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1. Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland

Author

Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Oftedal, Bente, Andersen, Zorana J., Janssen, Nicole A. H., So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard

Published
2023
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6. Long-Term Exposure to Low-Level P[M.sub.2.5] and Mortality: Investigation of Heterogeneity by Harmonizing Analyses in Large Cohort Studies in Canada, United States, and Europe

Author

Chen, Jie, Braun, Danielle, Christidis, Tanya, Cork, Michael, Rodopoulou, Sophia, Samoli, Evangelia, Stafoggia, Massimo, Wolf, Kathrin, Wu, Xiao, Yuchi, Weiran, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, de Hoogh, Kees, Janssen, Nicole A.H., Katsouyanni, Klea, Klompmaker, Jochem O., Kristoffersen, Doris Tove, Lim, Youn-Hee, Oftedal, Bente, Strak, Maciej, Vienneau, Danielle, Zhang, Jiawei, Burnett, Richard T., Hoek, Gerard, Dominici, Francesca, Brauer, Michael, and Brunekreef, Bert

Subjects
Mortality -- Statistics -- Environmental aspects -- Health aspects -- Europe -- Canada -- United States, Air pollution -- Statistics -- Health aspects, Particles -- Statistics -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter [less than or equal to]2.5 [micro]m (P[M.sub.2.5]) exposure with large heterogeneity in the magnitude of reported associations and the shape of concentration-response functions (CRFs). We aimed to evaluate the impact of key study design factors (including confounders, applied exposure model, population age, and outcome definition) on P[M.sub.2.5] effect estimates by harmonizing analyses on three previously published large studies in Canada [Mortality-Air Pollution Associations in Low Exposure Environments (MAPLE), 1991-2016], the United States (Medicare, 2000-2016), and Europe [Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), 2000-2016] as much as possible. METHODS: We harmonized the study populations to individuals 65+ years of age, applied the same satellite-derived P[M.sub.2.5] exposure estimates, and selected the same sets of potential confounders and the same outcome. We evaluated whether differences in previously published effect estimates across cohorts were reduced after harmonization among these factors. Additional analyses were conducted to assess the influence of key design features on estimated risks, including adjusted covariates and exposure assessment method. A combined CRF was assessed with meta-analysis based on the extended shape-constrained health impact function (eSCHIF). RESULTS: More than 81 million participants were included, contributing 692 million person-years of follow-up. Hazard ratios and 95% confidence intervals (CIs) for all-cause mortality associated with a 5-[micro]g/[m.sup.3] increase in P[M.sub.2.5] were 1.039 (1.032, 1.046) in MAPLE, 1.025 (1.021, 1.029) in Medicare, and 1.041 (1.014, 1.069) in ELAPSE. Applying a harmonized analytical approach marginally reduced difference in the observed associations across the three studies. Magnitude of the association was affected by the adjusted covariates, exposure assessment methodology, age of the population, and marginally by outcome definition. Shape of the CRFs differed across cohorts but generally showed associations down to the lowest observed P[M.sub.2.5] levels. A common CRF suggested a monotonically increased risk down to the lowest exposure level. https://doi.org/10.1289/EHP12141, Introduction Ambient particulate matter (PM) pollution has been identified as a leading risk factor for global disease burden. (1) Evaluating the risks attributable to PM with aerodynamic diameter [less than [...]

Published
2023
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8. Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study

Author

So, Rina, Chen, Jie, Stafoggia, Massimo, de Hoogh, Kees, Katsouyanni, Klea, Vienneau, Danielle, Samoli, Evangelia, Rodopoulou, Sophia, Loft, Steffen, Lim, Youn-Hee, Westendorp, Rudi G.J., Amini, Heresh, Cole-Hunter, Thomas, Bergmann, Marie, Shahri, Seyed Mahmood Taghavi, Zhang, Jiawei, Maric, Matija, Mortensen, Laust H., Bauwelinck, Mariska, Klompmaker, Jochem O., Atkinson, Richard W., Janssen, Nicole A.H., Oftedal, Bente, Renzi, Matteo, Forastiere, Francesco, Strak, Maciek, Brunekreef, Bert, Hoek, Gerard, and Andersen, Zorana J.

Published
2023
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11. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project

Author

Stafoggia, Massimo, Oftedal, Bente, Chen, Jie, Rodopoulou, Sophia, Renzi, Matteo, Atkinson, Richard W, Bauwelinck, Mariska, Klompmaker, Jochem O, Mehta, Amar, Vienneau, Danielle, Andersen, Zorana J, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, de Hoogh, Kees, Fecht, Daniela, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla A, Jöckel, Karl-Heinz, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Kristoffersen, Doris Tove, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter L S, Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Rizzuto, Debora, Schramm, Sara, Schwarze, Per E, Severi, Gianluca, Sigsgaard, Torben, Strak, Maciek, van der Schouw, Yvonne T, Verschuren, Monique, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Samoli, Evangelia, Forastiere, Francesco, Brunekreef, Bert, Hoek, Gerard, and Janssen, Nicole A H

Published
2022
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13. Association between Density of Food Retailers and Fitness Centers and Gestational Diabetes Mellitus in Eastern Massachusetts

Author

Shupler, Matthew, primary, Klompmaker, Jochem O., additional, Leung, Michael, additional, Petimar, Joshua, additional, Drouin-Chartier, Jean-Philippe, additional, Modest, Anna, additional, Hacker, Michele, additional, Farid, Huma, additional, James, Peter, additional, Hernandez-Diaz, Sonia, additional, and Papatheodorou, Stefania, additional

Published
2024
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14. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project

Author

Wolf, Kathrin, Hoffmann, Barbara, Andersen, Zorana J, Atkinson, Richard W, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Chen, Jie, de Faire, Ulf, de Hoogh, Kees, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hvidtfeldt, Ulla Arthur, Janssen, Nicole A H, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O, Lager, Anton, Liu, Shuo, MacDonald, Conor J, Magnusson, Patrik K E, Mehta, Amar J, Nagel, Gabriele, Oftedal, Bente, Pedersen, Nancy L, Pershagen, Göran, Raaschou-Nielsen, Ole, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, van der Schouw, Yvonne T, Schramm, Sara, Schwarze, Per, Sigsgaard, Torben, Sørensen, Mette, Stafoggia, Massimo, Strak, Maciek, Tjønneland, Anne, Verschuren, W M Monique, Vienneau, Danielle, Weinmayr, Gudrun, Hoek, Gerard, Peters, Annette, and Ljungman, Petter L S

Published
2021
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15. Racial, Ethnic, and Socioeconomic Disparities in Multiple Measures of Blue and Green Spaces in the United States

Author

Klompmaker, Jochem O., Hart, Jaime E., Bailey, Christopher R., Browning, Matthew H.E.M., Casey, Joan A., Hanley, Jared R., Minson, Christopher T., Ogletree, S. Scott, Rigolon, Alessandro, Laden, Francine, and James, Peter

Subjects
Open spaces -- Environmental aspects -- Health aspects, Environmental justice -- Analysis, Environmental issues, Health
Abstract

Background: Several studies have evaluated whether the distribution of natural environments differs between marginalized and privileged neighborhoods. However, most studies restricted their analyses to a single or handful of cities and used different natural environment measures. Objectives: We evaluated whether natural environments are inequitably distributed based on socioeconomic status (SES) and race/ethnicity in the contiguous United States. Methods: We obtained SES and race/ethnicity data (2015-2019) for all U.S. Census tracts. For each tract, we calculated the Normalized Different Vegetation Index (NDVI) for 2020, NatureScore (a proprietary measure of the quantity and quality of natural elements) for 2019, park cover for 2020, and blue space for 1984-2018. We used generalized additive models with adjustment for potential confounders and spatial autocorrelation to evaluate associations of SES and race/ethnicity with NDVI, NatureScore, park cover, and odds of containing blue space in all tracts (n = 71,532) and in urban tracts (n = 45,338). To compare effect estimates, we standardized NDVI, NatureScore, and park cover so that beta coefficients presented a percentage increase or decrease of the standard deviation (SD). Results: Tracts with higher SES had higher NDVI, NatureScore, park cover, and odds of containing blue space. For example, urban tracts in the highest median household income quintile had higher NDVI [44.8% of the SD (95% CI: 42.8, 46.8)] and park cover [16.2% of the SD (95% CI: 13.5, 19.0)] compared with urban tracts in the lowest median household income quintile. Across all tracts, a lower percentage of non- Hispanic White individuals and a higher percentage of Hispanic individuals were associated with lower NDVI and NatureScore. In urban tracts, we observed weak positive associations between percentage non-Hispanic Black and NDVI, NatureScore, and park cover; we did not find any clear associations for percentage Hispanics. Discussion: Multiple facets of the natural environment are inequitably distributed in the contiguous United States. https://doi.org/10.1289/EHP11164, Introduction Of all high- and middle-income countries, the United States has among the highest income-related disparities in self-reported health and health care measures. (1) Health disparities have been attributed to [...]

Published
2023
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17. Associations of Street-View Greenspace with Incident Cardiovascular Disease in the US-based Nationwide Nurses’ Health Study from 2000 to 2016

Author

Jimenez, Marcia Pescador, primary, Lin, Pi I Debby, additional, Suel, Esra, additional, Klompmaker, Jochem O, additional, Zhang, Wenwen, additional, Hystad, Perry, additional, Hankey, Steve, additional, Rimm, Eric B, additional, Coull, Brent, additional, Hart, Jaime E, additional, Laden, Francine, additional, and James, Peter, additional

Published
2023
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18. Erratum: 'Associations of Combined Exposures to Surrounding Green, Air Pollution, and Road Traffic Noise with Cardiometabolic Diseases'

Author

Klompmaker, Jochem O., Janssen, Nicole A.H., Bloemsma, Lizan D., Gehring, Ulrike, Wijga, Alet H., van den Brink, Carolien, Lebret, Erik, Brunekreef, Bert, and Hoek, Gerard

Subjects
Environmental issues, Health
Abstract

For the interaction analyses, we reported the differences in conditional effects (compared to the reference category) instead of the conditional effects, without clearly stating this and discussing results as conditional [...]

Published
2022
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19. Long-Term Exposure to Low-Level PM2.5 and Mortality: Investigation of Heterogeneity by Harmonizing Analyses in Large Cohort Studies in Canada, United States, and Europe.

Author

Jie Chen, Braun, Danielle, Christidis, Tanya, Cork, Michael, Rodopoulou, Sophia, Samoli, Evangelia, Stafoggia, Massimo, Wolf, Kathrin, Xiao Wu, Weiran Yuchi, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, de Hoogh, Kees, Janssen, Nicole A. H., Katsouyanni, Klea, Klompmaker, Jochem O., Kristoffersen, Doris Tove, Youn-Hee Lim, and Oftedal, Bente

Subjects
MORTALITY risk factors, PARTICULATE matter, AERODYNAMICS, RELATIVE medical risk, CONFIDENCE intervals, NOSOLOGY, META-analysis, RISK assessment, SOCIAL classes, DESCRIPTIVE statistics, DATA analysis software, ENVIRONMENTAL exposure, LONGITUDINAL method, PROPORTIONAL hazards models, MEDICARE, POISSON distribution
Abstract

BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) exposure with large heterogeneity in the magnitude of reported associations and the shape of concentration-response functions (CRFs). We aimed to evaluate the impact of key study design factors (including confounders, applied exposure model, population age, and outcome definition) on PM2.5 effect estimates by harmonizing analyses on three previously published large studies in Canada [Mortality-Air Pollution Associations in Low Exposure Environments (MAPLE), 1991-2016], the United States (Medicare, 2000-2016), and Europe [Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), 2000-2016] as much as possible. METHODS: We harmonized the study populations to individuals 65+ years of age, applied the same satellite-derived PM2.5 exposure estimates, and selected the same sets of potential confounders and the same outcome. We evaluated whether differences in previously published effect estimates across cohorts were reduced after harmonization among these factors. Additional analyses were conducted to assess the influence of key design features on estimated risks, including adjusted covariates and exposure assessment method. A combined CRF was assessed with meta-analysis based on the extended shape-constrained health impact function (eSCHIF). RESULTS: More than 81 million participants were included, contributing 692 million person-years of follow-up. Hazard ratios and 95% confidence intervals (CIs) for all-cause mortality associated with a 5-μg/m³ increase in PM2.5 were 1.039 (1.032, 1.046) in MAPLE, 1.025 (1.021, 1.029) in Medicare, and 1.041 (1.014, 1.069) in ELAPSE. Applying a harmonized analytical approach marginally reduced difference in the observed associations across the three studies. Magnitude of the association was affected by the adjusted covariates, exposure assessment methodology, age of the population, and marginally by outcome definition. Shape of the CRFs differed across cohorts but generally showed associations down to the lowest observed PM2.5 levels. A common CRF suggested a monotonically increased risk down to the lowest exposure level. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Invited Perspective: Diabetes and Road Traffic Noise at the Most and Least Exposed Facade

Author

Klompmaker, Jochem O. and Laden, Francine

Subjects
Traffic noise -- Health aspects, Sleep deprivation -- Risk factors -- Complications and side effects, Type 2 diabetes -- Environmental aspects -- Risk factors, Environmental issues, Health
Abstract

A wide variety of environmental exposures have been linked to diabetes (Dendup et al. 2018). Recently, a meta-analysis of five cohort studies reported a positive association between road traffic noise [...]

Published
2021
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24. Additional file 1 of Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland

Author

Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Oftedal, Bente, Andersen, Zorana J., Janssen, Nicole A. H., So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard

Abstract

Additional file 1: Table S1. Study population selection. Table S2. Exposure distributions. Table S3. Spearman correlations between exposures (top), and between exposures and neighbourhood socio-economic position (SEP) score (bottom). Table S4. Mean exposure by quintiles of neighbourhood socio-economic position. Table S5. Hazard ratios (95% confidence intervals) for single exposure associations between air pollution and noise exposures and mortality by cause, with increasing level of covariate adjustment in single exposure models. Table S6. Effect modification by sex, hazard ratios (95% confidence intervals) in two exposure models for associations with natural cause mortality (Model 3). Table S7. Non-mover analysis, hazard ratios (95% confidence intervals) in two exposure models for associations with natural cause mortality (Model 3).

Published
2023
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26. Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Author

So, Rina, primary, Andersen, Zorana J., additional, Chen, Jie, additional, Stafoggia, Massimo, additional, de Hoogh, Kees, additional, Katsouyanni, Klea, additional, Vienneau, Danielle, additional, Rodopoulou, Sophia, additional, Samoli, Evangelia, additional, Lim, Youn-Hee, additional, Jørgensen, Jeanette T., additional, Amini, Heresh, additional, Cole-Hunter, Tom, additional, Mahmood Taghavi Shahri, Seyed, additional, Maric, Matija, additional, Bergmann, Marie, additional, Liu, Shuo, additional, Azam, Shadi, additional, Loft, Steffen, additional, Westendorp, Rudi G.J., additional, Mortensen, Laust H., additional, Bauwelinck, Mariska, additional, Klompmaker, Jochem O., additional, Atkinson, Richard, additional, Janssen, Nicole A.H., additional, Oftedal, Bente, additional, Renzi, Matteo, additional, Forastiere, Francesco, additional, Strak, Maciek, additional, Thygesen, Lau C., additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Mehta, Amar J., additional

Published
2022
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28. Erratum: 'Associations of Combined Exposures to Surrounding Green, Air Pollution, and Road Traffic Noise with Cardiometabolic Diseases' (Environ Health Perspect. 127(8), 087003, (2019), 10.1289/EHP3857)

Author

Klompmaker, Jochem O., Janssen, Nicole A.H., Bloemsma, Lizan D., Gehring, Ulrike, Wijga, Alet H., van den Brink, Carolien, Lebret, Erik, Brunekreef, Bert, Hoek, Gerard, Institute for Risk Assesment Sciences, IRAS OH Epidemiology Chemical Agents, and IRAS OH Epidemiology Microbial Agents

Subjects
Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health
Published
2022

29. Long-term exposure to fine particle elemental components and mortality in Europe: Results from six European administrative cohorts within the ELAPSE project

Author

Rodopoulou, Sophia, primary, Stafoggia, Massimo, additional, Chen, Jie, additional, de Hoogh, Kees, additional, Bauwelinck, Mariska, additional, Mehta, Amar J., additional, Klompmaker, Jochem O., additional, Oftedal, Bente, additional, Vienneau, Danielle, additional, Janssen, Nicole A.H., additional, Strak, Maciej, additional, Andersen, Zorana J., additional, Renzi, Matteo, additional, Cesaroni, Giulia, additional, Nordheim, Carl Fredrik, additional, Bekkevold, Terese, additional, Atkinson, Richard, additional, Forastiere, Francesco, additional, Katsouyanni, Klea, additional, Brunekreef, Bert, additional, Samoli, Evangelia, additional, and Hoek, Gerard, additional

Published
2022
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30. Variability in the association between long-term exposure to ambient air pollution and mortality by exposure assessment method and covariate adjustment: A census-based country-wide cohort study

Author

Bauwelinck, Mariska, primary, Chen, Jie, additional, de Hoogh, Kees, additional, Katsouyanni, Klea, additional, Rodopoulou, Sophia, additional, Samoli, Evangelia, additional, Andersen, Zorana J., additional, Atkinson, Richard, additional, Casas, Lidia, additional, Deboosere, Patrick, additional, Demoury, Claire, additional, Janssen, Nicole, additional, Klompmaker, Jochem O., additional, Lefebvre, Wouter, additional, Mehta, Amar Jayant, additional, Nawrot, Tim S., additional, Oftedal, Bente, additional, Renzi, Matteo, additional, Stafoggia, Massimo, additional, Strak, Maciek, additional, Vandenheede, Hadewijch, additional, Vanpoucke, Charlotte, additional, Van Nieuwenhuyse, An, additional, Vienneau, Danielle, additional, Brunekreef, Bert, additional, and Hoek, Gerard, additional

Published
2022
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32. Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis

Author

Strak, Maciej, primary, Weinmayr, Gudrun, additional, Rodopoulou, Sophia, additional, Chen, Jie, additional, de Hoogh, Kees, additional, Andersen, Zorana J, additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bekkevold, Terese, additional, Bellander, Tom, additional, Boutron-Ruault, Marie-Christine, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Concin, Hans, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, Hvidtfeldt, Ulla Arthur, additional, Janssen, Nicole A H, additional, Jöckel, Karl-Heinz, additional, Jørgensen, Jeanette T, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O, additional, Lager, Anton, additional, Leander, Karin, additional, Liu, Shuo, additional, Ljungman, Petter, additional, Magnusson, Patrik K E, additional, Mehta, Amar J, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peters, Annette, additional, Raaschou-Nielsen, Ole, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, van der Schouw, Yvonne T, additional, Schramm, Sara, additional, Severi, Gianluca, additional, Sigsgaard, Torben, additional, Sørensen, Mette, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Verschuren, W M Monique, additional, Vienneau, Danielle, additional, Wolf, Kathrin, additional, Katsouyanni, Klea, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Samoli, Evangelia, additional

Published
2021
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34. Green space, air pollution, traffic noise and mental wellbeing throughout adolescence: Findings from the PIAMA study

Author

Bloemsma, Lizan D, Wijga, Alet H, Klompmaker, Jochem O, Hoek, Gerard, Janssen, Nicole A H, Lebret, Erik, Brunekreef, Bert, Gehring, Ulrike, IRAS OH Epidemiology Chemical Agents, IRAS OH Epidemiology Microbial Agents, IRAS OH Epidemiology Chemical Agents, and IRAS OH Epidemiology Microbial Agents

Subjects
MHI-5, Adult, Air Pollutants, Traffic-Related Pollution, Adolescent, NDVI, Parks, Recreational, Environmental exposures, Environmental Exposure, Adolescents, Young Adult, Environmental Science(all), Air Pollution, Humans, Particulate Matter, Child, General Environmental Science
Abstract

BACKGROUND: Green space, air pollution and traffic noise exposure may be associated with mental health in adolescents. We assessed the associations of long-term exposure to residential green space, ambient air pollution and traffic noise with mental wellbeing from age 11 to 20 years. METHODS: We included 3059 participants of the Dutch PIAMA birth cohort who completed the five-item Mental Health Inventory (MHI-5) at ages 11, 14, 17 and/or 20 years. We estimated exposure to green space (the average Normalized Difference Vegetation Index (NDVI) and percentages of green space in circular buffers of 300 m, 1000 m and 3000 m), ambient air pollution (particulate matter (PM10 and PM2.5), nitrogen dioxide, PM2.5 absorbance and the oxidative potential of PM2.5) and road traffic and railway noise (Lden) at the adolescents' home addresses at the times of completing the MHI-5. Associations with poor mental wellbeing (MHI-5 score ≤ 60) were assessed by generalized linear mixed models with a logit link, adjusting for covariates. RESULTS: The odds of poor mental wellbeing at age 11 to 20 years decreased with increasing exposure to green space in a 3000 m buffer (adjusted odds ratio (OR) 0.78 [95% CI 0.68-0.88] per IQR increase in the average NDVI; adjusted OR 0.77 [95% CI 0.67-0.88] per IQR increase in the total percentage of green space). These associations persisted after adjustment for air pollution and road traffic noise. Relationships between mental wellbeing and green space in buffers of 300 m and 1000 m were less consistent. Higher air pollution exposure was associated with higher odds of poor mental wellbeing, but these associations were strongly attenuated after adjustment for green space in a buffer of 3000 m, traffic noise and degree of urbanization. Traffic noise was not related to mental wellbeing throughout adolescence. CONCLUSIONS: Residential exposure to green space may be associated with a better mental wellbeing in adolescents.

Published
2021

35. Green space, air pollution, traffic noise and saliva cortisol in children: The PIAMA study

Author

Bloemsma, Lizan D, Wijga, Alet H, Klompmaker, Jochem O, Hoek, Gerard, Janssen, Nicole A H, Oldenwening, Marieke, Koppelman, Gerard H, Lebret, Erik, Brunekreef, Bert, Gehring, Ulrike, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, Dep IRAS, IRAS OH Epidemiology Microbial Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, Dep IRAS, IRAS OH Epidemiology Microbial Agents, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
endocrine system, Global and Planetary Change, Evening, Cortisol awakening response, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Stressor, Traffic noise, Public Health, Environmental and Occupational Health, Air pollution, medicine.disease_cause, Pollution, Environmental health, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Medicine, Chronic stress, Circadian rhythm, Original Research Article, business, Morning
Abstract

Supplemental Digital Content is available in the text., Background: Green space, air pollution, and traffic noise exposure may be associated with stress levels in children. A flattened diurnal cortisol slope (the decline in cortisol concentrations from awakening to evening) is an indicator of chronic stress. We examined associations of green space, ambient air pollution, and traffic noise with the diurnal cortisol slope in children 12 years of age. Methods: At age 12 years, 1,027 participants of the Dutch PIAMA birth cohort collected three saliva samples during 1 day. We estimated residential exposure to green space (i.e., the average Normalized Difference Vegetation Index [NDVI] and percentages of green space in circular buffers of 300 m and 3,000 m), air pollution, and traffic noise. Associations of these exposures with the diurnal cortisol slope (in nmol/L per hour) were assessed by multiple linear regression, adjusting for potential confounders. Results: Higher average NDVI and total percentage of green space in a 3,000 m buffer were associated with a larger diurnal decrease in cortisol levels (adjusted difference [95% confidence interval] = −0.11 nmol/L/hr [−0.21, 0.00 nmol/L/hr] per interquartile range increase in the average NDVI; −0.13 nmol/L/hr [−0.26, 0.00 nmol/L/hr] per interquartile range increase in the total percentage of green space). These associations were largely driven by associations with the percentage of agricultural green space and by associations in children living in nonurban areas. We observed no relationships between air pollution or traffic noise and the diurnal cortisol slope. Conclusions: Residential exposure to green space in a buffer of 3,000 m may be associated with lower stress levels in children 12 years of age.

Published
2021

38. Long‐term exposure to air pollution and liver cancer incidence in six European cohorts

Author

So, Rina, primary, Chen, Jie, additional, Mehta, Amar J., additional, Liu, Shuo, additional, Strak, Maciej, additional, Wolf, Kathrin, additional, Hvidtfeldt, Ulla A., additional, Rodopoulou, Sophia, additional, Stafoggia, Massimo, additional, Klompmaker, Jochem O., additional, Samoli, Evangelia, additional, Raaschou‐Nielsen, Ole, additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bellander, Tom, additional, Boutron‐Ruault, Marie‐Christine, additional, Brandt, Jørgen, additional, Brunekreef, Bert, additional, Cesaroni, Giulia, additional, Concin, Hans, additional, Forastiere, Francesco, additional, Gils, Carla H., additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, Hoogh, Kees, additional, Janssen, Nicole, additional, Lim, Youn‐hee, additional, Westendorp, Rudi, additional, Jørgensen, Jeanette T., additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Lager, Anton, additional, Lang, Alois, additional, Ljungman, Petter L., additional, Magnusson, Patrik K.E., additional, Nagel, Gabriele, additional, Simonsen, Mette K., additional, Pershagen, Göran, additional, Peter, Raphael S., additional, Peters, Annette, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, Sigsgaard, Torben, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Severi, Gianluca, additional, Fecht, Daniela, additional, Tjønneland, Anne, additional, Leander, Karin, additional, Hoek, Gerard, additional, and Andersen, Zorana J., additional

Published
2021
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40. Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

Author

Liu, Shuo, primary, Jørgensen, Jeanette Therming, additional, Ljungman, Petter, additional, Pershagen, Göran, additional, Bellander, Tom, additional, Leander, Karin, additional, Magnusson, Patrik K.E., additional, Rizzuto, Debora, additional, Hvidtfeldt, Ulla A., additional, Raaschou-Nielsen, Ole, additional, Wolf, Kathrin, additional, Hoffmann, Barbara, additional, Brunekreef, Bert, additional, Strak, Maciej, additional, Chen, Jie, additional, Mehta, Amar, additional, Atkinson, Richard W., additional, Bauwelinck, Mariska, additional, Varraso, Raphaëlle, additional, Boutron-Ruault, Marie-Christine, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Forastiere, Francesco, additional, Fecht, Daniela, additional, Gulliver, John, additional, Hertel, Ole, additional, de Hoogh, Kees, additional, Janssen, Nicole A.H., additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Peters, Annette, additional, Tjønneland, Anne, additional, Rodopoulou, Sophia P., additional, Samoli, Evangelia, additional, Kristoffersen, Doris Tove, additional, Sigsgaard, Torben, additional, Stafoggia, Massimo, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Hoek, Gerard, additional, and Andersen, Zorana Jovanovic, additional

Published
2021
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41. Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project

Author

Liu, Shuo, Jørgensen, Jeanette Therming, Ljungman, Petter L.S., Pershagen, Göran, Bellander, Tom D., Leander, Karin, Magnusson, Patrik K.E., Rizzuto, Debora, Hvidtfeldt, Ulla Arthur, Raaschou-Nielsen, Ole, Wolf, Kathrin, Hoffmann, Barbara H., Brunekreef, Bert, Strak, Maciej, Chen, Jie, Mehta, Amar Jayant, Atkinson, Richard W., Bauwelinck, Mariska, Varraso, Raphäelle, Boutron-Ruault, Marie Christine, Brandt, Jørgen, Cesaroni, Giulia, Forastiere, Francesco, Fecht, Daniela, Gulliver, John, Hertel, Ole, de Hoogh, Kees, Janssen, Nicole A.H., Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O., Nagel, Gabriële C., Oftedal, Bente Margaret, Peters, Annette Michael, Tjønneland, Anne, Rodopoulou, Sophia P., Samoli, Evangelia, Bekkevold, Terese, Sigsgaard, Torben, Stafoggia, Massimo, Vienneau, D. S., Weinmayr, Gudrun, Hoek, Gerard, Andersen, Zorana, Jørgensen, Jeanette, Ljungman, Petter, Bellander, Tom, Magnusson, Patrik, Hvidtfeldt, Ulla, Hoffmann, Barbara, Mehta, Amar, Atkinson, Richard, Boutron-Ruault, Marie-Christine, Janssen, Nicole, Klompmaker, Jochem, Nagel, Gabriele, Oftedal, Bente, Peters, Annette, Rodopoulou, Sophia, Vienneau, Danielle, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Environmental Protection Agency, EPA: R-82811201 U.S. Environmental Protection Agency, EPA China Scholarship Council, CSC: 201806010406 Vetenskapsrådet, VR: 2017-00641 Karolinska Institutet, KI, Research described in this article was conducted under contract to the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI, or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers., This work was supported by the Health Effects Institute Research Agreement #4954-RFA14-3/16-5-3 and the China Scholarship Council No. 201806010406. SALT and TwinGene are sub-studies of The Swedish Twin Registry (STR) which is managed by Karolinska Institutet and receives additional funding through the Swedish Research Council under the grant no 2017-00641., Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Interface Demography, Faculty of Economic and Social Sciences and Solvay Business School, and Sociology

Subjects
010504 meteorology & atmospheric sciences, [SDV]Life Sciences [q-bio], Air pollution, Low-level exposure, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, complex mixtures, Cohort Studies, Pulmonary Disease, Chronic Obstructive, Environmental Science(all), Environmental health, Air Pollution, medicine, Humans, Risk factor, Prospective cohort study, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, lcsh:GE1-350, Sweden, COPD, Air Pollutants, business.industry, Proportional hazards model, Incidence (epidemiology), Incidence, Hazard ratio, Environmental Exposure, medicine.disease, Confidence interval, 3. Good health, Europe, 13. Climate action, Particulate Matter, COPD incidence, business, Environmental Sciences
Abstract

Background: Air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD), but evidence is sparse and inconsistent. Objectives: We examined the association between long-term exposure to low-level air pollution and COPD incidence. Methods: Within the ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE) study, we pooled data from three cohorts, from Denmark and Sweden, with information on COPD hospital discharge diagnoses. Hybrid land use regression models were used to estimate annual mean concentrations of particulate matter with a diameter < 2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) in 2010 at participants’ baseline residential addresses, which were analysed in relation to COPD incidence using Cox proportional hazards models. Results: Of 98,058 participants, 4,928 developed COPD during 16.6 years mean follow-up. The adjusted hazard ratios (HRs) and 95% confidence intervals for associations with COPD incidence were 1.17 (1.06, 1.29) per 5 µg/m3 for PM2.5, 1.11 (1.06, 1.16) per 10 µg/m3 for NO2, and 1.11 (1.06, 1.15) per 0.5 10−5m−1 for BC. Associations persisted in subset participants with PM2.5 or NO2 levels below current EU and US limit values and WHO guidelines, with no evidence for a threshold. HRs for NO2 and BC remained unchanged in two-pollutant models with PM2.5, whereas the HR for PM2.5 was attenuated to unity with NO2 or BC. Conclusions: Long-term exposure to low-level air pollution is associated with the development of COPD, even below current EU and US limit values and possibly WHO guidelines. Traffic-related pollutants NO2 and BC may be the most relevant.

Published
2021

42. Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

Author

Liu, Shuo Jorgensen, Jeanette Therming Ljungman, Petter and Pershagen, Goran Bellander, Tom Leander, Karin Magnusson, Patrik K. E. Rizzuto, Debora Hvidtfeldt, Ulla A. Nielsen, Ole Raaschou Wolf, Kathrin Hoffmann, Barbara Brnekree, Bert and Strak, Maciej Chen, Jie Mehta, Amar Atkinson, Richard W. and Bauwelrick, Mariska Varraso, Raphaelle Boutron-Ruault, Marie-Christine Brandt, Jorgen Cesaroni, Giulia Forastiere, Francesco Fecht, Daniela Gulliver, John Herte, Ole de Hoogh, Kees Janssen, Nicole A. H. Katsouyanni, Klea Ketzel, Matthias Klompmaker, Jochem O. Nagel, Gabriele Oftedal, Bente Peters, Annette Tjonneland, Anne Rodopoulou, Sophia P. and Samoli, Evangelia Kristoffersen, Doris Tove Sigsgaard, Torben Stafoggia, Massimo Vienneau, Danielle Weinmayr, Gudrun Hoek, Gerard Andersen, Zorana Jovanovic

Abstract

Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter

Published
2021

43. Long-term exposure to air pollution and liver cancer incidence in six European cohorts

Author

So, Rina Chen, Jie Mehta, Amar J. Liu, Shuo Strak, Maciej Wolf, Kathrin Hvidtfeldt, Ulla A. Rodopoulou, Sophia and Stafoggia, Massimo Klompmaker, Jochem O. Samoli, Evangelia and Raaschou-Nielsen, Ole Atkinson, Richard Bauwelinck, Mariska and Bellander, Tom Boutron-Ruault, Marie-Christine Brandt, Jorgen Brunekreef, Bert Cesaroni, Giulia Concin, Hans and Forastiere, Francesco van Gils, Carla H. Gulliver, John and Hertel, Ole Hoffmann, Barbara de Hoogh, Kees Janssen, Nicole and Lim, Youn-Hee Westendorp, Rudi Jorgensen, Jeanette T. and Katsouyanni, Klea Ketzel, Matthias Lager, Anton Lang, Alois and Ljungman, Petter L. Magnusson, Patrik K. E. Nagel, Gabriele and Simonsen, Mette K. Pershagen, Goran Peter, Raphael S. and Peters, Annette Renzi, Matteo Rizzuto, Debora Sigsgaard, Torben Vienneau, Danielle Weinmayr, Gudrun Severi, Gianluca and Fecht, Daniela Tjonneland, Anne Leander, Karin Hoek, Gerard Andersen, Zorana J.

Subjects
complex mixtures
Abstract

Particulate matter air pollution and diesel engine exhaust have been classified as carcinogenic for lung cancer, yet few studies have explored associations with liver cancer. We used six European adult cohorts which were recruited between 1985 and 2005, pooled within the “Effects of low-level air pollution: A study in Europe” (ELAPSE) project, and followed for the incidence of liver cancer until 2011 to 2015. The annual average exposure to nitrogen dioxide (NO2), particulate matter with diameter

Published
2021

44. Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project

Author

Chen, Jie, primary, Rodopoulou, Sophia, additional, de Hoogh, Kees, additional, Strak, Maciej, additional, Andersen, Zorana J., additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Concin, Hans, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, Hvidtfeldt, Ulla Arthur, additional, Janssen, Nicole A. H., additional, Jöckel, Karl-Heinz, additional, Jørgensen, Jeanette, additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Lager, Anton, additional, Leander, Karin, additional, Liu, Shuo, additional, Ljungman, Petter, additional, MacDonald, Conor J., additional, Magnusson, Patrik K.E., additional, Mehta, Amar, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peters, Annette, additional, Raaschou-Nielsen, Ole, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, Samoli, Evangelia, additional, van der Schouw, Yvonne T., additional, Schramm, Sara, additional, Schwarze, Per, additional, Sigsgaard, Torben, additional, Sørensen, Mette, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Wolf, Kathrin, additional, Brunekreef, Bert, additional, and Hoek, Gerard, additional

Published
2021
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45. Modeling multi-level survival data in multi-center epidemiological cohort studies: Applications from the ELAPSE project

Author

Samoli, Evangelia, primary, Rodopoulou, Sophia, additional, Hvidtfeldt, Ulla A., additional, Wolf, Kathrin, additional, Stafoggia, Massimo, additional, Brunekreef, Bert, additional, Strak, Maciej, additional, Chen, Jie, additional, Andersen, Zorana J., additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Forastiere, Francesco, additional, Fecht, Daniela, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, de Hoogh, Kees, additional, Janssen, Nicole A.H., additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Liu, Shuo, additional, Ljungman, Petter, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peters, Annette, additional, Raaschou-Nielsen, Ole, additional, Renzi, Matteo, additional, Kristoffersen, Doris T., additional, Severi, Gianluca, additional, Sigsgaard, Torben, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Hoek, Gerard, additional, and Katsouyanni, Klea, additional

Published
2021
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46. Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort

Author

Hvidtfeldt, Ulla Arthur, primary, Chen, Jie, additional, Andersen, Zorana Jovanovic, additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Brunekreef, Bert, additional, Cesaroni, Giulia, additional, Concin, Hans, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, van Gils, Carla H., additional, Gulliver, John, additional, Hertel, Ole, additional, Hoek, Gerard, additional, Hoffmann, Barbara, additional, de Hoogh, Kees, additional, Janssen, Nicole, additional, Jørgensen, Jeanette Therming, additional, Katsouyanni, Klea, additional, Jöckel, Karl-Heinz, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Lang, Alois, additional, Leander, Karin, additional, Liu, Shuo, additional, Ljungman, Petter L.S., additional, Magnusson, Patrik K.E., additional, Mehta, Amar Jayant, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peter, Raphael Simon, additional, Peters, Annette, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, Rodopoulou, Sophia, additional, Samoli, Evangelia, additional, Schwarze, Per Everhard, additional, Severi, Gianluca, additional, Sigsgaard, Torben, additional, Stafoggia, Massimo, additional, Strak, Maciej, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Wolf, Kathrin, additional, and Raaschou-Nielsen, Ole, additional

Published
2021
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47. Comparison of associations between mortality and air pollution exposure estimated with a hybrid, a land-use regression and a dispersion model

Author

Klompmaker, Jochem O., primary, Janssen, Nicole, additional, Andersen, Zorana J., additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Chen, Jie, additional, de Hoogh, Kees, additional, Houthuijs, Danny, additional, Katsouyanni, Klea, additional, Marra, Marten, additional, Oftedal, Bente, additional, Rodopoulou, Sophia, additional, Samoli, Evangelia, additional, Stafoggia, Massimo, additional, Strak, Maciej, additional, Swart, Wim, additional, Wesseling, Joost, additional, Vienneau, Danielle, additional, Brunekreef, Bert, additional, and Hoek, Gerard, additional

Published
2021
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48. Long-term low-level ambient air pollution exposure and risk of lung cancer – A pooled analysis of 7 European cohorts

Author

Hvidtfeldt, Ulla Arthur, primary, Severi, Gianluca, additional, Andersen, Zorana Jovanovic, additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bellander, Tom, additional, Boutron-Ruault, Marie-Christine, additional, Brandt, Jørgen, additional, Brunekreef, Bert, additional, Cesaroni, Giulia, additional, Chen, Jie, additional, Concin, Hans, additional, Forastiere, Francesco, additional, van Gils, Carla H., additional, Gulliver, John, additional, Hertel, Ole, additional, Hoek, Gerard, additional, Hoffmann, Barbara, additional, de Hoogh, Kees, additional, Janssen, Nicole, additional, Jöckel, Karl-Heinz, additional, Jørgensen, Jeanette Therming, additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Krog, Norun Hjertager, additional, Lang, Alois, additional, Leander, Karin, additional, Liu, Shuo, additional, Ljungman, Petter L.S., additional, Magnusson, Patrik K.E., additional, Mehta, Amar Jayant, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peter, Raphael Simon, additional, Peters, Annette, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, Rodopoulou, Sophia, additional, Samoli, Evangelia, additional, Schwarze, Per Everhard, additional, Sigsgaard, Torben, additional, Simonsen, Mette Kildevæld, additional, Stafoggia, Massimo, additional, Strak, Maciek, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Wolf, Kathrin, additional, Raaschou-Nielsen, Ole, additional, and Fecht, Daniela, additional

Published
2021
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49. Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

Author

Liu, Shuo, primary, Jørgensen, Jeanette Therming, additional, Ljungman, Petter, additional, Pershagen, Göran, additional, Bellander, Tom, additional, Leander, Karin, additional, Magnusson, Patrik K.E., additional, Rizzuto, Debora, additional, Hvidtfeldt, Ulla A., additional, Raaschou-Nielsen, Ole, additional, Wolf, Kathrin, additional, Hoffmann, Barbara, additional, Brunekreef, Bert, additional, Strak, Maciej, additional, Chen, Jie, additional, Mehta, Amar, additional, Atkinson, Richard W., additional, Bauwelinck, Mariska, additional, Varraso, Raphaëlle, additional, Boutron-Ruault, Marie-Christine, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Forastiere, Francesco, additional, Fecht, Daniela, additional, Gulliver, John, additional, Hertel, Ole, additional, de Hoogh, Kees, additional, Janssen, Nicole A.H., additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Peters, Annette, additional, Tjønneland, Anne, additional, Rodopoulou, Sophia P., additional, Samoli, Evangelia, additional, Kristoffersen, Doris Tove, additional, Sigsgaard, Torben, additional, Stafoggia, Massimo, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Hoek, Gerard, additional, and Andersen, Zorana Jovanovic, additional

Published
2020
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50. Surrounding green, air pollution, traffic noise exposure and non-accidental and cause-specific mortality

Author

Klompmaker, Jochem O, Hoek, Gerard, Bloemsma, Lizan D, Marra, Marten, Wijga, Alet H, van den Brink, Carolien, Brunekreef, Bert, Lebret, Erik, Gehring, Ulrike, Janssen, Nicole A H, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), IRAS OH Epidemiology Microbial Agents, Dep IRAS, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), IRAS OH Epidemiology Microbial Agents, and Dep IRAS

Subjects
Adult, Male, Traffic-Related Pollution, 010504 meteorology & atmospheric sciences, NDVI, PM(2.5), Noise/adverse effects, Air pollution, NO(2), Netherlands/epidemiology, PM2.5, 010501 environmental sciences, Environment, medicine.disease_cause, NO2, 01 natural sciences, Normalized Difference Vegetation Index, Environmental health, 80 and over, medicine, Air Pollutants/adverse effects, Humans, Mortality, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, Netherlands, Aged, lcsh:GE1-350, Aged, 80 and over, Air Pollutants, Traffic-Related Pollution/adverse effects, Air pollutant concentrations, business.industry, Hazard ratio, Traffic noise, Cause specific mortality, Neurodegenerative Diseases, Environmental Exposure, Particulates, Middle Aged, Accidental, Female, Particulate Matter, business, Noise, Environmental Exposure/adverse effects
Abstract

Background: Most previous studies that investigated associations of surrounding green, air pollution or traffic noise with mortality focused on single exposures. Objectives: The aim of this study was to evaluate combined associations of long-term residential exposure to surrounding green, air pollution and traffic noise with total non-accidental and cause-specific mortality. Methods: We linked a national health survey (Public Health Monitor, PHM) conducted in 2012 to the Dutch longitudinal mortality database. Subjects of the survey who were 30 years or older on 1 January 2013 (n = 339,633) were followed from 1 January 2013 till 31 December 2017. We used Cox proportional hazard models to evaluate associations of residential surrounding green (including the average Normalized Difference Vegetation Index (NDVI) in buffers of 300 m and 1000 m), annual average air pollutant concentrations (including particulate matter (PM10, PM2.5), nitrogen dioxide (NO2)) and traffic noise with non-accidental, circulatory disease, respiratory disease, lung cancer and neurodegenerative disease mortality. Results: We observed 26,886 non-accidental deaths over 1.627.365 person-years of follow-up. Surrounding green, air pollution and traffic noise exposure were not significantly associated with non-accidental or cause-specific mortality. For non-accidental mortality, we found a hazard ratio (HR) of 0.99 (0.98, 1.01) per IQR increase in NDVI 300 m, a HR of 0.99 (95% CI: 0.97, 1.01) per IQR increase in NO2, a HR of 0.98 (0.97, 1.00) per IQR increase in PM2.5 and a HR of 0.99 (95% CI: 0.97, 1.01) per IQR increase in road-traffic noise. Analyses restricted to non-movers or excluding subjects aged 85+ years did not change the findings. Conclusion: We found no evidence for associations of long-term residential exposures to surrounding green, air pollution and traffic noise with non-accidental or cause-specific mortality in a large population based survey in the Netherlands, possibly related to the relatively short follow-up period. Keywords: NDVI, NO2, PM2.5, Traffic noise, Mortality

Published
2020

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