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Your search keyword '"Kloosterboer, Freke M."' showing total 9 results
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9 results on '"Kloosterboer, Freke M."'

2. Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

Author

Marijt, W.A. Erik, Heemskerk, Mirjam H.M., Kloosterboer, Freke M., Goulmy, Els, Kester, Michel G.D., van der Hoorn, Menno A.W.G., van Luxemburg-Heys, Simone A.P., Hoogeboom, Manja, Mutis, Tuna, Drijfhout, Jan Wouter, van Rood, Jon J., Willemze, Roel, and Falkenburg, J.H. Frederik

Subjects
Lymphocytes -- Physiological aspects, Cancer patients -- Care and treatment, Antigens -- Physiological aspects, Stem cells -- Physiological aspects, Hematopoiesis -- Analysis, Histocompatibility -- Analysis, Science and technology
Abstract

Donor lymphocyte infusion (DLI) into patients with a relapse of their leukemia or multiple myeloma after allogeneic stem cell transplantation (alloSCT) has been shown to be a successful treatment approach. The hematopoiesis-restricted minor histocompatibility antigens (mHAgs) HA-1 or HA-2 expressed on malignant cells of the recipient may serve as target antigens for alloreactive donor T cells. Recently we treated three mHAg HA-1- and/or HA-2-positive patients with a relapse of their disease after alloSCT with DLI from their mHAg HA-1- and/or HA-2-negative donors. Using HLA-A2/HA-1 and HA-2 peptide tetrameric complexes we showed the emergence of HA-1- and HA-2-specific CD[8.sup.+] T cells in the blood of the recipients 5-7 weeks after DLI. The appearance of these tetramer-positive cells was followed immediately by a complete remission of the disease and restoration of 100% donor chimerism in each of the patients. Furthermore, cloned tetramer-positive T cells isolated during the clinical response specifically recognized HA-1 and HA-2 expressing malignant progenitor cells of the recipient and inhibited the growth of leukemic precursor cells in vitro. Thus, HA-1- and HA-2-specific cytotoxic T lymphocytes emerging in the blood of patients after DLI demonstrate graft-versus-leukemia or myeloma reactivity resulting in a durable remission. This finding implies that in vitro generated HA-1- and HA-2-specific cytotoxic T lymphocytes could be used as adoptive immunotherapy to treat hematological malignances relapsing after alloSCT.

Published
2003

5. Multiple myeloma–reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene

Author

van Bergen, Cornelis A. M., primary, Kester, Michel G. D., additional, Jedema, Inge, additional, Heemskerk, Mirjam H. M., additional, van Luxemburg-Heijs, Simone A. P., additional, Kloosterboer, Freke M., additional, Marijt, W. A. Erik, additional, de Ru, Arnoud H., additional, Schaafsma, M. Ron, additional, Willemze, Roel, additional, van Veelen, Peter A., additional, and Falkenburg, J. H. Frederik, additional

Published
2007
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6. ATP Dependent Interferon Responsive (ADIR) Gene Encodes an Activation Induced Minor Histocompatibility Antigen Recognized on Multiple Myeloma by CD8+ T Cells.

Author

Van Bergen, Cornelis A., primary, Kester, Michel G., additional, Jedema, Inge, additional, Heemskerk, Mirjam H., additional, Van Luxemburg, Simone A., additional, Kloosterboer, Freke M., additional, Marijt, Erik W., additional, De Ru, Arnoud H., additional, Schaafsma, Martyn R., additional, Willemze, Roelof, additional, Van Veelen, Peter A., additional, and Falkenburg, J.H. Frederik, additional

Published
2006
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8. Identification of the Angiogenic Endothelial Cell Growth Factor-1/Thymidine Phosphorylase as a Target for Immunotherapy of Cancer.

Author

Slager, Elisabeth H., primary, Honders, M. Willy, primary, van der Meijden, Edith D., primary, van Luxemburg-Heijs, Simone A.P., primary, Kloosterboer, Freke M., primary, Kester, Michel G.D., primary, Jedema, Inge, primary, Marijt, W.A. Erik, primary, Schaafsma, M. Ronald, primary, Falkenburg, J.H. Frederik, primary, and Willemze, Roel, primary

Published
2005
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9. UTYgene codes for an HLA-B60–restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition

Author

Vogt, Mario H.J., Goulmy, Els, Kloosterboer, Freke M., Blokland, Els, de Paus, Roel A., Willemze, Roel, and Falkenburg, J. H. Frederik

Abstract

Rejection of a graft after human leukocyte antigen (HLA)-identical stem cell transplantation (SCT) can be caused by recipient's immunocompetent T lymphocytes recognizing minor histocompatibility antigens on donor stem cells. During rejection of a male stem cell graft by a female recipient, 2 male (H-Y)–specific cytotoxic T lymphocyte (CTL) clones were isolated from peripheral blood. One CTL clone recognized an HLA-A2–restricted H-Y antigen, encoded by the SMCYgene. Another CTL clone recognized an HLA-B60–restricted H-Y antigen. In this study UTYwas identified as the gene coding for the HLA-B60–restricted H-Y antigen. The UTY-derived H-Y antigen was characterized as a 10-amino acid residue peptide, RESEEESVSL. Although the epitope differed by 3 amino acids from its X-homologue, UTX, only 2 polymorphisms were essential for recognition by the CTL clone HLA-B60 HY. These results illustrate that CTLs against several H-Y antigens derived from different proteins can contribute simultaneously to graft rejection after HLA-identical, sex-mismatched SCT. Moreover, RESEEESVSL-specific T cells could be isolated from a female HLA-B60+ patient with myelodysplastic syndrome who has been treated with multiple blood transfusions, but not from control healthy HLA-B60+ female donors. This may indicate that RESEEESVSL-reactive T cells are more common in sensitized patients.

Published
2000
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