl F., Fielding, Roger A., Schwartz, Ann V., Ravussin, Eric, Redman, Leanne M., Champagne, Catherine, Gupta, Alok, Smith, Steven, Williamson, Donald, Begnaud, Michelle, Cerniauskas, Barbara, Davis, Allison, Gabrielle, Jeanne, Walden, Heather, Currier, Natalie, Shipp, Mandy, Masters, Sarah, Mcnicoll, Melody, Prince, Shelly, Brock, Courtney, Puyau, Renee, Earnest, Conrad, Rood, Jennifer, Stewart, Tiffany, Levitan, Lillian, Traylor, Crystal, Thomas, Susan, Toups, Valerie, Jones, Karen, Tatum, Stephanie, Waguespack, Celeste, Crotwell, Kimberly, Dalfrey, Lisa, Braymer, Amy, Hilliard, Rhonda, Thomas, Onolee, Arceneaux, Jennifer, Laprarie, Stacie, Strate, Allison, Ihrig, Jana, Mancuso, Susan, Beard, Christy, Hymel, Alicia, Shepard, Desti, Correa, John, Jarreau, Denise, Dahmer, Brenda, Bella, Grace, Soroe, Elizabeth, Conner, Bridget, Mccown, Paige, Anaya, Stephanie, Lupo, Melissa, Meydani, Simin, Greenberg, Isaac, Pittas, Anastassios, Scott, Tammy, Gilhooly, Cheryl, Gerber, Kimberly, Kaplan, Marjory, Karabetian, Christy, Kennedy, Russell, Robinson, Lisa, Senait, Assefa, Bembridge, Verona, Berlis, Maria, Buer, Scarlett, Carabello, Robert, Campbell, Cherie, Collins, Lauren, Doherty, Marybeth, Freed, Alicia, Hernandez, Chervonte, Jean-baptiste, Gyna, Krasinski, Mary, Lim-lucas, Marie, Maslova, Ekaterina, Maxwell, Barbara, Mcshea, Jean, Muchowski, Ann, Mulkerrin, Margaret, Murphy, Kerry, Nelsen, Carol, O'Neill, Megan, Rasmussen, Helen, Roche, Brenda, Roman, Eneida, Sproull, Gregory, Victor, St Marie, Storer, Susan, Strissel, Katherine, Valliere, Stephanie, Vilme, Margaret, Wheeler, Justin, Wiley, Jill, Yangarber, Fania, Holloszy, John O., Klein, Sam, Lambert, Charles, Mohammed, B. Selma, Stein, Rick, Cotton, Karen, Hof, Margaret, Massmann, Cherie, Obert, Kathleen, Pearlman, Marni, Reising, Tina M., Weber, Laura, Uhrich, Mary, Schram, Morgan, Meyer, Mel, Carlen, Chelsea, Kee, Lisa, Larson, Barbara, Mcferson, Mary, Sabatino, Rebecca, Toennies, Bridgett, Rochon, James, Bales, Connie W., Galan, Katherine M., Adrian, Richard, Allen, Eleanor Law, Blasko, William, Brown, Nikka, Butts, Maria, Cossin, Elaina K., Curry, Jennifer, Daniel, Jamie, Diemer, Kathleen S., Greiner, Lee, Johnson, Darryl, Jones, Cassandra, Lindblad, Lauren, Mcadams, Luanne, Mansfield, Marty, Murugesan, Senthil, Piner, Lucy, Plummer, Christopher, Revoir, Mike, Smith, Pamela, Spaulding, Monica, Topping, James, Clarke, Lucinda L., Liu, Chun W., Fraley, J. Kennard, Shepherd, John, Palermo, Lisa, Ewing, Susan, Rahorst, Michaela, Navy, Caroline, Lewis, Michael, Tracy, Russell P., Boyle, Rebekah, Cornell, Elaine, Daunais, Patrick, Draayer, Dean, Floersch, Melissa, Gagne, Nicole, Keating, Florence, Patnoad, Angela, Schmidt, Marcia, Gavin, Marcia, Wiener, Frida, Hughes, Ashley, Benken, Laura, Otto, Amy, Halter, Jeffrey, Buchner, David M., Elmer, Patricia, Espeland, Mark, Heymsfield, Steven B., Pi-sunyer, Xavier, Prohaska, Thomas, Shapses, Sue, Speakman, John, Weindruch, Richard, Hadley, Evan C., Hannah, Judy, Romashkan, Sergei, and Evans, Mary

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Waist, CALERIE, Longevity, Calorie restriction, Medicine (miscellaneous), Body composition, Humans, Longterm, Nonobese, Adipose Tissue, Adiposity, Body Fluid Compartments, Body Weight, Diet, Energy Metabolism, Female, Sex Factors, Time, Torso, Waist Circumference, Body Composition, Body Mass Index, Caloric Restriction, Energy Intake, Weight Loss, Nutrition and Dietetics, 030209 endocrinology & metabolism, Doubly labeled water, Biology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Weight loss, Internal medicine, medicine, Fluid compartments, 030104 developmental biology, Endocrinology, medicine.symptom, Body mass index
Abstract

Background: Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition.Objective: We evaluated the effect of a 2-y CR regimen on body composition including the influence of sex and body mass index (BMI; in kg/m2) among participants enrolled in CALERIE-2 (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy), a multicenter, randomized controlled trial.Design: Participants were 218 nonobese (BMI: 21.9-28.0) adults aged 21-51 y who were randomly assigned to 25% CR (CR, n = 143) or ad libitum control (AL, n = 75) in a 2:1 ratio. Measures at baseline and 12 and 24 mo included body weight, waist circumference, fat mass (FM), fat-free mass (FFM), and appendicular mass by dual-energy X-ray absorptiometry; activity-related energy expenditure (AREE) by doubly labeled water; and dietary protein intake by self-report. Values are expressed as means ± SDs.Results: The CR group achieved 11.9% ± 0.7% CR over 2-y and had significant decreases in weight (-7.6 ± 0.3 compared with 0.4 ± 0.5 kg), waist circumference (-6.2 ± 0.4 compared with 0.9 ± 0.5 cm), FM (-5.4 ± 0.3 compared with 0.5 ± 0.4 kg), and FFM (-2.0 ± 0.2 compared with -0.0 ± 0.2 kg) at 24 mo relative to the AL group (all between-group P < 0.001). Moreover, FFM as a percentage of body weight at 24 mo was higher, and percentage of FM was lower in the CR group than in the AL. AREE, but not protein intake, predicted preservation of FFM during CR (P < 0.01). Men in the CR group lost significantly more trunk fat (P = 0.03) and FFM expressed as a percentage of weight loss (P < 0.001) than women in the CR group.Conclusions: Two years of CR had broadly favorable effects on both whole-body and regional adiposity that could facilitate health span in humans. The decrements in FFM were commensurate with the reduced body mass; although men in the CR group lost more FFM than the women did, the percentage of FFM in the men in the CR group was higher than at baseline. CALERIE was registered at clinicaltrials.gov as NCT00427193.

Published
2017

15. Behind Bars, Three Men Graduate With Their NYU Degrees

Author

Klein, Sam

Subjects
Students, News, opinion and commentary, Sports and fitness
Abstract

Byline: Sam Klein Jermaine Haywood with his son, Jermaine Jr., after receiving his diploma through NYU's Prison Education Program. (Photo by Sam Klein) Jermaine Haywood, wearing a violet graduation gown [...]

Published
2018

16. Finding Mentorship at NYU Dentistry

Author

Klein, Sam

Subjects
Teachers, Career development, Mentoring, News, opinion and commentary, Sports and fitness
Abstract

Byline: Sam Klein When College of Dentistry alumnus Edly Destine first approached Marcus Johnson, another alumnus of NYU College of Dentistry, Johnson had no idea what was coming. After Johnson [...]

Published
2018

18. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Author

Meydani, Simin N., primary, Das, Sai K., additional, Pieper, Carl F., additional, Lewis, Michael R., additional, Klein, Sam, additional, Dixit, Vishwa D., additional, Gupta, Alok K., additional, Villareal, Dennis T., additional, Bhapkar, Manjushri, additional, Huang, Megan, additional, Fuss, Paul J., additional, Roberts, Susan B., additional, Holloszy, John O., additional, and Fontana, Luigi, additional

Published
2016
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19. Developer meets success with Westport Inn project

Author

KLEIN, SAM

Subjects
Fairfield Properties Inc. -- Management, Hotels and motels -- New York, Business, Real estate industry
Abstract

Every business undertaking involves challenges that are unique to it -- whether it's launching a new product or breathing new life into a dated one. Over the years, we've found [...]

Published
2001

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