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283 results on '"Knoke M"'

2. Automatic Tissue Differentiation in Parotidectomy using Hyperspectral Imaging

Author

Wisotzky Eric L., Schill Alexander, Hilsmann Anna, Eisert Peter, and Knoke Michael

Subjects
hyperspectral imaging, multispectral imaging, tissue differentiation, 3d-cnn, tissue classification, Medicine
Abstract

In head and neck surgery, continuous intraoperative tissue differentiation is of great importance to avoid injury to sensitive structures such as nerves and vessels. Hyperspectral imaging (HSI) with neural network analysis could support the surgeon in tissue differentiation. A 3D Convolutional Neural Network with hyperspectral data in the range of 400 − 1000 nm is used in this work. The acquisition system consisted of two multispectral snapshot cameras creating a stereo-HSI-system. For the analysis, 27 images with annotations of glandular tissue, nerve, muscle, skin and vein in 18 patients undergoing parotidectomy are included. Three patients are removed for evaluation following the leave-one-subjectout principle. The remaining images are used for training, with the data randomly divided into a training group and a validation group. In the validation, an overall accuracy of 98.7% is achieved, indicating robust training. In the evaluation on the excluded patients, an overall accuracy of 83.4% has been achieved showing good detection and identification abilities. The results clearly show that it is possible to achieve robust intraoperative tissue differentiation using hyperspectral imaging. Especially the high sensitivity in parotid or nerve tissue is of clinical importance. It is interesting to note that vein was often confused with muscle. This requires further analysis and shows that a very good and comprehensive data basis is essential. This is a major challenge, especially in surgery.

Published
2024
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4. Antiseptik in der Inneren Medizin

Author

Knoke, M., Kraatz, G., Kramer, Axel, editor, Gröschel, D., editor, Heeg, P., editor, Hingst, V., editor, Lippert, H., editor, Rotter, M., editor, and Weuffen, W., editor

Published
1993
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15. Editorial

Author

Müller, J. and Knoke, M.

Published
2004

26. Was bietenCandida-Biofilme Besonderes? Something special ofCandidabiofilms?

Author

Hannelore Bernhardt and Knoke M

Subjects
Voriconazole, Continuous flow, Chemistry, Biofilm, Dermatology, General Medicine, Corpus albicans, Microbiology, Cell system, Infectious Diseases, Dry weight, medicine, Anidulafungin, medicine.drug
Abstract

In a miniature continuous flow cell system we investigated the influence of voriconazole (VCZ) (27 trials) or anidulafungin (ANID) (five trials) on the antimycotic resistance of C. albicans (type strain SC5314 and three strains from blood cultures). The duration of the trials was up to 10 d. After continuous addition of VCZ or ANID to the media, biomass decreased and glucose levels and pH values increased. After exposure to VCZ, the dry weight of biofilm dropped by 90%. There was no evidence of resistance. No resistance also developed against ANID after 1 day or 3 days of exposure. No viable cells were detected in the biofilm after 5 days of exposure to ANID. Therefore, VCZ and ANID effectively inhibited biofilm formation of different C.albicans strains. Our experiments show that biofilm production is not necessarily associated with development of resistance.

Published
2008
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