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20 results on '"Klostergaard, Anja"'

1. Strategies to improve patient-reported outcome completion rates in longitudinal studies

Author

Nielsen, Lene Kongsgaard, King, Madeleine, Möller, Sören, Jarden, Mary, Andersen, Christen Lykkegaard, Frederiksen, Henrik, Gregersen, Henrik, Klostergaard, Anja, Steffensen, Morten Saaby, Pedersen, Per Trøllund, Hinge, Maja, Frederiksen, Mikael, Jensen, Bo Amdi, Helleberg, Carsten, Mylin, Anne Kærsgaard, and Abildgaard, Niels

Published
2020

2. Ixazomib-Thalidomide-Dexamethasone Induction Followed by Ixazomib or Placebo Maintenance in Nontransplant Eligible Newly Diagnosed Multiple Myeloma Patients: Long-term Results of HOVON-126/NMSG 21.13

Author

Groen, Kazimierz, primary, Schjesvold, Fredrik H., additional, van der Holt, Bronno, additional, Levin, Mark-David, additional, Seefat, Maarten R., additional, Hansson, Markus, additional, Leys, Maria B.L., additional, Regelink, Josien C., additional, Waage, Anders, additional, Szatkowski, Damian, additional, Axelsson, Per, additional, Hieu Do, Trung, additional, Svirskaite, Asta, additional, van der Spek, Ellen, additional, Haukas, Einar, additional, Knut-Bojanowska, Dorota, additional, Ypma, Paula F., additional, Blimark, Cecilie H., additional, Mellqvist, Ulf-Henrik, additional, van de Donk, Niels W.C.J., additional, Sonneveld, Pieter, additional, Klostergaard, Anja, additional, Vangsted, Annette J., additional, Abildgaard, Niels, additional, and Zweegman, Sonja, additional

Published
2023
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4. Geographical and ecological analyses of multiple myeloma in Denmark:Identification of potential hotspot areas and impact of urbanisation

Author

Bertelsen, Lise Dueholm, Børty Nielsen, Lars, Christensen, Heidi Søgaard, Bøgsted, Martin, Gregersen, Henrik, Pedersen, Robert Schou, Klostergaard, Anja, Schnack, Brian Iversen, Pedersen, Per Trøllund, Abildgaard, Niels, Hermansen, Emil, Vangsted, Annette Juul, Severinsen, Marianne Tang, Bertelsen, Lise Dueholm, Børty Nielsen, Lars, Christensen, Heidi Søgaard, Bøgsted, Martin, Gregersen, Henrik, Pedersen, Robert Schou, Klostergaard, Anja, Schnack, Brian Iversen, Pedersen, Per Trøllund, Abildgaard, Niels, Hermansen, Emil, Vangsted, Annette Juul, and Severinsen, Marianne Tang

Abstract

Background: The aetiology of multiple myeloma (MM) is unknown but various environmental exposures are suspected as risk factors. We present the first paper analysing the geographical distribution of MM in Denmark at the municipal level to investigate variations that could be explained by environmental exposures. Methods: Patients diagnosed with MM in Denmark during 2005–2020 were identified from nationwide registries and grouped into the 98 Danish municipalities based on residence. The age- and sex-standardised incidence rate (SIR) of each municipality was compared to the national incidence in a funnel plot with 95% control limits. Differences in SIRs of rural, suburban, and urban areas were evaluated with incidence rate ratios. Results: In total, 5243 MM patients were included. Overall, we found a heterogeneous geographical distribution of MM and a potential hotspot in southern Denmark. This hotspot contains three municipalities with SIRs above the 95% control limit assuming considerably higher rate of MM compared to the national incidence rate. A significant higher SIR was found in rural areas compared to urban areas. Conclusion: The geographical distribution of MM in Denmark indicates that the risk of developing MM depends on place of residence probably due to environmental factors.

Published
2023

5. Dansk Myelomatose Database – Resumé af årsrapport 2021

Author

Hermansen, Emil, Kristensen, Ida Bruun, Gregersen, Henrik, Klostergaard, Anja, Jensen, Bo Amdi, Dravecká, Jana, Hinge, Maja, Pedersen, Robert Schou, Pedersen, Per Trøllund, Christiansen, Niklas Mølbak, Fredsted, Anne, and Steding-Jessen, Marianne

Published
2023

6. Geographical and ecological analyses of multiple myeloma in Denmark: Identification of potential hotspot areas and impact of urbanisation

Author

Bertelsen, Lise Dueholm, primary, Børty Nielsen, Lars, additional, Christensen, Heidi Søgaard, additional, Bøgsted, Martin, additional, Gregersen, Henrik, additional, Pedersen, Robert Schou, additional, Klostergaard, Anja, additional, Schnack, Brian Iversen, additional, Pedersen, Per Trøllund, additional, Abildgaard, Niels, additional, Hermansen, Emil, additional, Vangsted, Annette Juul, additional, and Severinsen, Marianne Tang, additional

Published
2022
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7. Geographical and ecological analyses of multiple myeloma in Denmark: Identification of potential hotspot areas and impact of urbanisation.

Author

Bertelsen, Lise Dueholm, Børty Nielsen, Lars, Christensen, Heidi Søgaard, Bøgsted, Martin, Gregersen, Henrik, Pedersen, Robert Schou, Klostergaard, Anja, Schnack, Brian Iversen, Pedersen, Per Trøllund, Abildgaard, Niels, Hermansen, Emil, Vangsted, Annette Juul, and Severinsen, Marianne Tang

Subjects
MULTIPLE myeloma, URBANIZATION, ENVIRONMENTAL exposure, CITIES & towns, DISEASE clusters
Abstract

Background: The aetiology of multiple myeloma (MM) is unknown but various environmental exposures are suspected as risk factors. We present the first paper analysing the geographical distribution of MM in Denmark at the municipal level to investigate variations that could be explained by environmental exposures. Methods: Patients diagnosed with MM in Denmark during 2005–2020 were identified from nationwide registries and grouped into the 98 Danish municipalities based on residence. The age‐ and sex‐standardised incidence rate (SIR) of each municipality was compared to the national incidence in a funnel plot with 95% control limits. Differences in SIRs of rural, suburban, and urban areas were evaluated with incidence rate ratios. Results: In total, 5243 MM patients were included. Overall, we found a heterogeneous geographical distribution of MM and a potential hotspot in southern Denmark. This hotspot contains three municipalities with SIRs above the 95% control limit assuming considerably higher rate of MM compared to the national incidence rate. A significant higher SIR was found in rural areas compared to urban areas. Conclusion: The geographical distribution of MM in Denmark indicates that the risk of developing MM depends on place of residence probably due to environmental factors. [ABSTRACT FROM AUTHOR]

Published
2023
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8. The Impact of the COVID-19 Pandemic on Quality of Life in Danish Patients with Multiple Myeloma; Results from an Ongoing Longitudinal National Survey

Author

Redder, Louise, primary, Möller, Sören, additional, Johnsen, Anna Thit, additional, Jarden, Mary, additional, lykkegaard Andersen, Christen, additional, Frederiksen, Henrik, additional, Gregersen, Henrik, additional, Klostergaard, Anja, additional, Steffensen, Morten Saaby, additional, Pedersen, Per Troellund, additional, Hinge, Maja, additional, Frederiksen, Mikael, additional, Helleberg, Carsten, additional, Abildgaard, Niels, additional, and Nielsen, Lene Kongsgaard, additional

Published
2021
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9. Quality of Life in Danish Patients with Multiple Myeloma during the COVID-19 Pandemic

Author

Redder, Louise, primary, Möller, Sören, additional, Johnsen, Anna Thit, additional, Jarden, Mary, additional, Andersen, Christen Lykkegaard, additional, Jensen, Bo Amdi, additional, Frederiksen, Henrik, additional, Gregersen, Henrik, additional, Klostergaard, Anja, additional, Steffensen, Morten Saaby, additional, Pedersen, Per Trøllund, additional, Hinge, Maja, additional, Frederiksen, Mikael, additional, Helleberg, Carsten, additional, Mylin, Anne Kærsgaard, additional, Abildgaard, Niels, additional, and Nielsen, Lene Kongsgaard, additional

Published
2021
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11. Dansk Myelomatose Database:Årsrapport 2020

Author

Hermansen, Emil, Kristensen, Ida Bruun, Gregersen, Henrik, Klostergaard, Anja, Pedersen, Robert Schou, Plesner, Torben, Pedersen, Per Trøllund, Helleberg, Carsten, Dravecká, Jana, Abildgaard, Niels, Silkjær, Trine, Vase, Maja Ølholm, Lund, Thomas, Preiss, Birgitte S., Møller, Hanne E, Nielsen, Lene Kongsgaard, Hansen, Charlotte Toftmann, Vangsted, Annette, Mylin, Anne, and Ehmsen, Boje

Published
2021

12. Quality of Life in Danish Patients with Multiple Myeloma during the COVID-19 Pandemic

Author

Redder, Louise, Møller, Søren, Johnsen, Anna Thit, Jarden, Mary, Andersen, Christen Lykkegaard, Jensen, Bo Amdi, Frederiksen, Henrik, Gregersen, Henrik, Klostergaard, Anja, Steffensen, Morten Saaby, Pedersen, Per Trøllund, Hinge, Maja, Frederiksen, Mikael, Helleberg, Carsten, Mylin, Anne Kærsgaard, Abildgaard, Niels, Nielsen, Lene Kongsgaard, Redder, Louise, Møller, Søren, Johnsen, Anna Thit, Jarden, Mary, Andersen, Christen Lykkegaard, Jensen, Bo Amdi, Frederiksen, Henrik, Gregersen, Henrik, Klostergaard, Anja, Steffensen, Morten Saaby, Pedersen, Per Trøllund, Hinge, Maja, Frederiksen, Mikael, Helleberg, Carsten, Mylin, Anne Kærsgaard, Abildgaard, Niels, and Nielsen, Lene Kongsgaard

Published
2021

14. Strategies to improve patient-reported outcome completion rates in longitudinal studies

Author

Nielsen, Lene Kongsgaard, primary, King, Madeleine, additional, Möller, Sören, additional, Jarden, Mary, additional, Andersen, Christen Lykkegaard, additional, Frederiksen, Henrik, additional, Gregersen, Henrik, additional, Klostergaard, Anja, additional, Steffensen, Morten Saaby, additional, Pedersen, Per Trøllund, additional, Hinge, Maja, additional, Frederiksen, Mikael, additional, Jensen, Bo Amdi, additional, Helleberg, Carsten, additional, Mylin, Anne Kærsgaard, additional, and Abildgaard, Niels, additional

Published
2019
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15. Immunoparesis in newly diagnosed Multiple Myeloma patients: Effects on overall survival and progression free survival in the Danish population

Author

Sørrig, Rasmus, Klausen, Tobias W, Salomo, Morten, Vangsted, Annette J, Frølund, Ulf Christian, Andersen, Kristian T, Klostergaard, Anja, Helleberg, Carsten, Pedersen, Robert S, Pedersen, Per T, Helm-Petersen, Sissel, Teodorescu, Elena Manuela, Preiss, Birgitte, Abildgaard, Niels, Gimsing, Peter, Svirskaite, Asta, Johnsen, Hans Erik, Gregersen, Henrik, Gade, Inger Lise, and Bødker, Julie Støve

Subjects
Oncology, Male, European People, Physiology, Cell Transplantation, Denmark, lcsh:Medicine, Pathology and Laboratory Medicine, Biochemistry, Plasma Cell Disorders, Geographical locations, RISK STRATIFICATION, Hypogammaglobulinemia, Hematologic Cancers and Related Disorders, White Blood Cells, 0302 clinical medicine, Agammaglobulinemia, Animal Cells, Immune Physiology, Medicine and Health Sciences, Blood and Lymphatic System Procedures, CRITERIA, Ethnicities, lcsh:Science, Multiple myeloma, Aged, 80 and over, education.field_of_study, Multidisciplinary, Immune System Proteins, Hematology, Middle Aged, Prognosis, Europe, Myelomas, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cohort, Female, Cellular Types, Multiple Myeloma, Research Article, Adult, medicine.medical_specialty, Immune Cells, Population, Immunology, Plasma Cells, Surgical and Invasive Medical Procedures, Immune Suppression, Antibodies, MECHANISMS, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, medicine, Journal Article, Humans, Progression-free survival, Myelomas and Lymphoproliferative Diseases, European Union, education, Survival analysis, SUPPRESSION, Aged, Danish People, Transplantation, Blood Cells, business.industry, Proportional hazards model, UNINVOLVED IMMUNOGLOBULINS, lcsh:R, Biology and Life Sciences, Proteins, Cancers and Neoplasms, Cell Biology, medicine.disease, Survival Analysis, REGISTRY, CELLS, People and Places, Population Groupings, lcsh:Q, Bone marrow, business, 030215 immunology, Stem Cell Transplantation
Abstract

Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma Registry representing the entire MM population in Denmark from 2005-2013. Two-thousand two hundred and fifty three patients (90%) presented with reduction below lower normal levels of at least one uninvolved immunoglobulin. Using multivariable Cox regression we found that high age, high ISS score, high LDH and IgA MM were associated to both shorter overall survival and progression free survival. Furthermore, bone marrow plasma cell% was associated to short progression free survival. Immunoparesis had no independent significant effect on OS (HR 0.9 (95% CI: 0.7; 1.0; p = 0.12)). Likewise, the number of suppressed immunoglobulins or the relative degree of suppressed uninvolved immunoglobulins from lower normal level (quantitative immunoparesis) was not associated to OS in the multivariable analysis. However, quantitative immunoparesis with at least 25% reduction (from lower normal level) of uninvolved immunoglobulins was associated to shorter PFS for the entire population. The impact of quantitative immunoparesis on PFS was present irrespective of calendar periods 2005-2008 and 2009-2013. Our population-based study does not confirm that immunoparesis at diagnosis is an independent prognostic factor regarding OS. However, quantitative immunoparesis is associated to a shorter PFS.

Published
2017

16. Immunoparesis in newly diagnosed Multiple Myeloma patients:Effects on overall survival and progression free survival in the Danish population

Author

Sørrig, Rasmus, Klausen, Tobias W., Salomo, Morten, Vangsted, Annette J., Frølund, Ulf Christian, Andersen, Kristian T., Klostergaard, Anja, Helleberg, Carsten, Pedersen, Robert S., Pedersen, Per T., Helm-Petersen, Sissel, Teodorescu, Elena Manuela, Preiss, Birgitte, Abildgaard, Niels, Gimsing, Peter, Sørrig, Rasmus, Klausen, Tobias W., Salomo, Morten, Vangsted, Annette J., Frølund, Ulf Christian, Andersen, Kristian T., Klostergaard, Anja, Helleberg, Carsten, Pedersen, Robert S., Pedersen, Per T., Helm-Petersen, Sissel, Teodorescu, Elena Manuela, Preiss, Birgitte, Abildgaard, Niels, and Gimsing, Peter

Abstract

Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma Registry representing the entire MM population in Denmark from 2005–2013. Two-thousand two hundred and fifty three patients (90%) presented with reduction below lower normal levels of at least one uninvolved immunoglobulin. Using multivariable Cox regression we found that high age, high ISS score, high LDH and IgA MM were associated to both shorter overall survival and progression free survival. Furthermore, bone marrow plasma cell % was associated to short progression free survival. Immunoparesis had no independent significant effect on OS (HR 0.9 (95%CI: 0.7;1.0; p = 0.12)). Likewise, the number of suppressed immunoglobulins or the relative degree of suppressed uninvolved immunoglobulins from lower normal level (quantitative immunoparesis) was not associated to OS in the multivariable analysis. However, quantitative immunoparesis with at least 25% reduction (from lower normal level) of uninvolved immunoglobulins was associated to shorter PFS for the entire population. The impact of quantitative immunoparesis on PFS was present irrespective of calendar periods 2005–2008 and 2009–2013. Our population-based study does not confirm that immunoparesis at diagnosis is an independent prognostic factor regarding OS. However, quantitative immunoparesis is associated to a shorter PFS.

Published
2017

18. Ixazomib-Thalidomide-low dose dexamethasone induction followed by maintenance therapy with ixazomib or placebo in newly diagnosed multiple myeloma patients not eligible for autologous stem cell transplantation; results from the randomized phase II HOVON-126/NMSG 21.13 trial.

Author

Zweegman S, Stege CAM, Haukas E, Schjesvold FH, Levin MD, Waage A, Leys RBL, Klein SK, Szatkowski D, Axelsson P, Hieu Do T, Knut-Bojanowska D, van der Spek E, Svirskaite A, Klostergaard A, Salomo M, Blimark C, Ypma PF, Mellqvist UH, Poddighe PJ, Stevens-Kroef M, van de Donk NWCJ, Sonneveld P, Hansson M, van der Holt B, and Abildgaard N

Subjects
Antineoplastic Combined Chemotherapy Protocols therapeutic use, Boron Compounds, Bortezomib therapeutic use, Dexamethasone therapeutic use, Glycine analogs & derivatives, Humans, Stem Cell Transplantation, Thalidomide therapeutic use, Transplantation, Autologous, Treatment Outcome, Hematopoietic Stem Cell Transplantation, Multiple Myeloma diagnosis, Multiple Myeloma drug therapy
Published
2020
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19. [Neurogenic autonomic dysfunction in adults].

Author

Terkelsen AJ, Hansen J, Klostergaard A, Otto M, Mølgaard H, Hvas CL, Krogh K, Kirkeby HJ, Andersen H, and Jensen TS

Subjects
Adult, Algorithms, Humans, Hypotension, Orthostatic etiology, Parasympathetic Nervous System anatomy & histology, Sympathetic Nervous System anatomy & histology, Autonomic Nervous System Diseases complications, Autonomic Nervous System Diseases diagnosis, Autonomic Nervous System Diseases etiology, Autonomic Nervous System Diseases therapy
Abstract

Neurogenic autonomic dysfunction (NAD) is underdiagnosed, and it is likely in patients, who have orthostatic hypotension and symptoms from multiple organ systems as well as abnormal results from a neurological examination. A clinical and neurophysiological examination of the autonomic nervous system combined with a standardised paraclinical evaluation should be performed. NAD may be present in neurodegenerative disorders, vitamin deficiency, toxicity, infection, and in paraneoplastic, metabolic, hereditary and immune-mediated conditions.

Published
2018

20. [Neurogenic autonomic dysfunction in primary amyliodosis].

Author

Terkelsen AJ, Hansen J, Klostergaard A, Otto M, Mølgaard H, Hvas CL, Krogh K, Kirkeby HJ, Madsen LB, Andersen H, and Jensen TS

Subjects
Autonomic Nervous System Diseases complications, Humans, Immunoglobulin Light-chain Amyloidosis complications, Immunoglobulin Light-chain Amyloidosis pathology, Male, Middle Aged, Surveys and Questionnaires, Autonomic Nervous System Diseases diagnosis, Immunoglobulin Light-chain Amyloidosis diagnosis
Abstract

Neurogenic autonomic dysfunction (NAD) and polyneuropathy occur in common conditions like diabetes and alcoholism. However, it can also be seen in rare diseases like in this case report of amyloid light-chain amyloidosis: primary amyloidosis. A 56-year-old man presented with polyneuropathy, a sympathetic dysfunction causing orthostatic intolerance, syncope, parasympathetic dysfunction and involvement of the enteric nervous system. The report illustrates, that routine screening can be insufficient in diagnosing amyloidosis. NAD and polyneuropathy without clear aetiology may require a multidisciplinary elucidation of more rare diseases.

Published
2018

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