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Your search keyword '"Kobayashi, Yasuhiko"' showing total 613 results
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613 results on '"Kobayashi, Yasuhiko"'

8. A Novel Tuning Method for Neural Oscillators with a Ladder-Like Structure Based on Oscillation Analysis

Author

Hattori, Yuya, Suzuki, Michiyo, Soh, Zu, Kobayashi, Yasuhiko, Tsuji, Toshio, Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Diamantaras, Konstantinos, editor, Duch, Wlodek, editor, and Iliadis, Lazaros S., editor

Published
2010
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9. Computational Inferences on Alteration of Neurotransmission in Chemotaxis Learning in Caenorhabditis elegans

Author

Suzuki, Michiyo, Sakashita, Tetsuya, Tsuji, Toshio, Kobayashi, Yasuhiko, Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Diamantaras, Konstantinos, editor, Duch, Wlodek, editor, and Iliadis, Lazaros S., editor

Published
2010
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22. 食品照射の最前線 〜香辛料や牛レバーへの利用はどうなったのか〜

Author

Kobayashi, Yasuhiko

Abstract

認可された放射線を、定められた条件で食品や農作物に照射して、殺菌・殺虫・芽止めなどの処理を行う技術を食品照射と呼ぶ。実用的には、殺菌などの目的達成に充分な線量以上で、かつ食品の商品特性や嗜好性に悪影響が生じない範囲の適切な線量が照射される。 食品照射は、毒性学的・微生物学的安全性および栄養学的適格性の観点から最もよく検討された食品処理技術であり、意図した技術上の目的を達成するために適正な線量を照射した食品はいかなる線量でも適正な栄養を有し安全に摂取できる（WHO、1997）、安全性に関して喫緊の懸念事項はない（EFSA、2011）とされ、コーデックス国際食品規格（CODEX STAN 106-1983, Rev.1-2003）やISO規格（14470：食品照射 -電離放射線を用いた食品の処理工程の開発、妥当性確認および日常管理における要求事項）などの国際規格が整備されている。 そして、日本以外のすべての先進国で、国際機関の評価をもとに安全性を再評価し、必要に応じて国内の規格・基準を整備し、食品の安全確保と品質向上のために食品照射技術を利用してきた。現在、多くの国でスパイス・ハーブ類や冷凍食肉・魚介類の殺菌、香辛料や乾燥野菜、乾燥食品素材、食肉・魚介類などの微生物制御、熱帯果実や柑橘類の検疫殺虫処理、ニンニクの芽止め処理などが実用化されている。 しかし、日本では、世界に先駆けてCo-60のγ線照射による馬鈴薯（ジャガイモ）の芽止めが実用化されたにもかかわらず、他の食品への放射線照射の適用について慎重な姿勢が続いており、規制の見直しは全く進展していない。なぜ日本では、欧米各国で1980年代から進められてきた「安全性評価」→「技術的必要性・消費者利益・社会受容性の判断」→「法令の整備」という社会的合意形成のプロセスが機能しないのだろうか？

Published
2019

34. Heavy-ion microbeams--development and applications in biological studies

Author

Funayama, Tomoo, Hamada, Nobuyuki, Sakashita, Tetsuya, and Kobayashi, Yasuhiko

Subjects
Ion bombardment -- Methods, Ion bombardment -- Health aspects, Heavy ions -- Properties, Plasma engineering -- Research, Business, Chemistry, Electronics, Electronics and electrical industries
Abstract

High-linear-energy-transfer (LET) heavy charged particle radiation has been used in radiotherapy and radiation breeding because of its greater biological effectiveness compared with low-LET radiation. The health risk assessment for astronauts due to space radiation during interplanetary manned missions is also an important issue concerning the biological effects of heavy-ion radiation. Localized irradiation of specific regions within organisms using heavy-ion microbeam systems provides an attractive means of investigating the mechanism of heavy-ion radiation action. In addition, heavy-ion microbeams can be used as a radio-microsurgical tool for analyzing a broad range of biological phenomena. This paper reviews briefly the current status concerning the development of heavy-ion microbeams for use on living organisms with particular emphasis on its applications in biological studies in eukaryotes including plants, silkworm, nematode, and cultured plant and mammalian cells. Heavy-ion-induced bystander effects and its LET dependency will also be addressed. Index Terms--Biological applications, heavy-ion microbeam, microbeam apparatus.

Published
2008

47. The LexA protein from Deinococcus radiodurans is not involved in RecA induction following gamma irradiation

Author

Narumi, Issay, Satoh, Katsuya, Kikuchi, Masahiro, Funayama, Tomoo, Yanagisawa, Tadashi, Kobayashi, Yasuhiko, Watanabe, Hiroshi, and Yamamoto, Kazuo

Subjects
Protein biosynthesis -- Genetic aspects, Bacterial proteins -- Genetic aspects, Radiogenetics -- Research, Biological sciences
Abstract

Research demonstrates that lexA gene mutant Deinococcus radiodurans exhibits an increased level of RecA protein synthesis upon gamma irradiation, suggesting that LexA is not involved in the RecA induction process.

Published
2001

48. Histone Deacetylase Inhibitors Sensitize Murine B16F10 Melanoma Cells to Carbon Ion Irradiation by Inducing G1 Phase Arrest

Author

Saito, Katsuyo, Funayama, Tomoo, Yokota, Yuuichiro, Takashi, Murakami (埼玉医科大), and Kobayashi, Yasuhiko

Abstract

Epigenetic processes, in addition to genetic abnormalities, play a critical role in refractory malignant diseases and cause the unresponsiveness to various chemotherapeutic regimens and radiotherapy. Herein we demonstrate that histone deacetylase inhibitors (HDACis) can be used to sensitize malignant melanoma B16F10 cells to carbon ion irradiation. The cells were first treated with HDACis (romidepsin [FK228, depsipeptide], trichostatin A [TSA], valproic acid [VPA], and suberanilohydroxamic acid [SAHA, vorinostat]) and were then exposed to two types of radiation (carbon ions and gamma-rays). We found that HDACis enhanced the radiation-induced apoptosis and suppression of clonogenicity that was induced by irradiation, having a greater effect with carbon ion irradiation than with gamma-rays. Carbon ion irradiation and the HDACi treatment induced G2/M and G0/G1 cell cycle arrest, respectively. Thus, it is considered that HDACi treatment enhanced the killing effects of carbon ion irradiation against melanoma cells by inducing the arrest of G1 phase cells, which are sensitive to radiation due to a lack of DNA homologous recombination repair. Based on these findings, we propose that pretreatment with HDACis as radiosensitizers to induce G1 arrest combined with carbon ion irradiation may have clinical efficacy against refractory cancer.

Published
2017

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