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2. Effect of changes in plasma levels of free fatty acids on plasma glucagon, insulin, and growth hormone in man.

Author

Hicks BH, Taylor CI, Vij SK, Pek S, Knopf RF, Floyd JC Jr, and Fajans SS

Subjects
Adult, Arginine pharmacology, Blood Glucose metabolism, Heparin pharmacology, Humans, Male, Nicotinic Acids pharmacology, Triglycerides blood, Triglycerides pharmacology, Fatty Acids, Nonesterified blood, Glucagon blood, Growth Hormone blood, Insulin blood
Published
1977
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3. Amenorrhea, hyperprolactinemia and pituitary enlargement secondary to primary hypothyroidism. Successful treatment with thyroid replacement.

Author

Keye WR, Yuen BH, Knopf RF, and Jaffe RB

Subjects
Adult, Amenorrhea drug therapy, Female, Growth Hormone blood, Humans, Hypertrophy, Hypothyroidism blood, Hypothyroidism drug therapy, Hypothyroidism pathology, Insulin, Levodopa, Pregnancy, Sella Turcica, Thyrotropin blood, Thyrotropin-Releasing Hormone, Amenorrhea etiology, Hypothyroidism complications, Pituitary Gland pathology, Pituitary Gland physiology, Prolactin blood, Triiodothyronine therapeutic use
Abstract

A 22-year-old nulliparous woman presented with primary amenorrhea, primary hypothyroidism, hyperprolactinemia, and radiologic evidence of pituitary enlargement. Investigation demonstrated limited reserves of ACTH and growth hormone. Circulating concentrations of TSH and prolactin were elevated; they increased in response to thyrotropin releasing hormone and decreased following L-dopa administration. After treatment with L-tri-iodothyronine, serum TSH and prolactin levels fell markedly, reserves of growth hormone and ACTH returned to normal, menstrual periods began, and the patient conceived. She experienced an uncomplicated prenatal, intrapartum, and postpartum course. It is thought that this patient represents a distinct clinical entity: a syndrome of amenorrhea, hyperprolactinemia, and pituitary enlargement, all secondary to primary thyroid failure. This syndrome should be distinguished from the Forbes-Albright syndrome, as it is reversible with thyroid replacement therapy. Recognition of this syndrome may thus spare the patient unnecessary, and potentially dangerous, pituitary surgery or irradiation.

Published
1976

4. Endocrine and cardiovascular responses during phobic anxiety.

Author

Nesse RM, Curtis GC, Thyer BA, McCann DS, Huber-Smith MJ, and Knopf RF

Subjects
Adult, Behavior Therapy methods, Blood Pressure, Circadian Rhythm, Epinephrine blood, Female, Glucagon blood, Growth Hormone blood, Humans, Hydrocortisone blood, Insulin blood, Norepinephrine blood, Pancreatic Polypeptide blood, Phobic Disorders therapy, Pulse, Cardiovascular System physiopathology, Hormones physiology, Phobic Disorders physiopathology
Abstract

In vivo exposure therapy for phobias is uniquely suited for controlled studies of endocrine and physiologic responses during psychologic stress. In this study, exposure therapy induced significant increases in subjective anxiety, pulse, blood pressure, plasma norepinephrine, epinephrine, insulin, cortisol, and growth hormone, but did not change plasma glucagon or pancreatic polypeptide. Although the subjective and behavioral manifestations of anxiety were consistent and intense, the magnitude, consistency, timing, and concordance of endocrine and cardiovascular responses showed considerable variation.

Published
1985
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5. Synergistic effect of certain amino acid pairs upon insulin secretion in man.

Author

Floyd JC Jr, Fajans SS, Pek S, Thiffault CA, Knopf RF, and Conn JW

Subjects
Adolescent, Adult, Amino Acids administration & dosage, Arginine pharmacology, Blood Glucose analysis, Histidine pharmacology, Humans, Injections, Intravenous, Insulin blood, Insulin Secretion, Leucine pharmacology, Lysine pharmacology, Male, Phenylalanine pharmacology, Time Factors, Amino Acids pharmacology, Drug Synergism, Insulin metabolism
Published
1970
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6. Plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients.

Author

Knopf RF, Fajans SS, Pek S, Floyd JC Jr, Prchkov VK, and Conn JW

Subjects
Adult, Arginine, Blood Glucose analysis, Cortisone, Diabetes Mellitus genetics, Diabetic Retinopathy blood, Female, Glucose, Glucose Tolerance Test, Humans, Hyperglycemia blood, Male, Middle Aged, Prediabetic State blood, Diabetes Mellitus blood, Glucagon blood, Growth Hormone blood
Published
1973
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13. Adrenergic effects which modify arginine-induced insulin release in man.

Author

Floyd JC Jr, Fajans SS, Pek S, Knopf RF, Weissman P, and Conn JW

Subjects
Epinephrine pharmacology, Humans, Insulin Secretion, Phentolamine pharmacology, Propranolol pharmacology, Receptors, Adrenergic, Arginine pharmacology, Insulin metabolism, Receptors, Drug
Published
1971

14. Failure of sulfonylureas to suppress plasma glucagon in man.

Author

Pek S, Fajans SS, Floyd JC Jr, Knopf RF, and Conn JW

Subjects
Administration, Oral, Adult, Amino Acids administration & dosage, Blood Glucose analysis, Chlorpropamide administration & dosage, Female, Glucagon metabolism, Humans, Hypoglycemia blood, Hypoglycemia chemically induced, Injections, Intravenous, Insulin blood, Male, Radioimmunoassay, Tolbutamide administration & dosage, Glucagon blood, Sulfonylurea Compounds pharmacology
Published
1972
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15. A difference in mechanism by which leucine and other amino acids induce insulin release.

Author

Fajans SS, Floyd JC Jr, Knopf RF, Guntsche EM, Rull JA, Thiffault CA, and Conn JW

Subjects
Adenoma, Islet Cell metabolism, Adult, Blood Glucose analysis, Chlorpropamide pharmacology, Diazoxide pharmacology, Female, Humans, Insulin blood, Insulin Secretion, Male, Amino Acids pharmacology, Arginine pharmacology, Insulin metabolism, Leucine pharmacology, Valine pharmacology
Published
1967
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18. Stimulation of insulin secretion by amino acids.

Author

Floyd JC Jr, Fajans SS, Conn JW, Knopf RF, and Rull J

Subjects
Adult, Arginine analysis, Fatty Acids blood, Female, Histidine analysis, Humans, Insulin biosynthesis, Isoleucine analysis, Leucine analysis, Lysine analysis, Male, Methionine analysis, Phenylalanine analysis, Threonine analysis, Tryptophan analysis, Valine analysis, Amino Acids pharmacology, Blood Glucose biosynthesis, Hyperinsulinism etiology, Insulin blood
Published
1966
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20. Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.

Author

Fajans SS, Floyd JC Jr, Thiffault CA, Knopf RF, Harrison TS, and Conn JW

Subjects
Arginine antagonists & inhibitors, Blood Glucose analysis, Catecholamines analysis, Depression, Chemical, Diazoxide therapeutic use, Female, Glucagon antagonists & inhibitors, Glucose antagonists & inhibitors, Humans, Hyperglycemia chemically induced, Hypoglycemia drug therapy, Insulin blood, Insulin Secretion, Islets of Langerhans metabolism, Leucine antagonists & inhibitors, Male, Tolbutamide antagonists & inhibitors, Trichlormethiazide pharmacology, Adenoma, Islet Cell blood, Diazoxide pharmacology, Hyperinsulinism blood, Insulin metabolism, Islets of Langerhans drug effects
Published
1968
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21. Secretion of insulin induced by amino acids and glucose in diabetes mellitus.

Author

Floyd JC Jr, Fajans SS, Conn JW, Thiffault C, Knopf RF, and Guntsche E

Subjects
Adult, Amino Acids blood, Amino Acids therapeutic use, Arginine pharmacology, Blood Glucose, Diabetes Mellitus drug therapy, Female, Glucose therapeutic use, Glucose Tolerance Test, Humans, Injections, Intravenous, Insulin blood, Insulin Secretion, Islets of Langerhans drug effects, Male, Amino Acids pharmacology, Diabetes Mellitus physiopathology, Glucose pharmacology, Insulin metabolism, Islets of Langerhans physiopathology
Published
1968
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22. Subnormal secretion of insulin in mild diabetes mellitus.

Author

Floyd JC Jr, Fajans SS, Conn JW, Pek S, and Knopf RF

Subjects
Arginine, Cortisone, Diabetes Complications, Diabetes Mellitus genetics, Female, Glucose metabolism, Glucose Tolerance Test, Humans, Insulin Resistance, Insulin Secretion, Male, Obesity, Proteins metabolism, Amino Acids metabolism, Diabetes Mellitus physiopathology, Insulin metabolism, Islets of Langerhans metabolism
Published
1970
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26. NATURE OF RENAL ESCAPE FROM THE SODIUM-RETAINING EFFECT OF ALDOSTERONE IN PRIMARY ALDOSTERONISM AND IN NORMAL SUBJECTS.

Author

ROVNER DR, CONN JW, KNOPF RF, COHEN EL, and HSUEH MT

Subjects
Humans, Aldosterone, Creatine, Creatinine, Fluids and Secretions, Glomerular Filtration Rate, Hyperaldosteronism, Hypernatremia, Kidney Function Tests, Kidney Tubules, Natriuresis, Pharmacology, Potassium, Sodium, Sodium Chloride, Water-Electrolyte Balance, p-Aminohippuric Acid
Published
1965
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27. Synergistic effect of essential amino acids and glucose upon insulin secretion in man.

Author

Floyd JC Jr, Fajans SS, Pek S, Thiffault CA, Knopf RF, and Conn JW

Subjects
Adult, Arginine pharmacology, Autoanalysis, Blood Glucose analysis, Histidine pharmacology, Humans, Injections, Intravenous, Insulin blood, Insulin Secretion, Islets of Langerhans drug effects, Leucine pharmacology, Male, Radioimmunoassay, Stimulation, Chemical, Amino Acids pharmacology, Drug Synergism, Glucose pharmacology, Insulin metabolism
Published
1970
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28. Amino acids and insulin release in vivo.

Author

Fajans SS, Floyd JC Jr, Knopf RF, Pek S, Weissman P, and Conn JW

Subjects
Animals, Arginine pharmacology, Blood Glucose analysis, Chlorpropamide pharmacology, Cycloheptanes pharmacology, Diabetes Mellitus blood, Dietary Proteins, Dogs, Glucagon blood, Glucose pharmacology, Heptoses pharmacology, Humans, Hypoglycemia chemically induced, Leucine pharmacology, Pancreas drug effects, Piperidines pharmacology, Time Factors, Amino Acids pharmacology, Insulin blood
Published
1972

30. Insulin secretion in response to protein ingestion.

Author

Floyd JC Jr, Fajans SS, Conn JW, Knopf RF, and Rull J

Subjects
Adolescent, Adult, Autoanalysis, Blood Glucose, Chlorpropamide pharmacology, Fatty Acids blood, Female, Humans, Insulin blood, Male, Dietary Proteins metabolism, Insulin biosynthesis, Leucine blood
Published
1966
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