6 results on '"Knol, E.F. (Edward Frank)"'
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2. Management of cow’s milk allergy from an immunological perspective: What are the options?
- Author
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Knol, E.F. (Edward Frank), Jong, N.W. (Nicolette) de, Ulfman, L.H. (Laurien), Tiemessen, M.M. (Machteld), Knol, E.F. (Edward Frank), Jong, N.W. (Nicolette) de, Ulfman, L.H. (Laurien), and Tiemessen, M.M. (Machteld)
- Abstract
The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow’s milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes is effective in the reduction of allergic symptoms but it cannot be envisioned as a treatment. For the treatment and prevention of IgE-mediated cow’s milk allergy, it is thought that the induction of a sustained state of immunological tolerance is needed. In this review, we will discuss various approaches aimed at achieving immunological tolerance and their success. Furthermore, we will speculate on the involved immunological mechanism.
- Published
- 2019
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3. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic overview of systematic reviews
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Nurmatov, U. (Ulugbek), Dhami, S. (Sangeeta), Arasi, S. (Stefania), Roberts, G., Pfaar, O. (Oliver), Muraro, A. (Antonella), Ansotegui, I.J. (I.), Calderon, M. (Moises), Cingi, C. (Cemal), Durham, S. (Stephen), Gerth van Wijk, R. (Roy), Halken, S. (Susanne), Hamelmann, E. (Eckard), Hellings, P.W. (Peter), Jacobsen, L., Knol, E.F. (Edward Frank), Larenas-Linnemann, D. (Désirée), Lin, S.Y. (Sandra Y.), Maggina, V. (Vivian), Oude Elberink, H.N.G. (Hanneke N.G.), Pajno, G. (G.), Panwankar, R. (Ruby), Pastorello, E. (Elideanna), Pitsios, C., Rotiroti, G. (Giuseppina), Timmermans, F. (Frans), Tsilochristou, O. (Olympia), Varga, E.M., Wilkinson, J. (Jamie), Williams, A. (Andrew), Worm, M. (M.), Zhang, L. (Luo), Sheikh, A. (Aziz), Nurmatov, U. (Ulugbek), Dhami, S. (Sangeeta), Arasi, S. (Stefania), Roberts, G., Pfaar, O. (Oliver), Muraro, A. (Antonella), Ansotegui, I.J. (I.), Calderon, M. (Moises), Cingi, C. (Cemal), Durham, S. (Stephen), Gerth van Wijk, R. (Roy), Halken, S. (Susanne), Hamelmann, E. (Eckard), Hellings, P.W. (Peter), Jacobsen, L., Knol, E.F. (Edward Frank), Larenas-Linnemann, D. (Désirée), Lin, S.Y. (Sandra Y.), Maggina, V. (Vivian), Oude Elberink, H.N.G. (Hanneke N.G.), Pajno, G. (G.), Panwankar, R. (Ruby), Pastorello, E. (Elideanna), Pitsios, C., Rotiroti, G. (Giuseppina), Timmermans, F. (Frans), Tsilochristou, O. (Olympia), Varga, E.M., Wilkinson, J. (Jamie), Williams, A. (Andrew), Worm, M. (M.), Zhang, L. (Luo), and Sheikh, A. (Aziz)
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- 2017
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4. Allergy immunotherapy across the life cycle to promote active and healthy ageing: From research to policies
- Author
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Calderon, M. (Moises), Demoly, P., Casale, T.B. (Thomas), Akdis, C.A., Bachert, C. (Claus), Bewick, M., Bilò, B.M., Bohle, B. (B.), Bonini, S. (Sergio), Bush, A. (Andrew), Caimmi, D.P., Canonica, G. (Gwalter), Cardona, D. (Doris), Chiriac, A.M. (A.), Cox, L. (Linda), Custovic, A. (Adnan), Blay, F. de, Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G. (George), Durham, S.R. (Stephen), Eng, C. (Charis), Fiocchi, A. (Alessandro), Fox, A.T., Gerth van Wijk, R. (Roy), Gomez, R.M., Haathela, T., Halken, S. (Susanne), Hellings, P.W. (Peter), Jacobsen, L., Just, P.M., Tanno, L.K., Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Knol, E.F. (Edward Frank), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Linneberg, A. (Allan), Matricardi, M., Malling, H.-J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G. (Giovanni), Pastorello, E., Pfaar, O. (Oliver), Price, D. (David), Del Rio, P.R. (P. Rodriguez), Ruëff, R., Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A. (Aziz), Sisul, J.C. (J.), Solé, D. (D.), Sturm, G.J., Tabar, A., Van Ree, R., Ventura, M.T., Vidal, C. (Carmen), Varga, E.M., Worm, M. (M.), Zuberbier, T. (Torsten), Bousquet, J. (Jean), Calderon, M. (Moises), Demoly, P., Casale, T.B. (Thomas), Akdis, C.A., Bachert, C. (Claus), Bewick, M., Bilò, B.M., Bohle, B. (B.), Bonini, S. (Sergio), Bush, A. (Andrew), Caimmi, D.P., Canonica, G. (Gwalter), Cardona, D. (Doris), Chiriac, A.M. (A.), Cox, L. (Linda), Custovic, A. (Adnan), Blay, F. de, Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G. (George), Durham, S.R. (Stephen), Eng, C. (Charis), Fiocchi, A. (Alessandro), Fox, A.T., Gerth van Wijk, R. (Roy), Gomez, R.M., Haathela, T., Halken, S. (Susanne), Hellings, P.W. (Peter), Jacobsen, L., Just, P.M., Tanno, L.K., Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Knol, E.F. (Edward Frank), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Linneberg, A. (Allan), Matricardi, M., Malling, H.-J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G. (Giovanni), Pastorello, E., Pfaar, O. (Oliver), Price, D. (David), Del Rio, P.R. (P. Rodriguez), Ruëff, R., Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A. (Aziz), Sisul, J.C. (J.), Solé, D. (D.), Sturm, G.J., Tabar, A., Van Ree, R., Ventura, M.T., Vidal, C. (Carmen), Varga, E.M., Worm, M. (M.), Zuberbier, T. (Torsten), and Bousquet, J. (Jean)
- Abstract
Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.
- Published
- 2016
- Full Text
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5. Allergen immunotherapy for allergic rhinoconjunctivitis: Protocol for a systematic review
- Author
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Dhami, S. (Sangeeta), Nurmatov, U. (Ulugbek), Roberts, G., Pfaar, O. (Oliver), Muraro, A. (Antonella), Ansotegui, I.J. (I.), Calderon, M. (Moises), Cingi, C. (Cemal), Demoly, P., Durham, S.R. (Stephen), Gerth van Wijk, R. (Roy), Halken, S. (Susanne), Hamelmann, E. (Eckard), Hellings, P.W. (Peter), Jacobsen, L., Knol, E.F. (Edward Frank), Linnemann, D.L. (D. Larenas), Lin, S. (Sandra), Maggina, V. (Vivian), Oude Elberink, H.N.G. (Hanneke N.G.), Pajno, G. (G.), Panwankar, R. (Ruby), Pastorello, E. (Elideanna), Pitsios, C., Rotiroti, G. (Giuseppina), Timmermans, F. (Frans), Tsilochristou, O. (Olympia), Varga, E.M., Wilkinson, J. (Jamie), Williams, A. (Andrew), Worm, M. (M.), Zhang, L. (Luo), Sheikh, A. (Aziz), Dhami, S. (Sangeeta), Nurmatov, U. (Ulugbek), Roberts, G., Pfaar, O. (Oliver), Muraro, A. (Antonella), Ansotegui, I.J. (I.), Calderon, M. (Moises), Cingi, C. (Cemal), Demoly, P., Durham, S.R. (Stephen), Gerth van Wijk, R. (Roy), Halken, S. (Susanne), Hamelmann, E. (Eckard), Hellings, P.W. (Peter), Jacobsen, L., Knol, E.F. (Edward Frank), Linnemann, D.L. (D. Larenas), Lin, S. (Sandra), Maggina, V. (Vivian), Oude Elberink, H.N.G. (Hanneke N.G.), Pajno, G. (G.), Panwankar, R. (Ruby), Pastorello, E. (Elideanna), Pitsios, C., Rotiroti, G. (Giuseppina), Timmermans, F. (Frans), Tsilochristou, O. (Olympia), Varga, E.M., Wilkinson, J. (Jamie), Williams, A. (Andrew), Worm, M. (M.), Zhang, L. (Luo), and Sheikh, A. (Aziz)
- Abstract
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of allergic rhinoconjunctivitis. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently scree
- Published
- 2016
- Full Text
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6. Research needs in allergy: An EAACI position paper, in collaboration with EFA
- Author
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Papadopoulos, N., Agache, I., Bavbek, S. (Sevim), Bilo, B.M. (Beatrice M.), Braido, F. (Fulvio), Cardona, D. (Doris), Custovic, A. (Adnan), DeMonchy, J. (Jan), Demoly, P., Eigenmann, P.A. (Philippe), Gayraud, J. (J.), Grattan, C., Heffler, E. (E.), Hellings, P.W. (Peter), Jutel, M. (M.), Knol, E.F. (Edward Frank), Lötvall, J. (Jan), Murarol, A. (Antonella), Poulsen, L.K., Roberts, G., Schmid-Grendelmeier, P. (Peter), Skevaki, C. (Chrysanthi), Triggiani, M. (M.), VanRee, R. (Ronald), Werfel, T., Flood, B. (Breda), Palkonen, S., Savli, R. (Roberta), Allegri, P. (Pia), Annesi-Maesano, I. (Isabella), Annunziato, F. (Francesco), Antolin-Amerigo, D. (Dario), Apfelbacher, M. (Manuela), Blanca, M. (Miguel), Bogacka, E. (Ewa), Bonadonna, P. (Patrizia), Bonini, M. (Matteo), Boyman, O. (Onur), Brockow, K. (Knut), Burney, P. (Peter), Buters, J. (Jeroen), Butiene, I. (Indre), Calderon, M. (Moises), Cardell, L.O., Caubet, J.-C. (Jean-Christoph), Celenk, S. (Sevcan), Cichocka-Jarosz, E., Cingi, C. (Cemal), Couto, M. (Mariana), DeJong, N. (Nicolette), Del Giacco, S. (Stefano), Douladiris, N. (Nikolaos), Fassio, F. (Filippo), Fauquert, J.-L. (Jean-Luc), Fernandez, J. (Javier), Rivas, M.F. (Montserrat Fernandez), Ferrer, M. (Marta), Flohr, C. (Carsten), Gardner, J. (James), Genuneit, J. (Jon), Gevaert, P. (P.), Groblewska, A. (Anna), Hamelmann, E. (Eckard), Hoffmann, H.J. (Hans Jürgen), Hoffmann-Sommergruber, K. (K.), Hovhannisyan, L. (Lilit), Hox, V. (Valérie), Jahnsen, F.L. (Frode L.), Kalayci, O. (Omer), Kalpaklioglu, A.F. (Ayse Füsun), Kleine-Tebbe, J. (Jörg), Konstantinou, G. (George), Kurowski, M. (Marcin), Lau, S. (Susanne), Lauener, R. (Roger), Lauerma, A. (Antti), Logan, K. (K.), Magnan, A. (Antoine), Makowska, J. (Joanna), Makrinioti, H. (Heidi), Mangina, P. (Paraskevi), Manole, F. (Felicia), Mari, A. (A.), Mazón, A., Mills, C. (Clare), Mingomataj, E.Ç. (Ervin Ç), Niggemann, B., Nilsson, G. (Gunnar), Ollert, M. (Markus), O'Mahony, L. (Liam), O'Neil, S. (Serena), Pala, G. (Gianni), Papi, A. (Alberto), Passalacqua, G. (Giovanni), Perkin, M. (Michael), Pfaar, O. (Oliver), Pitsios, C., Quirce, S. (S.), Raap, U., Raulf-Heimsoth, M., Rhyner, C. (Claudio), Robson-Ansley, P. (Paula), Alves, R.R. (Rodrigo Rodrigues), Roje, Z. (Zeljka), Rondon, C. (Carmen), Rudzeviciene, O. (Odilija), Rueff, F. (Franziska), Rukhadze, M. (Maia), Rumi, G. (Gabriele), Sackesen, C. (Cansin), Santos, A.F. (Alexandra F.), Santucci, A. (Annalisa), Scharf, C. (Christian), Schmidt-Weber, C.B., Schnyder, B. (Benno), Schwarze, J. (Jürgen), Senna, G.E. (Gianenrico), Sergejeva, S. (Svetlana), Seys, S. (Sven), Siracusa, A. (Andrea), Skypala, I. (I.), Sokolowska, M. (Milena), Spertini, F. (Francois), Spiewak, R. (Radoslaw), Sprikkelman, A.B. (Aline), Sturm, G.J., Swoboda, I., Terreehorst, I., Toskala, E., Traidl-Hoffmann, C. (Claudia), Venter, C. (C.), Vlieg-Boerstra, B.J., Whitacker, P. (Paul), Worm, M. (M.), Xepapadaki, P. (Paraskevi), Akdis, C.A., Papadopoulos, N., Agache, I., Bavbek, S. (Sevim), Bilo, B.M. (Beatrice M.), Braido, F. (Fulvio), Cardona, D. (Doris), Custovic, A. (Adnan), DeMonchy, J. (Jan), Demoly, P., Eigenmann, P.A. (Philippe), Gayraud, J. (J.), Grattan, C., Heffler, E. (E.), Hellings, P.W. (Peter), Jutel, M. (M.), Knol, E.F. (Edward Frank), Lötvall, J. (Jan), Murarol, A. (Antonella), Poulsen, L.K., Roberts, G., Schmid-Grendelmeier, P. (Peter), Skevaki, C. (Chrysanthi), Triggiani, M. (M.), VanRee, R. (Ronald), Werfel, T., Flood, B. (Breda), Palkonen, S., Savli, R. (Roberta), Allegri, P. (Pia), Annesi-Maesano, I. (Isabella), Annunziato, F. (Francesco), Antolin-Amerigo, D. (Dario), Apfelbacher, M. (Manuela), Blanca, M. (Miguel), Bogacka, E. (Ewa), Bonadonna, P. (Patrizia), Bonini, M. (Matteo), Boyman, O. (Onur), Brockow, K. (Knut), Burney, P. (Peter), Buters, J. (Jeroen), Butiene, I. (Indre), Calderon, M. (Moises), Cardell, L.O., Caubet, J.-C. (Jean-Christoph), Celenk, S. (Sevcan), Cichocka-Jarosz, E., Cingi, C. (Cemal), Couto, M. (Mariana), DeJong, N. (Nicolette), Del Giacco, S. (Stefano), Douladiris, N. (Nikolaos), Fassio, F. (Filippo), Fauquert, J.-L. (Jean-Luc), Fernandez, J. (Javier), Rivas, M.F. (Montserrat Fernandez), Ferrer, M. (Marta), Flohr, C. (Carsten), Gardner, J. (James), Genuneit, J. (Jon), Gevaert, P. (P.), Groblewska, A. (Anna), Hamelmann, E. (Eckard), Hoffmann, H.J. (Hans Jürgen), Hoffmann-Sommergruber, K. (K.), Hovhannisyan, L. (Lilit), Hox, V. (Valérie), Jahnsen, F.L. (Frode L.), Kalayci, O. (Omer), Kalpaklioglu, A.F. (Ayse Füsun), Kleine-Tebbe, J. (Jörg), Konstantinou, G. (George), Kurowski, M. (Marcin), Lau, S. (Susanne), Lauener, R. (Roger), Lauerma, A. (Antti), Logan, K. (K.), Magnan, A. (Antoine), Makowska, J. (Joanna), Makrinioti, H. (Heidi), Mangina, P. (Paraskevi), Manole, F. (Felicia), Mari, A. (A.), Mazón, A., Mills, C. (Clare), Mingomataj, E.Ç. (Ervin Ç), Niggemann, B., Nilsson, G. (Gunnar), Ollert, M. (Markus), O'Mahony, L. (Liam), O'Neil, S. (Serena), Pala, G. (Gianni), Papi, A. (Alberto), Passalacqua, G. (Giovanni), Perkin, M. (Michael), Pfaar, O. (Oliver), Pitsios, C., Quirce, S. (S.), Raap, U., Raulf-Heimsoth, M., Rhyner, C. (Claudio), Robson-Ansley, P. (Paula), Alves, R.R. (Rodrigo Rodrigues), Roje, Z. (Zeljka), Rondon, C. (Carmen), Rudzeviciene, O. (Odilija), Rueff, F. (Franziska), Rukhadze, M. (Maia), Rumi, G. (Gabriele), Sackesen, C. (Cansin), Santos, A.F. (Alexandra F.), Santucci, A. (Annalisa), Scharf, C. (Christian), Schmidt-Weber, C.B., Schnyder, B. (Benno), Schwarze, J. (Jürgen), Senna, G.E. (Gianenrico), Sergejeva, S. (Svetlana), Seys, S. (Sven), Siracusa, A. (Andrea), Skypala, I. (I.), Sokolowska, M. (Milena), Spertini, F. (Francois), Spiewak, R. (Radoslaw), Sprikkelman, A.B. (Aline), Sturm, G.J., Swoboda, I., Terreehorst, I., Toskala, E., Traidl-Hoffmann, C. (Claudia), Venter, C. (C.), Vlieg-Boerstra, B.J., Whitacker, P. (Paul), Worm, M. (M.), Xepapadaki, P. (Paraskevi), and Akdis, C.A.
- Abstract
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and tre
- Published
- 2012
- Full Text
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