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1. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S, Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E, de González, Amy Berrington, Buring, Julie E, Fraser, Gary E, Freedman, Neal D, Gapstur, Susan M, Gierach, Gretchen, Giles, Graham G, Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F, Lan, Qing, Larsson, Susanna C, Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M, Milne, Roger L, Monroe, Kristine R, Neuhouser, Marian L, O'Brien, Katie M, Petrick, Jessica L, Purdue, Mark P, Rohan, Thomas E, Sandin, Sven, Sandler, Dale P, Sawada, Norie, Shadyab, Aladdin H, Simon, Tracey G, Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-I, Zheng, Wei, McGlynn, Katherine A, Campbell, Peter T, and Koshiol, Jill

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Prevention, Clinical Research, Contraception/Reproduction, Digestive Diseases, Cancer, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Adult, Aged, Biliary Tract Neoplasms, Female, Follow-Up Studies, Global Health, Humans, Incidence, Middle Aged, Prospective Studies, Registries, Reproduction, Risk Assessment, Risk Factors, Sex Factors, Survival Rate, Time Factors, Young Adult, Reproductive factors, Parity, Biliary tract cancer, Gallbladder cancer, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsGallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear.MethodsWe pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study.ResultsDuring 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR ≥5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only.ConclusionWe observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography.Lay summaryOur findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer and extrahepatic bile duct cancer. We did not see this same association in women from Western countries. Age at menopause was not associated with the risk of any biliary tract cancers.

Published
2020

7. Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project.

Author

Yu-Han Huang, Loftfield, Erikka, Argirion, Ilona, Adami, Hans-Olov, Albanes, Demetrius, Chan, Andrew T., Fedirko, Veronika, Fraser, Gary E., Freedman, Neal D., Giles, Graham G., Hartge, Patricia, Katzke, Verena, Knutsen, Synnove F., Lacey Jr, James, Liao, Linda M., Juhua Luo, Milne, Roger L., O'Brien, Katie M., Peters, Ulrike, and Poynter, Jenny N.

Published
2024
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14. Supplementary Table 1 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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15. Data from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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16. Supplementary Table 2 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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17. Supplementary Figure from Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., primary, Zhu, Bin, primary, Pfeiffer, Ruth M., primary, Petrick, Jessica L., primary, Adami, Hans-Olov, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Beane Freeman, Laura E., primary, Berrington de González, Amy, primary, Buring, Julie E., primary, Chan, Andrew T., primary, Chen, Yu, primary, Fraser, Gary E., primary, Freedman, Neal D., primary, Gao, Yu-Tang, primary, Gapstur, Susan M., primary, Gaziano, J. Michael, primary, Giles, Graham G., primary, Grant, Eric J., primary, Grodstein, Francine, primary, Hartge, Patricia, primary, Jenab, Mazda, primary, Kitahara, Cari M., primary, Knutsen, Synnove F., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lee, I-Min, primary, Liao, Linda M., primary, Luo, Juhua, primary, McGee, Emma E., primary, Milne, Roger L., primary, Monroe, Kristine R., primary, Neuhouser, Marian L., primary, O’Brien, Katie M., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Purdue, Mark P., primary, Robien, Kim, primary, Sandler, Dale P., primary, Sawada, Norie, primary, Schairer, Catherine, primary, Sesso, Howard D., primary, Simon, Tracey G., primary, Sinha, Rashmi, primary, Stolzenberg-Solomon, Rachael Z., primary, Tsugane, Shoichiro, primary, Wang, Renwei, primary, Weiderpass, Elisabete, primary, Weinstein, Stephanie J., primary, White, Emily, primary, Wolk, Alicja, primary, Yuan, Jian-Min, primary, Zeleniuch-Jacquotte, Anne, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Campbell, Peter T., primary, and Koshiol, Jill, primary

Published
2023
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18. Data from Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., primary, Zhu, Bin, primary, Pfeiffer, Ruth M., primary, Petrick, Jessica L., primary, Adami, Hans-Olov, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Beane Freeman, Laura E., primary, Berrington de González, Amy, primary, Buring, Julie E., primary, Chan, Andrew T., primary, Chen, Yu, primary, Fraser, Gary E., primary, Freedman, Neal D., primary, Gao, Yu-Tang, primary, Gapstur, Susan M., primary, Gaziano, J. Michael, primary, Giles, Graham G., primary, Grant, Eric J., primary, Grodstein, Francine, primary, Hartge, Patricia, primary, Jenab, Mazda, primary, Kitahara, Cari M., primary, Knutsen, Synnove F., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lee, I-Min, primary, Liao, Linda M., primary, Luo, Juhua, primary, McGee, Emma E., primary, Milne, Roger L., primary, Monroe, Kristine R., primary, Neuhouser, Marian L., primary, O’Brien, Katie M., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Purdue, Mark P., primary, Robien, Kim, primary, Sandler, Dale P., primary, Sawada, Norie, primary, Schairer, Catherine, primary, Sesso, Howard D., primary, Simon, Tracey G., primary, Sinha, Rashmi, primary, Stolzenberg-Solomon, Rachael Z., primary, Tsugane, Shoichiro, primary, Wang, Renwei, primary, Weiderpass, Elisabete, primary, Weinstein, Stephanie J., primary, White, Emily, primary, Wolk, Alicja, primary, Yuan, Jian-Min, primary, Zeleniuch-Jacquotte, Anne, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Campbell, Peter T., primary, and Koshiol, Jill, primary

Published
2023
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19. Supplementary Tables from Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., primary, Zhu, Bin, primary, Pfeiffer, Ruth M., primary, Petrick, Jessica L., primary, Adami, Hans-Olov, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Beane Freeman, Laura E., primary, Berrington de González, Amy, primary, Buring, Julie E., primary, Chan, Andrew T., primary, Chen, Yu, primary, Fraser, Gary E., primary, Freedman, Neal D., primary, Gao, Yu-Tang, primary, Gapstur, Susan M., primary, Gaziano, J. Michael, primary, Giles, Graham G., primary, Grant, Eric J., primary, Grodstein, Francine, primary, Hartge, Patricia, primary, Jenab, Mazda, primary, Kitahara, Cari M., primary, Knutsen, Synnove F., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lee, I-Min, primary, Liao, Linda M., primary, Luo, Juhua, primary, McGee, Emma E., primary, Milne, Roger L., primary, Monroe, Kristine R., primary, Neuhouser, Marian L., primary, O’Brien, Katie M., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Purdue, Mark P., primary, Robien, Kim, primary, Sandler, Dale P., primary, Sawada, Norie, primary, Schairer, Catherine, primary, Sesso, Howard D., primary, Simon, Tracey G., primary, Sinha, Rashmi, primary, Stolzenberg-Solomon, Rachael Z., primary, Tsugane, Shoichiro, primary, Wang, Renwei, primary, Weiderpass, Elisabete, primary, Weinstein, Stephanie J., primary, White, Emily, primary, Wolk, Alicja, primary, Yuan, Jian-Min, primary, Zeleniuch-Jacquotte, Anne, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Campbell, Peter T., primary, and Koshiol, Jill, primary

Published
2023
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21. Left ventricular diastolic abnormalities in vegetarians compared with non-vegetarians.

Author

Varadarajan, Padmini, Pai, Ramdas G., Fraser, Gary E., Abramov, Dmitry, Jabo, Brice, Mashchak, Andrew, Herring, Patricia, Burton, Barbara, Sveen, Lars E., and Knutsen, Synnove F.

Subjects
LEFT heart ventricle, ECHOCARDIOGRAPHY, BIOMARKERS, HYPERTENSION, OBESITY, VEGETARIANISM, BODY weight, CROSS-sectional method, AGE distribution, DIET, DIABETES, RACE, REGRESSION analysis, BODY surface area, SEX distribution, PHYSICAL activity, T-test (Statistics), FACTOR analysis, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, DIASTOLE (Cardiac cycle), HEART failure
Abstract

Vegetarians have less hypertension, diabetes mellitus and obesity, hence possibly lower risk of congestive heart failure (HF). We studied associations between vegetarian diets and echocardiographic markers of stage B HF. In a cross-sectional study, dietary pattern was ascertained by a validated FFQ. Echocardiograms were interpreted using standardised criteria. Participants were free-living subjects in Southern California who were older Adventist Health Study-2 cohort members. After exclusions, 133 subjects aged >60 years were enrolled. Their mean age was 72·7 (sd 8·7) years, 48·1 % were female, 32 % were African American and 71 % were vegetarian. Non-vegetarians had higher body weight (80·3 (sd 15·17) kg v. 71·3 (sd 16·2), P < 0·005), body surface area (1·92 (sd 0·24) m2 v. 1·81 (sd 0·22) m2, P = 0·01) and prevalence of hypertension (63 % v. 47 %, P = 0·10). Adjusting for age, sex, race and physical activity, it is found that vegetarians had greater echocardiographic mitral annular e' velocity (a measure of left ventricular (LV) relaxation) 7·44 v. 6·48 (non-vegetarian) cm/s (P = 0·011) and a yet greater contrast when vegans (7·66 cm/s, P = 0·011) were the group of interest. The ratio mid-to-late-diastolic mitral flow velocity (E/A) was also higher in vegans compared with non-vegetarians (1·02 and 0·84, respectively, P = 0·008). Mediation analyses suggested these associations may be partly related to higher blood pressures and BMI in the non-vegetarians. We conclude that vegetarians, especially vegans, appear to have better LV relaxation and fewer diastolic abnormalities than others. As dietary exposure is modifiable, one may speculate pending further investigation about the potential for reduction of stage B HF and later mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Cohort Profile : The Ovarian Cancer Cohort Consortium (OC3).

Author

Townsend, Mary K, Trabert, Britton, Fortner, Renée T, Arslan, Alan A, Buring, Julie E, Carter, Brian D, Giles, Graham G, Irvin, Sarah R, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Koh, Woon-Puay, Lacey, James V, Langseth, Hilde, Larsson, Susanna C, Lee, I-Min, Martínez, María Elena, Merritt, Melissa A, Milne, Roger L, O'Brien, Katie M, Orlich, Michael J, Palmer, Julie R, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Robien, Kim, Rohan, Thomas E, Rosenberg, Lynn, Sandin, Sven, Sandler, Dale P, Schouten, Leo J, Setiawan, V Wendy, Swerdlow, Anthony J, Ursin, Giske, van den Brandt, Piet A, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Wentzensen, Nicolas, Townsend, Mary K, Trabert, Britton, Fortner, Renée T, Arslan, Alan A, Buring, Julie E, Carter, Brian D, Giles, Graham G, Irvin, Sarah R, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Koh, Woon-Puay, Lacey, James V, Langseth, Hilde, Larsson, Susanna C, Lee, I-Min, Martínez, María Elena, Merritt, Melissa A, Milne, Roger L, O'Brien, Katie M, Orlich, Michael J, Palmer, Julie R, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Robien, Kim, Rohan, Thomas E, Rosenberg, Lynn, Sandin, Sven, Sandler, Dale P, Schouten, Leo J, Setiawan, V Wendy, Swerdlow, Anthony J, Ursin, Giske, van den Brandt, Piet A, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, and Wentzensen, Nicolas

Published
2022
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27. Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)

Author

Townsend, Mary K, primary, Trabert, Britton, additional, Fortner, Renée T, additional, Arslan, Alan A, additional, Buring, Julie E, additional, Carter, Brian D, additional, Giles, Graham G, additional, Irvin, Sarah R, additional, Jones, Michael E, additional, Kaaks, Rudolf, additional, Kirsh, Victoria A, additional, Knutsen, Synnove F, additional, Koh, Woon-Puay, additional, Lacey, James V, additional, Langseth, Hilde, additional, Larsson, Susanna C, additional, Lee, I-Min, additional, Martínez, María Elena, additional, Merritt, Melissa A, additional, Milne, Roger L, additional, O’Brien, Katie M, additional, Orlich, Michael J, additional, Palmer, Julie R, additional, Patel, Alpa V, additional, Peters, Ulrike, additional, Poynter, Jenny N, additional, Robien, Kim, additional, Rohan, Thomas E, additional, Rosenberg, Lynn, additional, Sandin, Sven, additional, Sandler, Dale P, additional, Schouten, Leo J, additional, Setiawan, V Wendy, additional, Swerdlow, Anthony J, additional, Ursin, Giske, additional, van den Brandt, Piet A, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zeleniuch-Jacquotte, Anne, additional, Tworoger, Shelley S, additional, and Wentzensen, Nicolas, additional

Published
2021
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29. The association between ambient fine particulate air pollution and lung cancer incidence: results from the AHSMOG-2 study

Author

Gharibvand, Lida, Shavlik, David, Ghamsary, Mark, Beeson, W. Lawrence, Soret, Samuel, Knutsen, Raymond, and Knutsen, Synnove F.

Subjects
Research, Risk factors, Health aspects, Lung cancer -- Risk factors -- Research, Air pollution research -- Health aspects, Particulate matter -- Health aspects -- Research
Abstract

Introduction Lung cancer (LC) is the leading cause of cancer deaths and the second leading cause of incident cancer among both men and women in the United States with 224,390 [...], BACKGROUND: There is a positive association between ambient fine particulate matter ≤ 2.5 µm in aerodynamic diameter ([PM.sub.2.5]) and incidence and mortality of lung cancer (LC), but few studies have assessed the relationship between ambient [PM.sub.2.5] and LC among never smokers. OBJECTIVES: We assessed the association between [PM.sub.2.5] and risk of LC using the Adventist Health and Smog Study-2 (AHSMOG-2), a cohort of health conscious nonsmokers where 81% have never smoked. METHODS: A total of 80,285 AHSMOG-2 participants were followed for an average of 7.5 years with respect to incident LC identified through linkage with U.S. state cancer registries. Estimates of ambient air pollution levels at participants' residences were obtained for 2000 and 2001, the years immediately prior to the start of the study. RESULTS: A total of 250 incident LC cases occurred during 598,927 person-years of follow-up. For each 10-µg/[m.sup.3] increment in [PM.sub.2.5], adjusted hazard ratio (HR) with 95% confidence interval (CI) for LC incidence was 1.43 (95% CI: 1.11, 1.84) in the two-pollutant multivariable model with ozone. Among those who spent > 1 hr/day outdoors or who had lived 5 or more years at their enrollment address, the HR was 1.68 (95% CI: 1.28, 2.22) and 1.54 (95% CI: 1.17, 2.04), respectively. CONCLUSION: Increased risk estimates of LC were observed for each 10-pg/[m.sup.3] increment in ambient [PM.sub.2.5] concentration. The estimate was higher among those with longer residence at enrollment address and those who spent > 1 hr/day outdoors. http://dx.doi.org/10.1289/EHP124

Published
2017
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31. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium

Author

Fortner, Renée T., primary, Rice, Megan S., additional, Knutsen, Synnove F., additional, Orlich, Michael J., additional, Visvanathan, Kala, additional, Patel, Alpa V., additional, Gaudet, Mia M., additional, Tjønneland, Anne, additional, Kvaskoff, Marina, additional, Kaaks, Rudolf, additional, Trichopolou, Antonia, additional, Pala, Valeria, additional, Onland-Moret, N. Charlotte, additional, Gram, Inger T., additional, Amiano, Pilar, additional, Idahl, Annika, additional, Allen, Naomi E., additional, Weiderpass, Elisabete, additional, Poynter, Jenny N., additional, Robien, Kim, additional, Giles, Graham G., additional, Milne, Roger L., additional, Setiawan, Veronica W., additional, Merritt, Melissa A., additional, van den Brandt, Piet A., additional, Zeleniuch-Jacquotte, Anne, additional, Arslan, Alan A., additional, O'Brien, Katie M., additional, Sandler, Dale P., additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Harris, Holly R., additional, Trabert, Britton, additional, Wentzensen, Nicolas, additional, Tworoger, Shelley S., additional, and Schouten, Leo J., additional

Published
2020
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32. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., additional, O'Brien, Katie M., additional, Townsend, Mary K., additional, Fortner, Renée T., additional, Iversen, Edwin S., additional, Hartge, Patricia, additional, White, Emily, additional, Amiano, Pilar, additional, Arslan, Alan A., additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie E., additional, Dossus, Laure, additional, Fraser, Gary E., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Harris, Holly R., additional, Bolton, Judith Hoffman, additional, Idahl, Annika, additional, Jones, Michael E., additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove F., additional, Kvaskoff, Marina, additional, Lacey, James V., additional, Lee, I-Min, additional, Milne, Roger L., additional, Onland-Moret, N. Charlotte, additional, Overvad, Kim, additional, Patel, Alpa V., additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Riboli, Elio, additional, Robien, Kim, additional, Rohan, Thomas E., additional, Sandler, Dale P., additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Setiawan, Veronica W., additional, Swerdlow, Anthony J., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, van den Brandt, Piet A., additional, Visvanathan, Kala, additional, Wilkens, Lynne R., additional, Wolk, Alicja, additional, Zeleniuch-Jacquotte, Anne, additional, and Wentzensen, Nicolas, additional

Published
2020
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33. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Fraser, Gary E., Freedman, Neal D., Gapstur, Susan M., Gierach, Gretchen, Giles, Graham G., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F., Lan, Qing, Larsson, Susanna C., Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Petrick, Jessica L., Purdue, Mark P., Rohan, Thomas E., Sandin, Sven, Sandler, Dale P., Sawada, Norie, Shadyab, Aladdin H., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-, I, Zheng, Wei, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, Jackson, Sarah S., Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Fraser, Gary E., Freedman, Neal D., Gapstur, Susan M., Gierach, Gretchen, Giles, Graham G., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F., Lan, Qing, Larsson, Susanna C., Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Petrick, Jessica L., Purdue, Mark P., Rohan, Thomas E., Sandin, Sven, Sandler, Dale P., Sawada, Norie, Shadyab, Aladdin H., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-, I, Zheng, Wei, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill

Abstract

Background & Aims: Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear. Methods: We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study. Results: During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR >= 5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only. Conclusion: We observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography. Lay summary: Our findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepat

Published
2020
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34. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site : The Ovarian Cancer Cohort Consortium

Author

Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.

Abstract

Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests. Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases. Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.

Published
2020
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35. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Abstract

Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.

Published
2020
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36. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Published
2020

37. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site:The Ovarian Cancer Cohort Consortium

Author

Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Hakansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Hakansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.

Abstract

Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests.Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases.Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site.Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.

Published
2020

39. Effects of walnuts on serum lipid levels and blood pressure in normal men

Author

Sabate, Joan, Fraser, Gary E., Burke, Kenneth, Knutsen, Synnove F., Bennett, Hannelore, and Lindsted, Kristian D.

Subjects
Blood cholesterol -- Health aspects, Nuts -- Physiological aspects, Diet in disease -- Research, Lipoproteins -- Health aspects
Abstract

Regular consumption of walnuts and other nuts may lower blood cholesterol. Eighteen healthy men between 21 and 43 years old followed a diet consistent with the National Cholesterol Education Program for four weeks, then switched for four weeks to a similar diet in which 20% of the calories were derived from walnuts. Both diets contained similar amounts of fat, carbohydrate, protein and fiber. Blood cholesterol levels dropped an average of 22 milligrams per deciliter (mg/dL) when the men were on the walnut diet. This was true regardless of their baseline cholesterol measurement. The level of low-density lipoprotein (LDL) cholesterol dropped also, as did the level of high-density lipoprotein (HDL) cholesterol. Blood pressure did not changed significantly. Walnuts are high in fat, but have seven times as much polyunsaturated fat as saturated fat. Other types of nuts may have similar cholesterol-lowering properties.

Published
1993

41. Validity of a physical activity questionnaire among African-American Seventh-Day Adventists

Author

Singh, Pramil N., Fraser, Gary E., Knutsen, Synnove F., Lindsted, Kristian D., and Bennett, Hannelore W.

Subjects
Health surveys -- Evaluation, African Americans -- Surveys, Seventh-Day Adventists -- Surveys, Exercise -- Surveys, Public health -- Research, Health, Sports and fitness
Abstract

This article examines the validity and reliability of a questionnaire used to assess the physical activity levels of African Americans who are Seventh-Day Adventists. Findings indicate that the questionnaire items accurately and reliably measured total levels of physical activity, moderate activity, and vigorous activity in this population.

Published
2001

42. Cardiovascular risk factor levels in ethnic Hawaiians

Author

Curb, J. David, Aluli, N. Emmmett, Kautz, Judith A., Petrovitch, Helen, Knutsen, Synnove F., Knutsen, Raymond, O'Conner, Helen K., and O'Conner, William E.

Subjects
Hawaiians -- Health aspects, Cardiovascular diseases -- Risk factors, Government, Health care industry
Abstract

The residents of Hawaii are descended from many ethnic groups. Those who are chiefly native Hawaiian have the lowest life expectancy and twice the mortality from cardiovascular disease. The basis for this vulnerability has not been well studied. The risk factors for cardiovascular disease among ethnic Hawaiians were evaluated using results from a survey conducted among 257 people who were at least 50 percent ethnically Hawaiian. This population was economically depressed and had poor access to health care. Sixty-five percent of Hawaiians were overweight, compared to 27 percent of the general US population, and 45 percent were grossly overweight. Upper-body fat, associated with risk of cardiovascular disease, predominated, especially in men. Forty-nine percent of females and 68 percent of males were smokers or had been. Twenty-five percent had high blood pressure, including most of those being treated with antihypertensive medication. A significant portion of the study group had elevated blood cholesterol levels, and the rate of diabetes was much higher than that among US whites. The study indicates a high incidence of multiple risk factors for cardiovascular disease among native Hawaiians, many of whom were unaware of the presence or significance of such factors. More extensive long-term studies performed in cooperation with Hawaiians are needed to characterize the health risks in this group. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

43. Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., additional, Zhu, Bin, additional, Pfeiffer, Ruth M., additional, Petrick, Jessica L., additional, Adami, Hans-Olov, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Beane Freeman, Laura E., additional, Berrington de González, Amy, additional, Buring, Julie E., additional, Chan, Andrew T., additional, Chen, Yu, additional, Fraser, Gary E., additional, Freedman, Neal D., additional, Gao, Yu-Tang, additional, Gapstur, Susan M., additional, Gaziano, J. Michael, additional, Giles, Graham G., additional, Grant, Eric J., additional, Grodstein, Francine, additional, Hartge, Patricia, additional, Jenab, Mazda, additional, Kitahara, Cari M., additional, Knutsen, Synnove F., additional, Koh, Woon-Puay, additional, Larsson, Susanna C., additional, Lee, I-Min, additional, Liao, Linda M., additional, Luo, Juhua, additional, McGee, Emma E., additional, Milne, Roger L., additional, Monroe, Kristine R., additional, Neuhouser, Marian L., additional, O’Brien, Katie M., additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Purdue, Mark P., additional, Robien, Kim, additional, Sandler, Dale P., additional, Sawada, Norie, additional, Schairer, Catherine, additional, Sesso, Howard D., additional, Simon, Tracey G., additional, Sinha, Rashmi, additional, Stolzenberg-Solomon, Rachael Z., additional, Tsugane, Shoichiro, additional, Wang, Renwei, additional, Weiderpass, Elisabete, additional, Weinstein, Stephanie J., additional, White, Emily, additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xuehong, additional, McGlynn, Katherine A., additional, Campbell, Peter T., additional, and Koshiol, Jill, additional

Published
2019
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44. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies

Author

McGee, Emma E, primary, Jackson, Sarah S, additional, Petrick, Jessica L, additional, Van Dyke, Alison L, additional, Adami, Hans-Olov, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Beane-Freeman, Laura E, additional, Berrington de Gonzalez, Amy, additional, Buring, Julie E, additional, Chan, Andrew T, additional, Chen, Yu, additional, Fraser, Gary E, additional, Freedman, Neal D, additional, Gao, Yu-Tang, additional, Gapstur, Susan M, additional, Gaziano, J Michael, additional, Giles, Graham G, additional, Grant, Eric J, additional, Grodstein, Francine, additional, Hartge, Patricia, additional, Jenab, Mazda, additional, Kitahara, Cari M, additional, Knutsen, Synnove F, additional, Koh, Woon-Puay, additional, Larsson, Susanna C, additional, Lee, I-Min, additional, Liao, Linda M, additional, Luo, Juhua, additional, Milne, Roger L, additional, Monroe, Kristine R, additional, Neuhouser, Marian L, additional, O’Brien, Katie M, additional, Peters, Ulrike, additional, Poynter, Jenny N, additional, Purdue, Mark P, additional, Robien, Kim, additional, Sandler, Dale P, additional, Sawada, Norie, additional, Schairer, Catherine, additional, Sesso, Howard D, additional, Simon, Tracey G, additional, Sinha, Rashmi, additional, Stolzenberg-Solomon, Rachael, additional, Tsugane, Shoichiro, additional, Wang, Renwei, additional, Weiderpass, Elisabete, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xuehong, additional, Zhu, Bin, additional, McGlynn, Katherine A, additional, Campbell, Peter T, additional, and Koshiol, Jill, additional

Published
2019
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46. Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., Van Dyke, Alison L., Zhu, Bin, Pfeiffer, Ruth M., Petrick, Jessica L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Freeman, Laura E. Beane, de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, McGee, Emma E., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z., Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, Jackson, Sarah S., Van Dyke, Alison L., Zhu, Bin, Pfeiffer, Ruth M., Petrick, Jessica L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Freeman, Laura E. Beane, de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, McGee, Emma E., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z., Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill

Abstract

Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m(2) increase in BMI, there were risk increases for GBC (HR = 1.27; 95% CI, 1.19-1.36), IHBDC (HR = 1.32; 95% CI, 1.21-1.45), and EHBDC (HR = 1.13; 95% CI, 1.03-1.23), but not AVC (HR = 0.99; 95% CI, 0.88-1.11). Increasing waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio were associated with GBC and IHBDC but not EHBDC or AVC. These results indicate that adult adiposity is associated with an increased risk of biliary tract cancer, particularly GBC and IHBDC. Moreover, they provide evidence for recommending weight maintenance programs to reduce the risk of developing these cancers. Significance: These findings identify a correlation between adiposity and biliary tract cancers, indicating that weight management programs may help minimize the risk of these diseases.

Published
2019
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47. Smoking, Alcohol, and Biliary Tract Cancer Risk : A Pooling Project of 26 Prospective Studies

Author

McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill

Abstract

Background: Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear. Methods: We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random-effects meta-analysis produced summary estimates. All statistical tests were two-sided. Results: Over a period of 38 369 156 person-years of follow-up, 1391 gallbladder, 758 intrahepatic bile duct, 1208 extrahepatic bile duct, and 623 ampulla of Vater cancer cases were identified. Ever, former, and current smoking were associated with increased extrahepatic bile duct and ampulla of Vater cancers risk (eg, current vs never smokers HR = 1.69, 95% CI = 1.34 to 2.13 and 2.22, 95% CI = 1.69 to 2.92, respectively), with dose-response effects for smoking pack-years, duration, and intensity (all P-trend<.01). Current smoking and smoking intensity were also associated with intrahepatic bile duct cancer (eg, >40 cigarettes per day vs never smokers HR = 2.15, 95 % CI = 1.15 to 4.00; P-trend = .001). No convincing association was observed between smoking and gallbladder cancer. Alcohol consumption was only associated with intrahepatic bile duct cancer, with increased risk for individuals consuming five or more vs zero drinks per day (HR = 2.35, 95%CI = 1.46 to 3.78; P-trend = .04). There was evidence of statistical heterogeneity among several cancer sites, particularly between gallbladder cancer and the other biliary tract cancers. Conclusions: Smoking appears to increase the risk of developing all biliary tract cancers except gallbladder cancer. Alcohol may increase the risk of intrahepatic bile duct cancer. Findings highlight etiologic heterogeneity across the biliary tract.

Published
2019
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