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266 results on '"Klussmann, J. P."'

4. Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors.

Author

Nachtsheim, Lisa, Jansen, L., Shabli, S., Arolt, C., Quaas, A., Klussmann, J. P., Mayer, M., and Wolber, P.

Subjects
SALIVARY gland cancer, SUBMANDIBULAR gland, SALIVARY glands, DISEASE risk factors, MULTIVARIATE analysis
Abstract

Background: Primary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associated risk factors, and survival. Methods: This analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan–Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence. Results: 21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive‐resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5‐year overall survival was 67%, the 5‐year disease‐free survival was 54%. Conclusion: Tumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered. [ABSTRACT FROM AUTHOR]

Published
2025
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6. Auswirkungen der SARS-CoV‑2-Pandemie auf die universitäre Hals-Nasen-Ohren-Heilkunde im Bereich der Forschung, Lehre und Weiterbildung

Author

Stöver, T., Dazert, S., Plontke, S. K., Kramer, S., Ambrosch, P., Arens, C., Betz, C., Beutner, D., Bohr, C., Bruchhage, K.-L., Canis, M., Dietz, A., Guntinas-Lichius, O., Hagen, R., Hosemann, W., Iro, H., Klussmann, J. P, Knopf, A., Lang, S., Leinung, M., Lenarz, T., Löwenheim, H., Matthias, C., Mlynski, R., Olze, H., Park, J., Plinkert, P., Radeloff, A., Rotter, N., Rudack, C., Bozzato, A., Schipper, J., Schrader, M., Schuler, P. J., Strieth, S., Stuck, B. A., Volkenstein, S., Westhofen, M., Wolf, G., Wollenberg, B., Zahnert, T., Zenk, J., and Hoffmann, T. K.

Published
2021
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15. Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies

Author

Kuzkina, A., primary, Rößle, J., additional, Seger, A., additional, Panzer, C., additional, Kohl, A., additional, Maltese, V., additional, Musacchio, T., additional, Blaschke, S. J., additional, Tamgüney, G., additional, Kaulitz, S., additional, Rak, K., additional, Scherzad, A., additional, Zimmermann, P. H., additional, Klussmann, J. P., additional, Hackenberg, S., additional, Volkmann, J., additional, Sommer, C., additional, Sommerauer, M., additional, and Doppler, K., additional

Published
2023
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24. Phase III study assessing the best of radiotherapy compared to the best of surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0-N1 oropharyngeal, supraglottic carcinoma and with T1, N0 hypopharyngeal carcinoma

Author

Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., Gregoire, V., Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., and Gregoire, V.

Published
2022

30. Effects of the SARS-CoV-2 pandemic on the otolaryngology university hospitals in the field of research, student teaching and specialist training

Author

Stoever, T., Dazert, S., Plontke, S. K., Kramer, S., Ambrosch, P., Arens, C., Betz, C., Beutner, D., Bohr, C., Bruchhage, K. -L., Canis, M., Dietz, A., Guntinas-Lichius, O., Hagen, R., Hosemann, W., Iro, H., Klussmann, J. P., Knopf, A., Lang, S., Leinung, M., Lenarz, T., Loewenheim, H., Matthias, C., Mlynski, R., Olze, H., Park, J., Plinkert, P., Radeloff, A., Rotter, N., Rudack, C., Bozzato, A., Schipper, J., Schrader, M., Schuler, P. J., Strieth, S., Stuck, B. A., Volkenstein, S., Westhofen, M., Wolf, G., Wollenberg, B., Zahnert, T., Zenk, J., Hoffmann, T. K., Stoever, T., Dazert, S., Plontke, S. K., Kramer, S., Ambrosch, P., Arens, C., Betz, C., Beutner, D., Bohr, C., Bruchhage, K. -L., Canis, M., Dietz, A., Guntinas-Lichius, O., Hagen, R., Hosemann, W., Iro, H., Klussmann, J. P., Knopf, A., Lang, S., Leinung, M., Lenarz, T., Loewenheim, H., Matthias, C., Mlynski, R., Olze, H., Park, J., Plinkert, P., Radeloff, A., Rotter, N., Rudack, C., Bozzato, A., Schipper, J., Schrader, M., Schuler, P. J., Strieth, S., Stuck, B. A., Volkenstein, S., Westhofen, M., Wolf, G., Wollenberg, B., Zahnert, T., Zenk, J., and Hoffmann, T. K.

Abstract

Background From spring 2020, SARS-CoV-2 began to spread worldwide, with what is now known as the first wave of the pandemic, starting in March 2020. This resulted in restructuring and shift of resources at many hospitals. The aim of our work was to detect the effects of the pandemic on the german Oto-Rhino-Laryngology (ORL) university hospitals in terms of research, student teaching and further specialist training. Material and methods The chairmen of the 39 ORL university hospitals in Germany were asked about the effects of the pandemic on research, student teaching and ORL specialist training (residency) in the period from March to April 2020 using a structured online survey. Results All 39 chairmen took part in the survey. Of these, 74.4% (29/39) stated that their research activities had deteriorated as a result of the pandemic. In 61.5% (24/39) pandemic-related research issues were addressed. All hospitals reported a restriction for in-house teaching and 97.5% (38/39) introduced new digital teaching methods. During the observation period, 74.4% of the chairmen did not see ORL specialist training (residency)at risk. Conclusion Our results provide an insight into the heterogeneous effects of the pandemic. The fast processing of pandemic-related research topics and the introduction of innovative digital concepts for student teaching impressively demonstrates the great innovative potential and the ability of the ORL university hospitals to react quickly in order to maintain their tasks in research, student teaching and ORL specialist training in the best possible way even during the pandemic.

Published
2021

31. HPV-related oropharyngeal squamous cell carcinoma-Incidence steadily rising

Author

Suchan, M., Wuerdemann, N., Sharma, S. J., Klussmann, J. P., Suchan, M., Wuerdemann, N., Sharma, S. J., and Klussmann, J. P.

Abstract

The incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is steadily increasing worldwide and has already exceeded cervical cancer rates in the USA. Due to their tumor biology, HPV-positive tumors of the oropharynx, which have been included in the eighth edition of the AJCC/UICC (American Joint Committee on Cancer/Union Internationale Contre le Cancer) Staging Manual since 2018, represent a separate entity. Following biopsy, diagnostic confirmation is performed by immunohistochemical detection of p16 expression, with p16 acting as a surrogate marker. Therapeutically, surgical and radiotherapeutic approaches are considered equivalent in terms of efficacy. With a 5-year overall survival of up to 80%, patients with HPV-positive OPSCC have a better prognosis compared to patients with HPV-negative OPSCC, where survival rates are between 40 and 50%.

Published
2021

42. Criteria for Re-Irradiation.

Author

Willmann, J., Andratschke, N., Klußmann, J. P., Gschwend, J. E., Tabatabai, G., and Niyazi, M.

Abstract

Background: The treatment options for patients with progressive malignant tumors despite primary radiotherapy are often limited. In selected cases, re-irradiation can be offered. This article concerns the selection criteria and results of re-irradiation for certain types of cancer. Methods: This review is based on pertinent publications retrieved by a selective search in PubMed, with particular attention to glioblastoma, head and neck tumors, and prostatic carcinoma. Results: The published studies of re-irradiation are few in number and often of limited methodological quality. For glioblastoma, a randomized controlled trial (RCT) found that adding re-irradiation to treatment with bevacizumab yielded no significant improvement in either median progression-free survival or median overall survival (hazard ratio [HR] 0.73; p = 0.05 and HR 0.98; p = 0.46, respectively). Re-irradiation is a treatment option for locoregional recurrences of head and neck tumors after primary radiotherapy, but it carries a risk of serious side effects. For unresectable recurrences of nasopharyngeal carcinoma, an RCT has shown that hyperfractionated re-irradiation is more effective than normofractionated re-irradiation (overall survival: HR 0.54, p = 0.014). For locally recurrent prostatic carcinoma after radiotherapy, re-irradiation can yield good oncologic outcomes with an acceptable level of urogenital and gastrointestinal side effects (5-year recurrence-free survival: stereotactic body radiation therapy (SBRT), 58%; high dose rate (HDR) brachytherapy, 77%; versus salvage prostatectomy, 72%). RCTs on this topic are lacking. Conclusion: Re-irradiation is a treatment option for selected cancer patients. As the available scientific evidence is limited, multidisciplinary collaboration and participatory decision-making are particularly important. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Auswirkungen der SARS-CoV-2-Pandemie auf die universitäre Hals-Nasen-Ohrenheilkunde im Bereich der Krankenversorgung

Author

Stöver, T., primary, Dazert, S., primary, Hoffmann, T. K., primary, Plontke, S. K., primary, Ambrosch, P., additional, Arens, C., additional, Betz, C., additional, Beutner, D., additional, Bohr, C., additional, Bruchhage, K.-L., additional, Canis, M., additional, Dietz, A., additional, Guntinas-Lichius, O., additional, Hagen, R., additional, Hosemann, W., additional, Iro, H., additional, Klussmann, J.-P., additional, Knopf, A., additional, Kramer, S., additional, Lang, S., additional, Leinung, M., additional, Lenarz, T., additional, Löwenheim, H., additional, Matthias, C., additional, Mlynski, R., additional, Olze, H., additional, Park, J., additional, Plinkert, P., additional, Radeloff, A., additional, Rotter, N., additional, Rudack, C., additional, Bozzato, A., additional, Schipper, J., additional, Schrader, M., additional, Strieth, S., additional, Stuck, B. A., additional, Volkenstein, S., additional, Westhofen, M., additional, Wolf, G., additional, Wollenberg, B., additional, Zahnert, T., additional, and Zenk, J., additional

Published
2020
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47. Auswirkungen der SARS-CoV-2-Pandemie auf die universitäre Hals-Nasen-Ohrenheilkunde im Bereich der Krankenversorgung

Author

Stöver, T., Dazert, S., Hoffmann, T.K., Plontke, S.K., Ambrosch, P., Arens, C., Betz, C., Beutner, D., Bohr, C., Bruchhage, K.-L., Canis, M., Dietz, A., Guntinas-Lichius, O., Hagen, R., Hosemann, W., Iro, H., Klussmann, J.-P., Knopf, A., Kramer, S., Lang, Stephan, Leinung, M., Lenarz, T., Löwenheim, H., Matthias, C., Mlynski, R., Olze, H., Park, J., Plinkert, P., Radeloff, A., Rotter, N., Rudack, C., Bozzato, A., Schipper, J., Schrader, M., Strieth, S., Stuck, B.A., Volkenstein, S., Westhofen, M., Wolf, G., Wollenberg, B., Zahnert, T., and Zenk, J.

Subjects
Medizin
Published
2020

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