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4 results on '"Ko-Han Chao"'

1. Atezolizumab-induced encephalitis with subdural hemorrhage and subarachnoid hemorrhage in a patient with hepatocellular carcinoma

Author

Ko-Han Chao and Tai-Chung Tseng

Subjects
Atezolizumab, Encephalitis, Hepatocellular carcinoma, Immune checkpoint inhibitors, Medicine (General), R5-920
Abstract

We report the case of a 76-year-old man who was diagnosed with advanced stage hepatocellular carcinoma and was treated with atezolizumab plus bevacizumab therapy. Two weeks after 1st dose, he presented with acute changes in consciousness followed by hypothermia. A cerebrospinal fluid test showed an elevated cell count, total protein, and albumin. Infectious, anatomical, endocrinal, and neoplastic etiologies were ruled out. Based on the findings, atezolizumab-induced encephalitis was suspected, and high dose steroid therapy was administered. The patient's conscious level and hypothermia recovered completely about 9 days after starting the steroids, and he recovered without any neurological sequelae. This case report reminds physicians that prompt administration of steroid treatment after early diagnosis of immune checkpoint inhibitor-related encephalitis is the key for patients to recover without apparent neurological sequelae.

Published
2023
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2. Characteristics of primary signet ring cell carcinoma of colon and rectum: a case control study

Author

Meng-Tzu Weng, Ko-Han Chao, Chien-Chih Tung, Hao-Chun Chang, I-Lun Shih, Been-Ren Lin, Ming-Jium Shieh, Chia-Tung Shun, Jau-Min Wong, and Shu-Chen Wei

Subjects
Colorectal cancer, Primary signet ring cell carcinoma, Young patients, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Primary signet ring cell carcinoma of the colon and rectum (PSRCCR) is rare, usually diagnosed at advanced stage with poor outcomes. We aimed to find possible diagnostic clues in order to help diagnosis. Methods A retrospective study of PSRCCR patients from 1993 to 2018 was reviewed at a single tertiary center. Colorectal adenocarcinoma patients as control group with 1:4 ratio was also enrolled. Results 18 patients with PSRCCR were identified. The prevalence rate was 0.16% (18 of 11,515). The mean age was 50.2 years-old in PSRCCR group and 63 years-old in non-SRCC colorectal cancer patients (p

Published
2022
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3. Aortoenteric fistula: Case series from a tertiary center in Taiwan

Author

Ko‐Han Chao, Chien-Chih Tung, and Yu‐Tse Chiu

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Gastrointestinal disease, business.industry, General surgery, medicine, Aortoenteric fistula, Center (algebra and category theory), General Medicine, medicine.disease, business, Upper gastrointestinal endoscopy, Endoscopy
Published
2020

4. Primary signet ring cell carcinoma of colon and rectum often presents as long segment stenosis in young patients

Author

Jau-Min Wong, Shu Chen Wei, Ko-Han Chao, Meng Tzu Weng, Chia-Tung Shun, Been-Ren Lin, I-Lun Shih, Chien-Chih Tung, Ming-Jium Shieh, and Hao-Chun Chang

Subjects
medicine.medical_specialty, Stenosis, medicine.anatomical_structure, business.industry, Signet ring cell carcinoma, medicine, Rectum, Radiology, medicine.disease, Long segment, business
Abstract

Background: Primary signet ring cell carcinoma of the colon and rectum (PSRCCR) is rare, usually diagnosed at advanced stage with poor outcomes. We aimed to find possible diagnostic clues in order to help diagnosis. Methods: A retrospective study of PSRCCR patients from 1993 to 2018 was reviewed at a single tertiary center. Colorectal adenocarcinoma patients as control group with 1:4 ratio was also enrolled. Results: 18 patients with PSRCCR were identified. The prevalence rate was 0.16% (18 of 11,515). The mean age was 50.2 years-old in PSRCCR group and 63 years-old in non-SRCC colorectal cancer patients ( p < 0.001). Diagnosis tool depends on CFS were much less in PSRCCR group than control group (44.4 % vs 93 %, p < 0.001). SRCC patients had higher level of CEA (68.3 vs 17.7 ng/mL, p =0.004) and lower level of Albumin (3.4 vs 4.3 g/dL, p < 0.001). The majority of PSRCCR tumor configuration was ulcerative and infiltrative. More PSRCCR pathology presented as high-grade carcinoma (66.7 vs 1.4 %, p < 0.001) and lymphovascular invasion (77.8 vs 44.4 %, p = 0.011) than control group. More PSRCCR patients were diagnosed at advanced stage (88.8 vs 40.3 %, p = 0.001). Higher mortality was also noticed in PSRCCR group than control group (72.2 vs 20.8 %, p < 0.001). Conclusion: For young patients with long segment colonic stenosis and ulcerative/ infiltrative mucosa but endoscopic biopsy failed to identify malignant cells, earlier operation or non-colon site biopsy is suggested for diagnosing the PSRCCR.

Published
2020

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