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1. The evolution of epilepsy surgery between 1991 and 2011 in nine major epilepsy centers across the United States, Germany, and Australia

Author

Jehi, L, Friedman, D, Carlson, C, Cascino, G, Dewar, S, Elger, C, Engel, J, Knowlton, R, Kuzniecky, R, McIntosh, A, O'Brien, TJ, Spencer, D, Sperling, MR, Worrell, G, Bingaman, B, Gonzalez-Martinez, J, Doyle, W, and French, J

Subjects
Neurology & Neurosurgery, Clinical Sciences, Neurosciences
Abstract

Objective Epilepsy surgery is the most effective treatment for select patients with drug-resistant epilepsy. In this article, we aim to provide an accurate understanding of the current epidemiologic characteristics of this intervention, as this knowledge is critical for guiding educational, academic, and resource priorities. Methods We profile the practice of epilepsy surgery between 1991 and 2011 in nine major epilepsy surgery centers in the United States, Germany, and Australia. Clinical, imaging, surgical, and histopathologic data were derived from the surgical databases at various centers. Results Although five of the centers performed their highest number of surgeries for mesial temporal sclerosis (MTS) in 1991, and three had their highest number of MTS surgeries in 2001, only one center achieved its peak number of MTS surgeries in 2011. The most productive year for MTS surgeries varied then by center; overall, the nine centers surveyed performed 48% (95% confidence interval [CI] -27.3% to -67.4%) fewer such surgeries in 2011 compared to either 1991 or 2001, whichever was higher. There was a parallel increase in the performance of surgery for nonlesional epilepsy. Further analysis of 5/9 centers showed a yearly increase of 0.6 ± 0.07% in the performance of invasive electroencephalography (EEG) without subsequent resections. Overall, although MTS was the main surgical substrate in 1991 and 2001 (proportion of total surgeries in study centers ranging from 33.3% to 70.2%); it occupied only 33.6% of all resections in 2011 in the context of an overall stable total surgical volume. Significance These findings highlight the major aspects of the evolution of epilepsy surgery across the past two decades in a sample of well-established epilepsy surgery centers, and the critical current challenges of this treatment option in addressing complex epilepsy cases requiring detailed evaluations. Possible causes and implications of these findings are discussed.

Published
2015

3. Association of ultra-rare coding variants with genetic generalized epilepsy: A case–control whole exome sequencing study

Author

Koko, M., Motelow, J. E., Stanley, K. E., Bobbili, D. R., Dhindsa, R. S., May, P., Alldredge, B. K., Allen, A. S., Altmuller, J., Amrom, D., Andermann, E., Auce, P., Avbersek, A., Baulac, S., Bautista, J. F., Becker, F., Bellows, S. T., Berghuis, B., Berkovic, S. F., Bluvstein, J., Boro, A., Bridgers, J., Burgess, R., Caglayan, H., Cascino, G. D., Cavalleri, G. L., Chung, S. -K., Cieuta-Walti, C., Cloutier, V., Consalvo, D., Cossette, P., Crumrine, P., Delanty, N., Depondt, C., Desbiens, R., Devinsky, O., Dlugos, D., Epstein, M. P., Everett, K., Fiol, M., Fountain, N. B., Francis, B., French, J., Freyer, C., Friedman, D., Gambardella, A., Geller, E. B., Girard, S., Glauser, T., Glynn, S., Goldstein, D. B., Gravel, M., Haas, K., Haut, S. R., Heinzen, E. L., Helbig, I., Hildebrand, M. S., Johnson, M. R., Jorgensen, A., Joshi, S., Kanner, A., Kirsch, H. E., Klein, K. M., Knowlton, R. C., Koeleman, B. P. C., Kossoff, E. H., Krause, R., Krenn, M., Kunz, W. S., Kuzniecky, R., Langley, S. R., Leguern, E., Lehesjoki, A. -E., Lerche, H., Leu, C., Lortie, A., Lowenstein, D. H., Marson, A. G., Mebane, C., Mefford, H. C., Meloche, C., Moreau, C., Motika, P. V., Muhle, H., Moller, R. S., Nabbout, R., Nguyen, D. K., Nikanorova, M., Novotny, E. J., Nurnberg, P., Ottman, R., O'Brien, T. J., Paolicchi, J. M., Parent, J. M., Park, K., Peter, S., Petrou, S., Petrovski, S., Pickrell, W. O., Poduri, A., Radtke, R. A., Rees, M. I., Regan, B. M., Ren, Z., Sadleir, L. G., Sander, J. W., Sander, T., Scheffer, I. E., Schubert, J., Shellhaas, R. A., Sherr, E. H., Shih, J. J., Shinnar, S., Sills, G. J., Singh, R. K., Siren, A., Sirven, J., Sisodiya, S. M., Smith, M. C., Sonsma, A. C. M., Striano, P., Sullivan, J., Thio, L. L., Thomas, R. H., Venkat, A., Vining, E. P. G., Von Allmen, G. K., Wang, Q., Weber, Y. G., Weckhuysen, S., Weisenberg, J. L., Widdess-Walsh, P., Winawer, M. R., Wolking, S., Zara, F., Zimprich, F., Canadian Epilepsy Network, Epi4K Consortium, Epilepsy Phenome/Genome Project, EpiPGX Consortium, EuroEPINOMICS-CoGIE Consortium, Department of Medical and Clinical Genetics, Medicum, Fonds National de la Recherche - FnR [sponsor], Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) [research center], Peter, Sarah, Petrou, Steven, Petrovski, Slavé, Pickrell, William O., Poduri, Annapurna, Radtke, Rodney A., Rees, Mark I., Regan, Brigid M., Ren, Zhong, Sadleir, Lynette G., Alldredge, Brian K., Sander, Josemir W., Sander, Thomas, Scheffer, Ingrid E., Schubert, Julian, Shellhaas, Renée A., Sherr, Elliott H., Shih, Jerry J., Shinnar, Shlomo, Sills, Graeme J., Singh, Rani K., Allen, Andrew S., Siren, Auli, Sirven, Joseph, Sisodiya, Sanjay M., Smith, Michael C., Sonsma, Anja C. M., Striano, Pasquale, Sullivan, Joseph, Thio, Liu Lin, Thomas, Rhys H., Venkat, Anu, Altmüller, Janine, Vining, Eileen P. G., Von Allmen, Gretchen K., Wang, Quanli, Weber, Yvonne G., Weckhuysen, Sarah, Weisenberg, Judith L., Widdess-Walsh, Peter, Winawer, Melodie R., Wolking, Stefan, Zara, Federico, Amrom, Dina, Zimprich, Fritz, Andermann, Eva, Auce, Pauls, Avbersek, Andreja, Baulac, Stéphanie, Bautista, Jocelyn F., Becker, Felicitas, Bellows, Susannah T., Berghuis, Bianca, Berkovic, Samuel F., Bluvstein, Judith, Boro, Alex, Bridgers, Joshua, Burgess, Rosemary, Caglayan, Hande, Cascino, Gregory D., Cavalleri, Gianpiero L., Chung, Seo-Kyung, Cieuta-Walti, Cécile, Cloutier, Véronique, Consalvo, Damian, Cossette, Patrick, Crumrine, Patricia, Delanty, Norman, Depondt, Chantal, Desbiens, Richard, Devinsky, Orrin, Dlugos, Dennis, Epstein, Michael P., Everett, Kate, Fiol, Miguel, Fountain, Nathan B., Francis, Ben, French, Jacqueline, Freyer, Catharine, Friedman, Daniel, Gambardella, Antonio, Geller, Eric B., Girard, Simon, Glauser, Tracy, Glynn, Simon, Goldstein, David B., Gravel, Micheline, Haas, Kevin, Haut, Sheryl R., Heinzen, Erin L., Helbig, Ingo, Hildebrand, Michael S., Johnson, Michael R., Jorgensen, Andrea, Joshi, Sucheta, Kanner, Andres, Kirsch, Heidi E., Klein, Karl M., Knowlton, Robert C., Koeleman, Bobby P. C., Kossoff, Eric H., Krause, Roland, Krenn, Martin, Kunz, Wolfram S., Kuzniecky, Ruben, Langley, Sarah R., LeGuern, Eric, Lehesjoki, Anna-Elina, Lerche, Holger, Leu, Costin, Lortie, Anne, Lowenstein, Daniel H., Marson, Anthony G., Mebane, Caroline, Mefford, Heather C., Meloche, Caroline, Moreau, Claudia, Motika, Paul V., Muhle, Hiltrud, Møller, Rikke S., Nabbout, Rima, Nguyen, Dang K., Nikanorova, Marina, Novotny, Edward J., Nürnberg, Peter, Ottman, Ruth, O'Brien, Terence J., Paolicchi, Juliann M., Parent, Jack M., and Park, Kristen

Subjects
GABA receptors, Neurology [D14] [Human health sciences], Clinical Sciences, GABA(A) receptors, GABRG2, familial epilepsy, Article, Clinical Research, Receptors, Exome Sequencing, Genetics, 2.1 Biological and endogenous factors, Humans, GGE, Genetic Predisposition to Disease, sporadic epilepsy, EpiPGX Consortium, Aetiology, gamma-Aminobutyric Acid, GABAA receptors, Epi4K Consortium, Epilepsy, Neurology & Neurosurgery, Neurologie [D14] [Sciences de la santé humaine], Generalized, GABA-A, Prevention, Human Genome, Neurosciences, 1184 Genetics, developmental biology, physiology, 3112 Neurosciences, Receptors, GABA-A, EuroEPINOMICS-CoGIE Consortium, Neurology, Case-Control Studies, Epilepsy, Generalized, Canadian Epilepsy Network, Neurology (clinical), Genetics & genetic processes [F10] [Life sciences], 3111 Biomedicine, Human medicine, Génétique & processus génétiques [F10] [Sciences du vivant], Epilepsy Phenome/Genome Project
Abstract

ObjectiveWe aimed to identify genes associated with genetic generalized epilepsy (GGE) by combining large cohorts enriched with individuals with a positive family history. Secondarily, we set out to compare the association of genes independently with familial and sporadic GGE.MethodsWe performed a case-control whole exome sequencing study in unrelated individuals of European descent diagnosed with GGE (previously recruited and sequenced through multiple international collaborations) and ancestry-matched controls. The association of ultra-rare variants (URVs; in 18834 protein-coding genes) with epilepsy was examined in 1928 individuals with GGE (vs. 8578 controls), then separately in 945 individuals with familial GGE (vs. 8626 controls), and finally in 1005 individuals with sporadic GGE (vs. 8621 controls). We additionally examined the association of URVs with familial and sporadic GGE in two gene sets important for inhibitory signaling (19genes encoding γ-aminobutyric acid type A [GABAA ] receptors, 113genes representing the GABAergic pathway).ResultsGABRG2 was associated with GGE (p=1.8×10-5 ), approaching study-wide significance in familial GGE (p=3.0×10-6 ), whereas no gene approached a significant association with sporadic GGE. Deleterious URVs in the most intolerant subgenic regions in genes encoding GABAA receptors were associated with familial GGE (odds ratio [OR]=3.9, 95% confidence interval [CI]=1.9-7.8, false discovery rate [FDR]-adjusted p=.0024), whereas their association with sporadic GGE had marginally lower odds (OR=3.1, 95% CI=1.3-6.7, FDR-adjusted p=.022). URVs in GABAergic pathway genes were associated with familial GGE (OR=1.8, 95% CI=1.3-2.5, FDR-adjusted p=.0024) but not with sporadic GGE (OR=1.3, 95% CI=.9-1.9, FDR-adjusted p=.19).SignificanceURVs in GABRG2 are likely an important risk factor for familial GGE. The association of gene sets of GABAergic signaling with familial GGE is more prominent than with sporadic GGE.

Published
2022

5. Diverse genetic causes of polymicrogyria with epilepsy

Author

Allen, AS, Aggarwal, V, Berkovic, SF, Cossette, P, Delanty, N, Dlugos, D, Eichler, EE, Epstein, MP, Freyer, C, Goldstein, DB, Guerrini, R, Glauser, T, Heinzen, EL, Johnson, MR, Kuzniecky, R, Lowenstein, DH, Marson, AG, Mefford, HC, O'Brien, TJ, Ottman, R, Poduri, A, Petrou, S, Petrovski, S, Ruzzo, EK, Scheffer, IE, Sherr, EH, Abou-Khalil, B, Amrom, D, Andermann, E, Andermann, F, Bluvstein, J, Boro, A, Cascino, G, Consalvo, D, Crumrine, P, Devinsky, O, Fountain, N, Friedman, D, Geller, E, Glynn, S, Haas, K, Haut, S, Joshi, S, Kirsch, H, Knowlton, R, Kossoff, E, Motika, PV, Paolicchi, JM, Parent, JM, Shellhaas, RA, Shih, JJ, Shinnar, S, Singh, RK, Sperling, M, Smith, MC, Sullivan, J, Vining, EPG, Von Allmen, GK, Widdess-Walsh, P, Winawer, MR, Bautista, J, Fiol, M, Hayward, J, Helmers, S, Park, K, Sirven, J, Thio, LL, Venkat, A, Weisenberg, J, Kuperman, R, McGuire, S, Novotny, E, Sadleir, L, Allen, AS, Aggarwal, V, Berkovic, SF, Cossette, P, Delanty, N, Dlugos, D, Eichler, EE, Epstein, MP, Freyer, C, Goldstein, DB, Guerrini, R, Glauser, T, Heinzen, EL, Johnson, MR, Kuzniecky, R, Lowenstein, DH, Marson, AG, Mefford, HC, O'Brien, TJ, Ottman, R, Poduri, A, Petrou, S, Petrovski, S, Ruzzo, EK, Scheffer, IE, Sherr, EH, Abou-Khalil, B, Amrom, D, Andermann, E, Andermann, F, Bluvstein, J, Boro, A, Cascino, G, Consalvo, D, Crumrine, P, Devinsky, O, Fountain, N, Friedman, D, Geller, E, Glynn, S, Haas, K, Haut, S, Joshi, S, Kirsch, H, Knowlton, R, Kossoff, E, Motika, PV, Paolicchi, JM, Parent, JM, Shellhaas, RA, Shih, JJ, Shinnar, S, Singh, RK, Sperling, M, Smith, MC, Sullivan, J, Vining, EPG, Von Allmen, GK, Widdess-Walsh, P, Winawer, MR, Bautista, J, Fiol, M, Hayward, J, Helmers, S, Park, K, Sirven, J, Thio, LL, Venkat, A, Weisenberg, J, Kuperman, R, McGuire, S, Novotny, E, and Sadleir, L

Abstract

OBJECTIVE: We sought to identify novel genes and to establish the contribution of known genes in a large cohort of patients with nonsyndromic sporadic polymicrogyria and epilepsy. METHODS: We enrolled participants with polymicrogyria and their parents through the Epilepsy Phenome/Genome Project. We performed phenotyping and whole exome sequencing (WES), trio analysis, and gene-level collapsing analysis to identify de novo or inherited variants, including germline or mosaic (postzygotic) single nucleotide variants, small insertion-deletion (indel) variants, and copy number variants present in leukocyte-derived DNA. RESULTS: Across the cohort of 86 individuals with polymicrogyria and epilepsy, we identified seven with pathogenic or likely pathogenic variants in PIK3R2, including four germline and three mosaic variants. PIK3R2 was the only gene harboring more than expected de novo variants across the entire cohort, and likewise the only gene that passed the genome-wide threshold of significance in the gene-level rare variant collapsing analysis. Consistent with previous reports, the PIK3R2 phenotype consisted of bilateral polymicrogyria concentrated in the perisylvian region with macrocephaly. Beyond PIK3R2, we also identified one case each with likely causal de novo variants in CCND2 and DYNC1H1 and biallelic variants in WDR62, all genes previously associated with polymicrogyria. Candidate genetic explanations in this cohort included single nucleotide de novo variants in other epilepsy-associated and neurodevelopmental disease-associated genes (SCN2A in two individuals, GRIA3, CACNA1C) and a 597-kb deletion at 15q25, a neurodevelopmental disease susceptibility locus. SIGNIFICANCE: This study confirms germline and postzygotically acquired de novo variants in PIK3R2 as an important cause of bilateral perisylvian polymicrogyria, notably with macrocephaly. In total, trio-based WES identified a genetic diagnosis in 12% and a candidate diagnosis in 6% of our polymicrogyria

Published
2021

7. The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

Author

Girardi, Fabio;Rous, Brian;Stiller, Charles A;Gatta, Gemma;Fersht, Naomi;Storm, Hans H;Rodrigues, Jessica R;Herrmann, Christian;Marcos-Gragera, Rafael;Peris-Bonet, Rafael;Valkov, Mikhail;Weir, Hannah K;Woods, Ryan R;You, Hui;Cueva, Patricia A;De, Prithwish;Di Carlo, Veronica;Johannesen, Tom Børge;Lima, Carlos A;Lynch, Charles F;Coleman, Michel P;Allemani, Claudia;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Ladipo, A;Ogunbiyi, O J;Ramaliba, T;Somdyala, N I M;Chaplin, M A;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Laspada, W D;Ibañez, S G;Lima, C A;Mafra da Costa, A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Azevedo e Silva, G;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Perez, P;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Woods, R R;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Anam, A;De, P;McClure, C A;Vriends, K A;Bertrand, C;Latreille, J;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Avila, R M;O’Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Johnson, C J;Ruppert, L P;Bentler, S;Charlton, M E;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Stern, K;Gershman, S T;Knowlton, R C;Alverson, G;Weaver, T;Bushhouse, S;Rogers, D and Girardi, Fabio;Rous, Brian;Stiller, Charles A;Gatta, Gemma;Fersht, Naomi;Storm, Hans H;Rodrigues, Jessica R;Herrmann, Christian;Marcos-Gragera, Rafael;Peris-Bonet, Rafael;Valkov, Mikhail;Weir, Hannah K;Woods, Ryan R;You, Hui;Cueva, Patricia A;De, Prithwish;Di Carlo, Veronica;Johannesen, Tom Børge;Lima, Carlos A;Lynch, Charles F;Coleman, Michel P;Allemani, Claudia;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Ladipo, A;Ogunbiyi, O J;Ramaliba, T;Somdyala, N I M;Chaplin, M A;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Laspada, W D;Ibañez, S G;Lima, C A;Mafra da Costa, A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Azevedo e Silva, G;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Perez, P;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Woods, R R;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Anam, A;De, P;McClure, C A;Vriends, K A;Bertrand, C;Latreille, J;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Avila, R M;O’Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Johnson, C J;Ruppert, L P;Bentler, S;Charlton, M E;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Stern, K;Gershman, S T;Knowlton, R C;Alverson, G;Weaver, T;Bushhouse, S;Rogers, D

Published
2020

12. Quantitative analysis of phenotypic elements augments traditional electroclinical classification of common familial epilepsies

Author

Abou-Khalil, B, Afawi, Z, Allen, AS, Bautista, JF, Bellows, ST, Berkovic, SF, Bluvstein, J, Burgess, R, Cascino, G, Cossette, P, Cristofaro, S, Crompton, DE, Delanty, N, Devinsky, O, Dlugos, D, Ellis, CA, Epstein, MP, Fountain, NB, Freyer, C, Geller, EB, Glauser, T, Glynn, S, Goldberg-Stern, H, Goldstein, DB, Gravel, M, Haas, K, Haut, S, Heinzen, EL, Kirsch, HE, Kivity, S, Knowlton, R, Korczyn, AD, Kossoff, E, Kuzniecky, R, Loeb, R, Lowenstein, DH, Marson, AG, McCormack, M, McKenna, K, Mefford, HC, Motika, P, Mullen, SA, O'Brien, TJ, Ottman, R, Paolicchi, J, Parent, JM, Paterson, S, Petrou, S, Petrovski, S, Pickrell, WO, Poduri, A, Rees, MI, Sadleir, LG, Scheffer, IE, Shih, J, Singh, R, Sirven, J, Smith, M, Smith, PEM, Thio, LL, Thomas, RH, Venkat, A, Vining, E, Von Allmen, G, Weisenberg, J, Widdess-Walsh, P, Winawer, MR, Abou-Khalil, B, Afawi, Z, Allen, AS, Bautista, JF, Bellows, ST, Berkovic, SF, Bluvstein, J, Burgess, R, Cascino, G, Cossette, P, Cristofaro, S, Crompton, DE, Delanty, N, Devinsky, O, Dlugos, D, Ellis, CA, Epstein, MP, Fountain, NB, Freyer, C, Geller, EB, Glauser, T, Glynn, S, Goldberg-Stern, H, Goldstein, DB, Gravel, M, Haas, K, Haut, S, Heinzen, EL, Kirsch, HE, Kivity, S, Knowlton, R, Korczyn, AD, Kossoff, E, Kuzniecky, R, Loeb, R, Lowenstein, DH, Marson, AG, McCormack, M, McKenna, K, Mefford, HC, Motika, P, Mullen, SA, O'Brien, TJ, Ottman, R, Paolicchi, J, Parent, JM, Paterson, S, Petrou, S, Petrovski, S, Pickrell, WO, Poduri, A, Rees, MI, Sadleir, LG, Scheffer, IE, Shih, J, Singh, R, Sirven, J, Smith, M, Smith, PEM, Thio, LL, Thomas, RH, Venkat, A, Vining, E, Von Allmen, G, Weisenberg, J, Widdess-Walsh, P, and Winawer, MR

Abstract

OBJECTIVE: Classification of epilepsy into types and subtypes is important for both clinical care and research into underlying disease mechanisms. A quantitative, data-driven approach may augment traditional electroclinical classification and shed new light on existing classification frameworks. METHODS: We used latent class analysis, a statistical method that assigns subjects into groups called latent classes based on phenotypic elements, to classify individuals with common familial epilepsies from the Epi4K Multiplex Families study. Phenotypic elements included seizure types, seizure symptoms, and other elements of the medical history. We compared class assignments to traditional electroclinical classifications and assessed familial aggregation of latent classes. RESULTS: A total of 1120 subjects with epilepsy were assigned to five latent classes. Classes 1 and 2 contained subjects with generalized epilepsy, largely reflecting the distinction between absence epilepsies and younger onset (class 1) versus myoclonic epilepsies and older onset (class 2). Classes 3 and 4 contained subjects with focal epilepsies, and in contrast to classes 1 and 2, these did not adhere as closely to clinically defined focal epilepsy subtypes. Class 5 contained nearly all subjects with febrile seizures plus or unknown epilepsy type, as well as a few subjects with generalized epilepsy and a few with focal epilepsy. Family concordance of latent classes was similar to or greater than concordance of clinically defined epilepsy types. SIGNIFICANCE: Quantitative classification of epilepsy has the potential to augment traditional electroclinical classification by (1) combining some syndromes into a single class, (2) splitting some syndromes into different classes, (3) helping to classify subjects who could not be classified clinically, and (4) defining the boundaries of clinically defined classifications. This approach can guide future research, including molecular genetic studies, by identifyi

Published
2019

13. Standardized Brain MRI Acquisition Protocols Improve Statistical Power in Multicenter Quantitative Morphometry Studies

Author

George, A, Kuzniecky, R, Rusinek, H, Pardoe, HR, French, J, Lowenstein, D, Cristofaro, S, McKenna, K, Mays, V, Shack, D, Barnard, S, Burke, C, Hegde, M, Glauser, T, O'Brien, T, Pollard, J, Ting, T, Meador, K, Darby, D, Morrison, C, Penovich, P, Schembri, A, Kanner, A, Altilab, HH, Barry, J, Hesdorffer, D, Hope, O, Nadkarni, S, Sperling, M, Winawer, M, Dlugos, D, Beal, J, Boro, A, Herman, S, Singh, R, Halford, J, Thio, LL, Pardoe, H, Cascino, G, Glynn, S, Jackson, G, Knowlton, R, Gidal, B, Abou-Khalil, B, Alldredge, B, Faught, E, Ficker, D, Klein, P, Mintzer, S, Detyniecki, K, Haut, S, Hixson, J, Holmes, M, Kalviainen, R, Widdess-Walsh, P, Krishnamurthy, K, Park, K, Gelfand, M, Kang, J, Krauss, G, Cole, A, Atkinson, P, Trinka, E, Kirschner, M, Schmid, E, Somerville, E, Zentner, C, Laue-Gizzi, H, Rodriguez, A, Devinsky, O, Nadkarni, M, Cook, M, Berkovic, S, Bebin, M, Szaflarsk, J, Szabo, C, Burneo, J, Abou-Khalil, BW, Weisenberg, J, Altilab, H, George, A, Kuzniecky, R, Rusinek, H, Pardoe, HR, French, J, Lowenstein, D, Cristofaro, S, McKenna, K, Mays, V, Shack, D, Barnard, S, Burke, C, Hegde, M, Glauser, T, O'Brien, T, Pollard, J, Ting, T, Meador, K, Darby, D, Morrison, C, Penovich, P, Schembri, A, Kanner, A, Altilab, HH, Barry, J, Hesdorffer, D, Hope, O, Nadkarni, S, Sperling, M, Winawer, M, Dlugos, D, Beal, J, Boro, A, Herman, S, Singh, R, Halford, J, Thio, LL, Pardoe, H, Cascino, G, Glynn, S, Jackson, G, Knowlton, R, Gidal, B, Abou-Khalil, B, Alldredge, B, Faught, E, Ficker, D, Klein, P, Mintzer, S, Detyniecki, K, Haut, S, Hixson, J, Holmes, M, Kalviainen, R, Widdess-Walsh, P, Krishnamurthy, K, Park, K, Gelfand, M, Kang, J, Krauss, G, Cole, A, Atkinson, P, Trinka, E, Kirschner, M, Schmid, E, Somerville, E, Zentner, C, Laue-Gizzi, H, Rodriguez, A, Devinsky, O, Nadkarni, M, Cook, M, Berkovic, S, Bebin, M, Szaflarsk, J, Szabo, C, Burneo, J, Abou-Khalil, BW, Weisenberg, J, and Altilab, H

Abstract

BACKGROUND AND PURPOSE: In this study, we used power analysis to calculate required sample sizes to detect group-level changes in quantitative neuroanatomical estimates derived from MRI scans obtained from multiple imaging centers. Sample size estimates were derived from (i) standardized 3T image acquisition protocols and (ii) nonstandardized clinically acquired images obtained at both 1.5 and 3T as part of the multicenter Human Epilepsy Project. Sample size estimates were compared to assess the benefit of standardizing acquisition protocols. METHODS: Cortical thickness, hippocampal volume, and whole brain volume were estimated from whole brain T1-weighted MRI scans processed using Freesurfer v6.0. Sample sizes required to detect a range of effect sizes were calculated using (i) standard t-test based power analysis methods and (ii) a nonparametric bootstrap approach. RESULTS: A total of 32 participants were included in our analyses, aged 29.9 ± 12.62 years. Standard deviation estimates were lower for all quantitative neuroanatomical metrics when assessed using standardized protocols. Required sample sizes per group to detect a given effect size were markedly reduced when using standardized protocols, particularly for cortical thickness changes <.2 mm and hippocampal volume changes <10%. CONCLUSIONS: The use of standardized protocols yielded up to a five-fold reduction in required sample sizes to detect disease-related neuroanatomical changes, and is particularly beneficial for detecting subtle effects. Standardizing image acquisition protocols across scanners prior to commencing a study is a valuable approach to increase the statistical power of multicenter MRI studies.

Published
2019

15. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Author

Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos Gragera, Rafael, Peris Bonet, Rafael, Piñeros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F. G, Coleman, Michel P, Allemani, Claudia, Bouzbid, S., Hamdi Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S. H., El Mistiri, M. M., Bayo, S., Malle, B., Manraj, S. S., Sewpaul Sungkur, R., Fabowale, Null, Ogunbiyi, O. J., Bradshaw, D., Somdyala, N. I. M., Stefan, D. C., Abdel Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M. S., Laura, E. A., Espinola, S. B., Calabrano, G. H., Carballo Quintero, B., Fita, R., Garcilazo, D. A., Giacciani, P. L., Diumenjo, M. C., Laspada, W. D., Green, M. A., Lanza, M. F., Ibañez, S. G., Lima, C. A., de Oliveira, E. Lobo, Daniel, C., Scandiuzzi, C., De Souza, P. C. F., Melo, C. D., Del Pino, K., Laporte, C., Curado, M. P., de Oliveira, J. C., Veneziano, C. L. A., Veneziano, D. B., Alexandre, T. S., Verdugo, A. S., Azevedo e. Silva, G., Galaz, J. C., Moya, J. A., Herrmann, D. A., Vargas, S., Herrera, V. M., Uribe, C. J., Bravo, L. E., Arias Ortiz, N. E., Jurado, D. M., Yépez, M. C., Galán, Y. H., Torres, P., Martínez Reyes, F., Pérez Meza, M. L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J. G., Torres Cintrón, C. R., Tortolero Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A. J., Woods, R. R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F. R., Ryan, S., Hannah, H., Dewar, R. A. D., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D. E., Mcclure, C., Vriends, K. A., Bertrand, C., Louchini, R., Robb, K. I., Stuart Panko, H., Demers, S., Wright, S., George, J. T., Shen, X., Brockhouse, J. T., O'Brien, D. K., Ward, K. C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A. G., Vigneau, F., Mackinnon, J. A., Wohler, B., Bayakly, A. R., Clarke, C. A., Glaser, S. L., West, D., Green, M. D., Hernandez, B. Y., Johnson, C. J., Jozwik, D., Charlton, M. E., Lynch, C. F., Huang, B., Tucker, T. C., Deapen, D., Liu, L., Hsieh, M. C., X. C., Wu, Stern, K., Gershman, S. T., Knowlton, R. C., Alverson, J., Copeland, G. E., Rogers, D. B., Lemons, D., Williamson, L. L., Hood, M., Hosain, G. M., Rees, J. R., Pawlish, K. S., Stroup, A., Key, C., Wiggins, C., Kahn, A. R., Schymura, M. J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S. S., Rubertone, J. J., Slack, S. J., Fulton, J. P., Rousseau, D. L., Janes, T. A., Schwartz, S. M., Bolick, S. W., Hurley, D. M., Richards, J., Whiteside, M. A., Nogueira, L. M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D. G., Cheteri, MB Keitheri, Farley, S., Hudson, A. G., Borchers, R., Stephenson, L., Espinoza, J. R., Weir, H. K., Edwards, B. K., Wang, N., Yang, L., Chen, J. S., Song, G. H., X. P., Gu, Zhang, P., H. M., Ge, Zhao, D. L., Zhang, J. H., Zhu, F. D., Tang, J. G., Shen, Y., Wang, J., Q. L., Li, Yang, X. P., Dong, J., Li, W., Cheng, L. P., Chen, J. G., Huang, Q. H., Huang, S. Q., Guo, G. P., Wei, K., Chen, W. Q., Zeng, H., Demetriou, A. V., Pavlou, P., Mang, W. K., Ngan, K. C., Kataki, A. C., Krishnatreya, M., Jayalekshmi, P. A., Sebastian, P., Sapkota, S. D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan Boker, L., Silverman, B. G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N. Bhoo, Chimedsuren, O., Tuvshingerel, S., Al Khater, A. H. M., Al Eid, H., Jung, K. W., Won, Y. J., Chiang, C. J., Lai, M. S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S. L., Sriplung, H., Eser, S., Yakut, C. I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A. A., Aleinikova, O. V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A. M., Faivre, J., Guizard, A. V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A. S., Daoulas, M., Clavel, J., Le Guyader Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S. R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R. A., Kumar, V., Ólafsdóttir, E. J., Tryggvadóttir, L., Comber, H., Walsh, P. M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M. F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, MILENA MARIA, Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M. L., Tisano, F., Fanetti, A. C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M. A., Piffer, S., Rosso, S., Sacchetto, Lidia, Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A. P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann Sroka, A., Trojanowski, M., Gózdz, S., Mezyk, R., Gradalska Lampart, M., Radziszewska, A. U., Didkowska, J. A., Wojciechowska, U., Blaszczyk, J., Kepska, K., Bielska Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R. A., Bastos, J., Silva, M. A., Antunes, L., Bento, M. J., Mayer da Silva, A., Miranda, A., Coza, D., Todescu, A. I., Valkov, M. Y., Adamcik, J., Safaei Diba, C., Primic Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J. R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J. M., Marcos, A. I., Marcos Gragera, R., Vilardell Gil, M. L., Molina, E., Sánchez, M. J., Sureda, P. Franch, Montserrat, M. Ramos, Chirlaque, M. D., Navarro, C., Ardanaz, E. E., Moreno Iribas, C. C., Fernández Delgado, R., Peris Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S. M., Herrmann, C., Bulliard, J. L., Maspoli Conconi, M., Frick, H., Kuehni, C. E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S. I., Matthes, K. L., Rashbass, J., Stiller, C. A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R. J., Brewster, D. H., Huws, D. W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M. P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšic, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Murphy, M. F. G., Chalker, E., Newman, L., Baker, D., Soeberg, M. J., Aitken, J., Scott, C., Stokes, B. C., Venn, A., Farrugia, H., Giles, G. G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Latorre, M. R. D. O., and Tanaka, L. F.

Subjects
Hematology
Published
2017

16. Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)

Author

Matz, M., Coleman, M., Carreira, H., Salmerã³n, D., Chirlaque, M., Allemani, C., Bouzbid, S., Hamdi-chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S., El Mistiri, M., Bayo, S., Malle, B., Manraj, S., Sewpaul-sungkur, R., Fabowale, A., Ogunbiyi, O., Bradshaw, D., Somdyala, N., Stefan, D., Abdel-rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M., Laura, E., Espinola, S., Calabrano, G., Carballo Quintero, B., Fita, R., Garcilazo, D., Giacciani, P., Diumenjo, M., Laspada, W., Green, M., Lanza, M., Ibañez, S., Lima, C., Lobo De Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C., Del Pino, K., Laporte, C., Curado, M., De Oliveira, J., Veneziano, C., Veneziano, D., Latorre, M., Tanaka, L., Azevedo E. Silva, G., Galaz, J., Moya, J., Herrmann, D., Vargas, S., Herrera, V., Uribe, C., Bravo, L., Arias-ortiz, N., Jurado, D., Yépez, M., Galán, Y., Torres, P., Martínez-reyes, F., Pérez-meza, M., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J., Torres-cintrón, C., Tortolero-luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A., Woods, R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F., Ryan, S., Hannah, H., Dewar, R., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D., Mcclure, C., Vriends, K., Bertrand, C., Louchini, R., Robb, K., Stuart-panko, H., Demers, S., Wright, S., George, J., Shen, X., Brockhouse, J., O'Brien, D., Ward, K., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A., Vigneau, F., Mackinnon, J., Wohler, B., Bayakly, A., Clarke, C., Glaser, S., West, D., Hernandez, B., Johnson, C., Jozwik, D., Charlton, M., Lynch, C., Huang, B., Tucker, T., Deapen, D., Liu, L., Hsieh, M., Xc, W., Stern, K., Gershman, S., Knowlton, R., Alverson, J., Copeland, G., Rogers, D., Lemons, D., Williamson, L., Hood, M., Hosain, G., Rees, J., Pawlish, K., Stroup, A., Key, C., Wiggins, C., Kahn, A., Schymura, M., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S., Rubertone, J., Slack, S., Fulton, J., Rousseau, D., Janes, Ta:, S., Bolick, S., Hurley, D., Richards, J., Whiteside, M., Nogueira, L., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D., Keitheri Cheteri, M., Farley, S., Hudson, A., Borchers, R., Stephenson, L., Espinoza, J., Weir, H., Edwards, B., Wang, N., Yang, L., Chen, J., Song, G., Xp, G., Zhang, P., Hm, G., Zhao, D., Zhang, J., Zhu, F., Tang, J., Shen, Y., Wang, J., Ql, L., Yang, X., Dong, J., Li, W., Cheng, L., Huang, Q., Huang, S., Guo, G., Wei, K., Chen, W., Zeng, H., Demetriou, A., Pavlou, P., Mang, W., Ngan, K., Kataki, A., Krishnatreya, M., Jayalekshmi, P., Sebastian, P., Sapkota, S., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-boker, L., Silverman, B., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A., Al-eid, H., Jung, K., Won, Y., Chiang, C., Lai, M., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S., Sriplung, H., Eser, S., Yakut, C., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A., Aleinikova, O., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A., Faivre, J., Guizard, A., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A., Daoulas, M., Clavel, J., Le Guyader-peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R., Kumar, V., Ólafsdóttir, E., Tryggvadóttir, L., Comber, H., Walsh, P., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M., Tisano, F., Fanetti, A., Maspero, S., Candela, G., Scuderi, T., Gentilini, M., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-lampart, M., Radziszewska, A., Didkowska, J., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R., Bastos, J., Silva, M., Antunes, L., Bento, M., Mayer-da-silva, A., Miranda, A., Coza, D., Todescu, A., Valkov, M., Adamcik, J., Safaei Diba, C., Primic-žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J., Bidaurrazaga, J., Larrañaga, N., Díaz García, J., Marcos, A., Marcos-gragera, R., Vilardell Gil, M., Molina, E., Sánchez, M., Franch Sureda, P., Ramos Montserrat, M., Navarro, C., Ardanaz, E., Moreno-iribas, C., Fernández-delgado, R., Peris-bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S., Herrmann, C., Bulliard, J., Maspoli-conconi, M., Frick, H., Kuehni, C., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S., Matthes, K., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R., Brewster, D., Huws, D., White, C., Finan, P., Bonaventure, A., Di Carlo, V., Harewood, R., Liu, K., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M., Aitken, J., Scott, C., Stokes, B., Venn, A., Farrugia, H., Giles, G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, M, Coleman, M, Carreira, H, Salmeròn, D, Chirlaque, M, Allemani, C, and Mazzucco, W

Subjects
0301 basic medicine, Oncology, Settore MED/42 - Igiene Generale E Applicata, 0302 clinical medicine, morphology, 80 and over, Stage (cooking), Aged, 80 and over, Ovarian Neoplasms, education.field_of_study, epidemiology, histology, ovarian cancer, stage, survival, Adolescent, Adult, Aged, Female, Humans, Middle Aged, Neoplasm Staging, Obstetrics and Gynecology, Transitional cell carcinoma, 030220 oncology & carcinogenesis, Clear cell carcinoma, Human, medicine.medical_specialty, Population, Socio-culturale, Article, 03 medical and health sciences, Internal medicine, medicine, ovarian cancer, epidemiology, survival, stage, morphology, histology, education, Cancer staging, Gynecology, business.industry, Ovarian Neoplasm, Cancer, medicine.disease, Cancer registry, 030104 developmental biology, Ovarian cancer, business
Abstract

Objective Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15–99years) diagnosed with ovarian cancer during 1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from 67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated age-standardised 5-year net survival by stage at diagnosis (localised or advanced). Results Survival from type I epithelial ovarian tumours for women diagnosed during 2005–09 ranged from 40 to 70%. Survival from type II epithelial tumours was much lower (20–45%). Survival from germ cell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%). Conclusions There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology.

Published
2017

18. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Allemani, Claudia, primary, Matsuda, Tomohiro, additional, Di Carlo, Veronica, additional, Harewood, Rhea, additional, Matz, Melissa, additional, Nikšić, Maja, additional, Bonaventure, Audrey, additional, Valkov, Mikhail, additional, Johnson, Christopher J, additional, Estève, Jacques, additional, Ogunbiyi, Olufemi J, additional, Azevedo e Silva, Gulnar, additional, Chen, Wan-Qing, additional, Eser, Sultan, additional, Engholm, Gerda, additional, Stiller, Charles A, additional, Monnereau, Alain, additional, Woods, Ryan R, additional, Visser, Otto, additional, Lim, Gek Hsiang, additional, Aitken, Joanne, additional, Weir, Hannah K, additional, Coleman, Michel P, additional, Bouzbid, S, additional, Hamdi-Chérif, M, additional, Zaidi, Z, additional, Meguenni, K, additional, Regagba, D, additional, Bayo, S, additional, Cheick Bougadari, T, additional, Manraj, S S, additional, Bendahhou, K, additional, Fabowale, A, additional, Bradshaw, D, additional, Somdyala, N I M, additional, Kumcher, I, additional, Moreno, F, additional, Calabrano, G H, additional, Espinola, S B, additional, Carballo Quintero, B, additional, Fita, R, additional, Diumenjo, M C, additional, Laspada, W D, additional, Ibañez, S G, additional, Lima, C A, additional, De Souza, P C F, additional, Del Pino, K, additional, Laporte, C, additional, Curado, M P, additional, de Oliveira, J C, additional, Veneziano, C L A, additional, Veneziano, D B, additional, Latorre, M R D O, additional, Tanaka, L F, additional, Rebelo, M S, additional, Santos, M O, additional, Galaz, J C, additional, Aparicio Aravena, M, additional, Sanhueza Monsalve, J, additional, Herrmann, D A, additional, Vargas, S, additional, Herrera, V M, additional, Uribe, C J, additional, Bravo, L E, additional, Garcia, L S, additional, Arias-Ortiz, N E, additional, Morantes, D, additional, Jurado, D M, additional, Yépez Chamorro, M C, additional, Delgado, S, additional, Ramirez, M, additional, Galán Alvarez, Y H, additional, Torres, P, additional, Martínez-Reyes, F, additional, Jaramillo, L, additional, Quinto, R, additional, Castillo, J, additional, Mendoza, M, additional, Cueva, P, additional, Yépez, J G, additional, Bhakkan, B, additional, Deloumeaux, J, additional, Joachim, C, additional, Macni, J, additional, Carrillo, R, additional, Shalkow Klincovstein, J, additional, Rivera Gomez, R, additional, Poquioma, E, additional, Tortolero-Luna, G, additional, Zavala, D, additional, Alonso, R, additional, Barrios, E, additional, Eckstrand, A, additional, Nikiforuk, C, additional, Noonan, G, additional, Turner, D, additional, Kumar, E, additional, Zhang, B, additional, McCrate, F R, additional, Ryan, S, additional, MacIntyre, M, additional, Saint-Jacques, N, additional, Nishri, D E, additional, McClure, C A, additional, Vriends, K A, additional, Kozie, S, additional, Stuart-Panko, H, additional, Freeman, T, additional, George, J T, additional, Brockhouse, J T, additional, O'Brien, D K, additional, Holt, A, additional, Almon, L, additional, Kwong, S, additional, Morris, C, additional, Rycroft, R, additional, Mueller, L, additional, Phillips, C E, additional, Brown, H, additional, Cromartie, B, additional, Schwartz, A G, additional, Vigneau, F, additional, Levin, G M, additional, Wohler, B, additional, Bayakly, R, additional, Ward, K C, additional, Gomez, S L, additional, McKinley, M, additional, Cress, R, additional, Green, M D, additional, Miyagi, K, additional, Ruppert, L P, additional, Lynch, C F, additional, Huang, B, additional, Tucker, T C, additional, Deapen, D, additional, Liu, L, additional, Hsieh, M C, additional, Wu, X C, additional, Schwenn, M, additional, Gershman, S T, additional, Knowlton, R C, additional, Alverson, G, additional, Copeland, G E, additional, Bushhouse, S, additional, Rogers, D B, additional, Jackson-Thompson, J, additional, Lemons, D, additional, Zimmerman, H J, additional, Hood, M, additional, Roberts-Johnson, J, additional, Rees, J R, additional, Riddle, B, additional, Pawlish, K S, additional, Stroup, A, additional, Key, C, additional, Wiggins, C, additional, Kahn, A R, additional, Schymura, M J, additional, Radhakrishnan, S, additional, Rao, C, additional, Giljahn, L K, additional, Slocumb, R M, additional, Espinoza, R E, additional, Khan, F, additional, Aird, K G, additional, Beran, T, additional, Rubertone, J J, additional, Slack, S J, additional, Garcia, L, additional, Rousseau, D L, additional, Janes, T A, additional, Schwartz, S M, additional, Bolick, S W, additional, Hurley, D M, additional, Whiteside, M A, additional, Miller-Gianturco, P, additional, Williams, M A, additional, Herget, K, additional, Sweeney, C, additional, Johnson, A T, additional, Keitheri Cheteri, M B, additional, Migliore Santiago, P, additional, Blankenship, S E, additional, Farley, S, additional, Borchers, R, additional, Malicki, R, additional, Espinoza, J R, additional, Grandpre, J, additional, Wilson, R, additional, Edwards, B K, additional, Mariotto, A, additional, Lei, Y, additional, Wang, N, additional, Chen, J S, additional, Zhou, Y, additional, He, Y T, additional, Song, G H, additional, Gu, X P, additional, Mei, D, additional, Mu, H J, additional, Ge, H M, additional, Wu, T H, additional, Li, Y Y, additional, Zhao, D L, additional, Jin, F, additional, Zhang, J H, additional, Zhu, F D, additional, Junhua, Q, additional, Yang, Y L, additional, Jiang, C X, additional, Biao, W, additional, Wang, J, additional, Li, Q L, additional, Yi, H, additional, Zhou, X, additional, Dong, J, additional, Li, W, additional, Fu, F X, additional, Liu, S Z, additional, Chen, J G, additional, Zhu, J, additional, Li, Y H, additional, Lu, Y Q, additional, Fan, M, additional, Huang, S Q, additional, Guo, G P, additional, Zhaolai, H, additional, Wei, K, additional, Zeng, H, additional, Demetriou, A V, additional, Mang, W K, additional, Ngan, K C, additional, Kataki, A C, additional, Krishnatreya, M, additional, Jayalekshmi, P A, additional, Sebastian, P, additional, Nandakumar, A, additional, Malekzadeh, R, additional, Roshandel, G, additional, Keinan-Boker, L, additional, Silverman, B G, additional, Ito, H, additional, Nakagawa, H, additional, Sato, M, additional, Tobori, F, additional, Nakata, I, additional, Teramoto, N, additional, Hattori, M, additional, Kaizaki, Y, additional, Moki, F, additional, Sugiyama, H, additional, Utada, M, additional, Nishimura, M, additional, Yoshida, K, additional, Kurosawa, K, additional, Nemoto, Y, additional, Narimatsu, H, additional, Sakaguchi, M, additional, Kanemura, S, additional, Naito, M, additional, Narisawa, R, additional, Miyashiro, I, additional, Nakata, K, additional, Sato, S, additional, Yoshii, M, additional, Oki, I, additional, Fukushima, N, additional, Shibata, A, additional, Iwasa, K, additional, Ono, C, additional, Nimri, O, additional, Jung, K W, additional, Won, Y J, additional, Alawadhi, E, additional, Elbasmi, A, additional, Ab Manan, A, additional, Adam, F, additional, Sanjaajmats, E, additional, Tudev, U, additional, Ochir, C, additional, Al Khater, A M, additional, El Mistiri, M M, additional, Teo, Y Y, additional, Chiang, C J, additional, Lee, W C, additional, Buasom, R, additional, Sangrajrang, S, additional, Kamsa-ard, S, additional, Wiangnon, S, additional, Daoprasert, K, additional, Pongnikorn, D, additional, Leklob, A, additional, Sangkitipaiboon, S, additional, Geater, S L, additional, Sriplung, H, additional, Ceylan, O, additional, Kög, I, additional, Dirican, O, additional, Köse, T, additional, Gurbuz, T, additional, Karaşahin, F E, additional, Turhan, D, additional, Aktaş, U, additional, Halat, Y, additional, Yakut, C I, additional, Altinisik, M, additional, Cavusoglu, Y, additional, Türkköylü, A, additional, Üçüncü, N, additional, Hackl, M, additional, Zborovskaya, A A, additional, Aleinikova, O V, additional, Henau, K, additional, Van Eycken, L, additional, Valerianova, Z, additional, Yordanova, M R, additional, Šekerija, M, additional, Dušek, L, additional, Zvolský, M, additional, Storm, H, additional, Innos, K, additional, Mägi, M, additional, Malila, N, additional, Seppä, K, additional, Jégu, J, additional, Velten, M, additional, Cornet, E, additional, Troussard, X, additional, Bouvier, A M, additional, Guizard, A V, additional, Bouvier, V, additional, Launoy, G, additional, Arveux, P, additional, Maynadié, M, additional, Mounier, M, additional, Woronoff, A S, additional, Daoulas, M, additional, Robaszkiewicz, M, additional, Clavel, J, additional, Goujon, S, additional, Lacour, B, additional, Baldi, I, additional, Pouchieu, C, additional, Amadeo, B, additional, Coureau, G, additional, Orazio, S, additional, Preux, P M, additional, Rharbaoui, F, additional, Marrer, E, additional, Trétarre, B, additional, Colonna, M, additional, Delafosse, P, additional, Ligier, K, additional, Plouvier, S, additional, Cowppli-Bony, A, additional, Molinié, F, additional, Bara, S, additional, Ganry, O, additional, Lapôtre-Ledoux, B, additional, Grosclaude, P, additional, Bossard, N, additional, Uhry, Z, additional, Bray, F, additional, Piñeros, M, additional, Stabenow, R, additional, Wilsdorf-Köhler, H, additional, Eberle, A, additional, Luttmann, S, additional, Löhden, I, additional, Nennecke, A L, additional, Kieschke, J, additional, Sirri, E, additional, Emrich, K, additional, Zeissig, S R, additional, Holleczek, B, additional, Eisemann, N, additional, Katalinic, A, additional, Asquez, R A, additional, Kumar, V, additional, Petridou, E, additional, Ólafsdóttir, E J, additional, Tryggvadóttir, L, additional, Clough-Gorr, K, additional, Walsh, P M, additional, Sundseth, H, additional, Mazzoleni, G, additional, Vittadello, F, additional, Coviello, E, additional, Cuccaro, F, additional, Galasso, R, additional, Sampietro, G, additional, Giacomin, A, additional, Magoni, M, additional, Ardizzone, A, additional, D'Argenzio, A, additional, Castaing, M, additional, Grosso, G, additional, Lavecchia, A M, additional, Sutera Sardo, A, additional, Gola, G, additional, Gatti, L, additional, Ricci, P, additional, Ferretti, S, additional, Serraino, D, additional, Zucchetto, A, additional, Celesia, M V, additional, Filiberti, R A, additional, Pannozzo, F, additional, Melcarne, A, additional, Quarta, F, additional, Russo, A G, additional, Carrozzi, G, additional, Cirilli, C, additional, Cavalieri d'Oro, L, additional, Rognoni, M, additional, Fusco, M, additional, Vitale, M F, additional, Usala, M, additional, Cusimano, R, additional, Mazzucco, W, additional, Michiara, M, additional, Sgargi, P, additional, Boschetti, L, additional, Borciani, E, additional, Seghini, P, additional, Maule, M M, additional, Merletti, F, additional, Tumino, R, additional, Mancuso, P, additional, Vicentini, M, additional, Cassetti, T, additional, Sassatelli, R, additional, Falcini, F, additional, Giorgetti, S, additional, Caiazzo, A L, additional, Cavallo, R, additional, Cesaraccio, R, additional, Pirino, D R, additional, Contrino, M L, additional, Tisano, F, additional, Fanetti, A C, additional, Maspero, S, additional, Carone, S, additional, Mincuzzi, A, additional, Candela, G, additional, Scuderi, T, additional, Gentilini, M A, additional, Piffer, S, additional, Rosso, S, additional, Barchielli, A, additional, Caldarella, A, additional, Bianconi, F, additional, Stracci, F, additional, Contiero, P, additional, Tagliabue, G, additional, Rugge, M, additional, Zorzi, M, additional, Beggiato, S, additional, Brustolin, A, additional, Berrino, F, additional, Gatta, G, additional, Sant, M, additional, Buzzoni, C, additional, Mangone, L, additional, Capocaccia, R, additional, De Angelis, R, additional, Zanetti, R, additional, Maurina, A, additional, Pildava, S, additional, Lipunova, N, additional, Vincerževskiené, I, additional, Agius, D, additional, Calleja, N, additional, Siesling, S, additional, Larønningen, S, additional, Møller, B, additional, Dyzmann-Sroka, A, additional, Trojanowski, M, additional, Góźdź, S, additional, Mężyk, R, additional, Mierzwa, T, additional, Molong, L, additional, Rachtan, J, additional, Szewczyk, S, additional, Błaszczyk, J, additional, Kępska, K, additional, Kościańska, B, additional, Tarocińska, K, additional, Zwierko, M, additional, Drosik, K, additional, Maksimowicz, K M, additional, Purwin-Porowska, E, additional, Reca, E, additional, Wójcik-Tomaszewska, J, additional, Tukiendorf, A, additional, Grądalska-Lampart, M, additional, Radziszewska, A U, additional, Gos, A, additional, Talerczyk, M, additional, Wyborska, M, additional, Didkowska, J A, additional, Wojciechowska, U, additional, Bielska-Lasota, M, additional, Forjaz de Lacerda, G, additional, Rego, R A, additional, Bastos, J, additional, Silva, M A, additional, Antunes, L, additional, Laranja Pontes, J, additional, Mayer-da-Silva, A, additional, Miranda, A, additional, Blaga, L M, additional, Coza, D, additional, Gusenkova, L, additional, Lazarevich, O, additional, Prudnikova, O, additional, Vjushkov, D M, additional, Egorova, A G, additional, Orlov, A E, additional, Kudyakov, L A, additional, Pikalova, L V, additional, Adamcik, J, additional, Safaei Diba, C, additional, Primic-Žakelj, M, additional, Zadnik, V, additional, Larrañaga, N, additional, Lopez de Munain, A, additional, Herrera, A A, additional, Redondas, R, additional, Marcos-Gragera, R, additional, Vilardell Gil, M L, additional, Molina, E, additional, Sánchez Perez, M J, additional, Franch Sureda, P, additional, Ramos Montserrat, M, additional, Chirlaque, M D, additional, Navarro, C, additional, Ardanaz, E E, additional, Guevara, M M, additional, Fernández-Delgado, R, additional, Peris-Bonet, R, additional, Carulla, M, additional, Galceran, J, additional, Alberich, C, additional, Vicente-Raneda, M, additional, Khan, S, additional, Pettersson, D, additional, Dickman, P, additional, Avelina, I, additional, Staehelin, K, additional, Camey, B, additional, Bouchardy, C, additional, Schaffar, R, additional, Frick, H, additional, Herrmann, C, additional, Bulliard, J L, additional, Maspoli-Conconi, M, additional, Kuehni, C E, additional, Redmond, S M, additional, Bordoni, A, additional, Ortelli, L, additional, Chiolero, A, additional, Konzelmann, I, additional, Matthes, K L, additional, Rohrmann, S, additional, Broggio, J, additional, Rashbass, J, additional, Fitzpatrick, D, additional, Gavin, A, additional, Clark, D I, additional, Deas, A J, additional, Huws, D W, additional, White, C, additional, Montel, L, additional, Rachet, B, additional, Turculet, A D, additional, Stephens, R, additional, Chalker, E, additional, Phung, H, additional, Walton, R, additional, You, H, additional, Guthridge, S, additional, Johnson, F, additional, Gordon, P, additional, D'Onise, K, additional, Priest, K, additional, Stokes, B C, additional, Venn, A, additional, Farrugia, H, additional, Thursfield, V, additional, Dowling, J, additional, Currow, D, additional, Hendrix, J, additional, and Lewis, C, additional

Published
2018
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19. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Allemani, Claudia;Matsuda, Tomohiro;Di Carlo, Veronica;Harewood, Rhea;Matz, Melissa;Nikšić, Maja;Bonaventure, Audrey;Valkov, Mikhail;Johnson, Christopher J;Estève, Jacques;Ogunbiyi, Olufemi J;Azevedo e Silva, Gulnar;Chen, Wan-Qing;Eser, Sultan;Engholm, Gerda;Stiller, Charles A;Monnereau, Alain;Woods, Ryan R;Visser, Otto;Lim, Gek Hsiang;Aitken, Joanne;Weir, Hannah K;Coleman, Michel P;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Fabowale, A;Bradshaw, D;Somdyala, N I M;Kumcher, I;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Diumenjo, M C;Laspada, W D;Ibañez, S G;Lima, C A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Nishri, D E;McClure, C A;Vriends, K A;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Brockhouse, J T;O'Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Ruppert, L P;Lynch, C F;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Gershman, S T;Knowlton, R C;Alverson, G;Copeland, G E;Bushhouse, S;Rogers, D B;Jackson-Thompson, J;Lemons, D;Zimmerman, H J;Hood, M;Roberts-Johnson, J;Rees, J R;Riddle and Allemani, Claudia;Matsuda, Tomohiro;Di Carlo, Veronica;Harewood, Rhea;Matz, Melissa;Nikšić, Maja;Bonaventure, Audrey;Valkov, Mikhail;Johnson, Christopher J;Estève, Jacques;Ogunbiyi, Olufemi J;Azevedo e Silva, Gulnar;Chen, Wan-Qing;Eser, Sultan;Engholm, Gerda;Stiller, Charles A;Monnereau, Alain;Woods, Ryan R;Visser, Otto;Lim, Gek Hsiang;Aitken, Joanne;Weir, Hannah K;Coleman, Michel P;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Fabowale, A;Bradshaw, D;Somdyala, N I M;Kumcher, I;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Diumenjo, M C;Laspada, W D;Ibañez, S G;Lima, C A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Nishri, D E;McClure, C A;Vriends, K A;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Brockhouse, J T;O'Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Ruppert, L P;Lynch, C F;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Gershman, S T;Knowlton, R C;Alverson, G;Copeland, G E;Bushhouse, S;Rogers, D B;Jackson-Thompson, J;Lemons, D;Zimmerman, H J;Hood, M;Roberts-Johnson, J;Rees, J R;Riddle

Published
2017

24. Coastal- Marine Conservation: Science and Policy

Author

Knowlton, R. E.

Subjects
Coastal- Marine Conservation: Science and Policy (Book) -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Published
2003

Catalog

Books, media, physical & digital resources
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