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4. EVIDENCE meta-analysis: evaluating minimal residual disease as an intermediate clinical end point for multiple myeloma

Author

Landgren, Ola, Prior, Thomas J., Masterson, Tara, Heuck, Christoph, Bueno, Orlando F., Dash, Ajeeta B., Einsele, Hermann, Goldschmidt, Hartmut, Knop, Stefan, Li, Cong, Mellqvist, Ulf-Henrik, McFadden, Ian, Oprea, Corina, Ross, Jeremy A., Talpes, Mihaela, Hydren, Jay R., Ahlstrom, Jennifer M., Kazandjian, Dickran, Weinhold, Niels, Zhang, Rick, Stetler-Stevenson, Maryalice, Marti, Gerald, and Devlin, Sean M.

Published
2024
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5. Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma

Author

Lee, Holly, Ahn, Sungwoo, Maity, Ranjan, Leblay, Noemie, Ziccheddu, Bachisio, Truger, Marietta, Chojnacka, Monika, Cirrincione, Anthony, Durante, Michael, Tilmont, Remi, Barakat, Elie, Poorebrahim, Mansour, Sinha, Sarthak, McIntyre, John, M.Y. Chan, Angela, Wilson, Holly, Kyman, Shari, Krishnan, Amrita, Landgren, Ola, Walter, Wencke, Meggendorfer, Manja, Haferlach, Claudia, Haferlach, Torsten, Einsele, Hermann, Kortüm, Martin K., Knop, Stefan, Alberge, Jean Baptiste, Rosenwald, Andreas, Keats, Jonathan J., Rasche, Leo, Maura, Francesco, Neri, Paola, and Bahlis, Nizar J.

Published
2023
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6. Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Author

Leipold, Alexander M., Werner, Rudolf A., Düll, Johannes, Jung, Pius, John, Mara, Stanojkovska, Emilia, Zhou, Xiang, Hornburger, Hannah, Ruckdeschel, Anna, Dietrich, Oliver, Imdahl, Fabian, Krammer, Tobias, Knop, Stefan, Rosenwald, Andreas, Buck, Andreas, Sander, Leif Erik, Einsele, Hermann, Kortüm, K. Martin, Saliba, Antoine-Emmanuel, and Rasche, Leo

Published
2023
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7. Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma (CC-220-MM-001): a multicentre, multicohort, open-label, phase 1/2 trial

Author

Lonial, Sagar, Popat, Rakesh, Hulin, Cyrille, Jagannath, Sundar, Oriol, Albert, Richardson, Paul G, Facon, Thierry, Weisel, Katja, Larsen, Jeremy T, Minnema, Monique C, Abdallah, Al-Ola, Badros, Ashraf Z, Knop, Stefan, Stadtmauer, Edward A, Cheng, Yiming, Amatangelo, Michael, Chen, Min, Nguyen, Tuong Vi, Amin, Alpesh, Peluso, Teresa, and van de Donk, Niels W C J

Published
2022
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9. Enhancing student understanding of rheumatic disease pathologies through augmented reality: findings from a multicentre trial.

Author

Pfeil, Alexander, Klemm, Philipp, Hueber, Axel J, Hoffmann, Tobias, Weise, Tobias, Oelzner, Peter, Knop, Stefan, Müller-Ladner, Ulf, Lange, Uwe, Wolf, Gunter, Schett, Georg, Simon, David, and Kleyer, Arnd

Subjects
MOBILE apps, PSORIATIC arthritis, RESEARCH funding, ACADEMIC medical centers, RHEUMATOID arthritis, ANKYLOSIS, UNDERGRADUATES, QUESTIONNAIRES, TEACHING methods, DESCRIPTIVE statistics, MEDICAL students, MEDICAL schools, RESEARCH, STUDENT attitudes, SPONDYLOARTHROPATHIES, AUGMENTED reality
Abstract

Objective The possibility of combining real and virtual environments is driving the increased use of augmented reality (AR) in education, including medical training. The aim of this multicentre study was to evaluate the students' perspective on the AR-based Rheumality GO!® app as a new teaching concept, presenting six real anonymized patient cases with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Methods The study encompassed 347 undergraduate medical students (232 women and 115 men) from four medical universities in Germany (Jena, Bad Nauheim/Gießen, Nuremberg, Erlangen). The course was divided into a theoretical refresher lecture followed by six AR-based cases in each of the three indications presented in the Rheumality GO! app. All participants evaluated the course after completion, assessing the benefit of the app from a student's perspective using a questionnaire with 16 questions covering six subject areas. Results The use of the AR-based app Rheumality GO! improved the understanding of pathologies in RA, PsA and axSpA for 99% of the participants. For 98% of respondents, the concept of AR with real patient data has made a positive impact on the teaching environment. On the other hand, 82% were in favour of the use of virtual tools (e.g. AR) in addition to this conventional approach. Conclusion The results of our survey showed that from the medical students' perspective, an AR-based concept like the Rheumality GO! app can complement rheumatology teaching in medical school as an effective and attractive tool though not replace bedside teaching. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Cardio-Hepatic Interaction in Cardiac Amyloidosis

Author

Ihne-Schubert, Sandra Michaela, primary, Goetze, Oliver, additional, Gerstendörfer, Felix, additional, Sahiti, Floran, additional, Schade, Ina, additional, Papagianni, Aikaterini, additional, Morbach, Caroline, additional, Frantz, Stefan, additional, Einsele, Hermann, additional, Knop, Stefan, additional, Sommer, Claudia, additional, Müllhaupt, Beat, additional, Schubert, Torben, additional, Störk, Stefan, additional, and Geier, Andreas, additional

Published
2024
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11. Randomized comparison between KTd and KRd induction therapy followed by maintenance therapy with K or observation in transplant‐ineligible patients with newly diagnosed multiple myeloma

Author

Ludwig, Heinz, primary, Melchardt, Thomas, additional, Sormann, Siegfried, additional, Schreder, Martin, additional, Andel, Johannes, additional, Hartmann, Bernd, additional, Tinchon, Christoph, additional, Zojer, Niklas, additional, Gunsilius, Eberhard, additional, Podar, Klaus, additional, Egle, Alexander, additional, Willenbacher, Wolfgang, additional, Wöll, Ewald, additional, Ruckser, Reinhard, additional, Bozic, Boris, additional, Krauth, Maria‐Theresa, additional, Petzer, Andreas, additional, Schmitt, Clemens, additional, Machherndl‐Spandl, Sigrid, additional, Agis, Hermine, additional, Fillitz, Michael, additional, Wang, Song‐Yau, additional, Zabernigg, August, additional, Knop, Stefan, additional, Paiva, Bruno, additional, and Greil, Richard, additional

Published
2024
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12. Daratumumab Plus Bortezomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Frailty Subgroup Analysis of ALCYONE

Author

Mateos, Maria-Victoria, Dimopoulos, Meletios A., Cavo, Michele, Suzuki, Kenshi, Knop, Stefan, Doyen, Chantal, Lucio, Paulo, Nagy, Zsolt, Pour, Ludek, Grosicki, Sebastian, Crepaldi, Andre, Liberati, Anna Marina, Campbell, Philip, Yoon, Sung-Soo, Iosava, Genadi, Fujisaki, Tomoaki, Garg, Mamta, Iida, Shinsuke, Bladé, Joan, Ukropec, Jon, Pei, Huiling, Van Rampelbergh, Rian, Kudva, Anupa, Qi, Ming, and San-Miguel, Jesus

Published
2021
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13. Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial

Author

Alegre Amor, Adrian, Baldini, Luca, Beksac, Meral, Belotti, Angelo, Benboubker, Lotfi, Besemer, Britta, Besisik, Sevgi, Bila, Jelena, Boccadoro, Mario, Cavo, Michele, De La Rubia Comos, Javier, Delimpasi, Sosana, Dimopoulos, Meletios A., Doyen, Chantal, Dytfeld, Dominik, Engelhardt, Monika, Facon, Thierry, Foà, Roberto, Goldschmidt, Hartmut, Grosicki, Sebastian, Hajek, Roman, Hayri Ozsan, Guner, Hulin, Cyrille, Iversen, Brian, Karlin, Lionel, Katodritou, Eirini, Knop, Stefan, Kyrtsonis, Marie-Christine, Lahuerta, Juan Jose, Leleu, Xavier, Martinez Chamorro, Carmen, Mateos Manteca, María-Victoria, Meuleman, Nathalie, Minnema, Monique, Moreau, Philippe, Offidani, Massino, Oriol Rocafiguera, Albert, Pehlivan, Mustafa, Pour, Ludek, Roerdink, Henk Th.J., Rosinol Dacsh, Laura, Salwender, Hans, Sonneveld, Pieter, Symeonidis, Anargyros, Toftmann Hansen, Charlotte, Tuglular, Tulin, Unal, Ali, Vlummens, Philip, Vural, Filiz, Wu, Ka Lung, Zweegman, Sonja, Dimopoulos, Meletios A, Terpos, Evangelos, Symeonidis, Argiris, Oriol, Albert, Mateos, Maria-Victoria, Einsele, Hermann, Orfanidis, Ioannis, Ahmadi, Tahamtan, Ukropec, Jon, Kampfenkel, Tobias, Schecter, Jordan M, Qiu, Yanping, Amin, Himal, Vermeulen, Jessica, and Carson, Robin

Published
2021
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15. Single German centre experience with patient journey and care-relevant needs in amyloidosis: The German AMY-NEEDS research and care program.

Author

Ihne-Schubert, Sandra Michaela, Leberzammer, Maria, Weidgans, Marcel, Frantz, Stefan, Einsele, Hermann, Knop, Stefan, Schubert, Torben, Bratan, Tanja, Störk, Stefan, and Neuderth, Silke

Subjects
MEDICAL personnel, PATIENTS' attitudes, AMYLOIDOSIS, ADVANCE directives (Medical care), DELAYED diagnosis
Abstract

Background: Amyloidosis is a rare multi-system disorder associated with frequently delayed diagnosis, enormous disease burden and psychosocial distress. Methods: Systematic assessment of needs was performed by a subtype-spanning questionnaire-based survey within the AMY-NEEDS research and care program. Results: 118 patients with proven amyloidosis (62.7% ATTR, 22.0% AL, 15.3% other forms) were included in August 2020 until February 2021 (mean age 71.2 ±11.3 years; 30% women). The median diagnostic delay between onset of symptoms and diagnosis was 9.0 (range: 2.5; 33.0) months. Local health care providers (HCPs) play a central role on the way to diagnosis. Diagnosis itself typically requires a clinical but not necessarily a university setting. In the treatment phase, the focus moves to the amyloidosis centre as primary contact and coordinator, with general practitioners (GPs) acting predominantly as a contact point in crisis and link to additional services. About half of patients reported impaired quality of life and one third suffering from anxiety and depressed mood, respectively. The majority of patients talk about their concerns with close caregivers and local HCPs. Advance care planning is a relevant, yet insufficiently met need. Conclusion: The journey of patients with amyloidotic disease, their contact partners and needs at different stages were characterized in detail within the German health care system. An amyloidosis-specific care concept has to master the multitude of interfaces connecting the numerous treatment providers involved with the amyloidosis centre and GPs as key players. Telemedical approaches could be a promising and well-accepted option allowing optimal coordination and communication. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Health-related quality of life in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation: results from the randomized phase III ALCYONE trial

Author

Knop, Stefan, Mateos, Maria-Victoria, Dimopoulos, Meletios A., Suzuki, Kenshi, Jakubowiak, Andrzej, Doyen, Chantal, Lucio, Paulo, Nagy, Zsolt, Usenko, Ganna, Pour, Ludek, Cook, Mark, Grosicki, Sebastian, Crepaldi, Andre, Liberati, Anna Marina, Campbell, Philip, Shelekhova, Tatiana, Yoon, Sung-Soo, Losava, Genadi, Fujisaki, Tomoaki, Garg, Mamta, Wang, Jianping, Wroblewski, Susan, Kudva, Anupa, Gries, Katharine S., Fastenau, John, San-Miguel, Jesus, and Cavo, Michele

Published
2021
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18. Ixazomib–Thalidomide–Dexamethasone for induction therapy followed by Ixazomib maintenance treatment in patients with relapsed/refractory multiple myeloma

Author

Ludwig, Heinz, Poenisch, Wolfram, Knop, Stefan, Egle, Alexander, Schreder, Martin, Lechner, Daniel, Hajek, Roman, Gunsilius, Eberhard, Krenosz, Karl Jochen, Petzer, Andreas, Weisel, Katja, Niederwieser, Dietger, Einsele, Hermann, Willenbacher, Wolfgang, Melchardt, Thomas, Greil, Richard, and Zojer, Niklas

Published
2019
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19. Assessing Osteolytic Lesion Size on Sequential CT Scans Is a Reliable Study Endpoint for Bone Remineralization in Newly Diagnosed Multiple Myeloma

Author

Grunz, Jan-Peter, primary, Kunz, Andreas Steven, additional, Baumann, Freerk T., additional, Hasenclever, Dirk, additional, Sieren, Malte Maria, additional, Heldmann, Stefan, additional, Bley, Thorsten Alexander, additional, Einsele, Hermann, additional, Knop, Stefan, additional, and Jundt, Franziska, additional

Published
2023
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20. S189: PROTEOGENOMIC LANDSCAPE OF MULTIPLE MYELOMA

Author

Ramberger, Evelyn, primary, Dolnik, Anna, additional, Ng, Yuen Lam Dora, additional, Ziehm, Matthias, additional, Popp, Oliver, additional, Sträng, Eric, additional, Kull, Miriam, additional, Sapozhnikova, Valeriia, additional, Grünschläger, Florian, additional, Benary, Manuela, additional, Müller, Sina, additional, Gao, Xiang, additional, Murgai, Arunima, additional, Haji, Mohamed, additional, Schmidt, Annika, additional, Lutz, Raphael, additional, Nogai, Axel, additional, Braune, Jan, additional, Laue, Dominik, additional, Langer, Christian, additional, Khandanpour, Cyrus, additional, Bassermann, Florain, additional, Döhner, Hartmut, additional, Engelhardt, Monika, additional, Straka, Christian, additional, Hundemer, Michael, additional, Haas, Simon, additional, Beule, Dieter, additional, Keller, Ulrich, additional, Einsele, Hermann, additional, Bullinger, Lars, additional, Knop, Stefan, additional, Mertins, Philipp, additional, and Krönke, Jan, additional

Published
2023
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21. P943: OUTCOME ANALYSIS BY CYTOGENETIC RISK GROUP AFTER RANDOMIZATION TO KRD OR KTD FOLLOWED BY K MAINTENANCE OR CONTROL IN PATIENTS WITH NTE NDMM (AGMT MM-02)

Author

Ludwig, Heinz, primary, Melchardt, Thomas, additional, Sormann, Siegfried, additional, Schreder, Martin, additional, Andel, Johannes, additional, Hartmann, Bernd, additional, Tinchon, Christoph, additional, Zojer, Niklas, additional, Gunsilius, Eberhard, additional, Podar, Klaus, additional, Egle, Alexander, additional, Willenbacher, Wolfgang, additional, Woell, Ewald, additional, Ruckser, Reinhard, additional, Bozic, Boris, additional, Theresa Krauth, Maria, additional, Petzer, Andreas, additional, Schmitt, Clemens A., additional, Machherndl-Spandl, Sigrid, additional, Agis, Hermine, additional, Fillitz, Michael, additional, Wang, Song-Yau, additional, Knop, Stefan, additional, Paiva, Bruno, additional, and Greil, Richard, additional

Published
2023
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27. Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Focus on Longitudinal Assessment of Donor Chimerism, Extramedullary Disease, and High-Risk Cytogenetic Features

Author

Rasche, Leo, Röllig, Christoph, Stuhler, Gernot, Danhof, Sophia, Mielke, Stephan, Grigoleit, Goetz Ulrich, Dissen, Lea, Schemmel, Lea, Middeke, Jan Moritz, Rücker, Viktoria, Schreder, Martin, Schetelig, Johannes, Bornhäuser, Martin, Einsele, Hermann, Thiede, Christian, and Knop, Stefan

Published
2016
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30. Supplement from A GRP78-Directed Monoclonal Antibody Recaptures Response in Refractory Multiple Myeloma with Extramedullary Involvement

Author

Rasche, Leo, primary, Menoret, Emmanuelle, primary, Dubljevic, Valentina, primary, Menu, Eline, primary, Vanderkerken, Karin, primary, Lapa, Constantin, primary, Steinbrunn, Torsten, primary, Chatterjee, Manik, primary, Knop, Stefan, primary, Düll, Johannes, primary, Greenwood, Deanne L., primary, Hensel, Frank, primary, Rosenwald, Andreas, primary, Einsele, Hermann, primary, and Brändlein, Stephanie, primary

Published
2023
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31. Tumor Intrinsic Mechanisms of Antigen Escape to Anti-BCMA and Anti-GPRC5D Targeted Immunotherapies in Multiple Myeloma

Author

Bahlis, Nizar, primary, Lee, Holly, additional, Ahn, Sungwoo, additional, Maity, Ranjan, additional, Leblay, Noémie, additional, Ziccheddu, Bachisio, additional, Chojnacka, Monika, additional, Cirrincione, Anthony, additional, Durante, Michael, additional, Barakat, Elie, additional, Tilmont, Remi, additional, Sinha, Sarthak, additional, Truger, Marietta, additional, Kyman, Shari, additional, Krishnan, Amrita, additional, Landgren, Ola, additional, Walter, Wencke, additional, Meggendorfer, Manja, additional, Haferlach, Claudia, additional, Haferlach, Torsten, additional, Einsele, Hermann, additional, Kortüm, K., additional, Knop, Stefan, additional, Alberge, Jean-Baptiste, additional, Keats, Jonathan, additional, Rasche, Leo, additional, Maura, Francesco, additional, and Neri, Paola, additional

Published
2023
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32. Tafamidis for cardiac transthyretin amyloidosis: application in a real-world setting in Germany

Author

Morbach, Caroline, primary, Papagianni, Aikaterini, additional, Ihne-Schubert, Sandra, additional, Cejka, Vladimir, additional, Steinhardt, Maximilian, additional, Fette, Georg, additional, Held, Melissa, additional, Geier, Andreas, additional, Einsele, Hermann, additional, Frantz, Stefan, additional, Knop, Stefan, additional, Sommer, Claudia, additional, and Störk, Stefan, additional

Published
2023
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33. Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): a phase 3b study in refractory multiple myeloma

Author

Dimopoulos, Meletios A., Palumbo, Antonio, Corradini, Paolo, Cavo, Michele, Delforge, Michel, Di Raimondo, Francesco, Weisel, Katja C., Oriol, Albert, Hansson, Markus, Vacca, Angelo, Blanchard, María Jesús, Goldschmidt, Hartmut, Doyen, Chantal, Kaiser, Martin, Petrini, Mario, Anttila, Pekka, Cafro, Anna Maria, Raymakers, Reinier, San-Miguel, Jesus, de Arriba, Felipe, Knop, Stefan, Röllig, Christoph, Ocio, Enrique M., Morgan, Gareth, Miller, Neil, Simcock, Mathew, Peluso, Teresa, Herring, Jennifer, Sternas, Lars, Zaki, Mohamed H., and Moreau, Philippe

Published
2016
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37. Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Author

Leipold, Alexander M., primary, Werner, Rudolf A., additional, Düll, Johannes, additional, Jung, Pius, additional, John, Mara, additional, Stanojkovska, Emilia, additional, Zhou, Xiang, additional, Hornburger, Hannah, additional, Ruckdeschel, Anna, additional, Dietrich, Oliver, additional, Imdahl, Fabian, additional, Krammer, Tobias, additional, Knop, Stefan, additional, Rosenwald, Andreas, additional, Buck, Andreas, additional, Sander, Leif Erik, additional, Einsele, Hermann, additional, Kortüm, K. Martin, additional, Saliba, Antoine-Emmanuel, additional, and Rasche, Leo, additional

Published
2022
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39. Randomized Comparison between Krd and Ktd Induction, Followed By K Maintenance or Control in Transplant Non-Eligible Patients with NDMM: Efficacy and Qol Data (AGMT-MM02 Trial)

Author

Ludwig, Heinz, primary, Melchardt, Thomas, additional, Sormann, Siegfried, additional, Zojer, Niklas, additional, Andel, Johannes, additional, Hartmann, Bernd L., additional, Tinchon, Christoph, additional, Gunsilius, Eberhard, additional, Podar, Klaus, additional, Egle, Alexander, additional, Willenbacher, Wolfgang, additional, Wöll, Ewald, additional, Schreder, Martin, additional, Ruckser, Reinhard, additional, Bozic, Boris, additional, Krauth, Maria-Theresa, additional, Petzer, Andreas, additional, Schmitt, Clemens A., additional, Machherndl-Spandl, Sigrid, additional, Agis, Hermine, additional, Fillitz, Michael, additional, Wang, Song-Yau, additional, Knop, Stefan, additional, Kainz, Sarah, additional, Paiva, Bruno, additional, and Greil, Richard, additional

Published
2022
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40. Long-Term Outcome of a Prospective Randomized Trial Comparing Continuous Lenalidomide/Dexamethasone with Lenalidomide/Dexamethasone Induction, MEL140 with Autologous Blood Stem Cell Transplantation and Single Agent Lenalidomide Maintenance in Patients of Age 60-75 Years with Newly Diagnosed Multiple Myeloma

Author

Straka, Christian, primary, Schaefer-Eckart, Kerstin, additional, Hertenstein, Bernd, additional, Bassermann, Florian, additional, Salwender, Hans, additional, Langer, Christian, additional, Krönke, Jan, additional, Kull, Miriam, additional, Schilling, Georgia, additional, Schieferdecker, Aneta, additional, Engelhardt, Monika, additional, Knop, Stefan, additional, Reusch, Julia, additional, Roesler, Wolf, additional, Metzner, Bernd, additional, Hebart, Holger, additional, Reichle, Albrecht, additional, Grube, Matthias, additional, Frickhofen, Norbert, additional, Gerecke, Christian, additional, Fuhrmann, Stephan, additional, Jung, Wolfram, additional, Gramatzki, Martin, additional, Decker, Thomas, additional, Dechow, Tobias, additional, Greiner, Jochen, additional, Brümmendorf, Tim H., additional, Ababei, Juliana, additional, Metzler, Ivana von, additional, Naumann, Ralph, additional, Fritz, Elisabeth, additional, Hentrich, Marcus, additional, Bojko, Peter, additional, Kubin, Thomas, additional, Schmidt, Christian, additional, Kaufmann, Martin, additional, Schmidt, Burkhard, additional, Hinke, Axel, additional, and Einsele, Hermann, additional

Published
2022
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41. Daratumumab Plus Bortezomib, Melphalan, and Prednisone (D-VMP) Versus Bortezomib, Melphalan, and Prednisone (VMP) Alone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of the Phase 3 Alcyone Study

Author

Mateos, Maria-Victoria, primary, San-Miguel, Jesús, additional, Cavo, Michele, additional, Bladé Creixenti, Joan, additional, Suzuki, Kenshi, additional, Jakubowiak, Andrzej, additional, Knop, Stefan, additional, Doyen, Chantal, additional, Lucio, Paulo, additional, Nagy, Zsolt, additional, Pour, Ludek, additional, Grosicki, Sebastian, additional, Crepaldi, Andre H, additional, Liberati, Anna Marina, additional, Campbell, Philip, additional, Shelekhova, Tatiana, additional, Yoon, Sung-Soo, additional, Iosava, Genadi, additional, Fujisaki, Tomoaki, additional, Garg, Mamta, additional, Pei, Huiling, additional, Krevvata, Maria, additional, Carson, Robin, additional, Borgsten, Fredrik, additional, and Dimopoulos, Meletios A., additional

Published
2022
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42. P-257: A phase 3, two-stage study of iberdomide, daratumumab, and dexamethasone (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in relapsed or refractory multiple myeloma: EXCALIBER-RRMM

Author

Lonial, Sagar, primary, Berdeja, Jesus G., additional, Dimopoulos, Meletios A., additional, Jagannath, Sundar, additional, Knop, Stefan, additional, Quach, Hang, additional, Rodríguez-Otero, Paula, additional, Richardson, Paul, additional, Acosta, Jorge, additional, Chu, Shuyu, additional, Chen, Min, additional, Abad, Patricia C., additional, Morando, Juliane, additional, and van de Donk, Niels W.C.J., additional

Published
2022
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43. Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma

Author

Mateos, María-Victoria, Dimopoulos, Meletios A., Cavo, Michele, Suzuki, Kenshi, Jakubowiak, Andrzej, Knop, Stefan, Doyen, Chantal, Lucio, Paulo, Nagy, Zsolt, Kaplan, Polina, Pour, Ludek, Cook, Mark, Grosicki, Sebastian, Crepaldi, Andre, Liberati, Anna M., Campbell, Philip, Shelekhova, Tatiana, Yoon, Sung-Soo, Iosava, Genadi, Fujisaki, Tomoaki, Garg, Mamta, Chiu, Christopher, Wang, Jianping, Carson, Robin, Crist, Wendy, Deraedt, William, Nguyen, Huong, Qi, Ming, and San-Miguel, Jesus

Published
2018
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44. Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma: DSMM XI trial

Author

Einsele, Hermann, Engelhardt, Monika, Tapprich, Christoph, Müller, Jürgen, Liebisch, Peter, Langer, Christian, Kropff, Martin, Mügge, Lars O., Jung, Wolfram, Wolf, Hans‐Heinrich, Metzner, Bernd, Hart, Christina, Gramatzki, Martin, Hertenstein, Bernd, Pfreundschuh, Michael, Rösler, Wolf, Fischer, Thomas, Maschmeyer, Georg, Kanz, Lothar, Hess, Georg, Jäger, Elke, Bentz, Martin, Dürk, Heinz A., Salwender, Hans, Hebart, Holger, Straka, Christian, and Knop, Stefan

Published
2017
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45. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity

Author

Eichner, Ruth, Heider, Michael, Fernandez-Saiz, Vanesa, van Bebber, Frauke, Garz, Anne-Kathrin, Lemeer, Simone, Rudelius, Martina, Targosz, Bianca-Sabrina, Jacobs, Laura, Knorn, Anna-Maria, Slawska, Jolanta, Platzbecker, Uwe, Germing, Ulrich, Langer, Christian, Knop, Stefan, Einsele, Herrmann, Peschel, Christian, Haass, Christian, Keller, Ulrich, Schmid, Bettina, Gotze, Katharina S., Kuster, Bernhard, and Bassermann, Florian

Subjects
Carcinogenesis -- Risk factors, Immunity -- Patient outcomes, Cellular proteins -- Health aspects, Biological sciences, Health
Abstract

Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN), a substrate receptor of the CRL4 ubiquitin ligase complex, is the primary target by which IMiDs mediate anticancer and teratogenic effects. Here we identify a ubiquitin-independent physiological chaperone-like function of CRBN that promotes maturation of the basigin (BSG; also known as CD147) and solute carrier family 16 member 1 (SLC16A1; also known as MCT1) proteins. This process allows for the formation and activation of the CD147-MCT1 transmembrane complex, which promotes various biological functions, including angiogenesis, proliferation, invasion and lactate export. We found that IMiDs outcompete CRBN for binding to CD147 and MCT1, leading to destabilization of the CD147-MCT1 complex. Accordingly, IMiD-sensitive MM cells lose CD147 and MCT1 expression after being exposed to IMiDs, whereas IMiD-resistant cells retain their expression. Furthermore, del(5q) MDS cells have elevated CD147 expression, which is attenuated after IMiD treatment. Finally, we show that BSG (CD147) knockdown phenocopies the teratogenic effects of thalidomide exposure in zebrafish. These findings provide a common mechanistic framework to explain both the teratogenic and pleiotropic antitumor effects of IMiDs., The drug thalidomide was originally prescribed as a sedative in the 1950s, and it became infamous for its devastating teratogenic effects (1). Due to their antiproliferative, anti-angiogenic and immunomodulatory properties, [...]

Published
2016
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48. Stellungnahme zur Nutzenbewertung des G-BA von Arzneimitteln gemäß § 35a SGB V, veröffentlicht am 1. Februar 2022, Vorgangsnummer 2021-11-01-D-753, IQWiG Bericht Nr. 1280

Author

Weisel, Katja, Wörmann, Bernhard, Kortüm, Martin, Munder, Markus, Goldschmidt, Hartmut, Engelhardt, Monika, Scheid, Christoph, Knop, Stefan, Deutsche Studiengruppe Multiples Myelom, Group, German Speaking Myeloma Multicenter, Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie, Deutschland. Gemeinsamer Bundesausschuss, Bassermann, Florian, and Einsele, Hermann

Subjects
Medizin und Gesundheit
Published
2022
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49. Additional file 1 of The influence of baseline characteristics, treatment and depression on health-related quality of life in patients with multiple myeloma: a prospective observational study

Author

Fischer, Julia, Knop, Stefan, Danhof, Sophia, Einsele, Hermann, Keller, Daniela, and Löffler, Claudia

Abstract

Additional file 1: Supplementary Table 1. Sociodemographic and clinical characteristics of the 70 patients with MM included in the study. Supplementary Table 2. P-values and mean-values. Supplementary Table 3. Summary of the most important results. Supplementary Table 4. Therapy of patients without stem cell transplantation. Supplementary Table 5. Therapy of patients with stem cell transplantation.

Published
2022
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50. AA amyloidosis in inflammatory active malignant paraganglioma

Author

Ihne, Sandra, primary, Kircher, Malte, additional, Papagianni, Aikaterini, additional, Goetze, Oliver, additional, Morbach, Caroline, additional, Werner, Rudolf A., additional, Zeller, Daniel, additional, Sommer, Claudia, additional, Rosenwald, Andreas, additional, Amann, Kerstin, additional, Linke, Reinhold P., additional, Lapa, Constantin, additional, Einsele, Hermann, additional, Geier, Andreas, additional, Obici, Laura, additional, Palladini, Giovanni, additional, Knop, Stefan, additional, and Störk, Stefan, additional

Published
2022
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