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2. Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2-Specific IgG

Author

Schwarzkopf, Sina, Krawczyk, Adalbert, Knop, Dietmar, Klump, Hannes, Heinold, Andreas, Heinemann, Falko M., Thummler, Laura, Temme, Christian, Breyer, Marianne, Witzke, Oliver, Dittmer, Ulf, Lenz, Veronika, Horn, Peter A., and Lindemann, Monika

Subjects
T cells -- Physiological aspects, Immunoglobulin G -- Testing, Health
Abstract

One promising therapeutic option to treat severely ill patients with coronavirus disease (COVID-19) is the use of convalescent plasma (CP) of donors who recovered from severe acute respiratory syndrome coronavirus [...]

Published
2021
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3. Comparison of SARS-CoV-2- and HCoV-Specific T Cell Response Using IFN-γ ELISpot

Author

Thümmler, Laura, Schwarzkopf, Sina, Knop, Dietmar, Ross, J. Alexander, Berg, Victoria, Horn, Peter, and Lindemann, Monika

Subjects
Medicine (General), R5-920, cross-reactivity, human endemic coronavirus, Medizin, ELISpot, virus diseases, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Transfusionsmedizin, Article, cross-reactivity -- ELISpot -- human endemic coronavirus, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Zellbiologie (Tumorforschung)
Abstract

OA Förderung 2021 Herd immunity is essential to control severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), especially in immunocompromised patients. Convalescent individuals should be vaccinated later due to vaccine shortage, as studies show that neutralizing antibodies generated during infection are stable for at least 6 months. Cellular immunity is also detectable for months. However, there is evidence of cross-reactivity of T cells with human endemic coronaviruses (HCoVs). Here, we show that cross-reactivity—which may prevent the specific detection of SARS-CoV-2-specific T cell responses—can be avoided if cells are stimulated with the N-terminus of the spike protein in IFN-γ ELISpot. In contrast to previous studies, we examined T-cell responses against all four known HCoVs using IFN-γ ELISpot in 19 convalescent volunteers and 10 fully vaccinated volunteers. In addition, we performed Spearman analyses to detect cross-reactivity of T cells. We observed no correlation between T-cell responses against SARS-CoV-2 and human endemic coronaviruses, either in the whole cohort or in the individual groups. The use of the respective stimuli could lead to a more accurate assessment of cellular immunity in recovered individuals. This testing procedure could help to define the best time point at which convalescents should receive SARS-CoV-2 vaccination.

Published
2021

4. Convalescent plasma treatment of critically ill intensive care COVID ‐19 patients

Author

Lindemann, Monika, primary, Lenz, Veronika, additional, Knop, Dietmar, additional, Klump, Hannes, additional, Alt, Mira, additional, Aufderhorst, Ulrich W., additional, Schipper, Leonie, additional, Schwarzkopf, Sina, additional, Meller, Lara, additional, Steckel, Nina, additional, Koldehoff, Michael, additional, Heinold, Andreas, additional, Heinemann, Falko M., additional, Fischer, Johannes, additional, Hutschenreuter, Gabriele, additional, Knabbe, Cornelius, additional, Dolff, Sebastian, additional, Brenner, Thorsten, additional, Dittmer, Ulf, additional, Witzke, Oliver, additional, Herbstreit, Frank, additional, Horn, Peter A., additional, and Krawczyk, Adalbert, additional

Published
2021
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5. SARS‐CoV‐2‐specific humoral and cellular immunity in two renal transplants and two hemodialysis patients treated with convalescent plasma

Author

Lindemann, Monika, primary, Krawczyk, Adalbert, additional, Dolff, Sebastian, additional, Konik, Margarethe, additional, Rohn, Hana, additional, Platte, Maximillian, additional, Thümmler, Laura, additional, Schwarzkopf, Sina, additional, Schipper, Leonie, additional, Bormann, Maren, additional, Sand, Lukas, additional, Breyer, Marianne, additional, Klump, Hannes, additional, Knop, Dietmar, additional, Lenz, Veronika, additional, Temme, Christian, additional, Dittmer, Ulf, additional, Horn, Peter A., additional, and Witzke, Oliver, additional

Published
2021
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7. SARS-CoV-2-specific humoral and cellular immunity in renal transplant and haemodialysis patients treated with convalescent plasma

Author

Lindemann, Monika, primary, Krawczyk, Adalbert, additional, Dolff, Sebastian, additional, Konik, Margarethe, additional, Rohn, Hana, additional, Platte, Maximillian, additional, Thümmler, Laura, additional, Schwarzkopf, Sina, additional, Schipper, Leonie, additional, Bormann, Maren, additional, van de Sand, Lukas, additional, Breyer, Marianne, additional, Klump, Hannes, additional, Knop, Dietmar, additional, Lenz, Veronika, additional, Temme, Christian, additional, Dittmer, Ulf, additional, Horn, Peter A., additional, and Witzke, Oliver, additional

Published
2020
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13. Adoptive Immune Transfer of Hepatitis B Virus Specific Immunity From Immunized Living Liver Donors to Liver Recipients

Author

Schumann, Alexandra, primary, Lindemann, Monika, additional, Valentin-Gamazo, Camino, additional, Lu, Mengji, additional, Elmaagacli, Ahmet, additional, Dahmen, Uta, additional, Knop, Dietmar, additional, Broelsch, Christoph E., additional, Grosse-Wilde, Hans, additional, Roggendorf, Michael, additional, and Fiedler, Melanie, additional

Published
2009
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