Search

A mega-constellation of low-altitude earth orbit (LEO) satellites (SATs) are envisaged to provide a global coverage SAT network in beyond fifth-generation (5G) cellular systems. However, such wide coverage rather makes it difficult to apply existing multiple access protocols, such as random access channel (RACH). To overcome this issue, in this paper, we propose a novel random access solution for LEO SAT networks, called as S-RACH. In contrast to existing standardized protocols, S-RACH is a model-free approach using deep reinforcement learning (DRL). Compared to RACH, we show from various simulations that our proposed S-RACH yields around 2x lower average access delay.

A mega-constellation of low-earth orbit (LEO) satellites has the potential to enable long-range communication with low latency. Integrating this with burgeoning unmanned aerial vehicle (UAV) assisted non-terrestrial networks will be a disruptive solution for beyond 5G systems provisioning large-scale three-dimensional connectivity. In this article, we study the problem of forwarding packets between two faraway ground terminals, through an LEO satellite selected from an orbiting constellation and a mobile high-altitude platform (HAP) such as a fixed-wing UAV. To maximize the end-to-end data rate, the satellite association and HAP location should be optimized, which is challenging due to a huge number of orbiting satellites and the resulting time-varying network topology. We tackle this problem using deep reinforcement learning (DRL) with a novel action dimension reduction technique. Simulation results corroborate that our proposed method achieves up to 5.74x higher average data rate compared to a direct communication baseline without SAT and HAP.

Itch is the cardinal symptom of atopic dermatitis (AD). β-Endorphin, a neuropeptide, is increased in both AD skin and sera. Interleukin (IL)-31, an itch-relevant cytokine, activates IL-31 receptors in keratinocytes. However, how IL-31 and β-endorphin interact in AD skin remains elusive.To investigate the mechanistic interaction of IL-31 and β-endorphin in AD.This was a prospective cross-sectional study. We recruited adult patients with AD and controls according to Hanifin's AD criteria. Serum levels of IL-31 and β-endorphin were measured by enzyme-linked immunosorbent assay. Expressions of IL-31 receptor A (IL-31RA) and β-endorphin in the skin were assessed by immunohistochemistry. Their expression in the skin and blood was compared and correlated in patients with AD and in controls. We also treated primary keratinocytes with IL-31 and measured calcium influx, β-endorphin production and signalling pathways to define their mechanistic interactions.β-Endorphin was increased in the supernatant from IL-31-treated keratinocytes. IL-31 receptor activation resulted in calcium influx and STAT3 activation; pretreatment with STAT3 inhibitor stopped the increase of β-endorphin. Notably, either replacement of extracellular calcium or treatment with 2-aminoethoxydiphenyl borate, an inhibitor for the store-operated channel, blocked STAT3 activation. We found higher levels of blood β-endorphin and IL-31, which were significantly correlated, in patients with AD. Moreover, IL-31RA and β-endorphin were increased and colocalized both in AD human skin and TPA-painted mouse skin.IL-31 receptor activation in keratinocytes induces calcium influx and STAT3-dependent production of β-endorphin. These results might contribute to an understanding of the regulatory mechanisms underlying peripheral itch.