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44 results on '"Ko, Eun-Ji"'

38. Expression profiles of HERV-K Env protein in normal and cancerous tissues

Author

Jo, Jin-Ok, primary, Kang, Yun-Jeong, additional, Ock, Mee Sun, additional, Song, Kyoung Seob, additional, Jeong, Moon-Jin, additional, Jeong, Soon-Jeong, additional, Choi, Yung Hyun, additional, Ko, Eun-Ji, additional, Leem, Sun-Hee, additional, Kim, Suhkmann, additional, Kim, Heui-Soo, additional, and Cha, Hee-Jae, additional

Published
2015
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43. A Synthetic Derivative SH 66 of Homoisoflavonoid from Liliaceae Exhibits Anti-Neuroinflammatory Activity against LPS-Induced Microglial Cells.

Author

Samsuzzaman M, Subedi L, Hong SM, Lee S, Gaire BP, Ko EJ, Choi JW, Seo SY, and Kim SY

Subjects
Animals, Mice, Cell Line, Isoflavones pharmacology, Isoflavones chemistry, Cytokines metabolism, Nitric Oxide metabolism, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Inflammasomes metabolism, Microglia drug effects, Microglia metabolism, Lipopolysaccharides pharmacology, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry
Abstract

Naturally occurring homoisoflavonoids isolated from some Liliaceae plants have been reported to have diverse biological activities (e.g., antioxidant, anti-inflammatory, and anti-angiogenic effects). The exact mechanism by which homoisoflavonones exert anti-neuroinflammatory effects against activated microglia-induced inflammatory cascades has not been well studied. Here, we aimed to explore the mechanism of homoisoflavonoid SH66 having a potential anti-inflammatory effect in lipopolysaccharide (LPS)-primed BV2 murine microglial cells. Microglia cells were pre-treated with SH66 followed by LPS (100 ng/mL) activation. SH66 treatment attenuated the production of inflammatory mediators, including nitric oxide and proinflammatory cytokines, by down-regulating mitogen-activated protein kinase signaling in LPS-activated microglia. The SH66-mediated inhibition of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome complex and the respective inflammatory biomarker-like active interleukin (IL)-1β were noted to be one of the key pathways of the anti-inflammatory effect. In addition, SH66 increased the neurite length in the N2a neuronal cell and the level of nerve growth factor in the C6 astrocyte cell. Our results demonstrated the anti-neuroinflammatory effect of SH66 against LPS-activated microglia-mediated inflammatory events by down-regulating the NLRP3 inflammasome complex, with respect to its neuroprotective effect. SH66 could be an interesting candidate for further research and development regarding prophylactics and therapeutics for inflammation-mediated neurological complications.

Published
2024
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44. Involvement of beta-lactamase inhibitory protein, BLIP-II, in morphological differentiation of Streptomyces exfoliatus SMF19.

Author

Kim ES, Song JY, Kim DW, Ko EJ, Jensen SE, and Lee KJ

Subjects
Bacterial Proteins genetics, Cell Membrane metabolism, Microscopy, Electron, Microscopy, Fluorescence, Mutation, Spores, Bacterial physiology, Streptomyces genetics, Streptomyces ultrastructure, beta-Lactamases genetics, beta-Lactamases metabolism, Bacterial Proteins metabolism, Streptomyces cytology, Streptomyces metabolism, beta-Lactamase Inhibitors
Abstract

The beta-lactamase inhibitory protein, BLIP-II, found in the culture supernatant of Streptomyces exfoliatus SMF19, shows no discernible sequence identity with other beta-lactamase inhibitory proteins identified in Streptomyces spp. A null mutant of the gene encoding BLIP-II (bliB::hygr) showed a bald appearance on solid media. Although BLIP-II was initially isolated from the supernatant of submerged cultures, sites of BLIP-II accumulation were seen in the cell envelope. The mutation of bliB was also associated with changes in the formation of septa and condensation of the chromosomal DNA associated with sporulation. The bliB mutant exhibited infrequent septa, showing dispersed chromosomal DNA throughout the mycelium, whereas the condensed chromosomes of the wild-type were separated by regularly spaced septa giving the appearance of a string of beads. Therefore, on the basis of these results, it is suggested that BLIP-II is a regulator of morphological differentiation in S. exfoliatus SMF19.

Published
2008

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